Gene by environment QTL mapping through multiple trait analyses in blood pressure salt-sensitivity: identification of a novel QTL in rat chromosome 5 by Tôrres César H, Pereira Alexandre C, Soler Júlia, Krieger José E

“…</p> <p>Methods</p> <p>We used multiple-trait analysis for quantitative trait locus mapping of loci having different effects on systolic blood pressure with NaCl exposure. …”
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Examining the candidacy of ghrelin as a gene responsible for variation in adult stature in a United Kingdom population with type 2 diabetes. by Gueorguiev, M, Wiltshire, S, Garcia, E, Mein, C, Lecoeur, C, Kristen, B, Allotey, R, Hattersley, A, Walker, M, O'rahilly, S, Froguel, P, Grossman, AB, McCarthy, M, Hitman, G, Korbonits, M

“…CONTEXT: Recently, a quantitative trait locus for stature was reported on chromosome 3p26 in patients with type 2 diabetes. …”

Submergence tolerance in rice: review of mechanism, breeding and, future prospects by Abisola, Oladosu Yusuff, Yusop, Mohd Rafii, Arolu, Fatai, Chukwu, Samuel Chibuike, Muhammad, Ismaila, Kareem, Isiaka, Salisu, Monsuru Adekunle, Arolu, Ibrahim Wasiu

“…Using marker-assisted backcrossing, the SUB1 QTL (quantitative trait locus) has been incorporated into many elite varieties within a short time and with high precision as compared with conventional breeding methods. …”
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Variation on a theme: mapping microglial heterogeneity by Washer, SJ, Bassett, AR, Cowley, SA

“…Using expression quantitative trait locus (eQTL) mapping techniques, they identify 129 genes whose expression in microglia is linked to disease, and show that induced pluripotent stem cell (iPSC) models can be used for functional validation of common genetic mutations in microglia-associated diseases. …”

Comparative plant development: the time of the leaf? by Tsiantis, M, Hay, A

“…The differential expression of regulatory proteins has emerged as an important factor in driving morphological innovations in the plant kingdom--an idea that is well supported by quantitative trait locus analyses.…”

Epigenome-Wide Study Identified Methylation Sites Associated with the Risk of Obesity by Majid Nikpay, Sepehr Ravati, Robert Dent, Ruth McPherson

“…We integrated methylation quantitative trait locus (mQTL) data with BMI GWAS information through a SNP-based multiomics approach to identify genomic regions where mQTLs for a methylation site co-localize with obesity risk SNPs. …”
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Compensatory trans‐regulatory alleles minimizing variation in TDH3 expression are common within Saccharomyces cerevisiae by Brian P. H. Metzger, Patricia J. Wittkopp

“…Using a powerful quantitative trait locus mapping method, we identified ∼100 trans‐acting expression quantitative trait locus in each of three crosses to a common reference strain, indicating that regulatory variation is more polygenic than previous studies have suggested. …”
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Mouse SNP Miner: an annotated database of mouse functional single nucleotide polymorphisms by Ramensky Vasily E, Reuveni Eli, Gross Cornelius

“…However, identifying the specific phenotype-causing DNA sequence variations within a quantitative trait locus has been much more difficult. The recent availability of genomic sequence from several mouse inbred strains (including C57BL/6J, 129X1/SvJ, 129S1/SvImJ, A/J, and DBA/2J) has made it possible to catalog DNA sequence differences within a quantitative trait locus derived from crosses between these strains. …”
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Characterization of introgression from the teosinte Zea mays ssp. mexicana to Mexican highland maize by Eric Gonzalez-Segovia, Sergio Pérez-Limon, G. Carolina Cíntora-Martínez, Alejandro Guerrero-Zavala, Garrett M. Janzen, Matthew B. Hufford, Jeffrey Ross-Ibarra, Ruairidh J. H. Sawers

“…We generated a genetic linkage map and performed Quantitative Trait Locus mapping in an F2 population derived from a cross between lowland and highland maize individuals. …”
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Whole brain and regional hyperintense white matter volume and blood pressure: overlap of genetic loci produced by bivariate, whole-genome linkage analyses by Kochunov, P, Glahn, D, Lancaster, J, Winkler, A, Kent, J, Olvera, R, Cole, SA, Dyer, T, Almasy, L, Duggirala, R, Fox, P, Blangero, J

“…</p> <p><strong>Results—</strong> Bivariate genomewide linkage analyses localized a significant quantitative trait locus influencing WB and regional (ependymal) HWM volumes and pulse pressure and systolic BP to chromosomal location 1q24 between markers D1S196 and D1S1619. …”

Epigenetics & Classical Genetics / by Hoover, Roger, author 648123, Ibarra, Markus, author 648211

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Analysis of morphine responses in mice reveals a QTL on Chromosome 7 [version 2; referees: 2 approved] by Wim E. Crusio, Esha Dhawan, Elissa J. Chesler, Anna Delprato

“…In this study we identified a quantitative trait locus (QTL) on mouse Chromosome 7 associated with locomotor activity and rearing post morphine treatment. …”
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A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. by Nicholson, G, Rantalainen, M, Li, J, Maher, A, Malmodin, D, Ahmadi, K, Faber, J, Barrett, A, Min, J, Rayner, N, Toft, H, Krestyaninova, M, Viksna, J, Neogi, S, Dumas, M, Sarkans, U, Donnelly, P, Illig, T, Adamski, J, Suhre, K, Allen, M, Zondervan, K, Spector, T, Nicholson, J, Lindon, J, Baunsgaard, D, Holmes, E, McCarthy, M, Holmes, C

“…We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. …”

Association studies in outbred mice in a new era of full-genome sequencing. by Yalcin, B, Flint, J

“…These resources constitute a major advance and make it possible to progress from a quantitative trait locus to a gene at an unprecedented speed.…”

Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast by Alex N Nguyen Ba, Katherine R Lawrence, Artur Rego-Costa, Shreyas Gopalakrishnan, Daniel Temko, Franziska Michor, Michael M Desai

“…Genome-wide association studies (GWAS) in humans and quantitative trait locus (QTL) mapping in model organisms can now explain much of the observed heritability in many traits, allowing us to predict phenotype from genotype. …”
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Towards mouse genetic-specific RNA-sequencing read mapping. by Nastassia Gobet, Maxime Jan, Paul Franken, Ioannis Xenarios

“…This can skew the transcriptome estimates that are used later for downstream analyses, such as expression quantitative trait locus (eQTL) detection. Here, we assessed the impact of reference-based analysis on the transcriptome and eQTLs in a widely-used mouse genetic population: the BXD panel of recombinant inbred lines. …”
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Cystathionine β-synthase as novel endogenous regulator of lymphangiogenesis via modulating VEGF receptor 2 and 3 by Niloofar Hatami, Christian Büttner, Felix Bock, Sara Simfors, Gwen Musial, André Reis, Claus Cursiefen, Thomas Clahsen

“…Quantitative trait locus analysis of BALB/cN x C57BL/6 N intercross identifies cystathionine β-synthase as a previously unknown regulator of lymphangiogenesis by affecting VEGF-R2/VEGF-R3 expression in lymphatic endothelial cells.…”
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Divergent combinations of cis-regulatory elements control the evolution of phenotypic plasticity. by Mohannad Dardiry, Gabi Eberhard, Hanh Witte, Christian Rödelsperger, James W Lightfoot, Ralf J Sommer

“…Here, we investigate the predatory nematode Pristionchus pacificus with its feeding structure plasticity using recombinant-inbred-line and quantitative-trait-locus (QTL) analyses between natural isolates. …”
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Localization, cDNA sequence and genomic organization of the rat seipin gene (Bscl2) and sequence analysis in inbred rat models of Type 2 diabetes mellitus. by Kaisaki, P, Sebag-Montefiore, L, Brown, J, Magre, J, Lathrop, M, Capeau, J, Gauguier, D

“…Radiation hybrid analysis localized the seipin gene (Bscl2) in rat to a major quantitative trait locus in rat chromosome 1 linked to glucose intolerance in the Goto-Kakizaki (GK) rat model of Type 2 diabetes. …”

Heart regeneration in the Mexican cavefish by Stockdale, W, Lemieux, M, Killen, A, Zhao, J, Hu, Z, Riepsaame, J, Hamilton, N, Kudoh, T, Riley, P, Van Aerle, R, Yamamoto, Y, Mommersteeg, M

“…Furthermore, using quantitative trait locus (QTL) analysis, we have linked the degree of heart regeneration to three loci in the genome, identifying candidate genes fundamental to the difference between scarring and regeneration. …”