Expression of several deubiquitinase and tyrosine phosphatase genes involved in inflammatory response in lymphoma by Nguyen Hoang Giang, Nguyen Trong Ha, Nguyen Thi Xuan

“…Within the context of the inflammatory response, two SH2 domain-containing protein tyrosine phosphatases (SHPs), namely SHP-1 and SHP-2, serve as negative regulators. …”
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Tumor cell apoptosis mediated by the orexins by A. S. Diatlova, N. S. Novikova, K. Z. Derevtsova, E. A. Korneva

“…ITIM recruits either SHP1 and SHP2 protein tyrosine phosphatases or SHIP1 and SHIP2 inositol phosphatases, to mediate negative signal transduction. …”
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Application of Post Solid-Phase Oxime Ligation to Fine-Tune Peptide–Protein Interactions by Xue Zhi Zhao, Fa Liu, Terrence R. Burke

“…The current review will focus on the authors’ use of peptide ligation to optimize PPI antagonists directed against several targets, including tumor susceptibility gene 101 (Tsg101), protein tyrosine phosphatases (PTPases) and the polo-like kinase 1 (Plk1). …”
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Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brai... by Angata, T, Kerr, S, Greaves, D, Varki, N, Crocker, P, Varki, A

“…As with others in this subgroup, the cytosolic domain of Siglec-11 is phosphorylated at tyrosine residue(s) upon pervanadate treatment of cells and then recruits the protein-tyrosine phosphatases SHP-1 and SHP-2. However, Siglec-11 has several novel features relative to the other CD33/Siglec-3-related Siglecs. …”

Unraveling the Secrets of a Double-Life Fungus by Genomics: <i>Ophiocordyceps australis</i> CCMB661 Displays Molecular Machinery for Both Parasitic and Endophytic Lifestyles by Thaís Almeida de Menezes, Flávia Figueira Aburjaile, Gabriel Quintanilha-Peixoto, Luiz Marcelo Ribeiro Tomé, Paula Luize Camargos Fonseca, Thairine Mendes-Pereira, Daniel Silva Araújo, Tarcisio Silva Melo, Rodrigo Bentes Kato, Jacques Hubert Charles Delabie, Sérvio Pontes Ribeiro, Bertram Brenig, Vasco Azevedo, Elisandro Ricardo Drechsler-Santos, Bruno Silva Andrade, Aristóteles Góes-Neto

“…In addition, the primary genes encoding proteins and critical enzymes during the infection process and those responsible for the host–pathogen interaction have been identified, including proteases (Pr1, Pr4), aminopeptidases, chitinases (Cht2), adhesins, lectins, lipases, and behavioral manipulators, such as enterotoxins, Protein Tyrosine Phosphatases (PTPs), and Glycoside Hydrolases (GHs). …”
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Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice by Janine Krüger, Sebastian Brachs, Manuela Trappiel, Ulrich Kintscher, Heike Meyborg, Ernst Wellnhofer, Christa Thöne-Reineke, Philipp Stawowy, Arne Östman, Andreas L. Birkenfeld, Frank D. Böhmer, Kai Kappert

“…Objective: Insulin resistance can be triggered by enhanced dephosphorylation of the insulin receptor or downstream components in the insulin signaling cascade through protein tyrosine phosphatases (PTPs). Downregulating density-enhanced phosphatase-1 (DEP-1) resulted in an improved metabolic status in previous analyses. …”
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LAR-RPTP Clustering Is Modulated by Competitive Binding between Synaptic Adhesion Partners and Heparan Sulfate by Seoung Youn Won, Cha Yeon Kim, Doyoun Kim, Jaewon Ko, Ji Won Um, Sung Bae Lee, Matthias Buck, Eunjoon Kim, Eunjoon Kim, Won Do Heo, Won Do Heo, Jie-Oh Lee, Ho Min Kim, Ho Min Kim

“…The leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) are cellular receptors of heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans that direct axonal growth and neuronal regeneration. …”
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PLCβ1-SHP-2 complex, PLCβ1 tyrosine dephosphorylation and SHP-2 phosphatase activity: a new part of Angiotensin II signaling? by Rossi Gian, Dal Maso Lucia, Pagnin Elisa, Davis Paul A, Bordin Luciana, Calò Lorenzo A, Pessina Achille C, Clari Giulio

“…<p>Abstract</p> <p>Background</p> <p>Angiotensin II (Ang II) signaling occurs via two major receptors which activate non-receptor tyrosin kinases that then interact with protein tyrosin-phosphatases (PTPs) to regulate cell function. …”
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Reduced expression of PTPRD correlates with poor prognosis in gastric adenocarcinoma. by Dandan Wang, Leilei Wang, Jun Zhou, Jihong Pan, Wei Qian, Jiafang Fu, Genglin Zhang, Youming Zhu, Chunshan Liu, Chunliang Wang, Zongkun Jin, Ziqing He, Jianmei Wu, Bin Shi

“…PTPRD, encoding protein tyrosine phosphatases receptor type D, is located at chromosome 9p23-24.1, a loci frequently lost in many types of tumors. …”
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Pan-cancer analysis revealing that PTPN2 is an indicator of risk stratification for acute myeloid leukemia by Xuanyu Wang, Sanyun Wu, Le Sun, Peipei Jin, Jianmin Zhang, Wen Liu, Zhuo Zhan, Zisong Wang, Xiaoping Liu, Li He

“…Abstract The non-receptor protein tyrosine phosphatases gene family (PTPNs) is involved in the tumorigenesis and development of many cancers, but the role of PTPNs in acute myeloid leukemia (AML) remains unclear. …”
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Silencing of PTPN18 Induced Ferroptosis in Endometrial Cancer Cells Through p-P38-Mediated GPX4/xCT Down-Regulation by Wang H, Peng S, Cai J, Bao S

“…PTPN18 is a member of the protein tyrosine phosphatases (PTP) family, which is associated with the occurrence and progression of various human cancers. …”
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Slitrk missense mutations associated with neuropsychiatric disorders distinctively impair Slitrk trafficking and synapse formation by Hyeyeon Kang, Kyung Ah Han, Seong Youn Won, Ho Min Kim, Young-Ho Lee, Jaewon Ko, JI WON UM

“…Slitrks are a six-member family of synapse organizers that control excitatory and inhibitory synapse formation by forming trans-synaptic adhesions with LAR receptor protein tyrosine phosphatases (PTPs). Intriguingly, genetic mutations of Slitrks have been associated with a multitude of neuropsychiatric disorders. …”
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Bis(maltolato)oxovanadium(IV) Induces Angiogenesis via Phosphorylation of VEGFR2 by Laura Parma, Hendrika A.B. Peters, Maria E. Johansson, Saray Gutiérrez, Henk Meijerink, Sjef de Kimpe, Margreet R. de Vries, Paul H.A. Quax

“…VEGFR2 activation is regulated by protein tyrosine phosphatases (PTPs), enzymes that dephosphorylate the receptor and reduce angiogenesis. …”
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Crystal structure of PTP-SL/PTPBR7 catalytic domain: implications for MAP kinase regulation. by Szedlacsek, SE, Aricescu, A, Fulga, T, Renault, L, Scheidig, A

“…Protein tyrosine phosphatases PTP-SL and PTPBR7 are isoforms belonging to cytosolic membrane-associated and to receptor-like PTPs (RPTPs), respectively. …”

Tyrosine phosphatases such as SHP-2 act in a balance with Src-family kinases in stabilization of postsynaptic clusters of acetylcholine receptors by Rüegg Markus A, Lin Shuo, Sadasivam Gayathri, Willmann Raffaella, Camilleri Alain A, Gesemann Matthias, Fuhrer Christian

“…This suggests that a balance between protein tyrosine phosphatases (PTPs) and protein tyrosine kinases (PTKs) such as those of the Src-family may be essential in stabilizing clusters of AChRs.…”
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Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H₂O₂ Toge... by Markus Dagnell, Qing Cheng, Elias S.J. Arnér

“…Protein tyrosine phosphatases (PTPs) can be regulated by several redox-dependent mechanisms and control growth factor-activated receptor tyrosine kinase phosphorylation cascades. …”
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Ferulic Acid Ameliorates Hepatic Inflammation and Fibrotic Liver Injury by Inhibiting PTP1B Activity and Subsequent Promoting AMPK Phosphorylation by Jianzhi Wu, Xiaoyong Xue, Guifang Fan, Yiqing Gu, Fei Zhou, Qi Zheng, Runping Liu, Yajing Li, Boning Ma, Shuo Li, Guangrui Huang, Lin Ma, Xiaojiaoyang Li

“…Adenosine monophosphate-activated protein kinase (AMPK) functions as a critical energy sensor and is regulated through the phosphorylation of liver kinases like LKB1 or dephosphorylation by protein tyrosine phosphatases (PTPs). However, the role of FA in carbon tetrachloride (CCl4)-induced chronic inflammation and liver fibrosis and AMPK activation has not been elucidated. …”
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Detection and expression of SapS, a class C nonspecific acid phosphatase with O-phospho-Ltyrosine- phosphatase activity, in Staphylococcus aureus isolates from patients with chroni... by Carlos Martínez-Canseco, Rebecca E. Franco-Bourland, Norma González-Huerta, Marco Antonio Paredes-Espinosa, Silvia Giono-Cerezo, Laura Sánchez-Chapul, Rogelio Paniagua-Pérez, René Valdez-Mijares, Cecilia Hernández-Flores

“…SapS shares biochemical similarities with known virulent bacterial, such as protein tyrosine phosphatases, suggesting it may be a virulence factor in chronic osteomyelitis.…”
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Combining vanadyl sulfate with Newcastle disease virus potentiates rapid innate immune-mediated regression with curative potential in murine cancer models by Thomas M. McAusland, Jacob P. van Vloten, Lisa A. Santry, Matthew M. Guilleman, Amira D. Rghei, Edgar M. Ferreira, Joelle C. Ingrao, Rozanne Arulanandam, Pierre P. Major, Leonardo Susta, Khalil Karimi, Jean-Simon Diallo, Byram W. Bridle, Sarah K. Wootton

“…Intratumoral injection of vanadyl sulfate, a pan-inhibitor of protein tyrosine phosphatases, in combination with NDV significantly increased the number and activation status of natural killer (NK) cells in the tumor microenvironment, concomitant with increased expression of interferon-β, granulocyte-macrophage colony-stimulating factor, and monocyte chemoattractant protein-1, leading to rapid tumor regression and long-term cures in mice bearing syngeneic B16-F10 melanomas. …”
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Dynamic transcriptomic profiles of zebrafish gills in response to zinc depletion by Cunningham Phil, Feeney Graham P, Kille Peter, Zheng Dongling, Handy Richard D, Hogstrand Christer

“…There was also significant bias for annotations relating to development, cell cycle, cell differentiation, gene regulation, butanoate metabolism, lysine degradation, protein tyrosin phosphatases, nucleobase, nucleoside and nucleotide metabolism, and cellular metabolic processes. …”
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