Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach. by Fanny Schmidt, Monique van den Eijnden, Rosanna Pescini Gobert, Gabriela P Saborio, Susanna Carboni, Chantal Alliod, Sandrine Pouly, Susan M Staugaitis, Ranjan Dutta, Bruce Trapp, Rob Hooft van Huijsduijnen

“…About 100 mammalian Protein Tyrosine Phosphatases (PTPs) are known, many of which are involved in signaling both in health and disease. …”
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Strategy for Leukemia Treatment Targeting SHP-1,2 and SHIP by Fang Hao, Chen Wang, Christine Sholy, Min Cao, Xunlei Kang

“…Protein tyrosine phosphatases (PTPs) are modulators of cellular functions such as differentiation, metabolism, migration, and survival. …”
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A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation. by Johnson, K, Bromley, S, Dustin, M, Thomas, M

“…Transmembrane protein tyrosine phosphatases, such as CD45, can act as both positive and negative regulators of cellular signaling. …”

Two receptor tyrosine phosphatases dictate the depth of axonal stabilizing layer in the visual system by Satoko Hakeda-Suzuki, Hiroki Takechi, Hinata Kawamura, Takashi Suzuki

“…Here, we show that two receptor protein tyrosine phosphatases (RPTPs), LAR and Ptp69D, act redundantly in photoreceptor afferents to stabilize axonal connections to the specific layers of the Drosophila visual system. …”
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The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell–cell adhesion by Gareth W Fearnley, Katherine A Young, James R Edgar, Robin Antrobus, Iain M Hay, Wei-Ching Liang, Nadia Martinez-Martin, WeiYu Lin, Janet E Deane, Hayley J Sharpe

“…The receptor-linked protein tyrosine phosphatases (RPTPs) receive cues from the extracellular environment and are well placed to influence cell signaling. …”
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EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling by Martin Baumdick, Yannick Brüggemann, Malte Schmick, Georgia Xouri, Ola Sabet, Lloyd Davis, Jason W Chin, Philippe IH Bastiaens

“…Autocatalytic activation of epidermal growth factor receptor (EGFR) coupled to dephosphorylating activity of protein tyrosine phosphatases (PTPs) ensures robust yet diverse responses to extracellular stimuli. …”
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Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR by Javier Emperador-Melero, Giovanni de Nola, Pascal S Kaeser

“…It has long been proposed that leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) are cell-adhesion proteins that control synapse assembly. …”
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Large-scale structural analysis of the classical human protein tyrosine phosphatome. by Barr, A, Ugochukwu, E, Lee, W, King, O, Filippakopoulos, P, Alfano, I, Savitsky, P, Burgess-Brown, N, Müller, S, Knapp, S

“…Protein tyrosine phosphatases (PTPs) play a critical role in regulating cellular functions by selectively dephosphorylating their substrates. …”

Impact of Leishmania mexicana infection on dendritic cell signaling and functions. by Irazú Contreras, José A Estrada, Hannah Guak, Caroline Martel, Alborz Borjian, Benjamin Ralph, Marina T Shio, Sylvie Fournier, Connie M Krawczyk, Martin Olivier

“…Herein, we report that Leishmania infection rapidly induced DC protein tyrosine phosphatases activity, leading to MAP kinases inactivation. …”
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Complex protein interactions mediate Drosophila Lar function in muscle tissue. by Jessica Kawakami, David Brooks, Rana Zalmai, Steven D Hartson, Samuel Bouyain, Erika R Geisbrecht

“…The type IIa family of receptor protein tyrosine phosphatases (RPTPs), including Lar, RPTPσ and RPTPδ, are well-studied in coordinating actin cytoskeletal rearrangements during axon guidance and synaptogenesis. …”
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T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand. by Choudhuri, K, Wiseman, D, Brown, M, Gould, K, Van Der Merwe, P

“…It has been proposed that TCR triggering is promoted by segregation at the T cell-APC interface of cell-surface molecules with small ectodomains (such as TCR-pMHC and accessory receptors) from molecules with large ectodomains (such as the receptor protein tyrosine phosphatases CD45 and CD148). Here we show that increasing the dimensions of the TCR-pMHC interaction by elongating the pMHC ectodomain greatly reduces TCR triggering without affecting TCR-pMHC ligation. …”

MAPK-specific tyrosine phosphatases: new targets for drug discovery? by Barr, A, Knapp, S

“…Protein tyrosine phosphatases (PTPs) have key roles in a diverse range of cellular processes, and their dysregulation is associated with several human diseases. …”

Temperature-induced protein secretion by Leishmania mexicana modulates macrophage signalling and function. by Kasra Hassani, Elisabeth Antoniak, Armando Jardim, Martin Olivier

“…Here we show that the exoproteome of L. mexicana upon TS induces cleavage and activation of the host protein tyrosine phosphatases, specifically SHP-1 and PTP1-B, in a murine bone-marrow-derived macrophage cell line. …”
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Abiotic Stresses Antagonize the Rice Defence Pathway through the Tyrosine-Dephosphorylation of OsMPK6. by Yoshihisa Ueno, Riichiro Yoshida, Mitsuko Kishi-Kaboshi, Akane Matsushita, Chang-Jie Jiang, Shingo Goto, Akira Takahashi, Hirohiko Hirochika, Hiroshi Takatsuji

“…An ABA treatment dephosphorylated/inactivated OsMPK6 via protein tyrosine phosphatases, OsPTP1/2, leading to the impaired activation of WRKY45 and a reduction in Magnaporthe oryzae resistance, even after BTH treatment. …”
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Stem cell factor and NSC87877 combine to enhance c-Kit mediated proliferation of human megakaryoblastic cells. by Pawan Kumar Raghav, Ajay Kumar Singh, Gurudutta Gangenahalli

“…This signaling is negatively regulated by protein tyrosine phosphatases (PTPs), SHP-1 and SHP-2. Although NSC87877 (N) is known to inhibit SHP-1/SHP-2, c-Kit-mediated HSCs proliferation by inhibiting SHP-1/SHP-2 has not been reported. …”
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A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity by Shuwei Liang, Eric Tran, Xin Du, Jiajun Dong, Harrison Sudholz, Hao Chen, Zihan Qu, Nicholas D. Huntington, Jeffrey J. Babon, Nadia J. Kershaw, Zhong-Yin Zhang, Jonathan B. Baell, Florian Wiede, Tony Tiganis

“…Abstract The inhibition of protein tyrosine phosphatases 1B (PTP1B) and N2 (PTPN2) has emerged as an exciting approach for bolstering T cell anti-tumor immunity. …”
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Targeted Ptpn11 deletion in mice reveals the essential role of SHP2 in osteoblast differentiation and skeletal homeostasis by Lijun Wang, Huiliang Yang, Jiahui Huang, Shaopeng Pei, Liyun Wang, Jian Q. Feng, Dian Jing, Hu Zhao, Henry M. Kronenberg, Douglas C. Moore, Wentian Yang

“…To date, most of the work in OBs has focused on phosphorylation by tyrosyl kinases, but little has been revealed about dephosphorylation by protein tyrosine phosphatases (PTPases). SHP2 (encoded by PTPN11) is a ubiquitously expressed PTPase. …”
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PTPN1 Deficiency Modulates BMPR2 Signaling and Induces Endothelial Dysfunction in Pulmonary Arterial Hypertension by Md Khadem Ali, Xuefei Tian, Lan Zhao, Katharina Schimmel, Christopher J. Rhodes, Martin R. Wilkins, Mark R. Nicolls, Edda F. Spiekerkoetter

“…How BMPR2 signaling is decreased in PAH is poorly understood. Protein tyrosine phosphatases (PTPs) play important roles in vascular remodeling in PAH. …”
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Exploring the Anti-Diabetic Potential of Quercetagitrin through Dual Inhibition of PTPN6 and PTPN9 by Geetanjali B. Gone, Geonhui Go, Gibeom Nam, Woojoo Jeong, Hyemin Kim, Soah Lee, Sang J. Chung

“…Protein tyrosine phosphatases (PTPs) are pivotal contributors to the development of type 2 diabetes (T2DM). …”
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Cardioprotection by Vanadium Compounds Targeting Akt-Mediated Signaling by Md. Shenuarin Bhuiyan, Kohji Fukunaga

“…Vanadium compounds activate Akt signaling through inhibition of protein tyrosine phosphatases, thereby eliciting cardioprotection in myocardial ischemia / reperfusion-induced injury and myocardial hypertrophy. …”
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