Oncogenic Tyrosine Phosphatases: Novel Therapeutic Targets for Melanoma Treatment by Elisa Pardella, Erica Pranzini, Angela Leo, Maria Letizia Taddei, Paolo Paoli, Giovanni Raugei

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Discovery of inhibitors of protein tyrosine phosphatase 1B contained in a natural products library from Mexican medicinal plants and fungi using a combination of enzymatic and in silico methods** by Miriam Díaz-Rojas, Martin González-Andrade, Rodrigo Aguayo-Ortiz, Rogelio Rodríguez-Sotres, Araceli Pérez-Vásquez, Abraham Madariaga-Mazón, Rachel Mata

“…This work aimed to discover protein tyrosine phosphatase 1B (PTP1B) inhibitors from a small molecule library of natural products (NPs) derived from selected Mexican medicinal plants and fungi to find new hits for developing antidiabetic drugs. …”
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Genotype-Phenotype Associations of the CD-Associated Single Nucleotide Polymorphism within the Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 22 in Patients of the Swiss IBD Cohort. by Marianne R Spalinger, Jonas Zeitz, Luc Biedermann, Jean-Benoit Rossel, Michael C Sulz, Pascal Frei, Sylvie Scharl, Stephan R Vavricka, Michael Fried, Gerhard Rogler, Michael Scharl, Swiss IBD Cohort Study Group

“…BACKGROUND:Protein tyrosine phosphatase non-receptor type 22 (PTPN22) plays an important role in immune cell function and intestinal homeostasis. …”
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Cisplatin causes covalent inhibition of protein-tyrosine phosphatase 1B (PTP1B) through reaction with its active site cysteine: Molecular, cellular and in vivo mice studies by Rongxing Liu, Wenchao Zhang, Panhong Gou, Jérémy Berthelet, Qing Nian, Guillaume Chevreux, Véronique Legros, Gautier Moroy, Linh-Chi Bui, Li Wang, Jean-Marie Dupret, Frédérique Deshayes, Fernando Rodrigues Lima

Subjects: “…Protein tyrosine phosphatase 1B…”
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Overexpression of Protein Tyrosine Phosphatase 1B in HepG2 Cells Ameliorates Insulin-mediated Suppression of Apolipoprotein B mRNA Translation Via Its Untranslated Regions by Gus Sidiropoulos, Rita Kohen Avramoglu, Wei Qiu, Parvin Pasalar, Khosrow Adeli

Subjects: “…Protein tyrosine phosphatase 1B…”
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In Search for Multi-Target Ligands as Potential Agents for Diabetes Mellitus and Its Complications—A Structure-Activity Relationship Study on Inhibitors of Aldose Reductase and Protein Tyrosine Phosphatase 1B by Rosaria Ottanà, Paolo Paoli, Mario Cappiello, Trung Ngoc Nguyen, Ilenia Adornato, Antonella Del Corso, Massimo Genovese, Ilaria Nesi, Roberta Moschini, Alexandra Naß, Gerhard Wolber, Rosanna Maccari

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Overexpression of Protein Tyrosine Phosphatase 1B in HepG2 Cells Ameliorates Insulin-mediated Suppression of Apolipoprotein B mRNA Translation Via Its Untranslated Regions by Parvin Pasalar, Wei Qiu, Rita Kohen Avramoglu, Gus Sidiropoulos, Khosrow Adeli

Subjects: “…Protein tyrosine phosphatase 1B…”
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Deletion of Protein Tyrosine Phosphatase 1B (PTP1B) Enhances Endothelial Cyclooxygenase 2 Expression and Protects Mice from Type 1 Diabetes-Induced Endothelial Dysfunction. by David J Herren, J Blake Norman, Ruchi Anderson, Michel L Tremblay, Anne-Cecile Huby, Eric J Belin de Chantemèle

“…Protein tyrosine phosphatase 1B (PTP1B) dephosphorylates receptors tyrosine kinase and acts as a molecular brake on insulin signaling pathway. …”
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Statement of Retraction: Protein tyrosine phosphatase receptor type Z1 inhibits the cisplatin resistance of ovarian cancer by regulating PI3K/AKT/mTOR signal pathway

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Insulin–Mimetic Dihydroxanthyletin-Type Coumarins from <i>Angelica decursiva</i> with Protein Tyrosine Phosphatase 1B and α-Glucosidase Inhibitory Activities and Docking Studies of Their Molecular Mechanisms by Md Yousof Ali, Susoma Jannat, Hyun Ah Jung, Jae Sue Choi

“…The goal of this study was to evaluate the potential of four natural major dihydroxanthyletin-type coumarins—(+)-<i>trans</i>-decursidinol, Pd-C-I, Pd-C-II, and Pd-C-III—to inhibit the enzymes, protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase. In the kinetic study of the PTP1B enzyme’s inhibition, we found that (+)-<i>trans</i>-decursidinol, Pd-C-I, and Pd-C-II led to competitive inhibition, while Pd-C-III displayed mixed-type inhibition. …”
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Receptor-Type Protein-Tyrosine Phosphatase ζ and Colony Stimulating Factor-1 Receptor in the Intestine: Cellular Expression and Cytokine- and Chemokine Responses by Interleukin-34 and Colony Stimulating Factor-1. by Stephanie Zwicker, Daniela Bureik, Madeleen Bosma, Gisele Lago Martinez, Sven Almer, Elisabeth A Boström

“…Receptor-type protein-tyrosine phosphatase ζ (PTPRZ1, RPTP-ζ), an additional IL-34 receptor, was recently identified. …”
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Regulation of platelet-activating factor-mediated interleukin-6 promoter activation by the 48 kDa but not the 45 kDa isoform of protein tyrosine phosphatase non-receptor type 2 by Geneviève Hamel-Côté, Fanny Lapointe, Steeve Véronneau, Marian Mayhue, Marek Rola-Pleszczynski, Jana Stankova

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PTPRK suppresses progression and chemo‐resistance of colon cancer cells via direct inhibition of pro‐oncogenic CD133 by Masashi Matsushita, Yusuke Mori, Kyosuke Uchiumi, Takehiro Ogata, Mizuyo Nakamura, Hiroyuki Yoda, Hiroaki Soda, Nobuhiro Takiguchi, Yoshihiro Nabeya, Osamu Shimozato, Toshinori Ozaki

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PTPRO Promotes Oxidized Low-Density Lipoprotein Induced Oxidative Stress and Cell Apoptosis through Toll-Like Receptor 4/Nuclear Factor κB Pathway by Caihong Liang, Xiaochen Wang, Jianping Hu, Xiaoqing Lian, Tiantian Zhu, Hui Zhang, Ning Gu, Jun Li

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Detection of Tumor-Specific PTPmu in Gynecological Cancer and Patient Derived Xenografts by Jason Vincent, Sonya E. L. Craig, Mette L. Johansen, Jyosthna Narla, Stefanie Avril, Analisa DiFeo, Susann M. Brady-Kalnay

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Ficus deltoidea extract down-regulates protein tyrosine phosphatase 1B expression in a rat model of type 2 diabetes mellitus: a new insight into its antidiabetic mechanism by Rehab F. Abdel-Rahman, Shahira M. Ezzat, Hanan A. Ogaly, Reham M. Abd-Elsalam, Alyaa F. Hessin, Mostafa I. Fekry, Dina F. Mansour, Shanaz O. Mohamed

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High prevalence of protein tyrosine phosphatase non-receptor N22 gene functional variant R620W in systemic lupus erythematosus patients from Kuwait: implications for disease susceptibility by Adel M. Al-Awadhi, Mohammad Z. Haider, Jalaja Sukumaran, Sowmya Balakrishnan

Subjects: “…Protein tyrosine phosphatase non receptor-22…”
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Association of protein tyrosine phosphatase non-receptor type 22 gene functional variant C1858T, HLA-DQ/DR genotypes and autoantibodies with susceptibility to type-1 diabetes mellitus in Kuwaiti Arabs. by Mohammad Z Haider, Majedah A Rasoul, Maria Al-Mahdi, Hessa Al-Kandari, Gursev S Dhaunsi

“…We have determined the prevalence of protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene functional variant (C1858T; R620W, rs2476601), HLA-DQ and DR alleles and three autoantibodies in Kuwaiti children with T1DM to evaluate their impact on genetic predisposition of the disease. …”
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Protein Tyrosine Phosphatase Non-Receptor 11 (<i>PTPN11</i>/Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC) by Cathy E. Richards, Yasir Y. Elamin, Aoife Carr, Kathy Gately, Shereen Rafee, Mattia Cremona, Emer Hanrahan, Robert Smyth, Daniel Ryan, Ross K. Morgan, Susan Kennedy, Lance Hudson, Joanna Fay, Kenneth O’Byrne, Bryan T. Hennessy, Sinead Toomey

“…<i>PTPN11</i> encodes the SHP2 protein tyrosine phosphatase that activates the mitogen-activated protein kinase (MAPK) pathway upstream of <i>KRAS</i> and MEK. …”
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Quantitative Tyrosine Phosphoproteome Profiling of AXL Receptor Tyrosine Kinase Signaling Network by Xinyan Wu, Li Wang, Nicole A. Pearson, Santosh Renuse, Ran Cheng, Ye Liang, Dong-Gi Mun, Anil K. Madugundu, Yaoyu Xu, Parkash S. Gill, Akhilesh Pandey

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