The Structure, Function and Regulation of Protein Tyrosine Phosphatase Receptor Type J and Its Role in Diseases by Huiting Li, Peng Zhang, Cencen Liu, Yiwei Wang, Yan Deng, Wei Dong, Yang Yu

Subjects: “…protein tyrosine phosphatase receptor type J (PTPRJ)…”
Get full text

Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses by Sanchez-Blanco, C, Clarke, F, Cornish, G, Depoil, D, Thompson, S, Dai, X, Rawlings, D, Dustin, M, Zamoyska, R, Cope, A, Purvis, H

“…PTPN22 encodes a protein tyrosine phosphatase that negatively regulates immuno-receptor proximal Src and Syk family kinases. …”

A versatile spectrophotometric protein tyrosine phosphatase assay based on 3-nitrophosphotyrosine containing substrates. by van Ameijde, J, Overvoorde, J, Knapp, S, den Hertog, J, Ruijtenbeek, R, Liskamp, R

“…A versatile assay for protein tyrosine phosphatases (PTP) employing 3-nitrophosphotyrosine containing peptidic substrates is described. …”

Differential allelic expression of protein tyrosine phosphatase NonReceptor 22 in rheumatoid arthritis patients by Harrison, P, Southam, L, Pointon, J, Chapman, K, Locklin, R, Sabokbar, A, Wordsworth, B

Role of zinc and magnesium ions in the modulation of phosphoryl transfer in protein tyrosine phosphatase 1B by Bellomo, E, Abro, A, Hogstrand, C, Maret, W, Domene, C

“…While the majority of phosphatases are metalloenzymes, the prevailing model for the reactions catalyzed by protein tyrosine phosphatases does not involve any metal ion, yet both metal cations and oxoanions affect their enzymatic activity. …”

Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses by Sanchez-Blanco, C, Clarke, F, Cornish, G, Depoil, D, Thompson, S, Dai, X, Rawlings, D, Dustin, M, Zamoyska, R, Cope, A, Purvis, H

“…PTPN22 encodes a protein tyrosine phosphatase that negatively regulates immuno-receptor proximal Src and Syk family kinases. …”

A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop by Wang, H, Perera, L, Jork, N, Riley, AM, Potter, BVL, Et al.

“…An important group of enzymes has been deprived of this analytical privilege: members of the protein tyrosine phosphatase (PTP) superfamily with catalytic WPD-loops lacking the indispensable general-acid/base within a tryptophan-proline-aspartate/glutamate context. …”

Structural stability of human protein tyrosine phosphatase ρ catalytic domain: effect of point mutations. by Pasquo, A, Consalvi, V, Knapp, S, Alfano, I, Ardini, M, Stefanini, S, Chiaraluce, R

“…Protein tyrosine phosphatase ρ (PTPρ) belongs to the classical receptor type IIB family of protein tyrosine phosphatase, the most frequently mutated tyrosine phosphatase in human cancer. …”

S-Nitrosation of Arabidopsis thaliana Protein Tyrosine Phosphatase 1 Prevents Its Irreversible Oxidation by Hydrogen Peroxide by Valérie Nicolas-Francès, Jordan Rossi, Claire Rosnoblet, Carole Pichereaux, Carole Pichereaux, Siham Hichami, Jeremy Astier, Agnès Klinguer, David Wendehenne, Angélique Besson-Bard

Subjects: Get full text

Functional Significance and Structure-Activity Relationship of Food-Derived Protein Tyrosine Phosphatase 1B Inhibitors by BAO Meili, WANG Zhenyu

Subjects: “…food-derived; natural compounds; type 2 diabetes; protein tyrosine phosphatase 1b inhibitor…”
Get full text

Design, Synthesis and Biological Evaluation of Stilbene Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B by Haibing He, Yinghua Ge, Hong Dai, Song Cui, Fei Ye, Jia Jin, Yujun Shi

Subjects: “…protein tyrosine phosphatase 1B (PTP1B)…”
Get full text

Analogues of Dihydroflavonol and Flavone as Protein Tyrosine Phosphatase 1B Inhibitors from the Leaves of Artocarpus elasticus by Abdul Bari Shah, Aizhamal Baiseitova, Gihwan Lee, Jeong Ho Kim, Ki Hun Park

Get full text

Role of Protein Tyrosine Phosphatase 1B Inhibitor in Early Brain Injury of Subarachnoid Hemorrhage in Mice by Zhong-Hua Zhang, Xiao-Ming Zhou, Xin Zhang

Subjects: “…protein tyrosine phosphatase 1B…”
Get full text

Protein-protein interactions in crystals of the human receptor-type protein tyrosine phosphatase ICA512 ectodomain. by María E Primo, Jean Jakoncic, Martín E Noguera, Valeria A Risso, Laura Sosa, Mauricio P Sica, Michele Solimena, Edgardo Poskus, Mario R Ermácora

“…ICA512 (or IA-2) is a transmembrane protein-tyrosine phosphatase located in secretory granules of neuroendocrine cells. …”
Get full text

Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors by Ningbo Qin, Tatsunori Sasaki, Wei Li, Jian Wang, Xiangyu Zhang, Dahong Li, Zhanlin Li, Maosheng Cheng, Huiming Hua, Kazuo Koike

Subjects: “…Protein tyrosine phosphatase 1B…”
Get full text

Evolutionary mechanisms driving the evolution of a large polydnavirus gene family coding for protein tyrosine phosphatases by Serbielle Céline, Dupas Stéphane, Perdereau Elfie, Héricourt François, Dupuy Catherine, Huguet Elisabeth, Drezen Jean-Michel

Subjects: Get full text

Regulation of CD4+ T Cell Signaling and Immunological Synapse by Protein Tyrosine Phosphatases: Molecular Mechanisms in Autoimmunity by Patricia Castro-Sánchez, Patricia Castro-Sánchez, Oscar Aguilar-Sopeña, Oscar Aguilar-Sopeña, Sergio Alegre-Gómez, Sergio Alegre-Gómez, Rocio Ramirez-Munoz, Rocio Ramirez-Munoz, Pedro Roda-Navarro, Pedro Roda-Navarro

“…This molecular dynamics is tightly regulated by phosphorylation networks, which are controlled by protein tyrosine phosphatases (PTPs). While some PTPs are known to be important regulators of adhesion, ligand discrimination or the stimulation threshold, there is still little information about the regulatory role of PTPs in cytoskeleton rearrangements and endosomal compartment dynamics. …”
Get full text

The protein tyrosine phosphatase PPH‐7 is required for fertility and embryonic development in C. elegans at elevated temperatures by Curdin A. Franziscus, Danilo Ritz, N. Constantin Kappel, Jachen A. Solinger, Alexander Schmidt, Anne Spang

Subjects: Get full text

Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases by Inmaculada García-Ruiz, Nerea Blanes Ruiz, Patricia Rada, Virginia Pardo, Laura Ruiz, Ana Blas-García, M. Pilar Valdecantos, Montserrat Grau Sanz, José A. Solís Herruzo, Ángela M. Valverde

“…The key role of protein tyrosine phosphatase 1B (PTP1B) in inflammatory responses has focused this study in understanding its implication in liver fibrosis. …”
Get full text

Structural Insights into the Active Site Formation of DUSP22 in N-loop-containing Protein Tyrosine Phosphatases by Chih-Hsuan Lai, Co-Chih Chang, Huai-Chia Chuang, Tse-Hua Tan, Ping-Chiang Lyu

“…Cysteine-based protein tyrosine phosphatases (Cys-based PTPs) perform dephosphorylation to regulate signaling pathways in cellular responses. …”
Get full text