True triaxial physics simulations and process tests of hydraulic fracturing in the Da’anzhai section of the Sichuan Basin tight oil reservoir by Song Li, Song Li, Yu Fan, Yu Fan, Yang Wang, Yuanshou Zhao, Zefei Lv, Zeng Ji, Weihua Chen, Jian Min, Jian Min

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Cost-Effectiveness Analysis of Gefitinib Plus Chemotherapy versus Gefitinib Alone for Advanced Non-Small-Cell Lung Cancer with EGFR Mutations in China by Shu Y, Zhang Q, He X, Chen L

“…Yamin Shu,1– 4,* Qilin Zhang,5,* Xucheng He,6 Li Chen1– 3 1Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, People’s Republic of China; 3Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Chengdu, People’s Republic of China; 4Department of Pharmacy, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 5Department of Pharmacy, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 6Pengzhou Second People’s Hospital, Pengzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li ChenDepartment of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of ChinaTel +86-2888570426Email johnnick201912@gmail.comObjective: The aim of this study was to evaluate the cost-effectiveness of gefitinib plus chemotherapy (GCP) versus gefitinib alone for advanced non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations in China.Methods: A decision-analytic Markov model was conducted to simulate the disease process of advanced NSCLC patients with EGFR mutations. …”
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Accurate Prediction of Coronary Heart Disease for Patients With Hypertension From Electronic Health Records With Big Data and Machine-Learning Methods: Model Development and Perfor... by Du, Zhenzhen, Yang, Yujie, Zheng, Jing, Li, Qi, Lin, Denan, Li, Ye, Fan, Jianping, Cheng, Wen, Chen, Xie-Hui, Cai, Yunpeng

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Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment by Wang D, Xu X, Zhang K, Sun B, Wang L, Meng L, Liu Q, Zheng C, Yang B, Sun H

“…Dandan Wang,1,* Xiaowei Xu,2,* Kai Zhang,3 Bin Sun,4 Lu Wang,1 Lin Meng,1 Qilin Liu,4 Changyu Zheng,5 Bai Yang,3 Hongchen Sun1,3,6 1Department of Pathology, School and Hospital of Stomatology, Jilin University, Changchun, People’s Republic of China; 2Department of Periodontology, School and Hospital of Stomatology, Jilin University, Changchun, People’s Republic of China; 3State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, People’s Republic of China; 4Department of Oral and Maxilloficial Syrgery, School and Hospital of Stomatology, Jilin University, Changchun, People’s Republic of China; 5Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA; 6Key Laboratory of Science and Technology for Stomatology Nanoengineering, The Education Department of Jilin Province, Changchun, People’s Republic of China *These authors contributed equally to this work Abstract: Oral cancer is a type of head and neck cancer that is the seventh most frequent cancer and the ninth most frequent cause of death globally. …”
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Association Between Serum Anion Gap and Mortality in Critically Ill Patients with COPD in ICU: Data from the MIMIC IV Database by Chen X, Yang Q, Gao L, Chen W, Gao X, Li Y, Ao L, Sun D

“…Xiaojing Chen,1– 3,* Qilin Yang,4,* Li Gao,1– 3 Weinan Chen,1 Xiaoyu Gao,1– 3 Yameng Li,1– 3 Liying Ao,5 Dejun Sun1– 3 1Department of Respiratory and Critical Care Medicine, Inner Mongolia People’s Hospital, Hohhot, 010017, People’s Republic of China; 2NHC Key Laboratory of Diagnosis & Treatment of COPD, Inner Mongolia People’s Hospital, Hohhot, 010017, People’s Republic of China; 3Inner Mongolia Key Laboratory of Respiratory Diseases, Inner Mongolia People’s Hospital, Hohhot, 010017, People’s Republic of China; 4Department of Critical Care, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; 5Department of Otolaryngology, Inner Mongolia People’s Hospital, Hohhot, 010017, People’s Republic of China*These authors contributed equally to this workCorrespondence: Dejun Sun, Department of Respiratory and Critical Care Medicine, Inner Mongolia People’s Hospital, No. 26 Zhaowuda Road, Saihan District, Hohhot, 010017, People’s Republic of China, Email nmg_sdj@163.comBackground: Serum anion gap (AG) has been proven to be associated with prognosis in critically ill patients. …”
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Microbial species pool-mediated diazotrophic community assembly in crop microbiomes during plant development by Chao Xiong, Brajesh K. Singh, Yong-Guan Zhu, Hang-Wei Hu, Pei-Pei Li, Yan-Lai Han, Li-Li Han, Qin-Bing Zhang, Jun-Tao Wang, Si-Yi Liu, Chuan-Fa Wu, An-Hui Ge, Li-Mei Zhang, Ji-Zheng He

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A Potential Participant in Type 2 Diabetes Bone Fragility: TIMP-1 at Sites of Osteocyte Lacunar-Canalicular System by Pei Q, Li J, Zhou P, Zhang J, Huang P, Fan J, Zou Z, Li X, Wang B

“…Qilin Pei,1,* Jun Li,2,* Pengfei Zhou,3,* Jun Zhang,1 Peng Huang,1 Jingchuan Fan,1 Zhen Zou,1 Xi Li,1 Bin Wang1 1Institute of Life Sciences, Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 2Department of Orthopedic Surgery, Chengdu Fifth People’s Hospital, Chengdu, Sichuan Province, 610072, People’s Republic of China; 3Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Stomatological Hospital of Chongqing Medical University, Chongqing, 401147, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bin Wang; Xi Li Email bwang@cqmu.edu.cn; lixi@shmu.edu.cnAbstract: Type 2 diabetes mellitus (T2DM) is associated with an increased risk of bone fracture, but the bone mineral density (BMD) is typically normal or higher in such patients. …”
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Protective Effects Of Astragalus Polysaccharides On Oxidative Stress In High Glucose-Induced Or SOD2-Silenced H9C2 Cells Based On PCR Array Analysis by Sun Q, Wu X, Wang H, Chen W, Zhao X, Yang Y, Chen W

“…Qilin Sun,1,* Xiaoyan Wu,1,* Hao Wang,2 Wenjie Chen,1 Xuelan Zhao,1 Yehong Yang,3 Wei Chen1,* 1Department of Geriatrics, Huashan Hospital, Fudan University, Shanghai 200040, People’s Republic of China; 2Experimental Teaching Center of Basic Medicine, Fudan University, Shanghai 200032, People’s Republic of China; 3Department of Endocrinology, Huashan Hospital, Fudan University, Shanghai 200040, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei ChenDepartment of Geriatrics, Huashan Hospital, Fudan University, No.12 Wu-lu-mu-qi Road, Shanghai 200040, People’s Republic of ChinaTel +86 21 5288999ext 7190 Email chenwei_0424@163.comYehong YangDepartment of Endocrinology, Huashan Hospital, Fudan University, No.12 Wu-lu-mu-qi Road, Shanghai 200040, People’s Republic of ChinaTel +86 21 5288999Email yehongyang@126.comBackground: Oxidative stress in cardiac myocytes is an important pathogenesis of diabetic cardiomyopathy (DCM). …”
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Microbial Characteristics of Locally Advanced Rectal Cancer Patients After Neoadjuvant Chemoradiation Therapy According to Pathologic Response by Fan Q, Shang F, Chen C, Zhou H, Fan J, Yang M, Nie X, Liu L, Cai K, Liu H

“…Qilin Fan,1,* Fumei Shang,1,* Chen Chen,1 Hongxia Zhou,1 Jun Fan,2 Ming Yang,2 Xiu Nie,2 Li Liu,3 Kailin Cai,4 Hongli Liu1 1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 3Department of Epidemiology and Biostatistics, The Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 4Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongli LiuCancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of ChinaTel +86-27-85871962Fax +86-27-65650733Email hongli_liu@hust.edu.cnKailin CaiDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of ChinaTel +86-27-85871962Fax +86-27-65650733Email caikailin@hust.edu.cnBackground: Intestinal microbiota play a critical role in the development of colorectal cancer. …”
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Trends in the Notification Rates and Treatment Outcome of Tuberculosis in Shandong Province, China, 2005–2021 by Han Q, Li Y, Liu Y, Zhu X, An Q, Li Y, Wang T, Zhang Y, Li Y, Fang W, Tao N, Li H

“…Qilin Han,1,2 Yifan Li,3 Yao Liu,1 Xuehan Zhu,1 Qiqi An,4 Yameng Li,5 Tingting Wang,5 Yuzhen Zhang,1,2 Yingying Li,5 Weiwei Fang,1,2 Ningning Tao,1,* Huaichen Li1,2,* 1Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People’s Republic of China; 2Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250117, People’s Republic of China; 3Department of Pulmonary and Critical Care Medicine, The Third Affiliated Hospital of Shandong First Medical University (Affiliated Hospital of Shandong Academy of Medical Sciences), Jinan, Shandong, 250031, People’s Republic of China; 4Department of Pulmonary and Critical Care Medicine, Xingyi People’s Hospital, Qianxinan, Guizhou, 561499, People’s Republic of China; 5Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250355, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ningning Tao, Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People’s Republic of China, Email 826794467@qq.com Huaichen Li, Department of Respiratory and Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jingwuweiqi Road, Huaiyin District, Jinan, Shandong, 250021, People’s Republic of China, Email lihuaichen@163.comPurpose: To analyze the time trends in the notification rates of registered tuberculosis (TB) and bacteriologically confirmed TB in Shandong Province. …”
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