Prevalence of reduced lung diffusing capacity and CT scan findings in smokers without airflow limitation: a population-based study by Joan B Soriano, Juan José Soler-Cataluña, Marc Miravitlles, Julio Ancochea, Elena García Castillo, Miguel Barrueco Ferrero, Begoña Gallego, Ramon Fernandez, Inmaculada Alfageme, Borja G Cosío, Cristina Represas, Pilar de Lucas, Ciro Casanova, Francisco García-Río, José Miguel Rodríguez González-Moro, María Guadalupe Sánchez Herrero, Claudia Valenzuela, Ana Pueyo Bastida, Lourdes Lázaro Asegurado, Luis Rodríguez Pascual, Mª José Mora, Luis Borderias Clau, Lourdes Arizón Mendoza, Sandra García, Juan AR Miranda, Julián Grande Gutiérrez, Jesús Agustín Manzano, Manuel González, Milagros Rosales, José AF Villar, Ana Priegue, Isabel Portela Ferreño, Cecilia Mouronte Roibás, Sara Fernández García, Rocío Cordova Díaz, Nuria Toledo Pons, Margalida Llabrés, José MM Trigo, Marta Forner, Pablo Cubero, Elisabet Vera, Mª BP Albero, Noelia González García, Agustín Valido Morales, Carolina Panadero, Cristina Benito Bernáldez, Maria Velarde, Antonio Santa Cruz Siminiani, Carlos Castillo Quintanilla, Rocío Ibáñez Meléndez, José JM Garcerán, Desirée Lozano Vicente, Pedro García Torres, Maria del Mar Valdivia, Juan PT Tajes, Montserrat Cizur Girones, Carmen Labiano Turrillas, Carlos Ruiz Martínez, Elena Hernando, Elvira Alfaro, José Manuel García, Jorge Lázaro, David Bravo, Laura Hidalgo, Silvia Francisco Terreros, Iñaki Zorrilla, Ainara Alonso Colmenero, Cristina Martínez González, Susana Margon, Rosirys Guzman Taveras, Alicia Álvarez, José RA Balbín, Juan Agüero Calvo, Jaume Ferrer Sancho, Esther Rodríguez González, Eduardo Loeb, José LI Alonso, Mª AR García, Juan Abreu González, Candelaria Martín García, Rebeca Muñoz, Haydée Martín García, Miguel AM Muñiz, Andrés AS Antuña, Jesús Allende González, Jose AG Blanco, Fernando JA Navascues, Manuel AV Montes, María Rodríguez Pericacho, Concepción Rodríguez García, Juan DA Mavárez

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Evaluation of real-world mepolizumab use in severe asthma across Europe: the SHARP experience with privacy-preserving federated analysis by Johannes A. Kroes, Rafael Alfonso-Cristancho, Aruna T. Bansal, Emmanuelle Berret, Kristina Bieksiene, Arnaud Bourdin, Luisa Brussino, Diogo Canhoto, Cristina Cardini, Gulfem Celik, Zsuzsanna Csoma, Barbro Dahlén, Ebru Damadoglu, Katrien Eger, Lisa Gauquelin, Bilun Gemicioglu, Ozlem Goksel, Sophie Graff, Enrico Heffler, Hendrik B. Hofstee, Peter Howarth, Rupert W. Jakes, Fabienne Jaun, Virginija Kalinauskaite-Zukauske, Peter Kopač, Namhee Kwon, Claudia C. Loureiro, Victor Lozoya García, Matthew Masoli, Mariana Paula Rezelj, Luis Pérez De Llano, Sanja Popović-Grle, David Ramos-Barbón, Ana Sà Sousa, Konstantinos Samitas, Florence Schleich, Concetta Sirena, Sabina Skrgat, Eleftherios Zervas, George Zichnalis, Elisabeth H. Bel, Jacob K. Sont, Simone Hashimoto, Anneke Ten Brinke

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Evaluation of Myocardial Gene Expression Profiling for Superior Diagnosis of Idiopathic Giant-Cell Myocarditis and Clinical Feasibility in a Large Cohort of Patients with Acute Car... by Felicitas Escher, Heiko Pietsch, Ganna Aleshcheva, Philip Wenzel, Friedrich Fruhwald, Christian Stumpf, Dirk Westermann, Johann Bauersachs, Frank Enseleit, Frank Ruschitzka, Herbert Nägele, Karl-Ludwig Laugwitz, Hendrik Haake, Norbert Frey, Johannes Brachmann, Kurt Huber, Rüdiger Christian Braun-Dullaeus, Martin W. Bergmann, Jörg Strotmann, Gerian Grönefeld, Jürgen Krülls-Münch, Ralf Westenfeld, Carsten Skurk, Ulf Landmesser, Burkert Pieske, Ulrich M. Gross, Lars Morawietz, Heinz-Peter Schultheiss

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Influenza virus decreases albumin uptake and megalin expression in alveolar epithelial cells by Andrés Alberro-Brage, Andrés Alberro-Brage, Andrés Alberro-Brage, Andrés Alberro-Brage, Vitalii Kryvenko, Vitalii Kryvenko, Vitalii Kryvenko, Vitalii Kryvenko, Christina Malainou, Christina Malainou, Christina Malainou, Christina Malainou, Stefan Günther, Rory E. Morty, Rory E. Morty, Rory E. Morty, Rory E. Morty, Rory E. Morty, Werner Seeger, Werner Seeger, Werner Seeger, Werner Seeger, Werner Seeger, Susanne Herold, Susanne Herold, Susanne Herold, Susanne Herold, Christos Samakovlis, Christos Samakovlis, Christos Samakovlis, Christos Samakovlis, Christos Samakovlis, István Vadász, István Vadász, István Vadász, István Vadász

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Activated Phosphoinositide 3-Kinase Delta Syndrome 1: Clinical and Immunological Data from an Italian Cohort of Patients by Giulio Tessarin, Stefano Rossi, Manuela Baronio, Luisa Gazzurelli, Michael Colpani, Alessio Benvenuto, Fiammetta Zunica, Fabio Cardinale, Baldassarre Martire, Letizia Brescia, Giorgio Costagliola, Laura Luti, Gabriella Casazza, Maria Cristina Menconi, Francesco Saettini, Laura Palumbo, Maria Federica Girelli, Raffaele Badolato, Gaetana Lanzi, Marco Chiarini, Daniele Moratto, Antonella Meini, Silvia Giliani, Maria Pia Bondioni, Alessandro Plebani, Vassilios Lougaris

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Change in management and outcome of mechanical ventilation in Korea: a prospective observational study by Jae Kyeom Sim, Sang-Min Lee, Hyung Koo Kang, Kyung Chan Kim, Young Sam Kim, Yun Seong Kim, Won-Yeon Lee, Sunghoon Park, So Young Park, Ju-Hee Park, Yun Su Sim, Kwangha Lee, Yeon Joo Lee, Jin Hwa Lee, Heung Bum Lee, Chae-Man Lim, Won-Il Choi, Ji Young Hong, Won Jun Song, Gee Young Suh

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Factores de riesgo y mortalidad de los derrames pleurales que precisan de una toracocentesis diagnóstica by Félix Baranda García, Irene Hernández Pérez, José Ignacio Pijoan Zubizarreta, Silvia Pérez Fernández, Ainhoa Gómez Bonilla, Beatriz Gómez Crespo, Jone Solórzano Santobeña, Imanol González Muñoz, Alejandro Rezola Carasusan, Milagros Iriberri Pascual

“…Methods: Retrospective observational study of patients undergoing diagnostic thoracentesis during the decade 2008-2017 in a pulmonology service. Demographic, biochemical, pathological and evolutionary variables were evaluated. …”
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Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts by Kaj E. C. Blokland, Kaj E. C. Blokland, Kaj E. C. Blokland, Kaj E. C. Blokland, Mehmet Nizamoglu, Mehmet Nizamoglu, Habibie Habibie, Habibie Habibie, Habibie Habibie, Theo Borghuis, Theo Borghuis, Michael Schuliga, Barbro N. Melgert, Barbro N. Melgert, Barbro N. Melgert, Darryl A. Knight, Darryl A. Knight, Darryl A. Knight, Corry-Anke Brandsma, Corry-Anke Brandsma, Simon D. Pouwels, Simon D. Pouwels, Simon D. Pouwels, Janette K. Burgess, Janette K. Burgess

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A comparative absorption study of sucrosomial® orodispersible vitamin D3 supplementation vs. a reference chewable tablet and soft gel capsule vitamin D3 in improving circulatory 25... by Aasiya Bano, Saida Abrar, Elisa Brilli, Germano Tarantino, Ali Akbar Bugti, Marco Fabbrini, Gabriele Conti, Silvia Turroni, Mahroo Bugti, Fauzia Afridi, Shah Mureed, Hakeem Zada, Ikram Din Ujjan, Saadia Ashraf, Aamir Ghafoor, Saeed Khan, Amjad Khan, Amjad Khan

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Clinical Predictors of Minimal Extrathyroid Invasion of Papillary Thyroid Cancer by Pavlo Lishchynskyi, Volodymyr Palamarchuk, Oleh Mazur, Volodymyr Kuts, Sergii Zemskov, Oleksandr Tovkai, Olexii Dronov

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Effectiveness of primary series, first, and second booster vaccination of monovalent mRNA COVID-19 vaccines against symptomatic SARS-CoV-2 infections and severe diseases during the... by Haruka Maeda, Nobuo Saito, Ataru Igarashi, Masayuki Ishida, Mayumi Terada, Shingo Masuda, Ryosuke Osawa, Naoto Hosokawa, Kei Nakashima, Hiroshi Kamura, Haruki Imura, Hiroki Inoue, Suguru Matsuzaka, Yukihiro Sugimoto, Osamu Kuwamitsu, Iori Motohashi, Toru Morikawa, Rentaro Oda, Yuiko Hoshina, Takashi Matono, Osamu Teshigahara, Eiichiro Sando, Sadaharu Asami, Satoshi Kudo, Noboru Akizuki, Yoshikazu Muto, Tomoichiro Hayakawa, Tomoo Kishaba, Yasuji Ohara, Yoshinao Kubo, Motoi Suzuki, Konosuke Morimoto

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Real‐world data using mHealth apps in rhinitis, rhinosinusitis and their multimorbidities by Bernardo Sousa‐Pinto, Aram Anto, Markus Berger, Stephanie Dramburg, Oliver Pfaar, Ludger Klimek, Marek Jutel, Wienczyslawa Czarlewski, Anna Bedbrook, Arunas Valiulis, Ioana Agache, Rita Amaral, Ignacio J. Ansotegui, Katharina Bastl, Uwe Berger, Karl C. Bergmann, Sinthia Bosnic‐Anticevich, Fulvio Braido, Luisa Brussino, Victoria Cardona, Thomas Casale, G. Walter Canonica, Lorenzo Cecchi, Denis Charpin, Tomás Chivato, Derek K. Chu, Cemal Cingi, Elisio M. Costa, Alvaro A. Cruz, Philippe Devillier, Stephen R. Durham, Motohiro Ebisawa, Alessandro Fiocchi, Wytske J. Fokkens, Bilun Gemicioğlu, Maia Gotua, Maria‐Antonieta Guzmán, Tari Haahtela, Juan Carlos Ivancevich, Piotr Kuna, Igor Kaidashev, Musa Khaitov, Violeta Kvedariene, Désirée E. Larenas‐Linnemann, Brian Lipworth, Daniel Laune, Paolo M. Matricardi, Mario Morais‐Almeida, Joaquim Mullol, Robert Naclerio, Hugo Neffen, Kristoff Nekam, Marek Niedoszytko, Yoshitaka Okamoto, Nikolaos G. Papadopoulos, Hae‐Sim Park, Giovanni Passalacqua, Vincenzo Patella, Simone Pelosi, Nhân Pham‐Thi, Ted A. Popov, Frederico S. Regateiro, Sietze Reitsma, Monica Rodriguez‐Gonzales, Nelson Rosario, Philip W. Rouadi, Boleslaw Samolinski, Ana Sá‐Sousa, Joaquin Sastre, Aziz Sheikh, Charlotte Suppli Ulrik, Luis Taborda‐Barata, Ana Todo‐Bom, Peter Valentin Tomazic, Sanna Toppila‐Salmi, Salvatore Tripodi, Ioanna Tsiligianni, Erkka Valovirta, Maria Teresa Ventura, Antonio A. Valero, Rafael José Vieira, Dana Wallace, Susan Waserman, Sian Williams, Arzu Yorgancioglu, Luo Zhang, Mihaela Zidarn, Jaron Zuberbier, Heidi Olze, Josep M. Antó, Torsten Zuberbier, João A. Fonseca, Jean Bousquet

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Predictors of COVID-19 severity: a systematic review and meta-analysis [version 1; peer review: 2 approved] by Mudatsir Mudatsir, Jonny Karunia Fajar, Laksmi Wulandari, Gatot Soegiarto, Muhammad Ilmawan, Yeni Purnamasari, Bagus Aulia Mahdi, Galih Dwi Jayanto, Suhendra Suhendra, Yennie Ayu Setianingsih, Romi Hamdani, Daniel Alexander Suseno, Kartika Agustina, Hamdan Yuwafi Naim, Muchamad Muchlas, Hamid Hunaif Dhofi Alluza, Nikma Alfi Rosida, Mayasari Mayasari, Mustofa Mustofa, Adam Hartono, Richi Aditya, Firman Prastiwi, Fransiskus Xaverius Meku, Monika Sitio, Abdullah Azmy, Anita Surya Santoso, Radhitio Adi Nugroho, Camoya Gersom, Ali A. Rabaan, Sri Masyeni, Firzan Nainu, Abram L. Wagner, Kuldeep Dhama, Harapan Harapan

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Domiciliary transcutaneous electrical stimulation in patients with obstructive sleep apnoea and limited adherence to continuous positive airway pressure therapy: a single-centre, o... by Deeban Ratneswaran, Michael Cheng, Ebrahim Nasser, Rajiv Madula, Martino Pengo, Kath Hope, Esther I. Schwarz, Yuanming Luo, Georgios Kaltsakas, Michael I. Polkey, John Moxham, Joerg Steier

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Clinical and transcriptomic features of persistent exacerbation‐prone severe asthma in U‐BIOPRED cohort by Uruj Hoda, Stelios Pavlidis, Aruna T. Bansal, Kentaro Takahashi, Sile Hu, Francois Ng Kee Kwong, Christos Rossios, Kai Sun, Pankaj Bhavsar, Matthew Loza, Frederic Baribaud, Pascal Chanez, Stephen J. Fowler, Ildiko Horvath, Paolo Montuschi, Florian Singer, Jacek Musial, Barbro Dahlen, Norbert Krug, Thomas Sandstrom, Dominic E. Shaw, Rene Lutter, Louise J. Fleming, Peter H. Howarth, Massimo Caruso, Ana R. Sousa, Julie Corfield, Charles Auffray, Bertrand De Meulder, Diane Lefaudeux, Sven‐Erik Dahlen, Ratko Djukanovic, Peter J. Sterk, Yike Guo, Ian M. Adcock, Kian Fan Chung, the U‐BIOPRED study group

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Sleep spindles across youth affected by schizophrenia or anti-N-methyl-D-aspartate-receptor encephalitis by Maria E. Dimitriades, Maria E. Dimitriades, Andjela Markovic, Andjela Markovic, Andjela Markovic, Silvano R. Gefferie, Silvano R. Gefferie, Ashura Buckley, David I. Driver, Judith L. Rapoport, Margherita Nosadini, Margherita Nosadini, Kevin Rostasy, Stefano Sartori, Stefano Sartori, Agnese Suppiej, Salome Kurth, Maurizia Franscini, Susanne Walitza, Susanne Walitza, Susanne Walitza, Reto Huber, Reto Huber, Reto Huber, Reto Huber, Leila Tarokh, Leila Tarokh, Bigna K. Bölsterli, Bigna K. Bölsterli, Bigna K. Bölsterli, Bigna K. Bölsterli, Miriam Gerstenberg, Miriam Gerstenberg

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Why movement disorders should be a formally acknowledged subspecialty of neurology editorial by Dirk Dressler, Ivan Milanov

“…More and more medical specialties developed and traditional specialties developed sub-specialties: internal medicine, over centuries together with surgery, the only two fields of medicine, developed infectiology, cardiology, gastroenterology, immunology, endocrinology, nephrology, pulmonology, haematology, infect ology and so on. And surgery did the same. …”
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RETRO-POPE: A Retrospective, Multicenter, Real-World Study of All-Cause Mortality in COPD by Koblizek V, Milenkovic B, Svoboda M, Kocianova J, Holub S, Zindr V, Ilic M, Jankovic J, Cupurdija V, Jarkovsky J, Popov B, Valipour A

“…Vladimir Koblizek,1,2 Branislava Milenkovic,3,4 Michal Svoboda,5,6 Jana Kocianova,7 Stanislav Holub,8 Vladimir Zindr,9 Miroslav Ilic,10,11 Jelena Jankovic,3,4 Vojislav Cupurdija,12,13 Jiri Jarkovsky,6 Boris Popov,14 Arschang Valipour15 1Department of Pneumology, University Hospital, Hradec Kralove, Czech Republic; 2Faculty of Medicine Hradec Kralove, Charles University, Hradec Kralove, Czech Republic; 3Clinic for Pulmonary Diseases, Clinical Center of Serbia, Belgrade, Serbia; 4Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 5Institute of Biostatistics and Analyses Ltd., Brno, Czech Republic; 6Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic; 7Outpatient Department of Pneumology Alveolus, APRO MED, Ostrava, Czech Republic; 8Outpatient Chest Clinic, Plicni Stredisko Teplice Ltd., Teplice, Czech Republic; 9Outpatient Chest Clinic, PNEUMO KV Ltd., Karlovy Vary, Czech Republic; 10Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia; 11Clinic for Tuberculosis and Interstitial Lung Diseases, PolyClinic Department, Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia; 12Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; 13Clinic for Pulmonology, University Clinical Center Kragujevac, Kragujevac, Serbia; 14Medicine Department, Boehringer Ingelheim Serbia d.o.o. …”
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Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe by Giulia Veronesi, David R. Baldwin, Claudia I. Henschke, Simone Ghislandi, Sergio Iavicoli, Matthijs Oudkerk, Harry J. De Koning, Joseph Shemesh, John K. Field, Javier J. Zulueta, Denis Horgan, Lucia Fiestas Navarrete, Maurizio Valentino Infante, Pierluigi Novellis, Rachael L. Murray, Nir Peled, Cristiano Rampinelli, Gaetano Rocco, Witold Rzyman, Giorgio Vittorio Scagliotti, Martin C. Tammemagi, Luca Bertolaccini, Natthaya Triphuridet, Rowena Yip, Alexia Rossi, Suresh Senan, Giuseppe Ferrante, Kate Brain, Carlijn van der Aalst, Lorenzo Bonomo, Dario Consonni, Jan P. Van Meerbeeck, Patrick Maisonneuve, Silvia Novello, Anand Devaraj, Zaigham Saghir, Giuseppe Pelosi

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Sustained Effectiveness of Benralizumab in Naïve and Biologics-Experienced Severe Eosinophilic Asthma Patients: Results from the ANANKE Study by Cameli P, Aliani M, Altieri E, Bracciale P, Brussino L, Caiaffa MF, Canonica GW, Caruso C, Centanni S, D'Amato M, De Michele F, Del Giacco S, Di Marco F, Pelaia G, Rogliani P, Romagnoli M, Schino P, Schroeder JW, Senna G, Vultaggio A, Benci M, Boarino S, Menzella F

“…Miulli”, Acquaviva delle Fonti (BA), Italy; 20Allergy and Clinical Immunology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy; 21Allergy Unit and Asthma Center, Verona University Hospital, Verona, Italy; 22Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Firenze, Italy; 23Medical Affairs R&I, AstraZeneca, Milano, Italy; 24Medical Evidence R&I, AstraZeneca, Milano, Italy; 25Pulmonology Unit, Ospedale “S. Valentino”, AULSS 2 Marca Trevigiana, Montebelluna (TV), ItalyCorrespondence: Paolo Cameli, Respiratory Diseases Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy, Email paolo.cameli@unisi.itPurpose: Severe eosinophilic asthma (SEA) patients often present overlapping inflammatory features rendering them eligible for multiple biologic therapies; switching biologic treatment is a strategy adopted to optimize asthma control when patients show partial or no response to previous biologics.Patients and Methods: ANANKE is a retrospective, multicenter Italian study (NCT04272463). …”
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