植物甾醇对脂多糖诱导小鼠炎症的抑制作用 Inhibition of phytosterols on lipopolysaccharide-induced inflammation in mice by 赵云博1， 王宁静1， 胡永员1， 牛永洁1， 孟永宏2 ZHAO Yunbo1, WANG Ningjing1, HU Yongyuan1, NIU Yongjie1, MENG Yonghong2

“…At the same time, compared with the lipopolysaccharide group, the protein tyrosine phosphatase-1 (SHP-1) in liver and spleen of mice prefed with phytosterols increased extremely significantly (P<0.01) after inflammation. …”
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Binding Free Energy Calculation Based on the Fragment Molecular Orbital Method and Its Application in Designing Novel SHP-2 Allosteric Inhibitors by Zhen Yuan, Xingyu Chen, Sisi Fan, Longfeng Chang, Linna Chu, Ying Zhang, Jie Wang, Shuang Li, Jinxin Xie, Jianguo Hu, Runyu Miao, Lili Zhu, Zhenjiang Zhao, Honglin Li, Shiliang Li

“…Furthermore, using FMOScore-guided lead optimization against Src homology-2-containing protein tyrosine phosphatase 2 (SHP-2), we discovered a novel and potent allosteric SHP-2 inhibitor (compound <b>8</b>).…”
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PTPN2 targets TAK1 for dephosphorylation to improve cellular senescence and promote adipose tissue browning in T2DM by Yapeng Liu, Lu Han, Lu Han, Ping Zhu, Ming Song, Yaoyuan Zhang, Linlin Meng, Wei Zhang, Cheng Zhang, Ming Zhong

“…The activity of brown adipose tissue, which is involved in the dissipation of energy via heat expenditure decreases under type 2 diabetic mellitus (T2DM) state when the number of pathological aging adipocytes increases. Protein tyrosine phosphatase non-receptor type 2 (PTPN2) regulates several biological processes by dephosphorylating several cellular substrates; however, whether PTPN2 regulates cellular senescence in adipocytes and the underlying mechanism has not been reported.Methods: We constructed a model of type 2 diabetic mice with PTPN2 overexpression to explore the role of PTPN2 in T2DM.Results: We revealed that PTPN2 facilitated adipose tissue browning by alleviating pathological senescence, thus improving glucose tolerance and IR in T2DM. …”
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Anatomical Transcriptome Atlas of the Male Mouse Reproductive System During Aging by Yanping Huang, Xiangping Li, Xiangzhou Sun, Jiahui Yao, Fengxin Gao, Zhenqing Wang, Jiaying Hu, Zhu Wang, Bin Ouyang, Xiangan Tu, Xuenong Zou, Wei Liu, Mujun Lu, Chunhua Deng, Qiyun Yang, Yun Xie, Yun Xie

“…Furthermore, we highlighted Protein tyrosine phosphatase receptor type C (Ptprc), Lymphocyte protein tyrosine kinase (Lck), Microtubule associated protein tau (Mapt), and Interferon induced protein with tetratricopeptide repeats 3 (Ifit3) as critical molecules in the aging of initial segment, caput, caput, and cauda epididymidis, respectively. …”
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Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling by Sabah Akhtar, Iman W. Achkar, Kodappully S. Siveen, Shilpa Kuttikrishnan, Kirti S. Prabhu, Abdul Q. Khan, Eiman I. Ahmed, Fairooz Sahir, Jayakumar Jerobin, Afsheen Raza, Afsheen Raza, Maysaloun Merhi, Maysaloun Merhi, Hesham M. Elsabah, Ruba Taha, Halima El Omri, Hatem Zayed, Said Dermime, Said Dermime, Martin Steinhoff, Martin Steinhoff, Martin Steinhoff, Martin Steinhoff, Shahab Uddin

“…The SNG-mediated apoptosis appears to be resulted from suppression of the constitutively active STAT3 with a concomitant increase in expression of protein tyrosine phosphatase (SHP-1). SNG treatment of MM cells leads to down-regulation of the anti-apoptotic proteins including cyclin D, Bcl-2, Bclxl, and XIAP. …”
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Identification and Characterization of Post-activated B Cells in Systemic Autoimmune Diseases by Sarah Y. Weißenberg, Sarah Y. Weißenberg, Franziska Szelinski, Franziska Szelinski, Eva Schrezenmeier, Ana-Luisa Stefanski, Annika Wiedemann, Hector Rincon-Arevalo, Hector Rincon-Arevalo, Hector Rincon-Arevalo, Anna Welle, Annemarie Jungmann, Karl Nordström, Jörn Walter, Juliana Imgenberg-Kreuz, Gunnel Nordmark, Lars Rönnblom, Prathyusha Bachali, Michelle D. Catalina, Amrie C. Grammer, Peter E. Lipsky, Andreia C. Lino, Andreia C. Lino, Thomas Dörner, Thomas Dörner

“…Upon BCR activation, decreased spleen tyrosine kinase (Syk) and Bruton's tyrosine kinase (Btk) phosphorylation was noted in AID memory B cells combined with constitutive co-localization of CD22 and protein tyrosine phosphatase (PTP) non-receptor type 6 (SHP-1) along with hyporesponsiveness to TLR9 signaling, a Syk-dependent response. …”
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The expression of peroxisome proliferator-activated receptor (ppar1 and ppar2) in naive and memory cd4+ t lymphocytes by Mohamed, Rafeezul

“…CD45 is a protein tyrosine phosphatase which plays an important role in TCR-mediated signaling through its activation of Lck by dephosphorylating the regulatory Tyros. …”
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Hsa_circ_0060450 Negatively Regulates Type I Interferon-Induced Inflammation by Serving as miR-199a-5p Sponge in Type 1 Diabetes Mellitus by Lan Yang, Lan Yang, Xiao Han, Xiao Han, Caiyan Zhang, Caiyan Zhang, Chengjun Sun, Saihua Huang, Saihua Huang, Wenfeng Xiao, Wenfeng Xiao, Yajing Gao, Yajing Gao, Qiuyan Liang, Qiuyan Liang, Feihong Luo, Wei Lu, Jinrong Fu, Yufeng Zhou, Yufeng Zhou

“…Subsequent assays revealed that hsa_circ_0060450 can serve as the sponge of miR-199a-5p, release its target gene, Src homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2), encoded by the tyrosine-protein phosphatase non-receptor type 11 gene (PTPN11), and further suppress the JAK-STAT signaling pathway triggered by type I interferon (IFN-I) to inhibit macrophage-mediated inflammation, which indicates the important roles of circRNAs in T1DM and represents a promising therapeutic molecule in the treatment of T1DM.…”
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PTPN12 down-regulated by miR-146b-3p gene affects the malignant progression of laryngeal squamous cell carcinoma by Lan Lili, Cao Huan, Zhao Lei, Cui Weina, Wang Baoshan

“…Classical protein tyrosine phosphatase nonreceptor type 12 (PTPN12) has been extensively studied to decipher its mechanism as a tumor suppressor gene in various human carcinomas; however, there is no comprehensive elucidation of the PTPN12 expression and its regulatory mechanisms in LSCC. …”
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Identification and validation of tissue or ctDNA PTPRD phosphatase domain deleterious mutations as prognostic and predictive biomarkers for immune checkpoint inhibitors in non-squa... by Yiting Sun, Jianchun Duan, Wenfeng Fang, Zhijie Wang, Xinyang Du, Xin Wang, Chengcheng Li, Shangli Cai, Jie Zhao, Sini Li, Li Zhang, Hua Bai, Jie Wang

“…The associations of genomic alterations in protein tyrosine phosphatase receptor-type (PTPRs) and ICIs responses are unknown. …”
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Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additiona... by Vitor Ferreira, Cintia Folgueira, María García-Altares, Maria Guillén, Mónica Ruíz-Rosario, Giada DiNunzio, Irma Garcia-Martinez, Rosa Alen, Christoph Bookmeyer, John G. Jones, Juan C. Cigudosa, Pilar López-Larrubia, Xavier Correig-Blanchar, Roger J. Davis, Guadalupe Sabio, Patricia Rada, Ángela M. Valverde

“…Since clinical studies have shown hepatic steatosis upon chronic treatment with OLA, herein we further investigated the role of the hypothalamus-liver interactome upon OLA administration in wild-type (WT) and protein tyrosine phosphatase 1B knockout (PTP1B–KO) mice, a preclinical model protected against metabolic syndrome. …”
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Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice by Carmen Rubio, Marta Puerto, Juan J. García-Rodríquez, Van B. Lu, Irma García-Martínez, Rosa Alén, Patricia Sanmartín-Salinas, M. Val Toledo-Lobo, Jorge Saiz, Javier Ruperez, Coral Barbas, Luis Menchén, Fiona M. Gribble, Frank Reimann, Luis G. Guijarro, Jose M. Carrascosa, Ángela M. Valverde

“…Objective: Non-alcoholic steatohepatitis (NASH) is characterized by a robust pro-inflammatory component at both hepatic and systemic levels together with a disease-specific gut microbiome signature. Protein tyrosine phosphatase 1 B (PTP1B) plays distinct roles in non-immune and immune cells, in the latter inhibiting pro-inflammatory signaling cascades. …”
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Immunogenicity and protective efficacy of a Salmonella Enteritidis sptP mutant as a live attenuated vaccine candidate by Zhijie Lin, Peipei Tang, Yang Jiao, Xilong Kang, Qiuchun Li, Xiulong Xu, Jun Sun, Zhiming Pan, Xinan Jiao

“…As a Salmonella Type III secretion system (T3SS) effector, Salmonella protein tyrosine phosphatase (SptP) is critical for virulence in this genus. …”
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A novel GRK2 inhibitor alleviates experimental arthritis through restraining Th17 cell differentiation by Juan Tao, Chunru Jiang, Paipai Guo, Huijuan Chen, Zhenduo Zhu, Tiantian Su, Weijie Zhou, Yu Tai, Chenchen Han, Yang Ma, Jingyu Chen, Wuyi Sun, Yuanyuan Wang, Wei Wei, Qingtong Wang

“…In mice with collagen-induced arthritis (CIA), both circulating and splenic Th17 subsets were expanded with increased STAT3 phosphorylation and decreased Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)-β-arrestin2 (arrb2)-STAT3 interaction in CD4+ helper T (Th) cells. …”
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Tubeimoside I Inhibits Cell Proliferation and Induces a Partly Disrupted and Cytoprotective Autophagy Through Rapidly Hyperactivation of MEK1/2-ERK1/2 Cascade via Promoting PTP1B i... by Juan Du, Juan Du, Zhen Dong, Zhen Dong, Zhen Dong, Li Tan, Li Tan, Mengqin Tan, Mengqin Tan, Fang Zhang, Kui Zhang, Kui Zhang, Guangzhao Pan, Guangzhao Pan, Chongyang Li, Chongyang Li, Shaomin Shi, Shaomin Shi, Yanli Zhang, Yanli Zhang, Yaling Liu, Hongjuan Cui, Hongjuan Cui, Hongjuan Cui

“…It is revealed that protein-tyrosine phosphatase 1B (PTP1B) might be one of the targets of TBMS1. …”
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Inhibition of PTPRE suppresses tumor progression and improves sorafenib response in hepatocellular carcinoma by Renshun Dong, Tianci Wang, Wei Dong, He Zhu, Qiumeng Liu, Huifang Liang, Xiaoping Chen, Bixiang Zhang, Xuewu Zhang

“…Our previous study reported that protein tyrosine phosphatase receptor epsilon (PTPRE) is a promoting factor in HCC progression. …”
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Two Duplicated Ptpn6 Homeologs Cooperatively and Negatively Regulate RLR-Mediated IFN Response in Hexaploid Gibel Carp by Jin-Feng Tong, Jin-Feng Tong, Jin-Feng Tong, Li Zhou, Li Zhou, Li Zhou, Shun Li, Shun Li, Long-Feng Lu, Long-Feng Lu, Zhuo-Cong Li, Zhuo-Cong Li, Zhi Li, Zhi Li, Rui-Hai Gan, Rui-Hai Gan, Rui-Hai Gan, Cheng-Yan Mou, Cheng-Yan Mou, Cheng-Yan Mou, Qi-Ya Zhang, Qi-Ya Zhang, Zhong-Wei Wang, Zhong-Wei Wang, Zhong-Wei Wang, Xiao-Juan Zhang, Yang Wang, Yang Wang, Yang Wang, Jian-Fang Gui, Jian-Fang Gui, Jian-Fang Gui

“…Src homology region 2 domain-containing phosphatase 1 (SHP1), encoded by the protein tyrosine phosphatase nonreceptor type 6 (ptpn6) gene, belongs to the family of protein tyrosine phosphatases (PTPs) and participates in multiple signaling pathways of immune cells. …”
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KIBRA (WWC1) Is a Metastasis Suppressor Gene Affected by Chromosome 5q Loss in Triple-Negative Breast Cancer by Jennifer F. Knight, Vanessa Y.C. Sung, Elena Kuzmin, Amber L. Couzens, Danielle A. de Verteuil, Colin D.H. Ratcliffe, Paula P. Coelho, Radia M. Johnson, Payman Samavarchi-Tehrani, Tina Gruosso, Harvey W. Smith, Wontae Lee, Sadiq M. Saleh, Dongmei Zuo, Hong Zhao, Marie-Christine Guiot, Ryan R. Davis, Jeffrey P. Gregg, Christopher Moraes, Anne-Claude Gingras, Morag Park

“…KIBRA functions co-operatively with the protein tyrosine phosphatase PTPN14 to trigger mechanotransduction-regulated signals that inhibit the nuclear localization of oncogenic transcriptional co-activators YAP/TAZ. …”
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Targeting macrophagic SHP2 for ameliorating osteoarthritis via TLR signaling by Ziying Sun, Qianqian Liu, Zhongyang Lv, Jiawei Li, Xingquan Xu, Heng Sun, Maochun Wang, Kuoyang Sun, Tianshu Shi, Zizheng Liu, Guihua Tan, Wenqiang Yan, Rui Wu, Yannick Xiaofan Yang, Shiro Ikegawa, Qing Jiang, Yang Sun, Dongquan Shi

“…Here, we report that SHP099, as an allosteric inhibitor of src-homology 2-containing protein tyrosine phosphatase 2 (SHP2), attenuated osteoarthritis progression by inhibiting M1 macrophage polarization. …”
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PEOPLE (NTC03447678), a phase II trial to test pembrolizumab as first-line treatment in patients with advanced NSCLC with PD-L1 by Filippo de Braud, Valter Torri, Giuseppe Lo Russo, Claudia Proto, Roberto Ferrara, Monica Ganzinelli, Marina Chiara Garassino, Giuseppe Viscardi, Giorgio Trinchieri, Mario Occhipinti, Rita Leporati, Marta Brambilla, Luca Agnelli, Silvia Brich, Francesco Sgambelluri, Roberta Mortarini, Andrea Anichini, Leonardo Provenzano, Daniele Lorenzini, Arsela Prelaj, James Dolezal, Teresa Beninato, Tiziana Triulzi, Alessandra Fabbri, Laura Mazzeo, Andrea Spagnoletti, Vanja Miskovic, Alessandra Laura Giulia Pedrocchi, Francesco Trovo', Sara Manglaviti, Claudia Giani, Paolo Ambrosini, Andrea Franza, John McCulloch, Tommaso Torelli, Giancarlo Pruneri

“…LASSO integration analysis, with an optimal lambda of 0.28, showed that peripheral blood natural killer cells/CD56dimCD16+ (HR 0.56, 0.41–0.76, p=0.006) abundance at baseline and non-classical CD14dimCD16+monocytes (HR 0.52, 0.36–0.75, p=0.004), eosinophils (CD15+CD16−) (HR 0.62, 0.44–0.89, p=0.03) and lymphocytes (HR 0.32, 0.19–0.56, p=0.001) after first radiologic evaluation correlated with favorable PFS as well as high baseline expression levels of CD244 (HR 0.74, 0.62–0.87, p=0.05) protein tyrosine phosphatase receptor type C (HR 0.55, 0.38–0.81, p=0.098) and killer cell lectin like receptor B1 (HR 0.76, 0.66–0.89, p=0.05). …”
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