Determination and Kinetic Characterization of a New Potential Inhibitor for AmsI Protein Tyrosine Phosphatase from the Apple Pathogen <i>Erwinia amylovora</i> by Simone Albani, Ivan Polsinelli, Luca Mazzei, Francesco Musiani, Stefano Benini

“…One of these genes, <i>amsI</i>, encodes for a Low Molecular Weight Protein Tyrosine Phosphatase (LMW-PTP) called <i>Ea</i>AmsI, which plays a key role in the regulation of the EPS production pathway. …”
Get full text

Corrigendum: Chimeric design, synthesis, and biological assays of a new nonpeptide insulin-mimetic vanadium compound to inhibit protein tyrosine phosphatase 1B by Scior T, Guevara-Garcia JA, Melendez FJ, et al

“…Error in author listDr Melendez was incorrectly affiliated in &amp;quot;Chimeric design, synthesis, and biological assays of a new nonpeptide insulinmimetic vanadium compound to inhibit protein tyrosine phosphatase 1B&amp;quot;, published in Drug Design, Development and Therapy.…”
Get full text

A New Paradigm for KIM-PTP Drug Discovery: Identification of Allosteric Sites with Potential for Selective Inhibition Using Virtual Screening and LEI Analysis by James Adams, Benjamin P. Thornton, Lydia Tabernero

Subjects: “…hematopoietic protein tyrosine phosphatase (HePTP)…”
Get full text

Retraction: Protein Tyrosine Phosphatase 1B and Insulin Resistance: Role of Endoplasmic Reticulum Stress/Reactive Oxygen Species/Nuclear Factor Kappa B Axis. by PLOS ONE Editors

Get full text

CX08005, a Protein Tyrosine Phosphatase 1B Inhibitor, Attenuated Hepatic Lipid Accumulation and Microcirculation Dysfunction Associated with Nonalcoholic Fatty Liver Disease by Jiang Li, Xiaolin Zhang, Jinying Tian, Juan Li, Xuechen Li, Song Wu, Yuying Liu, Jingyan Han, Fei Ye

Get full text

Polymorphisms in Protein Tyrosine Phosphatase Non-receptor Type 2 and 22 (PTPN2/22) Are Linked to Hyper-Proliferative T-Cells and Susceptibility to Mycobacteria in Rheumatoid Arthritis by Robert C. Sharp, Shazia A. Beg, Saleh A. Naser

“…We hypothesized earlier that Single Nucleotide Polymorphisms (SNPs) in the negative regulators Protein Tyrosine Phosphatase Non-receptor type 2 and 22 (PTPN2/22) lead to a dysregulated immune response, susceptibility to environmental triggers, and continued apoptosis as seen in chronic inflammation in RA and CD. …”
Get full text

Neuronal protein-tyrosine phosphatase 1B hinders sensory-motor functional recovery and causes affective disorders in two different focal ischemic stroke models by Shelly A Cruz, Zhaohong Qin, Konrad M Ricke, Alexandre F.R. Stewart, Hsiao-Huei Chen

“…Inflammation activates protein-tyrosine phosphatase 1B (PTP1B). Here, we tested the significance of PTP1B activation in glutamatergic projection neurons on functional recovery in two models of stroke: by photothrombosis, focal ischemic lesions were induced in the sensorimotor cortex (SM stroke) or in the peri-prefrontal cortex (peri-PFC stroke). …”
Get full text

Assessment of Antidiabetic Activity of the Shikonin by Allosteric Inhibition of Protein-Tyrosine Phosphatase 1B (PTP1B) Using State of Art: An In Silico and In Vitro Tactics by Mohd Saeed, Ambreen Shoaib, Munazzah Tasleem, Nadiyah M. Alabdallah, Md Jahoor Alam, Zeina El Asmar, Qazi Mohammad Sajid Jamal, Fevzi Bardakci, Saad S. Alqahtani, Irfan Ahmad Ansari, Riadh Badraoui

Subjects: Get full text

Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis by Fatima Amin Adamude, Ikenna Nnamdi Ezeaku, Abraham Ehinomhen Ubhenin, Ifeanyi Peter Onyeka, Ahmad Adamu Ambi, Ikechukwu Robert Uroko, Emeka John Dingwoke

Subjects: Get full text

Water Extract of Mungbean (<i>Vigna radiata</i> L.) Inhibits Protein Tyrosine Phosphatase-1B in Insulin-Resistant HepG2 Cells by Orathai Saeting, Kasemsiri Chandarajoti, Angsuma Phongphisutthinan, Parichat Hongsprabhas, Sudathip Sae-tan

Subjects: Get full text

Inhibition of protein tyrosine phosphatase improves mitochondrial bioenergetics and dynamics, reduces oxidative stress, and enhances adipogenic differentiation potential in metabolically impaired progenitor stem cells by Katarzyna Kornicka-Garbowska, Lynda Bourebaba, Michael Röcken, Krzysztof Marycz

“…Abstract Background Protein tyrosine phosphatase 1B (PTP1B) and low molecular weight protein tyrosine phosphatase (LMPTP) are implicated in the development of metabolic disorders. …”
Get full text

Hepatitis C Virus Core Protein Down-Regulates Expression of Src-Homology 2 Domain Containing Protein Tyrosine Phosphatase by Modulating Promoter DNA Methylation by Priya Devi, Seisuke Ota, Tanel Punga, Anders Bergqvist

“…Stable expression of the C protein specifically reduced Src homology domain 2-containing protein tyrosine phosphatase 1 (SHP-1) mRNA and protein accumulation. …”
Get full text

Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2) by Se Jeong Kwon, Dohee Ahn, Hyun-Mo Yang, Hyo Jin Kang, Sang J. Chung

Subjects: Get full text

Antiobesity and antidiabetes effects of Cyperus rotundus rhizomes presenting protein tyrosine phosphatase, dipeptidyl peptidase 4, metabolic enzymes, stress oxidant and inflammation inhibitory potential by Faiza I.A. Abdella, Amani Toumi, Sarra Boudriga, Tahani Y.A. Alanazi, Asma K. Alshamari, Ahlam Abdulrahman Alrashdi, Khaled Hamden

Get full text

Two homologous putative protein tyrosine phosphatases, OsPFA-DSP2 and AtPFA-DSP4, negatively regulate the pathogen response in transgenic plants. by Hanjie He, Jianbin Su, Shengying Shu, Yang Zhang, Ying Ao, Bing Liu, Dongru Feng, Jinfa Wang, Hongbin Wang

Get full text

Retraction: Protein Tyrosine Phosphatase 1B and Insulin Resistance: Role of Endoplasmic Reticulum Stress/Reactive Oxygen Species/Nuclear Factor Kappa B Axis by The Editors

Get full text

Increased Protein Tyrosine Phosphatase 1B (PTP1B) Activity and Cardiac Insulin Resistance Precede Mitochondrial and Contractile Dysfunction in Pressure‐Overloaded Hearts by T. Dung Nguyen, Michael Schwarzer, Andrea Schrepper, Paulo A. Amorim, Daniel Blum, Claudia Hain, Gloria Faerber, Judith Haendeler, Joachim Altschmied, Torsten Doenst

“…Consistently, we found elevated activity of protein tyrosine phosphatase 1B (PTP1B) at 10 and 20 weeks, which may blunt insulin action by dephosphorylating insulin receptor β. …”
Get full text

Chemical profile and inhibition of α-glycosidase and protein tyrosine phosphatase 1B (PTP1B) activities by flavonoids from licorice (Glycyrrhiza uralensis Fisch) by Zhenghong Guo, Xiuli Niu, Ting Xiao, Jingjing Lu, Wei Li, Yuqing Zhao

Subjects: “…α-glycosidase and protein tyrosine phosphatase 1B (PTP1B) inhibitory activities…”
Get full text

Correction: Involvement of Protein Tyrosine Phosphatases BcPtpA and BcPtpB in Regulation of Vegetative Development, Virulence and Multi-Stress Tolerance in Botrytis cinerea. by Qianqian Yang, Fangwei Yu, Yanni Yin, Zhonghua Ma

Get full text

Conditional Knockout of Src Homology 2 Domain-containing Protein Tyrosine Phosphatase-2 in Myeloid Cells Attenuates Renal Fibrosis after Unilateral Ureter Obstruction by Jing-Fei Teng, Kai Wang, Yao Li, Fa-Jun Qu, Qing Yuan, Xin-Gang Cui, Quan-Xing Wang, Dan-Feng Xu

Subjects: “…Fibrosis; Inflammation; Myeloid Cells; Obstructive Nephropathy; Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-2…”
Get full text