The Ursolic Acid-Rich Extract of <i>Dracocephalum heterophyllum</i> Benth. with Potent Antidiabetic and Cytotoxic Activities by Sodik Numonov, Farukh Sharopov, Muhammad Nasimullah Qureshi, Latofat Gaforzoda, Isomiddin Gulmurodov, Qosimjon Khalilov, William N Setzer, Maidina Habasi, Haji Akber Aisa

“…The antidiabetic effect, as measured by inhibition of protein-tyrosine phosphatase (PTP-1B), of the purified fraction of triterpenoids of <i>D. heterophyllum</i> increased by five-fold against the enzyme. …”
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Anti-diabetic effect of anthocyanin cyanidin-3-O-glucoside: data from insulin resistant hepatocyte and diabetic mouse by Xiang Ye, Wen Chen, Xu-Fan Huang, Fu-Jie Yan, Shui-Guang Deng, Xiao-Dong Zheng, Peng-Fei Shan

“…Subsequently, the expression of key proteins involved in IR was detected by western blotting analysis. Protein tyrosine phosphatase-1B (PTP1B), a negative regulator of insulin signaling, could reduce cellular sensitivity to insulin by inhibiting the phosphorylation of insulin receptor substrate-2 (IRS-2). …”
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Clinical Variability in a Family with Noonan Syndrome with a Homozygous PTPN11 Gene Variant in Two Individuals by Ruken Yıldırım, Edip Ünal, Şervan Özalkak, Akçahan Akalın, Ayça Aykut, Nevzat Yılmaz

“…In approximately 50% of patients, NS is caused by variants in the Protein Tyrosine Phosphatase Non-Receptor Type 11 (PTPN11) gene. …”
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SHP2 Inhibitors Show Anti-Myeloma Activity and Synergize With Bortezomib in the Treatment of Multiple Myeloma by Pan Zhou, Mengyu Xiao, Weiya Li, Xiaobai Sun, Yanliang Bai, Feiying Meng, Zunmin Zhu, Weiping Yuan, Kai Sun

“…Multiple myeloma (MM) is a plasma cell malignancy that remains incurable. The protein tyrosine phosphatase SHP2 is a central node regulating RAS/mitogen-activated protein kinase (MAPK)/extracellular signal regulated kinase (ERK) signaling pathway which plays a crucial role in the pathogenesis and proteasome inhibitor (PI) resistance of MM. …”
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Mulberry Leaf Compounds and Gut Microbiota in Alzheimer’s Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays by Xue Bai, Xinyi Zhao, Kaifeng Liu, Xiaotang Yang, Qizheng He, Yilin Gao, Wannan Li, Weiwei Han

“…In addition, we identified protein tyrosine phosphatase 1B (PTP1B) as a key target for kaempferol in these two diseases. …”
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R-PTP-κ Inhibits Contact-Dependent Cell Growth by Suppressing E2F Activity by Hyun Ahm Sohn, Minho Kang, Hyunjung Ha, Young Il Yeom, Kyung Chan Park, Dong Chul Lee

“…Here, we report that receptor-type protein tyrosine phosphatase-kappa (R-PTP-κ) is an important regulator of cell contact-dependent growth inhibition. …”
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Aberrant Cortical Layer Development of Brain Organoids Derived from Noonan Syndrome-iPSCs by Bumsoo Kim, Yongjun Koh, Hyunsu Do, Younghee Ju, Jong Bin Choi, Gahyang Cho, Han-Wook Yoo, Beom Hee Lee, Jinju Han, Jong-Eun Park, Yong-Mahn Han

“…Noonan syndrome (NS) is a genetic disorder mainly caused by gain-of-function mutations in Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2). Although diverse neurological manifestations are commonly diagnosed in NS patients, the mechanisms as to how SHP2 mutations induce the neurodevelopmental defects associated with NS remain elusive. …”
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Gsα deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling by Min Chen, Eric A. Wilson, Zhenzhong Cui, Hui Sun, Yogendra B. Shrestha, Brandon Podyma, Christina H. Le, Benedetta Naglieri, Karel Pacak, Oksana Gavrilova, Lee S. Weinstein

“…Instead, DMHGsKO mice had impaired leptin signaling along with increased expression of the leptin signaling inhibitor protein tyrosine phosphatase 1B in the DMH, which likely contributes to the observed hyperphagia and reductions in energy expenditure, locomotor activity, and cold-induced thermogenesis. …”
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Examining the levels of acetylation, DNA methylation and phosphorylation in HIV-1 positive and multidrug-resistant TB-HIV patients by Musa Marimani, Aijaz Ahmad, Sarah Stacey, Adriano Duse

“…By contrast, histone acetyltransferase (HAT), histone deacetylase (HDAC), protein tyrosine kinase (PtkA) and protein tyrosine phosphatase (PtpA) mRNA expression levels were substantially enhanced in HIV-1 infected and were lowest in healthy individuals. …”
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Therapeutic Mechanisms of Herbal Medicines Against Insulin Resistance: A Review by Jun Li, Jun Li, Litao Bai, Fan Wei, Jing Zhao, Danwei Wang, Yao Xiao, Weitian Yan, Junping Wei

“…The targets involved in these studies include insulin receptor substrate, phosphatidylinositol 3-kinase, glucose transporter, AMP-activated protein kinase, glycogen synthase kinase 3, mitogen-activated protein kinases, c-Jun-N-terminal kinase, nuclear factor-kappaB, protein tyrosine phosphatase 1B, nuclear factor-E2-related factor 2, and peroxisome proliferator-activated receptors. …”
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MmuPV1 E7's interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease. by James C Romero-Masters, Miranda Grace, Denis Lee, Joshua Lei, Melanie DePamphilis, Darya Buehler, Rong Hu, Ella Ward-Shaw, Simon Blaine-Sauer, Nathalie Lavoie, Elizabeth A White, Karl Munger, Paul F Lambert

“…We previously identified Protein Tyrosine Phosphatase Non-Receptor Type 14 (PTPN14), a tumor suppressor targeted by HPV E7 proteins, as a putative cellular target of MmuPV1 E7. …”
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Isolation, Identification, and Biotransformation of Teadenol A from Solid State Fermentation of Pu-erh Tea and In Vitro Antioxidant Activity by Xiao-qin Su, Gao-ju Zhang, Yan Ma, Mao Chen, Sheng-hu Chen, Shuang-mei Duan, Jin-qiong Wan, Fumio Hashimoto, Hai-peng Lv, Jia-hua Li, Zhi Lin, Ming Zhao

“…Teadenol A promoted the secretion of adiponectin and inhibited the expression of protein tyrosine phosphatase-1B. Antioxidant assays (e.g., 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity, total antioxidant capacity (T-AOC), hydrogen donating ability, and superoxide anion radical scavenging capacity) revealed that Teadenol A has antioxidant properties. …”
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The Metabolic Impact of Vitamin B12 in The Context of Metabolic Syndrome by Fatma El-Zahraa Mohamed, Hanan M.A. El-Taweel, Reham H. Alattar, Tarek Khamis, Abdel-Aziz F. Abdel-Aziz, Khalifa El-Dawy

“…On the other hand, there was a significant downregulation in the mRNA expression of Janus kinase3 (JAK3), signal transducer and activator of transcription3 (STAT3), Transforming growth factor–β (TGF-β), and protein tyrosine phosphatase 1B (PTPN1). In conclusion our findings suggested that vitamin B12 supplementation can mitigate the Impact of an STZ in diabetic rats. …”
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Soluble SIRP-Alpha Promotes Murine Acute Lung Injury Through Suppressing Macrophage Phagocytosis by Qinjun Shen, Li Zhao, Linyue Pan, Dandan Li, Gang Chen, Zhihong Chen, Zhilong Jiang

“…In addition, lack of SIRP-alpha reduced activation of Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP-1) and improved activation of signal transducer and activator of transcription-3 (STAT3) and STAT6. …”
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Identification of potential crucial genes and therapeutic targets for epilepsy by Shitao Wang, Zhenrong Xie, Tian Jun, Xuelu Ma, Mengen Zhang, Feng Rao, Hui Xu, Jinghong Lu, Xiangqian Ding, Zongyou Li

“…Results The study found that the protein tyrosine phosphatase receptor-type O gene (PTPRO) and the growth arrest and DNA damage inducible alpha gene (GADD45A) were significantly upregulated in epileptic rats compared to controls in both datasets. …”
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Manassantin A and B From Saururus chinensis Inhibit Interleukin-6–Induced Signal Transducer and Activator of Transcription 3 Activation in Hep3B Cells by Jong Sun Chang, Seung Woong Lee, Myo Sun Kim, Bo Ra Yun, Mi Hye Park, Seok-Geun Lee, Su-Jin Park, Woo Song Lee, Mun-Chual Rho

“…In addition, we found that Stat3 inhibitory effects of these compounds could be related to protein tyrosine phosphatase. These findings suggest that manassantin A and B could be useful remedies for treatment of inflammatory diseases by inhibiting IL-6 action. …”
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Hypoglycemic effect and mechanism of honokiol on type 2 diabetic mice by Sun J, Fu X, Liu Y, Wang Y, Huo B, Guo Y, Gao X, Li W, Hu X

“…The inhibitory potencies of honokiol on the protein tyrosine phosphatase 1B (PTP1B) activity were performed in reaction buffer. …”
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Unveiling the potential of marine-derived diterpenes from the order Alcyonacea as promising anti-obesity agents by Mohamed A. Tammam, Omnia Aly, Florbela Pereira, Aldoushy Mahdy, Amr El-Demerdash

“…In our pursuit of identifying natural alternatives for the development of effective and safe anti-obesity medications, we examined the potential of the methanolic extract of the Red Sea derived soft coral Sarcophyton glaucum, where serum levels of glucose, insulin, HOMA-IR, lipid profile, fetuin A and B, PTP1Β (Protein tyrosine phosphatase 1B), adropin and omentin were determined. …”
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GC‐MS, alpha‐amylase, and alpha‐glucosidase inhibition and molecular docking analysis of selected phytoconstituents of small wild date palm fruit (Phoenix pusilla) by Kumaraswamy Srinivasan, Ammar B. Altemimi, Radhakrishnan Narayanaswamy, Prabhakaran Vasantha Srinivasan, Mazin A. A. Najm, Nasser Mahna

“…The GC‐MS analysis showed the presence of 25 phytoconstituents from PPRF which was further assessed on the docking behavior of five targeted enzymes diabetes mellitus (DM) namely (i) human aldose reductase, (ii) protein tyrosine phosphatase 1B, (iii) pancreatic alpha‐amylase, (iv) peroxisome proliferator‐activated receptor gamma, and (v) dipeptidyl peptidase IV by using the AutoDock Vina method. …”
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LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection by Yuantao Li, Jingjing Guo, Haixia Zhang, Zhidan Li, Yushan Ren, Yuzhu Jiang, Xianbing Liu, Xuemei Hu

“…The levels of the main functional molecules (arginase-1 [Arg-1], interleukin-10 [IL-10]) and main signaling molecules (phosphorylated Src-homology 2 domain-containing protein tyrosine phosphatase [p-SHP2], phosphorylated signal transducer and activator of transcription 6 [p-STAT6]) in dMDSCs were all significantly reduced in human and mouse dMDSCs due to the decrease of LILRB4 expression induced by T. gondii infection. …”
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