Characterization of protein tyrosine phosphatase H1 knockout mice in animal models of local and systemic inflammation by Muzio Valeria, Lafont David T, Patrignani Claudia, Gréco Béatrice, van Huijsduijnen Rob, Zaratin Paola F

“…<p>Abstract</p> <p>Background</p> <p>PTPH1 is a protein tyrosine phosphatase expressed in T cells but its effect on immune response is still controversial. …”
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Activation of hydrogen peroxide to peroxytetradecanoic acid is responsible for potent inhibition of protein tyrosine phosphatase CD45. by Alicja Kuban-Jankowska, Jack A Tuszynski, Philip Winter, Magdalena Gorska, Narcyz Knap, Michal Wozniak

“…Hydrogen peroxide induces oxidation and consequently inactivation of many protein tyrosine phosphatases. It was found that hydrogen peroxide, in the presence of carboxylic acids, was efficiently activated to form even more potent oxidant - peroxy acid. …”
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Involvement of the Mitochondrial Protein Tyrosine Phosphatase PTPM1 in the Promotion of Conidiation, Development, and Pathogenicity in Colletotrichum graminicola by Shaowei Wang, Guihua Li, Guihua Li, Yi Wei, Yi Wei, Gang Wang, Yuejia Dang, Penghui Zhang, Shi-Hong Zhang, Shi-Hong Zhang

Subjects: “…mitochondrial protein tyrosine phosphatase (CgPTPM1)…”
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Common and female-specific roles of protein tyrosine phosphatase receptors N and N2 in mice reproduction by Srdjan J. Sokanovic, Stephanie Constantin, Aloa Lamarca Dams, Yuta Mochimaru, Kosara Smiljanic, Ivana Bjelobaba, Rafael M. Prévide, Stanko S. Stojilkovic

“…Abstract Simultaneous knockout of the neuroendocrine marker genes Ptprn and Ptprn2, which encode the protein tyrosine phosphatase receptors N and N2, causes infertility in female mice while males are fertile. …”
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Regulation of platelet-activating factor-induced interleukin-8 expression by protein tyrosine phosphatase 1B by Geneviève Hamel-Côté, Fanny Lapointe, Daniel Gendron, Marek Rola-Pleszczynski, Jana Stankova

“…The presence of multiple potential protein-tyrosine phosphatase (PTP) 1B substrates in PAF receptor signaling pathways brought us to investigate its involvement in PAF-induced cytokine expression in monocyte-derived dendritic cells (Mo-DCs) and to study the pathways involved in this modulation. …”
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Interaction of kinase-interaction-motif protein tyrosine phosphatases with the mitogen-activated protein kinase ERK2. by Dana M Francis, Dorothy Koveal, Antoni Tortajada, Rebecca Page, Wolfgang Peti

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Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse. by Syed-Wajahat Hassan, Karen M Doody, Serge Hardy, Noriko Uetani, Denis Cournoyer, Michel L Tremblay

“…T cell protein tyrosine phosphatase (TC-PTP/PTPN2) is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation, and inflammation. …”
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Gene Expression of Protein Tyrosine Phosphatase 1B and Endoplasmic Reticulum Stress During Septic Shock by Thomas Clavier, Thomas Clavier, Thomas Clavier, Steven Grangé, Thibaut Pressat-Laffouilhere, Emmanuel Besnier, Emmanuel Besnier, Sylvanie Renet, Sylvain Fraineau, Pierre-Alain Thiebaut, Vincent Richard, Benoit Veber, Fabienne Tamion, Fabienne Tamion

Subjects: “…protein tyrosine phosphatase…”
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Dynamic recruitment of protein tyrosine phosphatase PTPD1 to EGF stimulation sites potentiates EGFR activation. by Pedro Roda-Navarro, Philippe I Bastiaens

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Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase B (PtpB) inhibitors from natural products. by Alessandra Mascarello, Mattia Mori, Louise Domeneghini Chiaradia-Delatorre, Angela Camila Orbem Menegatti, Franco Delle Monache, Franco Ferrari, Rosendo Augusto Yunes, Ricardo José Nunes, Hernán Terenzi, Bruno Botta, Maurizio Botta

“…Protein tyrosine phosphatase B (PtpB) is one of the virulence factors secreted into the host cell by Mycobacterium tuberculosis. …”
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The Role of Protein Tyrosine Phosphatase (PTP)-1B in Cardiovascular Disease and Its Interplay with Insulin Resistance by Shahenda S. Abdelsalam, Hesham M. Korashy, Asad Zeidan, Abdelali Agouni

“…Several studies identified protein tyrosine phosphatase (PTP)-1B, a member of the PTP superfamily, as a major negative regulator for insulin receptor signaling and a novel molecular player in endothelial dysfunction and cardiovascular disease. …”
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Protein Tyrosine Phosphatase Inhibition Prevents Experimental Cerebral Malaria by Precluding CXCR3 Expression on T Cells by Kristin M. Van Den Ham, Logan K. Smith, Martin J. Richer, Martin Olivier

“…Herein, we demonstrate that inhibition of protein tyrosine phosphatase (PTP) activity significantly attenuates T cell sequestration within the brain and prevents the development of neuropathology. …”
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Baculovirus entry into the central nervous system of Spodoptera exigua caterpillars is independent of the viral protein tyrosine phosphatase by Simone N. Gasque, Yue Han, Iris van der Ham, Dorothy van Leeuwen, Monique M. van Oers, Alexander Haverkamp, Vera I. D. Ros

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Protein tyrosine phosphatase profiling studies during brown adipogenic differentiation of mouse primary brown preadipocytes by Won Kon Kim, Anna Park, Hye-Ryung Choi, Hyeyun Jung, Baek Soo Han, Sang Chul Lee, Kwang-Hee Bae

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Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α by Maiko Wakita, Atsushi Yamagata, Tomoko Shiroshima, Hironori Izumi, Asami Maeda, Mizuki Sendo, Ayako Imai, Keiko Kubota, Sakurako Goto-Ito, Yusuke Sato, Hisashi Mori, Tomoyuki Yoshida, Shuya Fukai

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Status of research on natural protein tyrosine phosphatase 1B inhibitors as potential antidiabetic agents: Update by Zhenyang Liu, Hongwei Gao, Ziyu Zhao, Mengrui Huang, Shengnan Wang, Jiuyu Zhan

Subjects: “…Protein tyrosine phosphatase 1B (PTP1B)…”
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A role for the protein tyrosine phosphatase CD45 in macrophage adhesion through the regulation of paxillin degradation. by Joëlle St-Pierre, Hanne L Ostergaard

“…CD45 is a protein tyrosine phosphatase expressed on all cells of hematopoietic origin that is known to regulate Src family kinases. …”
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Real-Time Monitoring of the Dephosphorylating Activity of Protein Tyrosine Phosphatases Using Microarrays with 3-Nitrophosphotyrosine Substrates by van Ameijde, J, Overvoorde, J, Knapp, S, den Hertog, J, Ruijtenbeek, R, Liskamp, R

“…Herein, a new real-time, dynamic protein tyrosine phosphatase (PTP) substrate microarray assay measuring product formation is described. …”

Extracellular regulation of type IIa receptor protein tyrosine phosphatases: mechanistic insights from structural analyses. by Coles, C, Jones, E, Aricescu, A

“…The receptor protein tyrosine phosphatases (RPTPs) exhibit a wide repertoire of cellular signalling functions. …”

Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution. by Barr, A, Debreczeni, J, Eswaran, J, Knapp, S