miR-624-5p promoted tumorigenesis and metastasis by suppressing hippo signaling through targeting PTPRB in osteosarcoma cells by Yongjun Luo, Wei Liu, Pengyu Tang, Dongdong Jiang, Changjiang Gu, Yumin Huang, Fangyi Gong, Yuluo Rong, Dingfei Qian, Jian Chen, Zheng Zhou, Shujie Zhao, Jiaxing Wang, Tao Xu, Yongzhong Wei, Guoyong Yin, Jin Fan, Weihua Cai

“…Results miR-624-5p expression was upregulated in OS cells and tissues, and overexpressing miR-624-5p led to a higher malignant level of OS, including cell proliferation, migration and invasion in vitro and in vivo. Protein tyrosine phosphatase receptor type B (PTPRB) was negatively correlated with miR-624-5p expression in OS tissues. …”
Get full text

The Tyrosine Phosphatase Activity of PTPN22 Is Involved in T Cell Development via the Regulation of TCR Expression by Bin Bai, Tong Li, Jiahui Zhao, Yanjiao Zhao, Xiaonan Zhang, Tao Wang, Na Zhang, Xipeng Wang, Xinlei Ba, Jialin Xu, Yang Yu, Bing Wang

“…The protein tyrosine phosphatase PTPN22 inhibits T cell activation by dephosphorylating some essential proteins in the T cell receptor (TCR)-mediated signaling pathway, such as the lymphocyte-specific protein tyrosine kinase (Lck), Src family tyrosine kinases Fyn, and the phosphorylation levels of Zeta-chain-associated protein kinase-70 (ZAP70). …”
Get full text

PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism by Weixing Dai, Wenqiang Xiang, Lingyu Han, Zixu Yuan, Renjie Wang, Yanlei Ma, Yongzhi Yang, Sanjun Cai, Ye Xu, Shaobo Mo, Qingguo Li, Guoxiang Cai

“…Abstract Background Abnormal expression of protein tyrosine phosphatases (PTPs) has been reported to be a crucial cause of cancer. …”
Get full text

Association of PTPN22-C1858T Polymorphism With Susceptibility to Mycobacterium tuberculosis and Mycobacterium leprae Infection: A Meta-Analysis by Shuping Li, Shuping Li, Xiaohua Wang, Xiaohua Wang, Yuming Zhao, Juan Yang, Juan Yang, Tianjiao Cui, Tianjiao Cui, Zhizhuang Joe Zhao, Yun Chen, Zhihua Zheng, Zhihua Zheng

“…It was previously published that single-nucleotide polymorphism rs2476601 (PTPN22 [protein tyrosine phosphatase non-receptor type 22]-C1858T) might be related to increased sensibility to Mycobacterium tuberculosis and M. leprae infection. …”
Get full text

Myocardial protection of S-nitroso-L-cysteine in diabetic cardiomyopathy mice by Lulu Peng, Mengying Zhu, Shengqi Huo, Wei Shi, Tao Jiang, Tao Jiang, Dewei Peng, Moran Wang, Yue Jiang, Junyi Guo, Lintong Men, Bingyu Huang, Qian Wang, Jiagao Lv, Li Lin, Sheng Li

“…Previously, we showed that S-nitroso-L-cysteine(CSNO), an endogenous S-nitrosothiol derived from eNOS, inhibited the activity of protein tyrosine phosphatase 1B (PTP1B), a critical negative modulator of insulin signaling. …”
Get full text

Chondroitinase ABC Promotes Axon Regeneration and Reduces Retrograde Apoptosis Signaling in Lamprey by Jianli Hu, William Rodemer, Guixin Zhang, Li-Qing Jin, Shuxin Li, Shuxin Li, Michael E. Selzer, Michael E. Selzer

“…However, due to the complexity of the mammalian CNS, it is still unclear whether this involves true regeneration or only collateral sprouting by uninjured axons, whether it affects the expression of CSPG receptors such as protein tyrosine phosphatase sigma (PTPσ), and whether it influences retrograde neuronal apoptosis after SCI. …”
Get full text

LncRNA‐CCAT5‐mediated crosstalk between Wnt/β‐Catenin and STAT3 signaling suggests novel therapeutic approaches for metastatic gastric cancer with high Wnt activity by Chenchen Liu, Aiwen Shen, Junquan Song, Lei Cheng, Meng Zhang, Yanong Wang, Xiaowen Liu

“…Mechanistically, CCAT5 bound to the C‐end domain of signal transducer and activator of transcription 3 (STAT3) and blocks Src homology 2 domain‐containing protein tyrosine phosphatase 1 (SHP‐1)‐mediated STAT3Y705 dephosphorylation, leading to STAT3 nuclear entry and transactivation, thus accelerating GC progression. …”
Get full text

The PTP1B inhibitor MSI-1436 ameliorates liver insulin sensitivity by modulating autophagy, ER stress and systemic inflammation in Equine metabolic syndrome affected horses by Lynda Bourebaba, Lynda Bourebaba, Anna Serwotka-Suszczak, Ariadna Pielok, Mateusz Sikora, Malwina Mularczyk, Malwina Mularczyk, Krzysztof Marycz, Krzysztof Marycz

“…Among the several molecular mechanisms underlying EMS pathogenesis, increased negative insulin signalling regulation mediated by protein tyrosine phosphatase 1 B (PTP1B) has emerged as a critical axis in the development of liver insulin resistance and general metabolic distress associated to increased ER stress, inflammation and disrupted autophagy. …”
Get full text

DNA methylation and cardiovascular disease in humans: a systematic review and database of known CpG methylation sites by Mykhailo Krolevets, Vincent ten Cate, Jürgen H. Prochaska, Andreas Schulz, Steffen Rapp, Stefan Tenzer, Miguel A. Andrade-Navarro, Steve Horvath, Christof Niehrs, Philipp S. Wild

“…Most frequently reported were TEAD1 (TEA Domain Transcription Factor 1) and PTPRN2 (Protein Tyrosine Phosphatase Receptor Type N2) in association with outcomes ranging from vascular to cardiac disease. …”
Get full text

Differences in the expression of the phosphatase PTP-1B in patients with localized prostate cancer with and without adverse pathological features by Maria T. Bourlon, Maria T. Bourlon, Shaddai Urbina-Ramirez, Haydee C. Verduzco-Aguirre, Mauricio Mora-Pineda, Hugo E. Velazquez, Eucario Leon-Rodriguez, Yemil Atisha-Fregoso, María G. De Anda-Gonzalez

“…Clinicians lack reliable markers to predict these APF preoperatively. Protein tyrosine phosphatase 1B (PTP-1B) is involved in migration and invasion of PC, and its expression could predict presence of APF. …”
Get full text

Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following spinal cord injury by Scott Dyck, Hardeep Kataria, Arsalan Alizadeh, Kallivalappil T. Santhosh, Bradley Lang, Jerry Silver, Soheila Karimi-Abdolrezaee

“…The recent discovery of CSPG-specific receptors, leukocyte common antigen-related (LAR) and protein tyrosine phosphatase-sigma (PTPσ), allows unraveling the cellular and molecular mechanisms of CSPGs in SCI. …”
Get full text

Shp2 Deficiency in Kupffer Cells and Hepatocytes Aggravates Hepatocarcinogenesis by Recruiting Non-Kupffer MacrophagesSummary by Li Du, Yichun Ji, Bing Xin, Jiemeng Zhang, Li-Chun Lu, Christopher K. Glass, Gen-Sheng Feng

“…Methods: We used the C-type lectin domain family 4 member F (Clec4f)-cre system to delete Src-homology 2 domain-containing tyrosine phosphatase 2 (Shp2)/protein tyrosine phosphatase nonreceptor 11 (Ptpn11) in KCs, and a combination of Clec4f-cre and adeno-associated virus–cre to delete Shp2 in KCs and hepatocytes to investigate the effects on hepatocellular carcinoma development and immune cell compositions/activities. …”
Get full text

Cannabinoid receptor type 1 (CB1R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3 by Gergő Szanda, Tony Jourdan, Éva Wisniewski, Resat Cinar, Grzegorz Godlewski, Anikó Rajki, Jie Liu, Lee Chedester, Bence Szalai, András Dávid Tóth, Eszter Soltész-Katona, László Hunyady, Asuka Inoue, Viktória Bea Horváth, András Spät, Joseph Tam, George Kunos

“…Measurement of STAT3 activation by semi-automated confocal microscopy in cultured neurons revealed that this CB1R-mediated inhibition requires both T cell protein tyrosine phosphatase (TC-PTP) and β-arrestin1 but is independent of changes in cAMP. …”
Get full text

Hemgn Protects Hematopoietic Stem and Progenitor Cells Against Transplantation Stress Through Negatively Regulating IFN‐γ Signaling by Ke Zhao, Jin‐Fang Liu, Ya‐Xin Zhu, Xiao‐Ming Dong, Rong‐Hua Yin, Xian Liu, Hui‐Ying Gao, Feng‐Jun Xiao, Rui Gao, Qi Wang, Yi‐Qun Zhan, Miao Yu, Hui Chen, Hong‐Mei Ning, Cai‐Bo Zhang, Xiao‐Ming Yang, Chang‐Yan Li

“…Mechanistical studies reveal that Hemgn deficiency sustain nuclear Stat1 tyrosine phosphorylation via suppressing T‐cell protein tyrosine phosphatase TC45 activity. Spermidine, a selective activator of TC45, rescues exacerbated phenotype of HSPCs in IFN‐γ‐treated Hemgn−/− mice. …”
Get full text

Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity by Darienne R. Myers, Clare L. Abram, David Wildes, Amira Belwafa, Alia M. N. Welsh, Christopher J. Schulze, Tiffany J. Choy, Tram Nguyen, Neil Omaque, Yongmei Hu, Mallika Singh, Rich Hansen, Mark A. Goldsmith, Elsa Quintana, Jacqueline A. M. Smith, Clifford A. Lowell

“…Shp1, encoded by the gene Ptpn6, is a protein tyrosine phosphatase that transduces inhibitory signals downstream of immunoreceptors in many immune cell types. …”
Get full text

Heteronemin, a Marine Sesterterpenoid-Type Metabolite, Induces Apoptosis in Prostate LNcap Cells via Oxidative and ER Stress Combined with the Inhibition of Topoisomerase II and Hs... by Man-Gang Lee, Yi-Chang Liu, Yi-Lun Lee, Mohamed El-Shazly, Kuei-Hung Lai, Shou-Ping Shih, Seng-Chung Ke, Ming-Chang Hong, Ying-Chi Du, Juan-Cheng Yang, Ping-Jyun Sung, Zhi-Hong Wen, Mei-Chin Lu

“…Moreover, our findings indicated that the pretreatment of LNcap cells with an inhibitor of protein tyrosine phosphatase (PTPi) diminished growth inhibition, oxidative and Endoplasmic Reticulum (ER) stress, as well as activation of Chop/Hsp70 induced by heteronemin, suggesting PTP activation plays a crucial rule in the cytotoxic activity of heteronemin. …”
Get full text

Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects by Maja Solman, Sasja Blokzijl-Franke, Florian Piques, Chuan Yan, Qiqi Yang, Marion Strullu, Sarah M Kamel, Pakize Ak, Jeroen Bakkers, David M Langenau, Hélène Cavé, Jeroen den Hertog

“…Gain-of-function mutations in the protein-tyrosine phosphatase SHP2 are the most frequently occurring mutations in sporadic juvenile myelomonocytic leukemia (JMML) and JMML-like myeloproliferative neoplasm (MPN) associated with Noonan syndrome (NS). …”
Get full text

The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling by Jessica Fiebelkow, André Guendel, Beate Guendel, Nora Mehwald, Tomasz Jetka, Michal Komorowski, Steffen Waldherr, Fred Schaper, Anna Dittrich

“…Under physiological conditions JAK/STAT signalling is rigorously controlled and timely orchestrated by regulatory mechanisms such as expression of the feedback-inhibitor SOCS3 and activation of the protein-tyrosine phosphatase SHP2 (PTPN11). Interestingly, the function of negative regulators seems not to be restricted to controlling the strength and timely orchestration of IL-6-induced STAT3 activation. …”
Get full text

Chicken novel leukocyte immunoglobulin-like receptor subfamilies B1 and B3 are transcriptional regulators of major histocompatibility complex class I genes and signaling pathways by Anh Duc Truong, Yeojin Hong, Janggeun Lee, Kyungbaek Lee, Ha Thi Thanh Tran, Hoang Vu Dang, Viet Khong Nguyen, Hyun S. Lillehoj, Yeong Ho Hong

“…These motifs bind to SHP-2 (protein tyrosine phosphatase, non-receptor type 11) that plays a regulatory role in immune functions. …”
Get full text

Tyrosine Phosphatase PTPRO Deficiency in ERBB2-Positive Breast Cancer Contributes to Poor Prognosis and Lapatinib Resistance by Hongmei Dong, Liang Du, Liang Du, Liang Du, Songwang Cai, Wan Lin, Chaoying Chen, Chaoying Chen, Matthew Still, Zhimeng Yao, Robert P. Coppes, Yunlong Pan, Dianzheng Zhang, Shegan Gao, Hao Zhang

“…Since the expression of protein tyrosine phosphatase receptor-type O (PTPRO), a member of the R3 subfamily of receptor protein tyrosine phosphatases (PTPs), is inversely correlated with the aggressiveness of multiple malignancies, we decided to explore the correlation between PTPRO and lapatinib resistance in ERBB2-positive breast cancer. …”
Get full text