Structural and biochemical analysis of a unique phosphatase from Bdellovibrio bacteriovorus reveals its structural and functional relationship with the protein tyrosine phosphatase class of phytase. by Robert J Gruninger, John Thibault, Michael J Capeness, Robert Till, Steven C Mosimann, R Elizabeth Sockett, Brent L Selinger, Andrew L Lovering

“…Bd1204 does not display catalytic activity against some common protein tyrosine phosphatase substrates but is highly specific for hydrolysis of phosphomonoester bonds of inositol hexakisphosphate. …”
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Three New Pigment Protein Tyrosine Phosphatases Inhibitors from the Insect Parasite Fungus Cordyceps gracilioides: Terreusinone A, Pinophilin C and Cryptosporioptide A by Pei-Yao Wei, Lin-Xia Liu, Ting Liu, Chuan Chen, Du-Qiang Luo, Bao-Zhong Shi

Subjects: “…protein tyrosine phosphatases inhibitors…”
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Correction: Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and Is a Minor Regulator of Glucose Homeostasis. by Carl Owen, Alicja Czopek, Abdelali Agouni, Louise Grant, Robert Judson, Emma K. Lees, George D. Mcilroy, Olga Göransson, Andy Welch, Kendra K. Bence, Barbara B. Kahn, Benjamin G. Neel, Nimesh Mody, Mirela Delibegović

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Hepatic protein-tyrosine phosphatase 1B disruption and pharmacological inhibition attenuate ethanol-induced oxidative stress and ameliorate alcoholic liver disease in mice by Ming-Fo Hsu, Shinichiro Koike, Aline Mello, Laura E. Nagy, Fawaz G. Haj

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Allelic Variation in Protein Tyrosine Phosphatase Receptor Type-C in Cattle Influences Erythrocyte, Leukocyte and Humoral Responses to Infestation With the Cattle Tick Rhipicephalus australis by Nicholas N. Jonsson, David K. Cox, Emily K. Piper, Emily F. Mantilla Valdivieso, Constantin Constantinoiu, Louise A. Jackson, Michael J. Stear, Elizabeth M. Ross, Ala E. Tabor

“…The protein tyrosine phosphatase receptor type-C (PTPRC) gene encodes the common leukocyte antigen (CD45) receptor. …”
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Correction: Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and Is a Minor Regulator of Glucose Homeostasis

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Protein Tyrosine Phosphatase N2 Is a Positive Regulator of Lipopolysaccharide Signaling in Raw264.7 Cell through Derepression of Src Tyrosine Kinase. by Huyen Trang Ha Thi, Seo-Won Choi, Young-Mi Kim, Hye-Youn Kim, Suntaek Hong

“…T cell protein tyrosine phosphatase N2 (PTPN2) is a phosphotyrosine-specific nonreceptor phosphatase and is ubiquitously expressed in tissues. …”
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The Protein Tyrosine Phosphatase H1 PTPH1 Supports Proliferation of Keratinocytes and is a Target of the Human Papillomavirus Type 8 E6 Oncogene by Stefanie Taute, Philipp Böhnke, Jasmin Sprissler, Stephanie Buchholz, Martin Hufbauer, Baki Akgül, Gertrud Steger

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Behavioral and neurological analyses of adult mice carrying null and distinct loss-of-receptor function mutations in protein tyrosine phosphatase receptor type Z (PTPRZ). by Naomi Tanga, Kazuya Kuboyama, Ayako Kishimoto, Miho Kihara, Hiroshi Kiyonari, Toshio Watanabe, Akihiro Fujikawa, Masaharu Noda

“…Protein tyrosine phosphatase receptor type Z (PTPRZ) is preferentially expressed in the central nervous system as two transmembrane receptor isoforms PTPRZ-A/B and one secretory isoform PTPRZ-S. …”
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Src homology-2 domain-containing protein tyrosine phosphatase (SHP) 2 and p38 regulate the expression of chemokine CXCL8 in human astrocytes. by Manmeet K Mamik, Anuja Ghorpade

“…In order to determine the signaling pathways involved in CXCL8 regulation in astrocytes, we employed pharmacological inhibitors for non-receptor Src homology-2 domain-containing protein tyrosine phosphatase (SHP) 2 and mitogen-activated protein kinases (MAPK) pathway and observed reduced expression of CXCL8 following IL-1β stimulation. …”
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Fast Screening of Protein Tyrosine Phosphatase 1B Inhibitor from <i>Salvia miltiorrhiza</i> Bge by Cell Display-Based Ligand Fishing by Xiaolin Bai, Wenqin Fan, Yingjie Luo, Yipei Liu, Yongmei Zhang, Xun Liao

“…<i>Salvia miltiorrhiza</i> Bge is a medicinal plant (Chinese name “Danshen”) widely used for the treatment of hyperglycemia in traditional Chinese medicine. Protein tyrosine phosphatase 1B (PTP1B) has been recognized as a potential target for insulin sensitizing for the treatment of diabetes. …”
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Negative regulation of the SH2-homology-containing protein-tyrosine phosphatase-1 (Shp-1) P2 promoter by the HTLV-1 tax oncoprotein by Tao Hong, Murakami Akikazu, Noonan Kristin M, Nakase Koichi, Kydd Andre R, Cheng Jihua, Zhu Quan, Marasco Wayne A

Off-target effects of protein tyrosine phosphatase inhibitors on oncostatin M-treated human epidermal keratinocytes: the phosphatase targeting STAT1 remains unknown by Brian V. Hong, Ji H. Lee, Robert H. Rice

“…Present work explores the possibility that vanadate is a more effective protein tyrosine phosphatase inhibitor in human keratinocytes than previously observed in fibroblasts. …”
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A screen of FDA-approved drugs identifies inhibitors of protein tyrosine phosphatase 4A3 (PTP4A3 or PRL-3) by Dylan R. Rivas, Mark Vincent C. Dela Cerna, Caroline N. Smith, Shilpa Sampathi, Blaine G. Patty, Donghan Lee, Jessica S. Blackburn

“…Abstract Protein tyrosine phosphatase 4A3 (PTP4A3 or PRL-3) is highly expressed in a variety of cancers, where it promotes tumor cell migration and metastasis leading to poor prognosis. …”
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Involvement of protein tyrosine phosphatases BcPtpA and BcPtpB in regulation of vegetative development, virulence and multi-stress tolerance in Botrytis cinerea. by Qianqian Yang, Fangwei Yu, Yanni Yin, Zhonghua Ma

“…In this study, we deleted two putative protein tyrosine phosphatase (PTP) genes (BcPTPA and BcPTPB) in Botrytis cinerea, encoding the orthologs of Saccharomyces cerevisiae Ptp2 and Ptp3, respectively. …”
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Correction: Protein Tyrosine Phosphatase µ (PTP µ or PTPRM), a Negative Regulator of Proliferation and Invasion of Breast Cancer Cells, Is Associated with Disease Prognosis

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Correction: Protein Tyrosine Phosphatase µ (PTP µ or PTPRM), a Negative Regulator of Proliferation and Invasion of Breast Cancer Cells, Is Associated with Disease Prognosis. by Ping-Hui Sun, Lin Ye, Malcolm D. Mason, Wen G. Jiang

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Biochemical, Enzymatic, and Computational Characterization of Recurrent Somatic Mutations of the Human Protein Tyrosine Phosphatase PTP1B in Primary Mediastinal B Cell Lymphoma by Rongxing Liu, Yujie Sun, Jérémy Berthelet, Linh-Chi Bui, Ximing Xu, Mireille Viguier, Jean-Marie Dupret, Frédérique Deshayes, Fernando Rodrigues Lima

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Protein tyrosine phosphatase 1B and insulin resistance: role of endoplasmic reticulum stress/reactive oxygen species/nuclear factor kappa B axis. by Evgeniy Panzhinskiy, Jun Ren, Sreejayan Nair

“…Obesity-induced endoplasmic reticulum (ER) stress has been proposed as an important pathway in the development of insulin resistance. Protein-tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signaling and is tethered to the ER-membrane. …”
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Roux-en-Y Gastric Bypass Improves Hepatic Glucose Metabolism Involving Down-Regulation of Protein Tyrosine Phosphatase 1B in Obese Rats by Song Mu, Jiayu Liu, Wei Guo, Shuping Zhang, Xiaoqiu Xiao, Zhihong Wang, Jun Zhang

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