MmuPV1 E7’s interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease by James C. Romero-Masters, Miranda Grace, Denis Lee, Joshua Lei, Melanie DePamphilis, Darya Buehler, Rong Hu, Ella Ward-Shaw, Simon Blaine-Sauer, Nathalie Lavoie, Elizabeth A. White, Karl Munger, Paul F. Lambert

“…We previously identified Protein Tyrosine Phosphatase Non-Receptor Type 14 (PTPN14), a tumor suppressor targeted by HPV E7 proteins, as a putative cellular target of MmuPV1 E7. …”
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Inhibition of PTP1B Promotes M2 Polarization via MicroRNA-26a/MKP1 Signaling Pathway in Murine Macrophages by Xiaolong Xu, Xiaolong Xu, Xiaolong Xu, Xiaolong Xu, Xuerui Wang, Xuerui Wang, Yuhong Guo, Yuhong Guo, Yunjing Bai, Yunjing Bai, Shasha He, Shasha He, Ning Wang, Yan Lin, Marc Fisher, Qingquan Liu, Qingquan Liu, Yongming Yao, Yongming Yao

“…In our recent bioinformatic analysis, we confirmed that the inhibition of protein tyrosine phosphatase-1B (PTP1B) significantly promoted the expression of MKP1 in murine macrophages. …”
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Sympathetic overdrive and unrestrained adipose lipolysis drive alcohol-induced hepatic steatosis in rodents by Chunxue Zhou, Henry H. Ruiz, Li Ling, Giulia Maurizi, Kenichi Sakamoto, Claudia G. Liberini, Ling Wang, Adrien Stanley, Hale E. Egritag, Sofia M. Sanz, Claudia Lindtner, Mary A. Butera, Christoph Buettner

“…Methods: We examined the role of lipolysis, and the brain–SNS–adipose tissue axis and stress in alcohol induced hepatic triglyceride accumulation in a series of rodent models: pharmacological inhibition of the negative regulator of insulin signaling protein-tyrosine phosphatase 1β (PTP1b) in the rat brain, tyrosine hydroxylase (TH) knockout mice as a pharmacogenetic model of sympathectomy, adipocyte specific adipose triglyceride lipase (ATGL) knockout mice, wildtype (WT) mice treated with β3 adrenergic agonist or undergoing restraint stress. …”
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Sweet Taste Preference: Relationships with Other Tastes, Liking for Sugary Foods and Exploratory Genome-Wide Association Analysis in Subjects with Metabolic Syndrome by Rebeca Fernández-Carrión, Jose V. Sorlí, Oscar Coltell, Eva C. Pascual, Carolina Ortega-Azorín, Rocío Barragán, Ignacio M. Giménez-Alba, Andrea Alvarez-Sala, Montserrat Fitó, Jose M. Ordovas, Dolores Corella

“…In the exploratory SNP-based genome-wide association study (GWAS), we identified some SNPs associated with sweet taste preference, both at the suggestive and at the genome-wide level, especially a lead SNP in the PTPRN2 (Protein Tyrosine Phosphatase Receptor Type N2) gene, whose minor allele was associated with a lower sweet taste preference. …”
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Pharmacological Inhibition of miR-130 Family Suppresses Bladder Tumor Growth by Targeting Various Oncogenic Pathways via PTPN1 by Yuya Monoe, Kentaro Jingushi, Akitaka Kawase, Takayuki Hirono, Ryo Hirose, Yoshino Nakatsuji, Kaori Kitae, Yuko Ueda, Hiroaki Hase, Yuichi Abe, Jun Adachi, Takeshi Tomonaga, Kazutake Tsujikawa

“…SILAC-based proteome analysis and a luciferase assay identified protein tyrosine phosphatase non-receptor type 1 (PTPN1), which is implicated as a negative regulator of multiple signaling pathways downstream of RTKs as a target gene of the miR-130 family. …”
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HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway by Yunzhi Liu, Qishan Xu, Fan Deng, Zhuojun Zheng, Jialiang Luo, Ping Wang, Jia Zhou, Xiao Lu, Liyun Zhang, Zhengliang Chen, Qifan Zhang, Qingyun Chen, Daming Zuo

“…Mechanically, HERC2 coupled with the endoplasmic reticulum (ER)-resident protein tyrosine phosphatase 1B (PTP1B) and limited PTP1B translocation from ER to ER-plasma membrane junction, which ameliorated the inhibitory role of PTP1B in Janus kinase 2 (JAK2) phosphorylation. …”
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Traditional Use, Phytochemical Profiles and Pharmacological Properties of <i>Artemisia</i> Genus from Central Asia by Aliya Nurlybekova, Aidana Kudaibergen, Aizhan Kazymbetova, Magzhan Amangeldi, Aizhamal Baiseitova, Meirambek Ospanov, Haji Akber Aisa, Yang Ye, Mohamed Ali Ibrahim, Janar Jenis

“…Furthermore, our aim is to search for promising and potentially active <i>Artemisia</i> species candidates, encouraging us to analyze Protein Tyrosine Phosphatase 1B (PTP1B), α-glucosidase and bacterial neuraminidase (BNA) inhibition as well as the antioxidant potentials of <i>Artemisia</i> plant extracts, in which endemic species have not been explored for their secondary metabolites and biological activities so far. …”
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PTPN3 is a potential target for a new cancer immunotherapy that has a dual effect of T cell activation and direct cancer inhibition in lung neuroendocrine tumor by Satoko Koga, Hideya Onishi, Shogo Masuda, Akiko Fujimura, Shu Ichimiya, Kazunori Nakayama, Akira Imaizumi, Kenichi Nishiyama, Masayuki Kojima, Kei Miyoshi, Katsuya Nakamura, Masayo Umebayashi, Takashi Morisaki, Masafumi Nakamura

“…In our previous study, we found that inhibition of protein tyrosine phosphatase non-receptor type 3 (PTPN3), which is expressed in lymphocytes, enhances lymphocyte activation, suggesting PTPN3 may act as an immune checkpoint molecule. …”
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Gene Expression Landscape of Chronic Myeloid Leukemia K562 Cells Overexpressing the Tumor Suppressor Gene PTPRG by Giulia Lombardi, Roberta Valeria Latorre, Alessandro Mosca, Diego Calvanese, Luisa Tomasello, Christian Boni, Manuela Ferracin, Massimo Negrini, Nader Al Dewik, Mohamed Yassin, Mohamed A. Ismail, Bruno Carpentieri, Claudio Sorio, Paola Lecca

“…This study concerns the analysis of the modulation of Chronic Myeloid Leukemia (CML) cell model K562 transcriptome following transfection with the tumor suppressor gene encoding for Protein Tyrosine Phosphatase Receptor Type G (PTPRG) and treatment with the tyrosine kinase inhibitor (TKI) Imatinib. …”
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Cisplatin or Doxorubicin Reduces Cell Viability via the PTPIVA3-JAK2-STAT3 Cascade in Hepatocellular Carcinoma by Li CJ, Tsai HW, Chen YL, Wang CI, Lin YH, Chu PM, Chi HC, Huang YC, Chen CY

“…Western blotting, qRT‒PCR and immunohistochemistry were utilized to examine the protein tyrosine phosphatase IVA3 (PTP4A3) level and associated signaling pathways. …”
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Identification of common and specific fibrosis-related genes in three common chronic kidney diseases by Zhangning Fu, Xiaodong Geng, Chao Liu, Wanjun Shen, Zheyi Dong, Guannan Sun, Guangyan Cai, Xiangmei Chen, Quan Hong

“…Quantitative real-time PCR (qRT-PCR) was performed to validate the expression of the selected genes.Results Protein tyrosine phosphatase receptor type C (PTPRC), intercellular cell adhesion molecule-1 (ICAM1), vascular cell adhesion molecule-1 (VCAM1), interleukin 10 receptor alpha (IL10RA) and CC chemokine receptor 2 (CCR2) were identified as the potential common genes for kidney fibrosis in different types of CKD, while peroxisome proliferator-activated receptor alpha (PPARA), lactate oxidase (LOX), secreted phosphoprotein 1 (SPP1) were identified as the specific fibrosis-associated genes for DN, IgAN and MN respectively. qRT-PCR demonstrated that the expression levels of these selected genes were consistent with the NanoString analysis.Conclusions There were both commonalities and differences in the mechanisms of fibrosis in different types of CKD, the commonalities might be used as the common therapeutic targets for kidney fibrosis in CKD, while the differences might be used as the diagnostic markers for DN, IgAN and MN respectively. …”
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AT2 Receptor Mediated Activation of the Tyrosine Phosphatase PTP1B Blocks Caveolin-1 Enhanced Migration, Invasion and Metastasis of Cancer Cells by Samuel Martínez-Meza, Jorge Díaz, Alejandra Sandoval-Bórquez, Manuel Valenzuela-Valderrama, Natalia Díaz-Valdivia, Victoria Rojas-Celis, Pamela Contreras, Ricardo Huilcaman, María Paz Ocaranza, Mario Chiong, Lisette Leyton, Sergio Lavandero, Andrew F.G. Quest

“…Moreover, AT2R activation increased non-receptor protein tyrosine phosphatase 1B (PTP1B) activity, decreased phosphorylation of CAV1 on tyrosine-14 as well as Rab5/Rac1 activity, and reduced lung metastasis of B16F10(cav-1) cells in C57BL/6 mice. …”
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Expression Changes and Impact of the Extracellular Matrix on Etoposide Resistant Human Retinoblastoma Cell Lines by Jacqueline Reinhard, Natalie Wagner, Miriam M. Krämer, Marvin Jarocki, Stephanie C. Joachim, H. Burkhard Dick, Andreas Faissner, Vinodh Kakkassery

“…Furthermore, a downregulation was detected for the matrix metalloproteinases <i>MMP2</i>, <i>MMP7</i>, <i>MMP9</i>, the tissue-inhibitor of metalloproteinase <i>TIMP2</i>, the Integrin receptor subunits <i>ITGA4</i>, <i>ITGA5</i> and <i>ITGB1,</i> and all <i>receptor protein tyrosine phosphatase β/ζ</i> isoforms. Downregulation of <i>Brevican</i>, <i>Collagen IV</i>, <i>Tenascin-R</i>, <i>MMP2</i>, <i>TIMP2,</i> and <i>ITGA5</i> was also verified in Etoposide resistant Y79 cells compared to sensitive ones. …”
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Enhancing Chemotherapy Efficacy in Pten-Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity by Alberto Toso, Ajinkya Revandkar, Diletta Di Mitri, Ilaria Guccini, Michele Proietti, Manuela Sarti, Sandra Pinton, Jiangwen Zhang, Madhuri Kalathur, Gianluca Civenni, David Jarrossay, Erica Montani, Camilla Marini, Ramon Garcia-Escudero, Eugenio Scanziani, Fabio Grassi, Pier Paolo Pandolfi, Carlo V. Catapano, Andrea Alimonti

“…Activation of the Jak2/Stat3 pathway in Pten-null tumors is sustained by the downregulation of the protein tyrosine phosphatase PTPN11/SHP2, providing evidence for the existence of a novel PTEN/SHP2 axis. …”
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Implication of the PTN/RPTPβ/ζ Signaling Pathway in Acute Ethanol Neuroinflammation in Both Sexes: A Comparative Study with LPS by María Rodríguez-Zapata, Milagros Galán-Llario, Héctor Cañeque-Rufo, Julio Sevillano, María Gracia Sánchez-Alonso, José M. Zapico, Marcel Ferrer-Alcón, María Uribarri, Beatriz de Pascual-Teresa, María del Pilar Ramos-Álvarez, Gonzalo Herradón, Carmen Pérez-García, Esther Gramage

“…Pleiotrophin (PTN) is a cytokine that inhibits Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ. PTN and MY10, an RPTPβ/ζ pharmacological inhibitor, modulate ethanol behavioral and microglial responses in adult mice. …”
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Immunogenetic basis of chicken’s heterophil to lymphocyte ratio revealed by genome-wide indel variants analysis by Jin ZHANG, Jie WANG, Qiao WANG, Huan-xian CUI, Ji-qiang DING, Zi-xuan WANG, Mamadou THIAM, Qing-he LI, Gui-ping ZHAO

“…The expression of protein tyrosine phosphatase non-receptor type 5 (PTPN5) (r=0.75, P=0.033) and oxysterol binding protein like 5 (OSBPL5) (r=0.89, P=0.0027) were positively correlated with H/L. …”
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PPFIA4 promotes castration-resistant prostate cancer by enhancing mitochondrial metabolism through MTHFD2 by Ru Zhao, Tingting Feng, Lin Gao, Feifei Sun, Qianqian Zhou, Xin Wang, Junmei Liu, Wenbo Zhang, Meng Wang, Xueting Xiong, Wenqiao Jia, Weiwen Chen, Lin Wang, Bo Han

“…Methods We investigate the expression of the protein tyrosine phosphatase receptor type F polypeptide interacting protein alpha 4 (PPFIA4) using public datasets and tumor specimens from PCa cases by immunohistochemistry. …”
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Identification of the growth cone as a probe and driver of neuronal migration in the injured brain by Chikako Nakajima, Masato Sawada, Erika Umeda, Yuma Takagi, Norihiko Nakashima, Kazuya Kuboyama, Naoko Kaneko, Satoaki Yamamoto, Haruno Nakamura, Naoki Shimada, Koichiro Nakamura, Kumiko Matsuno, Shoji Uesugi, Nynke A. Vepřek, Florian Küllmer, Veselin Nasufović, Hironobu Uchiyama, Masaru Nakada, Yuji Otsuka, Yasuyuki Ito, Vicente Herranz-Pérez, José Manuel García-Verdugo, Nobuhiko Ohno, Hans-Dieter Arndt, Dirk Trauner, Yasuhiko Tabata, Michihiro Igarashi, Kazunobu Sawamoto

“…We show that migrating neurons in mice possess a growth cone at the tip of their leading process, similar to that of axons, in terms of the cytoskeletal dynamics and functional responsivity through protein tyrosine phosphatase receptor type sigma (PTPσ). Migrating-neuron growth cones respond to chondroitin sulfate (CS) through PTPσ and collapse, which leads to inhibition of neuronal migration. …”
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Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel by Xiaoyi Mo, Peiyuan Pang, Yulin Wang, Dexiang Jiang, Mengyu Zhang, Yang Li, Peiyu Wang, Qizhi Geng, Chang Xie, Hai-Ning Du, Bo Zhong, Dongdong Li, Jing Yao

“…We further show that TRPV2 phosphorylation is dynamically balanced by protein tyrosine phosphatase non-receptor type 1 (PTPN1). PTPN1 inhibition increases TRPV2 phosphorylation, further reducing the activation temperature threshold. …”
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A New Oleanane Type Saponin from the Aerial Parts of <i>Nigella sativa</i> with Anti-Oxidant and Anti-Diabetic Potential by Amna Parveen, Muhammad Asim Farooq, Whang Wan Kyunn

“…The anti-diabetic study was carried out by DPPH, ABTS, <inline-formula> <math display="inline"> <semantics> <mi mathvariant="sans-serif">α</mi> </semantics> </math> </inline-formula>-glucosidase, and protein tyrosine phosphatase 1B assays at doses of 12.5 to 250 µM. …”
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