Extrinsic Protein Tyrosine Phosphatase Non-Receptor 22 Signals Contribute to CD8 T Cell Exhaustion and Promote Persistence of Chronic Lymphocytic Choriomeningitis Virus Infection by Tatiana Jofra, Giuseppe Galvani, Mirela Kuka, Roberta Di Fonte, Bechara G. Mfarrej, Matteo Iannacone, Shahram Salek-Ardakani, Manuela Battaglia, Georgia Fousteri

Subjects: “…protein tyrosine phosphatase non-receptor 22…”
Get full text

ASSOCIATION OF CTLA-4 AND PTPN-22 GENES POLYMORPHISMS WITH INCREASED RISK OF AUTOIMMUNE THYROIDITIS IN TATAR POPULATION by E. M. Biktagirova, O. A. Kravtsova, L. I. Sattarova, G. R. Vagapova

Subjects: Get full text

Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae by Maaike Allers, Petra A. Bakker, Jelmer Hoeksma, Herman P. Spaink, Jeroen den Hertog

Subjects: Get full text

Cucurbitane triterpenoids from Momordica charantia L. and their inhibitory activity against α-glucosidase, α-amylase and protein tyrosine phosphatase 1B (PTP1B) by Jiayin Yue, Jing Xu, Jiaqing Cao, Xiaoshu Zhang, Yuqing Zhao

“…Some of the tested isolates showed inhibitory activity against the protein tyrosine phosphatase 1B (PTP1B) and α-amylase, with compound 6 exhibiting the strongest activity against PTP1B. …”
Get full text

Verbascoside Inhibits Glioblastoma Cell Proliferation, Migration and Invasion While Promoting Apoptosis Through Upregulation of Protein Tyrosine Phosphatase SHP-1 and Inhibition of STAT3 Phosphorylation by Wei-Qiang Jia, Zhao-Tao Wang, Ming-Ming Zou, Jian-Hao Lin, Ye-Hai Li, Liang Zhang, Ru-Xiang Xu

Subjects: “…Src homology 2 domain-containing protein tyrosine phosphatase 1…”
Get full text

Insulin Sensitization by a Novel Partial Peroxisome Proliferator-Activated Receptor γ Agonist With Protein Tyrosine Phosphatase 1B Inhibitory Activity in Experimental Osteoporotic Rats by Masahiro Kubo, Masaki Fukui, Yuma Ito, Tatsuya Kitao, Hiroaki Shirahase, Eiichi Hinoi, Yukio Yoneda

“…KY-201, but not rosiglitazone inhibited protein tyrosine phosphatase 1B (PTP1B) and increased phosphorylation of the insulin receptor in HepG2 cells. …”
Get full text

Correction: Inhibition of protein tyrosine phosphatase improves mitochondrial bioenergetics and dynamics, reduces oxidative stress, and enhances adipogenic differentiation potential in metabolically impaired progenitor stem cells by Katarzyna Kornicka-Garbowska, Lynda Bourebaba, Michael Röcken, Krzysztof Marycz

Get full text

Protein Tyrosine Phosphatase SHP-2 Is Positively Involved in Platelet-Derived Growth Factor–Signaling in Vascular Neointima Formation via the Reactive Oxygen Species–Related Pathway by Kyung-Jong Won, Hwan Myung Lee, Chang-Kwon Lee, Hai Yue Lin, Haerang Na, Ki Won Lim, Hui Yul Roh, Seobo Sim, Hyuk Song, Wahn Soo Choi, Seung Hyun Lee, Bokyung Kim

“…The roles of Src homology domain 2–containing protein tyrosine phosphatase 2 (SHP-2) and its signaling in atherosclerosis have not been explored. …”
Get full text

Inhibition of Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase-2 Facilitates CD31hiEndomucinhi Blood Vessel and Bone Formation in Ovariectomized Mice by Hao Yin, Jie Huang, Xu Cao, Zhen-Xing Wang, Jia Cao, Yin Hu, Juan Luo, Yi-Juan Tan, Tuan-Hui Chen, Chun-Yuan Chen, Hui Xie

“…Inhibition of Src homology 2 domain-containing protein tyrosine phosphatase-2 (SHP-2) has been shown to block the fusion of preosteoclasts into mature osteoclasts. …”
Get full text

Anti-Inflammatory and Protein Tyrosine Phosphatase 1B Inhibitory Metabolites from the Antarctic Marine-Derived Fungal Strain <i>Penicillium glabrum</i> SF-7123 by Tran Minh Ha, Dong-Cheol Kim, Jae Hak Sohn, Joung Han Yim, Hyuncheol Oh

Get full text

The Non-Receptor Protein Tyrosine Phosphatase PTPN6 Mediates a Positive Regulatory Approach From the Interferon Regulatory Factor to the JAK/STAT Pathway in Litopenaeus vannamei by Mengting Luo, Xiaopeng Xu, Xiaopeng Xu, Xiaopeng Xu, Xinxin Liu, Wenjie Shen, Linwei Yang, Linwei Yang, Linwei Yang, Zhiming Zhu, Shaoping Weng, Shaoping Weng, Shaoping Weng, Jianguo He, Jianguo He, Jianguo He, Hongliang Zuo, Hongliang Zuo, Hongliang Zuo

Subjects: “…non-receptor protein tyrosine phosphatase…”
Get full text

Computational Methods in Cooperation with Experimental Approaches to Design Protein Tyrosine Phosphatase 1B Inhibitors in Type 2 Diabetes Drug Design: A Review of the Achievements of This Century by Mara Ibeth Campos-Almazán, Alicia Hernández-Campos, Rafael Castillo, Erick Sierra-Campos, Mónica Valdez-Solana, Claudia Avitia-Domínguez, Alfredo Téllez-Valencia

“…Protein tyrosine phosphatase 1B (PTP1B) dephosphorylates phosphotyrosine residues and is an important regulator of several signaling pathways, such as insulin, leptin, and the ErbB signaling network, among others. …”
Get full text

Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation. by Dustin, L, Plas, DR, Wong, J, Hu, Y, Soto, C, Chan, A, Thomas, M

“…The Src-homology domain 2 (SH2)-containing cytoplasmic tyrosine phosphatase, SHP-1 (SH2-containing protein tyrosine phosphatase-1), interacts with several B cell surface and intracellular signal transduction molecules through its SH2 domains. …”

Isolation of Betulinic Acid, its Methyl Ester and Guaiane Sesquiterpenoids with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Roots of Saussurea lappaC.B.Clarke by MinKyun Na, In Hyun Hwang, Seung Ho Lee, Eun Young Bae, Bo Yeon Kim, Jong Seog Ahn, Ji Young Choi

Subjects: “…Protein tyrosine phosphatase 1B…”
Get full text

Anti-obesity and hypolipidemic effects of Rheum undulatum in high-fat diet-fed C57BL/6 mice through protein tyrosine phosphatase 1B inhibition by Woojung Lee, Goo Yoon, Ye Ran Hwang, Yong Kee Kim, Su-Nam Kim

“…Protein tyrosine phosphatase 1B (PTP1B) is important in the regulationof metabolic diseases and has emerged as a promising signalingtarget. …”
Get full text

Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521 by Masayuki Nakano, Kinnosuke Yahiro, Eiki Yamasaki, Hisao Kurazono, Junko Akada, Yoshio Yamaoka, Takuro Niidome, Masanori Hatakeyama, Hidekazu Suzuki, Taro Yamamoto, Joel Moss, Hajime Isomoto, Toshiya Hirayama

“…Silencing of receptor protein tyrosine phosphatase (RPTP)α, a VacA receptor, reduced VacA-induced Src phosphorylation. …”
Get full text

Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis. by Belén Morón, Marianne Spalinger, Stephanie Kasper, Kirstin Atrott, Isabelle Frey-Wagner, Michael Fried, Declan F McCole, Gerhard Rogler, Michael Scharl

“…Spermidine is a dietary polyamine that is able to activate protein tyrosine phosphatase non-receptor type 2 (PTPN2). As PTPN2 is known to be a negative regulator of interferon-gamma (IFN-γ)-induced responses, and IFN-γ stimulation of immune cells is a critical process in the immunopathology of inflammatory bowel disease (IBD), we wished to explore the potential of spermidine for reducing pro-inflammatory effects in vitro and in vivo.Human THP-1 monocytes were treated with IFN-γ and/or spermidine. …”
Get full text

Experimental and Computational Study to Reveal the Potential of Non-Polar Constituents from <i>Hizikia fusiformis</i> as Dual Protein Tyrosine Phosphatase 1B and α-Glucosidase Inhibitors by Su Hui Seong, Duc Hung Nguyen, Aditi Wagle, Mi Hee Woo, Hyun Ah Jung, Jae Sue Choi

“…In our previous study, we observed that the methanol extract of <i>H. fusiformis</i> and its non-polar fractions showed potent protein tyrosine phosphatase 1B (PTP1B) and &#945;-glucosidase inhibition. …”
Get full text

Novel Antioxidants and <i>α</i>-Glycosidase and Protein Tyrosine Phosphatase 1B Inhibitors from an Endophytic Fungus <i>Penicillium brefeldianum</i> F4a by Yan Bai, Ping Yi, Songya Zhang, Jiangchun Hu, Huaqi Pan

Subjects: Get full text

The Discovery of Potent SHP2 Inhibitors with Anti-Proliferative Activity in Breast Cancer Cell Lines by Rose Ghemrawi, Mostafa Khair, Shaima Hasan, Raghad Aldulaymi, Shaikha S. AlNeyadi, Noor Atatreh, Mohammad A. Ghattas

Subjects: Get full text