Analysis of g s-transferase, protien tyrosine phosphatase 1B, nuclear factor kappa-B1 and leptin receptor genetic polymorphisms as risk factors for Malaysian type 2 diabetes mellit... by Etemad, Ali

“…The main objective of this study was to determine the association of genetic polymorphisms of Glutathion S-Transferase (GST), Protein Tyrosine Phosphatase 1B (PTP1B), Nuclear Factor Kappa-B1 (NFK-B1) and Leptin Receptor (LEPR) genes in Malaysian T2DM subjects in comparison with healthy individuals. …”
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Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy by Javier Celis-Gutierrez, Peter Blattmann, Yunhao Zhai, Nicolas Jarmuzynski, Kilian Ruminski, Claude Grégoire, Youcef Ounoughene, Frédéric Fiore, Ruedi Aebersold, Romain Roncagalli, Matthias Gstaiger, Bernard Malissen

“…We also solve the existing controversy regarding the role of the SHP-1 and SHP-2 protein-tyrosine phosphatases in mediating PD-1 coinhibition. …”
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Regulation of tyrosine phosphorylation cascades by phosphatases: What the actions of vanadium teach us by Hulley, P, Davison, A

“…Much current research focuses on protein tyrosine phosphatases. Researchers of cellular regulation use vanadium as a probe because of its unparalleled ability to selectively inhibit protein tyrosine phosphatases at submicromolar concentrations. …”

The receptor PTPRU is a redox sensitive pseudophosphatase by Iain M. Hay, Gareth W. Fearnley, Pablo Rios, Maja Köhn, Hayley J. Sharpe, Janet E. Deane

“…Receptor-linked protein tyrosine phosphatases (RPTPs) usually contain an active membrane proximal domain and an inactive pseudophosphatase domain. …”
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Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2 by Ryouhei Tsutsumi, Jana Harizanova, Rabea Stockert, Katrin Schröder, Philippe I. H. Bastiaens, Benjamin G. Neel

“…Protein-tyrosine phosphatases (PTPs) are thought to be major targets of receptor-activated reactive oxygen species (ROS). …”
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PTPσ inhibitors promote hematopoietic stem cell regeneration by Yurun Zhang, Martina Roos, Heather Himburg, Christina M. Termini, Mamle Quarmyne, Michelle Li, Liman Zhao, Jenny Kan, Tiancheng Fang, Xiao Yan, Katherine Pohl, Emelyne Diers, Hyo Jin Gim, Robert Damoiseaux, Julian Whitelegge, William McBride, Michael E. Jung, John P. Chute

“…Protein tyrosine phosphatase sigma (PTPσ) deficient haematopoietic stem cells (HSCs) demonstrate increased engraftment following transplantation. …”
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Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. by Bryan M Zhao, Sarah L Keasey, Joseph E Tropea, George T Lountos, Beverly K Dyas, Scott Cherry, Sreejith Raran-Kurussi, David S Waugh, Robert G Ulrich

“…Protein tyrosine phosphatases dephosphorylate tyrosine residues of proteins, whereas, dual specificity phosphatases (DUSPs) are a subgroup of protein tyrosine phosphatases that dephosphorylate not only Tyr(P) residue, but also the Ser(P) and Thr(P) residues of proteins. …”
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Structural basis of liprin-α-promoted LAR-RPTP clustering for modulation of phosphatase activity by Xingqiao Xie, Ling Luo, Mingfu Liang, Wenchao Zhang, Ting Zhang, Cong Yu, Zhiyi Wei

“…Leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) mediate guided axon growth and synapse formation and liprin-α proteins are their intracellular binding partners. …”
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Vanadium Complexes with Thioanilide Derivatives of Amino Acids: Inhibition of Human Phosphatases and Specificity in Various Cell Models of Metabolic Disturbances by Grzegorz Kazek, Monika Głuch-Lutwin, Barbara Mordyl, Elżbieta Menaszek, Monika Kubacka, Anna Jurowska, Dariusz Cież, Bartosz Trzewik, Janusz Szklarzewicz, Monika A. Papież

“…They showed the inhibition of human protein tyrosine phosphatases (PTP1B, LAR, SHP1, and SHP2) in the submicromolar range, as well as the inhibition of non-tyrosine phosphatases (CDC25A and PPA2) similar to bis(maltolato)oxidovanadium(IV) (BMOV). …”
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Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder by Haruka Munezane, Hiroaki Oizumi, Tomoko Wakabayashi, Shu Nishio, Tomoko Hirasawa, Takashi Sato, Akihiro Harada, Tomoyuki Yoshida, Takahiro Eguchi, Yuji Yamanashi, Tadafumi Hashimoto, Takeshi Iwatsubo

“…Keywords: motor neuron, neuromuscular development, collagen, receptor protein tyrosine phosphatase…”
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Transcriptomic data on the role of PEST-domain-enriched tyrosine phosphatase in the regulation of antigen-mediated activation and antiallergic action of glucocorticoids in mast cel... by George K. Ainooson, Victor Gourain, Michael Stassen, Andrew C.B. Cato

“…Protein tyrosine phosphatases and glucocorticoids are known to regulate allergic and antiallergic action in activated mast cells. …”
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Uma perspectiva computacional sobre catálise enzimática A computational perspective on enzymatic catalysis by Guilherme M. Arantes

“…Reaction mechanisms, in particular that catalysed by protein tyrosine phosphatases, illustrate the concepts.…”
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Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro by Daniela J. Carroll, Yun Cao, Bruce S. Bochner, Jeremy A. O’Sullivan

“…Most members of the Siglec family possess similar cytoplasmic signaling motifs and recruit the protein tyrosine phosphatases SHP-1/2, consistent with ITIM-mediated signaling, to dampen cellular activation. …”
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The Ubiquitin-Associated and SH3 Domain-Containing Proteins (UBASH3) Family in Mammalian Development and Immune Response by Katarina Vukojević, Violeta Šoljić, Vlatka Martinović, Fila Raguž, Natalija Filipović

“…UBASH3A and UBASH3B are protein families of atypical protein tyrosine phosphatases that function as regulators of various cellular processes during mammalian development. …”
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The Eyes Absent Proteins: Unusual HAD Family Tyrosine Phosphatases by Kaushik Roychoudhury, Rashmi S. Hegde

“…EYA proteins have the unique distinction of being structurally and mechanistically classified as HAD enzymes, yet, unlike other HAD phosphatases, they are protein tyrosine phosphatases (PTPs). Further, the EYA proteins are unique among the 107 classical PTPs in the human genome because they do not use a Cysteine residue as a nucleophile in the dephosphorylation reaction. …”
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The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells by Farhad Seif, Majid Khoshmirsafa, Hossein Aazami, Monireh Mohsenzadegan, Gholamreza Sedighi, Mohammadali Bahar

“…This pathway is regulated by an array of regulator proteins, including Suppressors of Cytokine Signaling (SOCS), Protein Inhibitors of Activated STATs (PIAS) and Protein Tyrosine Phosphatases (PTPs) determining the initiation, duration and termination of the signaling cascades. …”
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Advances in the Signaling Pathways Downstream of Glial-Scar Axon Growth Inhibitors by Armin Sami, Armin Sami, Michael E. Selzer, Michael E. Selzer, Shuxin Li, Shuxin Li

“…CSPGs bind with high affinity to several transmembrane receptors, including two members of the leukocyte common antigen related (LAR) subfamily of receptor protein tyrosine phosphatases (RPTPs). Recent studies demonstrate that multiple intracellular signaling pathways downstream of these two RPTPs mediate the growth-inhibitory actions of CSPGs. …”
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Sticks and Stones, a conserved cell surface ligand for the Type IIa RPTP Lar, regulates neural circuit wiring in Drosophila by Namrata Bali, Hyung-Kook (Peter) Lee, Kai Zinn

“…Type IIa receptor-like protein tyrosine phosphatases (RPTPs) are essential for neural development. …”
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Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2. by Kunihiko Hatanaka, Anthony A Lanahan, Masahiro Murakami, Michael Simons

“…In the present study, we aimed to investigate the detailed mechanism of FGF regulation of VE-cadherin function that leads to endothelial junction stabilization.In vitro studies demonstrated that the loss of FGF signaling disrupts the VE-cadherin-catenin complex at adherens junctions by increasing tyrosine phosphorylation levels of VE-cadherin. Among protein tyrosine phosphatases (PTPs) known to be involved in the maintenance of the VE-cadherin complex, suppression of FGF signaling reduces SHP2 expression levels and SHP2/VE-cadherin interaction due to accelerated SHP2 protein degradation. …”
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Dual-Specificity Phosphatases and Kidney Diseases by Haiyang Li, Jiachuan Xiong, Yu Du, Yinghui Huang, Jinghong Zhao

“…Background: Dual-specificity phosphatases (DUSPs) belong to the family of protein tyrosine phosphatases, which can dephosphorylate both serine/threonine and tyrosine residues. …”
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