Interferon-γ augments GABA release in the developing neocortex via nitric oxide synthase/soluble guanylate cyclase and constrains network activity by Noah Döhne, Alice Falck, Gabriel M. S. Janach, Egor Byvaltcev, Egor Byvaltcev, Ulf Strauss

“…Here, we investigated the acute effects of IFN-γ on γ-amino-butyric acid (GABA)ergic currents in layer 5 pyramidal neurons of the somatosensory cortex of rats at the end of the first postnatal week, a period of GABA-dependent cortical maturation. …”
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Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss by Matthew A. White, Ziqiang Lin, Eugene Kim, Christopher M. Henstridge, Emiliano Pena Altamira, Camille K. Hunt, Ella Burchill, Isobel Callaghan, Andrea Loreto, Heledd Brown-Wright, Richard Mead, Camilla Simmons, Diana Cash, Michael P. Coleman, Jemeen Sreedharan

“…Deletion of Sarm1 also attenuated loss of layer V pyramidal neuronal dendritic spines in the primary motor cortex. …”
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Designing and Exploration of the Biological Potentials of Novel Centrosymmetric Heteroleptic Copper(II) Carboxylates by Viola, Niaz Muhammad, Awal Noor, Muhammad Sirajuddin, Maciej Kubicki, Shahnaz Rahim, Abdus Samad, Shaukat Shujah, Abdul Wadood, Saqib Ali

“…A binuclear paddlewheel structural arrangement with a square pyramidal geometry was confirmed for copper atoms in the complexes via single-crystal X-ray analysis. …”
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Post-weaning social isolation in male mice leads to abnormal aggression and disrupted network organization in the prefrontal cortex: Contribution of parvalbumin interneurons with o... by Laszlo Biro, Christina Miskolczi, Huba Szebik, Biborka Bruzsik, Zoltan Kristof Varga, Laszlo Szente, Mate Toth, Jozsef Halasz, Eva Mikics

“…Our results suggest that the increased excitatory input of PV+ cells could emerge as a compensatory mechanism for the PV+ neuron-mediated impaired inhibition of mPFC layer 5 pyramidal neurons, since we found lower numbers of GABAergic PV+ puncta on the perisomatic region of these cells. …”
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The rice pds1 locus genetically interacts with partner to cause panicle exsertion defects and ectopic tillers in spikelets by Qigui Jiang, Yindi Zeng, Baiyang Yu, Weijian Cen, Siyuan Lu, Peilong Jia, Xuan Wang, Baoxiang Qin, Zhongquan Cai, Jijing Luo

“…Conclusions In this study, histological and genetic analyses revealed that the pyramided pds loci resulted in genetic incompatibility or hybrid weakness in rice might be caused by a genetic interaction between pds loci derived from different rice varieties. …”
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Molecular Characterization of Diverse Wheat Genetic Resources for Resistance to Yellow Rust Pathogen (<i>Puccinia striiformis</i>) by Muhammad Saeed, Muhammad Ibrahim, Waqas Ahmad, Muhammad Tayyab, Safira Attacha, Mudassar Nawaz Khan, Sultan Akbar Jadoon, Syed Jehangir Shah, Shaista Zeb, Liaqat Shah, Fazal Munsif, Ahmad Zubair, Jie Lu, Hongqi Si, Chuanxi Ma

“…This study further implies that pyramiding all stage resistance genes (Yr5, Yr10, Yr15, and Yr26) with adult plant resistance genes (Yr18 and Yr62) should provide sustained YR resistance. …”
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Synaptic dysfunction of Aldh1a1 neurons in the ventral tegmental area causes impulsive behaviors by Xinyan Li, Wenting Chen, Xian Huang, Wei Jing, Tongmei Zhang, Quntao Yu, Hongyan Yu, Hao Li, Qing Tian, Yumei Ding, Youming Lu

“…Results We demonstrate that Aldh1a1 neurons encode delay of gratification that measures self-control skills in decision making by projecting inhibitory synapses directly onto excitatory glutamate neurons in the intermediate lateral septum (EGNIS) and receiving synaptic inputs from layer 5b pyramidal neurons in the medial prefrontal cortex (L5PN). …”
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Neuroprotective potential of Cordia dichotoma in Parkinson's syndrome induced by haloperidol: An animal study by Keserla Bhavani, A. Muthukumar, Mansour Almuqbil, Kuntal Das, Yakshitha V., Moneer E. Almadani, Ahmed Alshehri, Adel Alghamdi, Syed Arif Hussain, Bader Hussain Alamer, Ebtesam Abdulrahman Jibreel, Syed Imam Rabbani, Turki Mohammed Alosaimi, Waleed Farah Alharbi, Sultan Mohammed Aldosari, Syed Mohammed Basheeruddin Asdaq

“…Histopathological changes in the test group showed a significant reduction in haloperidol damage to normal morphology in cortical, hippocampus, substantia nigra, and pyramidal. Conclusion: The observations of the study suggest that Cordia dichotoma attenuated the haloperidol-induced neurological changes, indicating that the plant might benefit in the treatment of Parkinson’s disease. …”
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Clinical and neuropathological features of ALS/FTD with TIA1 mutations by Veronica Hirsch-Reinshagen, Cyril Pottier, Alexandra M. Nicholson, Matt Baker, Ging-Yuek R. Hsiung, Charles Krieger, Pheth Sengdy, Kevin B. Boylan, Dennis W. Dickson, Marsel Mesulam, Sandra Weintraub, Eileen Bigio, Lorne Zinman, Julia Keith, Ekaterina Rogaeva, Sasha A. Zivkovic, David Lacomis, J. Paul Taylor, Rosa Rademakers, Ian R. A. Mackenzie

“…Detailed evaluation of the pyramidal motor system found a similar degree of neurodegeneration and TDP-43 pathology as in sALS and C9orf72+ cases; however, cases with TIA1 mutations had increased numbers of lower motor neurons containing round eosinophilic and Lewy body-like inclusions on HE stain and round compact cytoplasmic inclusions with TDP-43 immunohistochemistry. …”
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Brainstem pathology in amyotrophic lateral sclerosis and primary lateral sclerosis: A longitudinal neuroimaging study by Peter Bede, Rangariroyashe H. Chipika, Eoin Finegan, Stacey Li Hi Shing, Mark A. Doherty, Jennifer C. Hengeveld, Alice Vajda, Siobhan Hutchinson, Colette Donaghy, Russell L. McLaughlin, Orla Hardiman

“…In ALS, vertex analyses confirm the flattening of the medullary pyramids bilaterally in comparison to healthy controls and widespread pontine shape deformations in contrast to PLS. …”
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Adult-onset vanishing white matter disease with the EIF2B2 gene mutation presenting as menometrorrhagia by Cuibai Wei, Qi Qin, Fei Chen, Aihong Zhou, Fen Wang, Xiumei Zuo, Rong Chen, Jihui Lyu, Jianping Jia

“…Case presentation The patient described here suffered from long-term menometrorrhagia prior to manifesting progressive neurological impairments that included tremors, bilateral pyramidal tract injury, cerebellar ataxia, and dementia. …”
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Tetranuclear copper(II) complex of 2-hydroxy-N,N′-bis[1-(2-hydroxyphenyl)ethylidene]propane-1,3-diamine by Alassane Saïdou Diallo, Ibrahima Elhadji Thiam, Mbossé Gueye-Ndiaye, Moussa Dieng, James Orton, Coles Simon, Mohamed Gaye

“…Each of the two pentacoordinated CuII cations has a distorted NO4 square-pyramidal environment. The geometry of each of the two CuNO3 units is best described as a slightly square-planar environment. …”
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Sex-related dimorphism in dentate gyrus atrophy and behavioral phenotypes in an inducible tTa:APPsi transgenic model of Alzheimer's disease by Tatiana Melnikova, DaMin Park, Lauren Becker, Deidre Lee, Eugenia Cho, Nuzhat Sayyida, Jing Tian, Karen Bandeen-Roche, David R. Borchelt, Alena V. Savonenko

“…Both males and females showed atrophy of the dentate gyrus (DG) of the dorsal hippocampus, associated with widening of the pyramidal layer of the CA1 area in both sexes. Ventral DG was preserved. …”
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In utero exposure to methylmercury impairs cognitive function in adult offspring: Insights from proteomic modulation by Wenjuan Wang, Li Zhang, Caiyun Deng, Fang Chen, Qing Yu, Yi Hu, Qin Lu, Ping Li, Aihua Zhang

“…Simultaneously, MeHg reduced the postsynaptic density, diminished the active zone, amplified the synaptic cleft and changed the synaptic interface of pyramidal cells. Western blot analysis further revealed that MeHg significantly reduced the levels of Forkhead box protein (FOXP2), Synaptophysin (SYP) and Postsynaptic density protein 95 (PSD-95), and down-regulated the N-methyl-D-aspartate receptor 1 (NMDAR1), N-methyl-D-aspartate receptor 2 A (NR2A) and N-methyl-D-aspartate receptor 2B (NR2B). …”
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MAKNA SEJARAH DAN BUDAYA DALAM SITUS JATIGEDE SUMEDANG by Dade Mahzuni

“…Their cemeteries show that there was acculturation between Islam (the orientation) and local beliefs (pyramidal structure). The folktales of the sites contain cultural and literary values. …”
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mTORC1 function in hippocampal parvalbumin interneurons: regulation of firing and long-term potentiation of intrinsic excitability but not long-term contextual fear memory and cont... by Abdessattar Khlaifia, Eve Honoré, Julien Artinian, Isabel Laplante, Jean-Claude Lacaille

“…PV INs receive excitatory inputs from CA3 Schaffer collaterals and local CA1 pyramidal cells, and they provide perisomatic inhibition. …”
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Experience of diagnostics and treatment of 34 cases of foramen magnum meningiomas by Yuriy G. Shanko, Arnold F. Smeyanovich, Vladimir V. Bulgak

“…The remaining tumor portion was completely removed after 5 months.In the early postoperative period, lower cranial nerves and C1-C2 rootlets dysfunctions were registered in 19 (55.9%) patients, and 13 (38.2%) patients had mild or moderate pyramidal disorders. Cerebellar ataxia was revealed in 22 (64.7%) observations. …”
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Autologous skin-derived neural precursor cell therapy reverses canine Alzheimer dementia-like syndrome in a proof of concept veterinary trial by Michael Valenzuela, T. Duncan, A. Abey, A. Johnson, C. Boulamatsis, M. A. Dalton, E. Jacobson, L. Brunel, G. Child, D. Simpson, M. Buckland, A. Lowe, J. Siette, F. Westbrook, P. McGreevy

“…In addition, this model confirmed donor cell survival and migration throughout the hippocampus, neuronal differentiation in situ, and physiologically-correct integration into pyramidal layer circuits. Conclusions With further development, SKN cell therapy may have potential for treating carefully chosen AD patients based on neurosynaptic restoration in the hippocampus.…”
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Nitrous oxide‐related neurological disorders: Clinical, laboratory, neuroimaging, and electrophysiological findings by Jiwei Jiang, Xiuli Shang, Xiaoting Wang, Hanze Chen, Wenyi Li, Yanli Wang, Jun Xu

“…Results The principal clinical manifestations of N2O‐related neurological disorders (n = 63; 38 men, 25 women; mean age ± SD: 22.60 ± 4.46 years) were sensory disturbance, followed by gait disturbance and pyramidal tract damage. A significant negative correlation existed between serum vitamin B12 levels and clinical severity (r = −0.309, p = .014), which disappeared after linear regression. …”
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Oligomeric amyloid-beta induces MAPK-mediated activation of brain cytosolic and calcium-independent phospholipase A2 in a spatial-specific manner by Juan Pablo Palavicini, Chunyan Wang, Linyuan Chen, Kristen Hosang, Jianing Wang, Takami Tomiyama, Hiroshi Mori, Xianlin Han

“…Brain histological studies implicated cPLA2 activity with arachidonic acid accumulation within myelin-rich regions, and iPLA2 activity with docosahexaenoic acid accumulation within pyramidal neuron-rich regions. Taken together, our results suggest that PLA2-mediated accumulation of free PUFAs drives AD-related disruption of brain lipid metabolism.…”
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