Computational and Pharmacological Evaluation of Ferrocene-Based Acyl Ureas and Homoleptic Cadmium Carboxylate Derivatives for Anti-diabetic Potential by Shahar Bano, Arif-ullah Khan, Faiza Asghar, Faiza Asghar, Muhammad Usman, Amin Badshah, Saqib Ali

“…PFA, DPC1, DMC1, DOC1, DPAA and CPAA exhibited high binding affinities (ACE ≥ −350 Kcal/mol) against targets: aldose reductase, peroxisome proliferator-activated receptor γ, 11β-hydroxysteroid dehydrogenase-1, C-alpha glucosidase and glucokinase, while showed moderate affinities (ACE ≥ −250 Kcal/mol) against N-alpha glucosidase, dipeptidyl peptidase-IV, phosphorylated-Akt, glycogen synthase kinase-3β, fructose-1,6-bisphosphatase and phosphoenolpyruvate carboxykinase, whereas revealed lower affinities (ACE < −250 Kcal/mol) vs. alpha amylase, protein tyrosine phosphatases 1B, glycogen phosphorylase and phosphatidylinositol 3 kinase. …”
Get full text

SHP1 and SHP2 inhibition enhances the pro-differentiative effect of phorbol esters: an alternative approach against acute myeloid leukemia by Alejandro Pérez-Fernández, Guillermo López-Ruano, Rodrigo Prieto-Bermejo, Carla Ijurko, María Díez-Campelo, Fermín Sánchez-Guijo, Ángel Hernández-Hernández

“…Here, the involvement of the protein tyrosine phosphatases SHP1 and SHP2 on leukemic cells differentiation is shown, along with the therapeutic possibilities of their targeting to enhance the differentiation induction effect of phorbol esters. …”
Get full text

The phosphatase Shp1 interacts with and dephosphorylates cortactin to inhibit invadopodia function by Alessia Varone, Chiara Amoruso, Marcello Monti, Manpreet Patheja, Adelaide Greco, Luigi Auletta, Antonella Zannetti, Daniela Corda

“…Protein tyrosine kinases such as Src are known to regulate invadopodia assembly, little is however known on the role of protein tyrosine phosphatases in this process. Among these enzymes, we have selected the tyrosine phosphatase Shp1 to investigate its potential role in invadopodia assembly, due to its involvement in cancer development. …”
Get full text

Extracellular SOD-derived H2O2 promotes VEGF signaling in caveolae/lipid rafts and post-ischemic angiogenesis in mice. by Jin Oshikawa, Norifumi Urao, Ha Won Kim, Nihal Kaplan, Masooma Razvi, Ronald McKinney, Leslie B Poole, Tohru Fukai, Masuko Ushio-Fukai

“…One of the targets of ROS is protein tyrosine phosphatases (PTPs). ecSOD induces oxidation and inactivation of both PTP1B and DEP1, which negatively regulates VEGFR2-pY, in caveolae/lipid rafts, but not non-lipid rafts. …”
Get full text

Redundancy and compensation in axon guidance: genetic analysis of the <it>Drosophila </it>Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily by Bahri Sami, Nguyen Huong, Jeon Mili, Zinn Kai

“…<p>Abstract</p> <p>Background</p> <p><it>Drosophila </it>has six receptor protein tyrosine phosphatases (RPTPs), five of which are expressed primarily in neurons. …”
Get full text

Immune checkpoint PTPN2 predicts prognosis and immunotherapy response in human cancers by Xiaolong Tang, Xue Sui, Yongshuo Liu

“…Background: PTPN2, a member of the non-receptor protein tyrosine phosphatases family, holds a crucial role in tumorigenesis and cancer immunotherapy. …”
Get full text

Regulation of the Mitochondrion-Fatty Acid Axis for the Metabolic Reprogramming of <named-content content-type="genus-species">Chlamydia trachomatis</named-content> during Treatmen... by Kensuke Shima, Inga Kaufhold, Thomas Eder, Nadja Käding, Nis Schmidt, Iretiolu M. Ogunsulire, René Deenen, Karl Köhrer, Dirk Friedrich, Sophie E. Isay, Florian Grebien, Matthias Klinger, Barbara C. Richer, Ulrich L. Günther, George S. Deepe, Thomas Rattei, Jan Rupp

“…In C. trachomatis infection, inactivation of STAT3 by host protein tyrosine phosphatases increased mitochondrial respiration in both the absence and presence of β-lactam antimicrobials. …”
Get full text

Comprehensive analysis of PTPN family expression and prognosis in acute myeloid leukemia by Yong Liu, Jing Zhang, Zefan Du, Junbin Huang, Yucai Cheng, Wenfang Yi, Tianwen Li, Jing Yang, Chun Chen

“…Background: Tyrosyl phosphorylation is carried out by a group of enzymes known as non-receptor protein tyrosine phosphatases (PTPNs). In the current investigation, it is hoped to shed light on the relationships between the expression patterns of PTPN family members and the prognosis of acute myeloid leukemia (AML). …”
Get full text

Allergen-Specific IgA Antibodies Block IgE-Mediated Activation of Mast Cells and Basophils by Yasmeen S. El Ansari, Yasmeen S. El Ansari, Cynthia Kanagaratham, Cynthia Kanagaratham, Oliver T. Burton, Jenna V. Santos, Brianna-Marie A. Hollister, Owen L. Lewis, Harald Renz, Hans C. Oettgen, Hans C. Oettgen

“…In addition to bearing activating receptors like FcεRI, these effector cells of allergy express inhibitory ones including FcγR2b, an IgG Fc receptor with a cytosolic inhibitory motif that activates protein tyrosine phosphatases that suppress IgE-mediated activation. …”
Get full text

ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases by Doaa Glal, Doaa Glal, Janaki N. Sudhakar, Hsueh-Han Lu, Ming-Che Liu, Hung-Yu Chiang, Yen-Chun Liu, Ching-Feng Cheng, Jr-Wen Shui

“…Intriguingly, ATF3 itself does not act on STAT3 directly, instead ATF3 regulates pSTAT3 by negatively targeting protein tyrosine phosphatases (PTPs) including SHP2 and PTP-Meg2. …”
Get full text

<named-content content-type="genus-species">Porphyromonas gingivalis</named-content> Tyrosine Phosphatase Php1 Promotes Community Development and Pathogenicity by Young-Jung Jung, Daniel P. Miller, John D. Perpich, Zackary R. Fitzsimonds, Daonan Shen, Jun Ohshima, Richard J. Lamont

“…Metal-dependent protein tyrosine phosphatases that belong to the polymerase and histindinol phosphatase (PHP) family are widespread in Gram-positive bacteria. …”
Get full text

The expression patterns and the diagnostic/prognostic roles of PTPN family members in digestive tract cancers by Jing Chen, Xu Zhao, Yuan Yuan, Jing-Jing Jing

“…Abstract Background Non-receptor protein tyrosine phosphatases (PTPNs) are a set of enzymes involved in the tyrosyl phosphorylation. …”
Get full text

Functional Metagenomics Reveals a New Catalytic Domain, the Metallo-β-Lactamase Superfamily Domain, Associated with Phytase Activity by Genis Andrés Castillo Villamizar, Katrina Funkner, Heiko Nacke, Karolin Foerster, Rolf Daniel

“…The catalytic signatures of phytases are restricted to the molecular domains of four protein superfamilies: histidine phosphatases, protein tyrosine phosphatases, the purple acid phosphatases and the β-propeller phosphatases. …”
Get full text