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281
Gene by environment QTL mapping through multiple trait analyses in blood pressure salt-sensitivity: identification of a novel QTL in rat chromosome 5
Published 2006-05-01“…</p> <p>Methods</p> <p>We used multiple-trait analysis for quantitative trait locus mapping of loci having different effects on systolic blood pressure with NaCl exposure. …”
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282
Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes.
Published 2007“…CONTEXT: Recently, a quantitative trait locus for stature was reported on chromosome 3p26 in patients with type 2 diabetes. …”
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283
Submergence tolerance in rice: review of mechanism, breeding and, future prospects
Published 2020“…Using marker-assisted backcrossing, the SUB1 QTL (quantitative trait locus) has been incorporated into many elite varieties within a short time and with high precision as compared with conventional breeding methods. …”
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284
Variation on a theme: mapping microglial heterogeneity
Published 2021“…Using expression quantitative trait locus (eQTL) mapping techniques, they identify 129 genes whose expression in microglia is linked to disease, and show that induced pluripotent stem cell (iPSC) models can be used for functional validation of common genetic mutations in microglia-associated diseases. …”
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285
Comparative plant development: the time of the leaf?
Published 2003“…The differential expression of regulatory proteins has emerged as an important factor in driving morphological innovations in the plant kingdom--an idea that is well supported by quantitative trait locus analyses.…”
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286
Epigenome-Wide Study Identified Methylation Sites Associated with the Risk of Obesity
Published 2021-06-01“…We integrated methylation quantitative trait locus (mQTL) data with BMI GWAS information through a SNP-based multiomics approach to identify genomic regions where mQTLs for a methylation site co-localize with obesity risk SNPs. …”
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287
Compensatory trans‐regulatory alleles minimizing variation in TDH3 expression are common within Saccharomyces cerevisiae
Published 2019-10-01“…Using a powerful quantitative trait locus mapping method, we identified ∼100 trans‐acting expression quantitative trait locus in each of three crosses to a common reference strain, indicating that regulatory variation is more polygenic than previous studies have suggested. …”
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288
Mouse SNP Miner: an annotated database of mouse functional single nucleotide polymorphisms
Published 2007-01-01“…However, identifying the specific phenotype-causing DNA sequence variations within a quantitative trait locus has been much more difficult. The recent availability of genomic sequence from several mouse inbred strains (including C57BL/6J, 129X1/SvJ, 129S1/SvImJ, A/J, and DBA/2J) has made it possible to catalog DNA sequence differences within a quantitative trait locus derived from crosses between these strains. …”
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289
Characterization of introgression from the teosinte Zea mays ssp. mexicana to Mexican highland maize
Published 2019-05-01“…We generated a genetic linkage map and performed Quantitative Trait Locus mapping in an F2 population derived from a cross between lowland and highland maize individuals. …”
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290
Whole brain and regional hyperintense white matter volume and blood pressure: overlap of genetic loci produced by bivariate, whole-genome linkage analyses
Published 2010“…</p> <p><strong>Results—</strong> Bivariate genomewide linkage analyses localized a significant quantitative trait locus influencing WB and regional (ependymal) HWM volumes and pulse pressure and systolic BP to chromosomal location 1q24 between markers D1S196 and D1S1619. …”
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291
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292
Analysis of morphine responses in mice reveals a QTL on Chromosome 7 [version 2; referees: 2 approved]
Published 2016-10-01“…In this study we identified a quantitative trait locus (QTL) on mouse Chromosome 7 associated with locomotor activity and rearing post morphine treatment. …”
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293
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.
Published 2011“…We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. …”
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294
Association studies in outbred mice in a new era of full-genome sequencing.
Published 2012“…These resources constitute a major advance and make it possible to progress from a quantitative trait locus to a gene at an unprecedented speed.…”
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295
Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast
Published 2022-02-01“…Genome-wide association studies (GWAS) in humans and quantitative trait locus (QTL) mapping in model organisms can now explain much of the observed heritability in many traits, allowing us to predict phenotype from genotype. …”
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296
Towards mouse genetic-specific RNA-sequencing read mapping.
Published 2022-09-01“…This can skew the transcriptome estimates that are used later for downstream analyses, such as expression quantitative trait locus (eQTL) detection. Here, we assessed the impact of reference-based analysis on the transcriptome and eQTLs in a widely-used mouse genetic population: the BXD panel of recombinant inbred lines. …”
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297
Cystathionine β-synthase as novel endogenous regulator of lymphangiogenesis via modulating VEGF receptor 2 and 3
Published 2022-09-01“…Quantitative trait locus analysis of BALB/cN x C57BL/6 N intercross identifies cystathionine β-synthase as a previously unknown regulator of lymphangiogenesis by affecting VEGF-R2/VEGF-R3 expression in lymphatic endothelial cells.…”
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298
Divergent combinations of cis-regulatory elements control the evolution of phenotypic plasticity.
Published 2023-08-01“…Here, we investigate the predatory nematode Pristionchus pacificus with its feeding structure plasticity using recombinant-inbred-line and quantitative-trait-locus (QTL) analyses between natural isolates. …”
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299
Localization, cDNA sequence and genomic organization of the rat seipin gene (Bscl2) and sequence analysis in inbred rat models of Type 2 diabetes mellitus.
Published 2002“…Radiation hybrid analysis localized the seipin gene (Bscl2) in rat to a major quantitative trait locus in rat chromosome 1 linked to glucose intolerance in the Goto-Kakizaki (GK) rat model of Type 2 diabetes. …”
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300
Heart regeneration in the Mexican cavefish
Published 2018“…Furthermore, using quantitative trait locus (QTL) analysis, we have linked the degree of heart regeneration to three loci in the genome, identifying candidate genes fundamental to the difference between scarring and regeneration. …”
Journal article