Aberrant DNA methylation of PTPRG as one possible mechanism of its under‐expression in CML patients in the State of Qatar by Mohamed A. Ismail, Muthanna Samara, Ali Al Sayab, Mohamed Alsharshani, Mohamed A. Yassin, Govindarajulu Varadharaj, Marzia Vezzalini, Luisa Tomasello, Maria Monne, Hisham Morsi, M. Walid Qoronfleh, Hatem Zayed, Richard Cook, Claudio Sorio, Helmout Modjtahedi, Nader I. Al‐Dewik

“…Abstract Background Several studies showed that aberrant DNA methylation is involved in leukemia and cancer pathogenesis. Protein tyrosine phosphatase receptor gamma (PTPRG) expression is a natural inhibitory mechanism that is downregulated in chronic myeloid leukemia (CML) disease. …”
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Integrating plasma proteomes with genome-wide association data for causal protein identification in multiple myeloma by Qiangsheng Wang, Qiqin Shi, Zhenqian Wang, Jiawen Lu, Jian Hou

“…Seven proteins were inversely associated with MM, which referred to suppressor of cytokine signaling 3 (SOCS3; 0.90 [0.86, 0.94]), Fc-gamma receptor III-B (FCGR3B; 0.75 [0.65,0.86]), glypican-1 (GPC1; 0.69 [0.58,0.83]), follistatin-related protein 1, protein tyrosine phosphatase non-receptor type 4 (PTPN4), granzyme B, complement C1q subcomponent subunit C (C1QC). …”
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Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19 by David Kartchner, Kevin McCoy, Janhvi Dubey, Dongyu Zhang, Kevin Zheng, Rushda Umrani, James J. Kim, Cassie S. Mitchell

“…The top-ranking concepts relating COVID-19 to resistant hypertension included: cGMP-dependent protein kinase II, MAP3K1, haspin, ral guanine nucleotide exchange factor, N-(3-Oxododecanoyl)-L-homoserine lactone, aspartic endopeptidases, metabotropic glutamate receptors, choline-phosphate cytidylyltransferase, protein tyrosine phosphatase, tat genes, MAP3K10, uridine kinase, dicer enzyme, CMD1B, USP17L2, FLNA, exportin 5, somatotropin releasing hormone, beta-melanocyte stimulating hormone, pegylated leptin, beta-lipoprotein, corticotropin, growth hormone-releasing peptide 2, pro-opiomelanocortin, alpha-melanocyte stimulating hormone, prolactin, thyroid hormone, poly-beta-hydroxybutyrate depolymerase, CR 1392, BCR-ABL fusion gene, high density lipoprotein sphingomyelin, pregnancy-associated murine protein 1, recQ4 helicase, immunoglobulin heavy chain variable domain, aglycotransferrin, host cell factor C1, ATP6V0D1, imipramine demethylase, TRIM40, H3C2 gene, COL1A1+COL1A2 gene, QARS gene, VPS54, TPM2, MPST, EXOSC2, ribosomal protein S10, TAP-144, gonadotropins, human gonadotropin releasing hormone 1, beta-lipotropin, octreotide, salmon calcitonin, des-n-octanoyl ghrelin, liraglutide, gastrins. …”
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Genetic dissection of mutual interference between two consecutive learning tasks in Drosophila by Jianjian Zhao, Xuchen Zhang, Bohan Zhao, Wantong Hu, Tongxin Diao, Liyuan Wang, Yi Zhong, Qian Li

“…Acutely overexpressing Corkscrew (CSW), an evolutionarily conserved protein tyrosine phosphatase SHP2, in mushroom body (MB) neurons reduces Pro-I, whereas acute knockdown of CSW exacerbates Pro-I. …”
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Metabolites from the Paracel Islands Soft Coral <i>Sinularia</i> cf. <i>molesta</i> by Mei-Jun Chu, Xu-Li Tang, Xiao Han, Tao Li, Xiang-Chao Luo, Ming-Ming Jiang, Leen van Ofwegen, Lian-Zhong Luo, Gang Zhang, Ping-Lin Li, Guo-Qiang Li

“…Compounds <b>4</b>, <b>5</b>, and <b>8</b> showed significant inhibitory activities against protein tyrosine phosphatase 1B (PTP1B) with IC₅₀ values of 218, 344, and 1.24 &#956;M, respectively.…”
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Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury by Bin Xu, Dongsun Park, Yosuke Ohtake, Hui Li, Umar Hayat, Junjun Liu, Michael E. Selzer, Frank M. Longo, Shuxin Li

“…Recent studies support that the receptor protein tyrosine phosphatase σ (PTPσ) and its subfamily member leukocyte common antigen related phosphatase (LAR) act as transmembrane receptors to mediate CSPG inhibition. …”
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Transcriptomic analysis of glucosidase II beta subunit (GluIIß) knockout A549 cells reveals its roles in regulation of cell adhesion molecules (CAMs) and anti-tumor immunity by Worapong Khaodee, Guo Xiyuan, Moe Thi Thi Han, Chatchai Tayapiwatana, Sawitree Chiampanichayakul, Songyot Anuchapreeda, Ratchada Cressey

“…Whereas PTPRF (Protein Tyrosine Phosphatase Receptor Type F) was significantly decreased only in 1 out of 3 knockout clones. …”
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Improvement of Lipoplexes With a Sialic Acid Mimetic to Target the C1858T PTPN22 Variant for Immunotherapy in Endocrine Autoimmunity by Andrea Arena, Eugenia Belcastro, Francesca Ceccacci, Stefania Petrini, Libenzio Adrian Conti, Olivia Pagliarosi, Ezio Giorda, Simona Sennato, Riccardo Schiaffini, Peng Wang, James C. Paulson, Giovanna Mancini, Alessandra Fierabracci

“…The C1858T variant of the protein tyrosine phosphatase N22 (PTPN22) gene is associated with pathophysiological phenotypes in several autoimmune conditions, namely, Type 1 diabetes and autoimmune thyroiditis. …”
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PTPRK, an EGFR Phosphatase, Is Decreased in CeD Biopsies and Intestinal Organoids by Merlin Nanayakkara, Claudia Bellomo, Francesca Furone, Mariantonia Maglio, Antonella Marano, Giuliana Lania, Monia Porpora, Martina Nicoletti, Salvatore Auricchio, Maria Vittoria Barone

“…The celiac intestine is characterized by an inversion of the differentiation/proliferation program of the enterocytes, with an increase in the proliferative compartment and crypt hyperplasia, which are the mechanisms that regulate the increased proliferation in CeD that arenot completely understood.The aim of this study is to understand the role of Protein Tyrosine Phosphatase Receptor Type K (PTPRK), a nodal phosphatase that regulates EGFR activation in the proliferation of the enterocytes from CeD biopsies and organoids. …”
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Exploration of T cell immune responses by expression of a dominant-negative SHP1 and SHP2 by Julia Taylor, Anna Bulek, Isaac Gannon, Mathew Robson, Evangelia Kokalaki, Thomas Grothier, Callum McKenzie, Mohamed El-Kholy, Maria Stavrou, Charlotte Traynor-White, Wen Chean Lim, Panagiota Panagiotou, Saket Srivastava, Vania Baldan, James Sillibourne, Mathieu Ferrari, Martin Pule, Martin Pule, Simon Thomas

“…Both SHP1 and SHP2 contain dual SH2 domains responsible for localization to the endodomain of inhibitory receptors and a protein tyrosine phosphatase domain which dephosphorylates and thus inhibits key mediators of T cell activation. …”
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Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder by Christie L. Burton, Mathieu Lemire, Bowei Xiao, Elizabeth C. Corfield, Lauren Erdman, Janita Bralten, Geert Poelmans, Dongmei Yu, S.-M. Shaheen, Tara Goodale, Vanessa M. Sinopoli, OCD Working Group of the Psychiatric Genomics Consortium, Noam Soreni, Gregory L. Hanna, Kate D. Fitzgerald, David Rosenberg, Gerald Nestadt, Andrew D. Paterson, Lisa J. Strug, Russell J. Schachar, Jennifer Crosbie, Paul D. Arnold

“…A locus tagged by rs7856850 in an intron of PTPRD (protein tyrosine phosphatase δ) was significantly associated with OC traits at the genome-wide significance level (p = 2.48 × 10−8). rs7856850 was also associated with OCD in a meta-analysis of OCD case/control genome-wide datasets (p = 0.0069). …”
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Combining docking, molecular dynamics simulations, AD-MET pharmacokinetics properties, and MMGBSA calculations to create specialized protocols for running effective virtual screeni... by Emmanuel Israel Edache, Adamu Uzairu, Paul Andrew Mamza, Gideon Adamu Shallangwa, Fatma Hilal Yagin, Nagwan Abdel Samee, Noha F. Mahmoud

“…For a few chosen autoimmune disorder receptors (protein tyrosine phosphatase, nonreceptor type 22 (lymphoid) isoform 1 (PTPN22), type 1 diabetes, rheumatoid arthritis, and SARS-CoV-2 Mpro, the optimal binding characteristics of the compounds were described. …”
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Characteristics of Mycobacterium tuberculosis PtpA interaction and activity on the alpha subunit of human mitochondrial trifunctional protein, a key enzyme of lipid metabolism by Mariana Margenat, Gabriela Betancour, Vivian Irving, Alicia Costábile, Tania García-Cedrés, María Magdalena Portela, María Magdalena Portela, Federico Carrión, Fernando E. Herrera, Andrea Villarino

“…During Mycobacterium tuberculosis (Mtb) infection, the virulence factor PtpA belonging to the protein tyrosine phosphatase family is delivered into the cytosol of the macrophage. …”
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Host MKRN1-Mediated Mycobacterial PPE Protein Ubiquitination Suppresses Innate Immune Response by Yafeng Dou, Yan Xie, Lingyun Zhang, Sheng Liu, Dandan Xu, Yuying Wei, Yongshuai Li, Xiao-Lian Zhang, Xiao-Lian Zhang, Xiao-Lian Zhang

“…K63-ubiquitination of PPE68 further bound src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1) to suppress K63-linked polyubiquitin chains of tumor necrosis factor receptor-associated factor 6 (TRAF6), and then remarkably suppressed TRAF6-driven NF-κB and AP-1 signaling and TNF-α, IL-6 and NO production. …”
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Identification and verification of PTPN3 as a novel biomarker in predicting cancer prognosis, immunity, and immunotherapeutic efficacy by Ziting Zhou, Zhengjun Lin, Mingrui Wang, Lifan Wang, Yuqiao Ji, Jing Yang, Yaocheng Yang, Guanghui Zhu, Tang Liu

“…Abstract Background The importance of protein tyrosine phosphatase non-receptor type 3 (PTPN3) in controlling multifaceted tumor cell behaviors throughout cancer development has received widespread attention. …”
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Evaluation of the Antidiabetic Activity and Chemical Composition of Geranium collinum Root Extracts—Computational and Experimental Investigations by Sodik Numonov, Salamet Edirs, Khayrulla Bobakulov, Muhammad Nasimullah Qureshi, Khurshed Bozorov, Farukh Sharopov, William N. Setzer, Haiqing Zhao, Maidina Habasi, Mizhgona Sharofova, Haji Akber Aisa

“…The 50% aqueous-ethanolic extract possesses potent antidiabetic activity, with IC50 values of 0.10 μg/mL and 0.09 μg/mL for the enzymes protein-tyrosine phosphatase (1B PTP-1B) and α-glucosidase, respectively. …”
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Short-Term Strength Exercise Reduces Hepatic Insulin Resistance in Obese Mice by Reducing PTP1B Content, Regardless of Changes in Body Weight by Kellen Cristina da Cruz Rodrigues, Rodrigo Martins Pereira, Guilherme Francisco Peruca, Lucas Wesley Torres Barbosa, Marcella Ramos Sant’Ana, Vitor Rosetto Muñoz, Ana Paula Morelli, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Eduardo Rochete Ropelle, José Rodrigo Pauli, Leandro Pereira de Moura

“…The liver is a key organ to glucose homeostasis since insulin resistance in this organ increases hepatic glucose production (HGP) and fasting hyperglycemia. The protein-tyrosine phosphatase 1B (PTP1B) may dephosphorylate the IR and IRS, contributing to insulin resistance in this organ. …”
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Dual Role of PTPN22 but Not NLRP3 Inflammasome Polymorphisms in Type 1 Diabetes and Celiac Disease in Children by Darja Smigoc Schweiger, Katja Goricar, Tinka Hovnik, Andrijana Mendez, Natasa Bratina, Natasa Bratina, Jernej Brecelj, Jernej Brecelj, Blanka Vidan-Jeras, Tadej Battelino, Tadej Battelino, Vita Dolzan

“…On the other hand several studies suggested that NLRP3 inflammasome contributes to maintenance of gastrointestinal immune homeostasis and that activation of NLRP3 is regulated by protein tyrosine phosphatase non-receptor 22 (PTPN22). PTPN22 polymorphism was implicated in the risk for various autoimmune diseases including type 1 diabetes (T1D) but not for celiac disease (CD). …”
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Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase by Seung Ho Baek, Jong Hyun Lee, Chulwon Kim, Jeong-Hyeon Ko, Seung-Hee Ryu, Seok-Geun Lee, Woong Mo Yang, Jae-Young Um, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Gautam Sethi, Kwang Seok Ahn

“…Treatment of protein tyrosine phosphatase (PTP) inhibitor blocked suppression of STAT3 phosphorylation by GAC 17:1, thereby indicating a critical role for a PTP. …”
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Volatile Secondary Metabolites with Potent Antidiabetic Activity from the Roots of <i>Prangos pabularia</i> Lindl.—Computational and Experimental Investigations by Sodik Numonov, Farukh S. Sharopov, Sunbula Atolikhshoeva, Abduahad Safomuddin, Mahinur Bakri, William N. Setzer, Azizullo Musoev, Mizhgona Sharofova, Maidina Habasi, Haji Akber Aisa

“…To our best knowledge, there are no previously published reports concerning the antidiabetic activity and the chemical composition of the essential oil obtained from roots of <i>P. pabularia</i>. (2) Methods: The volatile secondary metabolites were obtained by hydrodistillation from the underground parts of <i>P. pabularia</i> growing wild in Tajikistan and were analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). Protein tyrosine phosphatase 1B (PTP-1B) inhibition assay and molecular docking analysis were carried out to evaluate the potential antidiabetic activity of the <i>P. pabularia</i> essential oil. (3) Results: The main constituents of the volatile oil of <i>P. pabularia</i> were 5-pentylcyclohexa-1,3-diene (44.6%), menthone (12.6%), 1-tridecyne (10.9%), and osthole (6.0%). …”
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