RECEPTOR PROTEIN TYROSINE PHOSPHATASE AND HEPARAN SULFATE PROTEOGLYCANS REGULATED AXON COLLATERAL FORMATION FROM THE CORTICOSPINAL TRACT by Misato Yasumura, Tokuichi Iguchi, Manabu Taniguchi, Yuichiro Oka, Makoto Sato

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The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues by Ashley M. Smith, Katie K. Maguire-Nguyen, Thomas A. Rando, Michael A. Zasloff, Kevin B. Strange, Viravuth P. Yin

“…Davis Center for Regenerative Biology and Medicine with colleagues in the US found that treating zebrafish with an intraperitoneal injection of MSI-1436, which inhibits the enzyme ‘protein tyrosine phosphatase 1B’, increased the rate of regeneration of an amputated caudal fin and of partially removed heart muscle without apparent tissue malformation. …”
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Protein Tyrosine Phosphatase Non-Receptor Type 2 Function in Dendritic Cells Is Crucial to Maintain Tissue Tolerance by Larissa Hering, Egle Katkeviciute, Marlene Schwarzfischer, Philipp Busenhart, Claudia Gottier, Dunja Mrdjen, Juliana Komuczki, Marcin Wawrzyniak, Silvia Lang, Kirstin Atrott, Burkhard Becher, Gerhard Rogler, Gerhard Rogler, Michael Scharl, Michael Scharl, Marianne R. Spalinger

“…Protein tyrosine phosphatase non-receptor type 2 (PTPN2) plays a pivotal role in immune homeostasis and has been associated with human autoimmune and chronic inflammatory diseases. …”
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Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors. by Chanel E Smart, Marjan E Askarian Amiri, Ania Wronski, Marcel E Dinger, Joanna Crawford, Dmitry A Ovchinnikov, Ana Cristina Vargas, Lynne Reid, Peter T Simpson, Sarah Song, Christiane Wiesner, Juliet D French, Richa K Dave, Leonard da Silva, Amy Purdon, Megan Andrew, John S Mattick, Sunil R Lakhani, Melissa A Brown, Stuart Kellie

“…The protein tyrosine phosphatase receptor J, PTPRJ, is a tumor suppressor gene that has been implicated in a range of cancers, including breast cancer, yet little is known about its role in normal breast physiology or in mammary gland tumorigenesis. …”
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Association of the protein tyrosine phosphatase non-receptor 22 polymorphism (PTPN22) with endometriosis: a meta-analysis by Noel Pabalan, Hamdi Jarjanazi, Denise Maria Christofolini, Bianca Bianco, Caio Parente Barbosa

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The <it>protein tyrosine phosphatase receptor type R </it>gene is an early and frequent target of silencing in human colorectal tumorigenesis by Buffoli Federico, Went Philip, Ilinsky Valery V, Sabates-Bellver Jacob, Cattaneo Elisa, Menigatti Mirco, Marquez Victor E, Jiricny Josef, Marra Giancarlo

“…One of these, the <it>protein-tyrosine phosphatase receptor type R </it>(<it>PTPRR</it>) gene, was dramatically downregulated from the earliest stages of cellular transformation. …”
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Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression by Schepens, Jan TG, Kasri, Nael Nadif, Augustine, George James, Hendriks, Wiljan JAJ, Erkens, Mirthe, Tanaka-Yamamoto, Keiko, Cheron, Guy, Márquez-Ruiz, Javier, Prigogine, Cynthia

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Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases by Lippert, AH, Paluch, C, Gaglioni, M, Vuong, MT, McColl, J, Jenkins, E, Fellermeyer, M, Clarke, J, Sharma, S, Moreira da Silva, S, Akkaya, B, Anzilotti, C, Morgan, SH, Jessup, CF, Koerbel, M, Gileadi, U, Leitner, J, Knox, R, Chirifu, M, Huo, J, Yu, S, Ashman, N, Lui, Y, Wilkinson, I, Attfield, KE, Fugger, L, Robertson, NJ, Lynch, CJ, Murray, L, Steinberger, P, Santos, AM, Lee, SF, Cornall, RJ, Klenerman, D, Davis, SJ

“…We hypothesized that antibody agonists trigger signaling by sterically excluding large receptor-type protein tyrosine phosphatases (RPTPs) such as CD45 from sites of receptor engagement. …”

Receptor-type Protein Tyrosine Phosphatase β Regulates Met Phosphorylation and Function in Head and Neck Squamous Cell Carcinoma by Yiru Xu, Jin Zhou, Thomas E Carey, Jonathan B McHugh, John J Voorhees, Gary J Fisher

“…Met function is dependent on tyrosine phosphorylation that is under direct control by receptor-type protein tyrosine phosphatase β (RPTP-β). We report here that RPTP-β expression is significantly downregulated in HNSCC cells derived from metastatic tumors compared to subject-matched cells from primary tumors. …”
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Inactivation and unfolding of protein tyrosine phosphatase from Thermus thermophilus HB27 during urea and guanidine hydrochloride denaturation. by Yejing Wang, Huawei He, Lina Liu, Chunyan Gao, Shui Xu, Ping Zhao, Qingyou Xia

“…The effects of urea and guanidine hydrochloride (GdnHCl) on the activity, conformation and unfolding process of protein tyrosine phosphatase (PTPase), a thermostable low molecular weight protein from Thermus thermophilus HB27, have been studied. …”
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New dammarane-type triterpenoids from the leaves of Panax notoginseng and their protein tyrosine phosphatase 1B inhibitory activity by Dawei Li, Jiaqing Cao, Xiuli Bi, Xichun Xia, Wei Li, Yuqing Zhao

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Association of the protein-tyrosine phosphatase DEP-1 with its substrate FLT3 visualized by in situ proximity ligation assay. by Sylvia-Annette Böhmer, Irene Weibrecht, Ola Söderberg, Frank-D Böhmer

“…Protein-tyrosine phosphatases (PTPs) are important regulators of signal transduction processes. …”
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New Hippolide Derivatives with Protein Tyrosine Phosphatase 1B Inhibitory Activity from the Marine Sponge Hippospongia lachne by Shu-Juan Piao, Wei-Hua Jiao, Fan Yang, Yang-Hua Yi, Ying-Tong Di, Bing-Nan Han, Hou-Wen Lin

“…Compounds 1 and 5 showed moderate protein tyrosine phosphatase 1B (PTP1B) inhibitory activities with IC50 values of 5.2 μM and 8.7 μM, respectively, more potent than previously reported hippolides.…”
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Physical inactivity induces insulin resistance in plantaris muscle through protein tyrosine phosphatase 1B activation in mice by Saori Kakehi, Saori Kakehi, Yoshifumi Tamura, Yoshifumi Tamura, Shin-ichi Ikeda, Shin-ichi Ikeda, Naoko Kaga, Hikari Taka, Yuya Nishida, Ryuzo Kawamori, Ryuzo Kawamori, Hirotaka Watada, Hirotaka Watada

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Protein tyrosine phosphatase PTPRO represses lung adenocarcinoma progression by inducing mitochondria-dependent apoptosis and restraining tumor metastasis by Yuan Dai, Shuangshuang Shi, Hongda Liu, Hong Zhou, Wenqiu Ding, Chenyang Liu, Linling Jin, Weiping Xie, Hui Kong, Qun Zhang

“…Protein tyrosine phosphatase receptor type O (PTPRO), an RPTP, has been revealed as a putative suppressor in the development of particular tumors. …”
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Structural Bases for Hesperetin Derivatives: Inhibition of Protein Tyrosine Phosphatase 1B, Kinetics Mechanism and Molecular Docking Study by Md Yousof Ali, Susoma Jannat, Hyun-Ah Jung, Jae-Sue Choi

“…In the present study, we investigated the structure-activity relationship of naturally occurring hesperetin derivatives, as well as the effects of their glycosylation on the inhibition of diabetes-related enzyme systems, protein tyrosine phosphatase 1B (PTP1B) and α-glycosidase. Among the tested hesperetin derivatives, hesperetin 5-<i>O</i>-glucoside, a single-glucose-containing flavanone glycoside, significantly inhibited PTP1B with an IC₅₀ value of 37.14 ± 0.07 µM. …”
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Inhibition of Trypanosoma evansi Protein-Tyrosine Phosphatase by Myristic Acid Analogues Isolated from Khaya senegalensis and Tamarindus indica by Dingwoke EJ, Adamude FA, Chukwuocha CE, Ambi AA, Nwobodo NN, Sallau AB, Nzelibe HC

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Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases by Caroline Chandra Tjin, Kate D. Otley, Tyler D. Baguley, Pradeep Kurup, Jian Xu, Angus C. Nairn, Paul J. Lombroso, Jonathan A. Ellman

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Role of Receptor Protein Tyrosine Phosphatase β/ζ in Neuron–Microglia Communication in a Cellular Model of Parkinson’s Disease by Marta del Campo, Rosalía Fernández-Calle, Marta Vicente-Rodríguez, Sara Martín Martínez, Esther Gramage, José María Zapico, María Haro, Gonzalo Herradon

“…PTN is an endogenous inhibitor of Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ, which is abundantly expressed in the CNS. …”
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Neural stem cells from protein tyrosine phosphatase sigma knockout mice generate an altered neuronal phenotype in culture by Rotin Daniela, Siu Roberta, Axford Michelle M, Pacey Laura KK, Kirkham David L, Doering Laurie C

“…<p>Abstract</p> <p>Background</p> <p>The LAR family Protein Tyrosine Phosphatase sigma (PTPσ) has been implicated in neuroendocrine and neuronal development, and shows strong expression in specific regions within the CNS, including the subventricular zone (SVZ). …”
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