Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution. by Barr, A, Debreczeni, J, Eswaran, J, Knapp, S

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Molecular cloning, chromosomal mapping, and developmental expression of a novel protein tyrosine phosphatase-like gene. by Uwanogho, D, Hardcastle, Z, Balogh, P, Mirza, G, Thornburg, K, Ragoussis, J, Sharpe, P

“…Protein tyrosine phosphatases (PTPs) mediate the dephosphorylation of phosphotyrosine. …”

Immunotherapeutic implications of negative regulation by protein tyrosine phosphatases in T cells: the emerging cases of PTP1B and TCPTP by Luis Alberto Perez-Quintero, Luis Alberto Perez-Quintero, Belma Melda Abidin, Belma Melda Abidin, Michel L. Tremblay, Michel L. Tremblay

Subjects: “…protein tyrosine phosphatases…”
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Protein tyrosine phosphatase PTPL1 suppresses lung cancer through Src/ERK/YAP1 signaling by Jing Wang, Shuanghui Li, Xiujuan Zhang, Ning Zhu, Ruzetuoheti Yiminniyaze, Liang Dong, Chengwei Li, Wumaier Gulinuer, Jingwen Xia, Jing Li, Daibing Zhou, Xinning Liu, Youzhi Zhang, Yuanyuan Zhang, Shengqing Li

“…Abstract Background To reveal the function of protein tyrosine phosphatase‐L1 (PTPL1) in lung adenocarcinoma. …”
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Expression of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B in Escherichia coli and Its Recovery from Inclusion Body by Lalu Rudyat Telly Savalas, Prapti Sedijani, Saprizal Hadisaputra, Jannatin Ardhuha, Chomsa Asih Lestari, Etty Nurul Wahidah

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Protein tyrosine phosphatase non-receptor type 2 as the therapeutic target of atherosclerotic diseases: past, present and future by Xiao-Er Tang, Ya-Qiong Cheng, Chao-Ke Tang

“…Tyrosine-protein phosphatase non-receptor type 2(PTPN2), an important member of the protein tyrosine phosphatase family, can regulate various signaling pathways and biological processes by dephosphorylating receptor protein tyrosine kinases. …”
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An In Silico Study Investigating Camptothecin-Analog Interaction with Human Protein Tyrosine Phosphatase, SHP2 (PTPN11) by Donald Bajia, Katarzyna Derwich

“…Therefore, this study aims to provide in silico rationale for the recognition and binding of FL118 and irinotecan with the catalytic domain of human protein tyrosine phosphatase-SHP2 (PTPc-SH2-SHP2, chain A). The docking interaction of the human SHP2 protein’s catalytic domain as well as Y279C and R465G mutants with FL118 and irinotecan ligands were calculated and analyzed using the Autodock 4.2 programme, setting the docking grid to target the protein’s active site. …”
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Protein tyrosine phosphatase 1B (PTP1B) as a potential therapeutic target for neurological disorders by Jordi Olloquequi, Amanda Cano, Elena Sanchez-López, Marina Carrasco, Ester Verdaguer, Ana Fortuna, Jaume Folch, Mònica Bulló, Carme Auladell, Antoni Camins, Miren Ettcheto

“…Protein tyrosine phosphatase 1B (PTP1B) is a typical member of the PTP family, considered a direct negative regulator of several receptor and receptor-associated tyrosine kinases. …”
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Regulation of Microtubule Nucleation in Mouse Bone Marrow-Derived Mast Cells by Protein Tyrosine Phosphatase SHP-1 by Anastasiya Klebanovych, Vladimíra Sládková, Tetyana Sulimenko, Věra Vosecká, Zuzana Rubíková, Martin Čapek, Eduarda Dráberová, Pavel Dráber, Vadym Sulimenko

“…In this study, we report on the regulation of microtubule nucleation in bone marrow-derived mast cells (BMMCs) by Src homology 2 (SH2) domain-containing protein tyrosine phosphatase 1 (SHP-1; <i>Ptpn6</i>). Reciprocal immunoprecipitation experiments and pull-down assays revealed that SHP-1 is present in complexes containing &#947;-tubulin complex proteins and protein tyrosine kinase Syk. …”
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Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy. by Marianne R Spalinger, Silvia Lang, Stephan R Vavricka, Michael Fried, Gerhard Rogler, Michael Scharl

“…BACKGROUND: Variations within the gene locus encoding protein tyrosine phosphatase non-receptor type 22 (PTPN22) are associated with the risk to develop inflammatory bowel disease (IBD). …”
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Defining the molecular basis of interaction between R3 receptor-type protein tyrosine phosphatases and VE-cadherin. by Olga Dorofejeva, Alastair J Barr

“…Receptor-type protein tyrosine phosphatases (RPTPs) of the R3 subgroup play key roles in the immune, vascular and nervous systems. …”
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Regulation of signaling at regions of cell-cell contact by endoplasmic reticulum-bound protein-tyrosine phosphatase 1B. by Fawaz G Haj, Ola Sabet, Ali Kinkhabwala, Sabine Wimmer-Kleikamp, Vassilis Roukos, Hong-Mei Han, Markus Grabenbauer, Martin Bierbaum, Claude Antony, Benjamin G Neel, Philippe I Bastiaens

“…Protein-tyrosine phosphatase 1B (PTP1B) is a ubiquitously expressed PTP that is anchored to the endoplasmic reticulum (ER). …”
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Destabilization of the SHP2 and SHP1 protein tyrosine phosphatase domains by a non-conserved “backdoor” cysteine by Matthew T.N. Yarnall, Sean H. Kim, Samuel Korntner, Anthony C. Bishop

Subjects: “…Protein tyrosine phosphatases…”
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Antidepressant activity of enicostemma littorale blume in shp2 (protein tyrosine phosphatase)-inhibited animal model of depression by V A Doss, Dharaniyambigai Kuberapandian

“…Methods: Animal models of depression were raised by physical methods and administration of methyl isobutyl ketone (100 mg/kg b.w., i.p.,) and a protein tyrosine phosphatase inhibitor, sodium orthovanadate (30 mg/kg b.w., i.p.,) to young Wistar rats. …”
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Inhibition of protein tyrosine phosphatase (PTP1B) and α-glucosidase by geranylated flavonoids from Paulownia tomentosa by Yeong Hun Song, Zia Uddin, Young Min Jin, Zuopeng Li, Marcus John Curtis-Long, Kwang Dong Kim, Jung Keun Cho, Ki Hun Park

“…Protein tyrosine phosphatase 1B (PTP1B) and α-glucosidase are important targets to treat obesity and diabetes, due to their deep correlation with insulin and leptin signalling, and glucose regulation. …”
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Protein Tyrosine Phosphatase Gamma (PTPγ) is a Novel Leukocyte Marker Highly Expressed by CD34+ Precursors by Andrea Mafficini, Marzia Vezzalini, Loris Zamai, Laura Galeotti, Gabriella Bergamini, Marco Della Peruta, Paola Melotti, Claudio Sorio

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Enzyme mechanistic studies of NMA1982, a protein tyrosine phosphatase and potential virulence factor in Neisseria meningitidis by Shuangding Wu, Mathieu Coureuil, Xavier Nassif, Lutz Tautz

“…The overall fold of NMA1982 closely resembles that of protein tyrosine phosphatases (PTPs). However, the hallmark C(X)5R PTP signature motif, containing the catalytic cysteine and invariant arginine, is shorter by one amino acid in NMA1982. …”
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Human Protein Tyrosine Phosphatase 1B (PTP1B): From Structure to Clinical Inhibitor Perspectives by Rongxing Liu, Cécile Mathieu, Jérémy Berthelet, Wenchao Zhang, Jean-Marie Dupret, Fernando Rodrigues Lima

“…PTP1B, one of the most central protein tyrosine phosphatases (PTPs), is a key player in several human diseases and disorders, such as diabetes, obesity, and hematopoietic malignancies, through modulation of different signaling pathways. …”
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Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes. by Ahmed Bettaieb, Kosuke Matsuo, Izumi Matsuo, Shuo Wang, Ramzi Melhem, Antonis E Koromilas, Fawaz G Haj

“…Protein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of glucose homeostasis and body mass, and has been implicated in endoplasmic reticulum (ER) stress. …”
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ER-bound protein tyrosine phosphatase PTP1B interacts with Src at the plasma membrane/substrate interface. by Melisa C Monteleone, Ana E González Wusener, Juan E Burdisso, Cecilia Conde, Alfredo Cáceres, Carlos O Arregui

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