Novel Potential Therapeutic Targets of PTPN Families for Lung Cancer by Chin-Chou Wang, Wan-Jou Shen, Gangga Anuraga, Hoang Dang Khoa Ta, Do Thi Minh Xuan, Sih-Tong Chen, Chiu-Fan Shen, Jia-Zhen Jiang, Zhengda Sun, Chih-Yang Wang, Wei-Jan Wang

“…Here, we used two different comprehensive bioinformatics analysis and revealed protein tyrosine phosphatase non-receptor type (PTPN) family genes, especially PTPN1 and PTPN22, were downregulated in lung cancer tissue in comparison with normal samples. …”
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Association of PTPN22 SNP1858 (rs2476601) and Gene SNP1123 (rs2488457) Polymorphism With Primary Immune Thrombocytopenia Susceptibility: A Meta-Analysis of Case-Control Studies and... by Haokun Tian, Weikai Xu, Lequan Wen, Lirui Tang, Xinyuan Zhang, Tiangang Song, Changsen Yang, Peng Huang, Peng Huang

“…Objective: Systematic review of the association of protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene 1858 and 1123 sites single nucleotide polymorphism (SNP) with the susceptibility of primary immune thrombocytopenia (ITP).Method: Database searched includes PubMed, Embase, Web of Science, CNKI, CBM, VIP and WanFang Data. …”
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The CREB/KMT5A complex regulates PTP1B to modulate high glucose-induced endothelial inflammatory factor levels in diabetic nephropathy by Ting Huang, Xue Li, Fei Wang, Lihong Lu, Wenting Hou, Minmin Zhu, Changhong Miao

“…The overproduction of various inflammatory factors is involved in the pathogenesis of DN. Protein tyrosine phosphatase 1B (PTP1B) modulates the expression of a series of cytokines and nuclear factor kappa B (NF-κB) activity. cAMP response element-binding protein (CREB) and lysine methyltransferase 5A (KMT5A) have been reported to participate in the maintenance of a healthy endothelium. …”
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Estrogen Decreases Cytoskeletal Organization by Forming an ERα/SHP2/c-Src Complex in Osteoclasts to Protect against Ovariectomy-Induced Bone Loss in Mice by Hyun-Jung Park, Malihatosadat Gholam-Zadeh, Sun-Young Yoon, Jae-Hee Suh, Hye-Seon Choi

“…E₂ exposure decreased physical interactions between NADPH oxidase 1 (NOX1) and the oxidized form of c-Src homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2), leading to higher levels of reduced SHP2. …”
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Pseudophosphatase STYX is induced by Helicobacter pylori and promotes gastric cancer progression by inhibiting FBXO31 function by Jiansong Liu, Yichen Zang, Cunying Ma, Dandan Wang, Zhuangfei Tian, Xia Xu, Wenjuan Li, Jihui Jia, Zhifang Liu

“…The catalytically inactive pseudophosphatase STYX (serine/threonine/tyrosine interacting protein) is a member of the protein tyrosine phosphatase family. It has been recently reported that STYX functions as a potential oncogene in different types of cancers. …”
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PTPN4 germline variants result in aberrant neurodevelopment and growth by Joanna J. Chmielewska, Deepika Burkardt, Jorge Luis Granadillo, Rachel Slaugh, Shamile Morgan, Joshua Rotenberg, Boris Keren, Cyril Mignot, Luis Escobar, Peter Turnpenny, Melissa Zuteck, Laurie H. Seaver, Rafal Ploski, Magdalena Dziembowska, Anthony Wynshaw-Boris, Abidemi Adegbola

“…Summary: Protein-tyrosine phosphatases (PTPs) are pleomorphic regulators of eukaryotic cellular responses to extracellular signals that function by modulating the phosphotyrosine of specific proteins. …”
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Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling by Vidyasiri Vemulapalli, Lily A Chylek, Alison Erickson, Anamarija Pfeiffer, Khal-Hentz Gabriel, Jonathan LaRochelle, Kartik Subramanian, Ruili Cao, Kimberley Stegmaier, Morvarid Mohseni, Matthew J LaMarche, Michael G Acker, Peter K Sorger, Steven P Gygi, Stephen C Blacklow

“…SHP2 is a protein tyrosine phosphatase that normally potentiates intracellular signaling by growth factors, antigen receptors, and some cytokines, yet is frequently mutated in human cancer. …”
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THY1 (CD90) Maintains the Adherens Junctions in Nasopharyngeal Carcinoma via Inhibition of SRC Activation by Luo Chen, Wai Yin Chau, Hei Tung Yuen, Xiao Han Liu, Robert Zhong Qi, Maria Li Lung, Hong Lok Lung

“…Through proteomic analysis, we identified that platelet-derived growth factor receptor β (PDGF-Rβ) and protein tyrosine phosphatase nonreceptor type 22 (PTPN22) are novel and potential binding partners of THY1, which were subsequently verified by co-immunoprecipitation (co-IP) analysis. …”
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PTPN14 promotes gastric cancer progression by PI3KA/AKT/mTOR pathway by Hui Li, Bingxin Guan, Sen Liu, Haiting Liu, Lin Song, Guohao Zhang, Ruinan Zhao, Chengjun Zhou, Peng Gao

“…New strategies for treating gastric cancer need to be further explored. Protein tyrosine phosphatases play vital roles in cancer. A growing stream of studies shows that strategies or inhibitors targeting protein tyrosine phosphatases have been developed. …”
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The prevalence of newly diagnosed autoimmune diseases among patients with Graves’ disease and autoimmune polyglandular syndrome of adults by E. A. Troshina, A. A. Larina, M. S. Sheremeta, N. M. Malisheva

“…Materials and methods.Sera of 94 patients with Gravess disease, 116 patients with APS 24 types and 80 healthy subjects were screened for 21-OH Ab, insulin-Ab (IAA), Islet Cell-Ab (ICA), glutamic acid decarboxylase-Ab (GADA), protein tyrosine phosphatase-Ab (IA2), Zinc Transporter 8-Ab (ZnT8), Anti-gliadin-Ab (IgA+IgG) (AGA), Anti-transglutaminase-Ab (IgA+IgG) (Anti-tTG), Anti-parietal cell-Ab (APCA), Intrinsic Factor-Ab (IF), Rheumatoid factor (RF), Anti Ovarian Antibodies (AOA). …”
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PTPN22 association in systemic lupus erythematosus (SLE) with respect to individual ancestry and clinical sub-phenotypes. by Bahram Namjou, Xana Kim-Howard, Celi Sun, Adam Adler, Sharon A Chung, Kenneth M Kaufman, Jennifer A Kelly, Stuart B Glenn, Joel M Guthridge, Robert H Scofield, Robert P Kimberly, Elizabeth E Brown, Graciela S Alarcón, Jeffrey C Edberg, Jae-Hoon Kim, Jiyoung Choi, Rosalind Ramsey-Goldman, Michelle A Petri, John D Reveille, Luis M Vilá, Susan A Boackle, Barry I Freedman, Betty P Tsao, Carl D Langefeld, Timothy J Vyse, Chaim O Jacob, Bernardo Pons-Estel, Argentine Collaborative Group, Timothy B Niewold, Kathy L Moser Sivils, Joan T Merrill, Juan-Manuel Anaya, Gary S Gilkeson, Patrick M Gaffney, Sang-Cheol Bae, Marta E Alarcón-Riquelme, BIOLUPUS and GENLES Networks, John B Harley, Lindsey A Criswell, Judith A James, Swapan K Nath

“…Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a negative regulator of T-cell activation associated with several autoimmune diseases, including systemic lupus erythematosus (SLE). …”
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Tyrosine phosphatase PTPN11/SHP2 in solid tumors - bull’s eye for targeted therapy? by Xun Chen, Xun Chen, Steffen Johannes Keller, Philipp Hafner, Asma Y. Alrawashdeh, Thomas Yul Avery, Johana Norona, Johana Norona, Jinxue Zhou, Dietrich Alexander Ruess, Dietrich Alexander Ruess

“…In the context of the present landscape of clinical trials with allosteric SHP2-inhibitors we discuss the multitude of opportunities but also limitations of a strategy targeting this non-receptor protein tyrosine phosphatase for treatment of solid tumors.…”
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Parkes Weber Syndrome: Contribution of the Genotype to the Diagnosis by Themis-Areti A. Andreoti, Aleksandra Tuleja, Yvonne Döring, Massimo Maiolo, André Schaller, Erik Vassella, Christiane Zweier, Laurence M. Boon, Miikka Vikkula, Jochen Rössler, Sarah M. Bernhard, Iris Baumgartner

“…Three patients were reclassified as nonsyndromic AVM (Kristen Rat Sarcoma Viral oncogene homolog [KRAS], KRAS+tumor protein p53, and protein tyrosine phosphatase non-receptor type 11). Finally, 7 patients fulfilled all clinical diagnostic criteria of PWS. …”
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Angiogenic Endothelial Cell Signaling in Cardiac Hypertrophy and Heart Failure by Rajinikanth Gogiraju, Rajinikanth Gogiraju, Rajinikanth Gogiraju, Rajinikanth Gogiraju, Magdalena L. Bochenek, Magdalena L. Bochenek, Magdalena L. Bochenek, Katrin Schäfer, Katrin Schäfer, Katrin Schäfer, Katrin Schäfer

“…In this regard, we will particularly highlight findings on negative regulators of angiogenesis, including protein tyrosine phosphatase-1B and tumor suppressor p53, and how they link signaling involved in cell growth and metabolic control to cardiac angiogenesis. …”
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Comprehensive circular RNA expression profile in radiation-treated HeLa cells and analysis of radioresistance-related circRNAs by Duo Yu, Yunfeng Li, Zhihui Ming, Hongyong Wang, Zhuo Dong, Ling Qiu, Tiejun Wang

“…The identified CC terms were cell–cell adherens junction, nucleoplasm and cytosol, and the identified MF terms were protein binding and protein tyrosine phosphatase activity. The top five KEGG pathways were MAPK signaling pathway, endocytosis, axon guidance, neurotrophin signaling pathway, and SNARE interactions in vesicular transport. …”
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PTPN11 (SHP2) Is Indispensable for Growth Factors and Cytokine Signal Transduction During Bovine Oocyte Maturation and Blastocyst Development by Muhammad Idrees, Lianguang Xu, Seok-Hwan Song, Myeong-Don Joo, Kyeong-Lim Lee, Tahir Muhammad, Marwa El Sheikh, Tabinda Sidrat, Il-Keun Kong

“…<i>PTPN11</i> (Protein Tyrosine Phosphatase, non-receptor type 11) encoding protein SHP2, a positive transducer of RTKs (Receptor Tyrosine Kinases) and cytokine receptors, can play a significant role in bovine oocyte maturation and embryo development, but this phenomenon has not yet been explored. …”
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Comprehensive analysis of PTPN gene family revealing PTPN7 as a novel biomarker for immuno-hot tumors in breast cancer by Fengxu Wang, Xuehai Wang, Lei Liu, Siyuan Deng, Wenqian Ji, Yang Liu, Xiangdong Wang, Rui Wang, Xinyuan Zhao, Erli Gao

“…Background: The non-receptor protein tyrosine phosphatase (PTPN) gene family has been considered to be involved in the oncogenesis and development of multiple cancers. …”
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New Thiodiketopiperazine and 3,4-Dihydroisocoumarin Derivatives from the Marine-Derived Fungus <i>Aspergillus terreus</i> by Jing-Shuai Wu, Xiao-Hui Shi, Guang-Shan Yao, Chang-Lun Shao, Xiu-Mei Fu, Xiu-Li Zhang, Hua-Shi Guan, Chang-Yun Wang

“…In addition, compound <b>3</b> exhibited an inhibitory effect on protein tyrosine phosphatase 1 B (PTP1B), an important hypoglycemic target, with an inhibitory concentration (IC)₅₀ value of 12.25 &#956;M.…”
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Endothelial barrier dysfunction in systemic inflammation is mediated by soluble VE-cadherin interfering VE-PTP signaling by Juna-Lisa Knop, Natalie Burkard, Mahshid Danesh, Sebastian Kintrup, Thomas Dandekar, Mugdha Srivastava, Rebecca Springer, Matthias Hiermaier, Nana-Maria Wagner, Jens Waschke, Sven Flemming, Nicolas Schlegel

“…Newly generated recombinant human sVE-cadherin (extracellular domains EC1-5) induced loss of endothelial barrier function in both human microvascular endothelial cells in vitro and in rat mesenteric microvessels in vivo and reduced microcirculatory flow. sVE-cadherinEC1-5 disturbed VE-cadherin-mediated adhesion and perturbed VE-protein tyrosine phosphatase (VE-PTP)/VE-cadherin interaction resulting in RhoGEF1-mediated RhoA activation. …”
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miR-141 mediates recovery from acute kidney injury by Lucy J. Newbury, Kate Simpson, Usman Khalid, Imogen John, Lluís Bailach de Rivera, Yueh-An Lu, Melisa Lopez-Anton, William J. Watkins, Robert H. Jenkins, Donald J. Fraser, Timothy Bowen

“…Of nine messenger RNA targets with two or more miR-141 3’-untranslated region binding sites, we confirmed protein tyrosine phosphatase receptor type G (PTPRG) as a direct miR-141 target in PTECs. …”
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