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341
An allelic series at the EDNRB2 locus controls diverse piebalding patterns in the domestic pigeon.
Published 2023-10-01“…Using a combination of quantitative trait locus mapping in F2 laboratory crosses and genome-wide association analysis, we identify a locus associated with piebalding across many pigeon breeds. …”
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342
A Comparison of Methods to Estimate Additive–by–Additive–by–Additive of QTL×QTL×QTL Interaction Effects by Monte Carlo Simulation Studies
Published 2023-06-01“…Understanding the genetic architecture of complex traits is a major challenge in the post-genomic era, especially for quantitative trait locus (QTL) effects, QTL–by–QTL interactions and QTL–by–QTL–by–QTL interactions. …”
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343
Quantitative genetics theory for genomic selection and efficiency of breeding value prediction in open-pollinated populations
Published 2016-06-01“…ABSTRACT To date, the quantitative genetics theory for genomic selection has focused mainly on the relationship between marker and additive variances assuming one marker and one quantitative trait locus (QTL). This study extends the quantitative genetics theory to genomic selection in order to prove that prediction of breeding values based on thousands of single nucleotide polymorphisms (SNPs) depends on linkage disequilibrium (LD) between markers and QTLs, assuming dominance. …”
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344
Solving the regulation puzzle of periderm development using advances in fruit skin
Published 2022-09-01“…Recently, progress in histochemical as well as transcriptome and proteome analyses, and quantitative trait locus (QTL) mapping have revealed the regulatory molecular mechanism in the periderm based on the identification of switch genes. …”
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345
Genetic Architecture of Cereal Leaf Beetle Resistance in Wheat
Published 2020-08-01“…In line with the strong effect of heading time, we identified <i>Ppd-D1</i> as a major quantitative trait locus (QTL), explaining 35% of the genotypic variance of cereal leaf beetle resistance. …”
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346
Systematic identification of trans eQTLs as putative drivers of known disease associations.
Published 2013“…To help overcome this problem, we performed expression quantitative trait locus (eQTL) meta-analysis in non-transformed peripheral blood samples from 5,311 individuals with replication in 2,775 individuals. …”
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347
Fine scale mapping of a genetic locus for conditioned fear.
Published 2003“…Here we use high-resolution mapping in genetically heterogeneous mice to show that a quantitative trait locus influencing conditioned fear can be separated from loci influencing open-field activity. …”
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348
Genetic analysis of complex traits in the emerging Collaborative Cross
Published 2011“…We map discrete, complex, and biomolecular traits and contrast two quantitative trait locus (QTL) mapping approaches. Analysis based on inferred haplotypes improves power, reduces false discovery, and provides information to identify and prioritize candidate genes that is unique to multifounder crosses like the CC. …”
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349
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
Published 2022“…We first prioritize lipid-associated genes with expression quantitative trait locus (eQTL) colocalizations, and then add chromatin interaction data to narrow the search for functional genes. …”
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350
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
Published 2011“…The CAD-associated SNP in the PDGFD locus showed tissue-specific cis expression quantitative trait locus effects. These findings implicate new pathways for CAD susceptibility.…”
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351
Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse genome.
Published 2004“…The draft genomic sequence of the rat now provides essential information for annotating rat quantitative trait locus (QTL) maps. Following the survey of unique rat microsatellite (11,585 including 1648 new markers) and EST (10,067) markers currently available, we have incorporated a selection of 7952 rat EST sequences in an improved version of the integrated linkage-radiation hybrid map of the rat containing 2058 microsatellite markers which provided over 10,000 potential anchor points between rat QTL and the genomic sequence of the rat. …”
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352
Mapping cis-and trans-regulatory effects across multiple tissues in twins
Published 2012“…Common variants regulating expression in cis have been mapped in many expression quantitative trait locus (eQTL) studies, typically in single tissues from unrelated individuals. …”
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353
Genomic dissection of variation in clutch size and egg mass in a wild great tit (Parus major) population.
Published 2013“…Here, we analyse the genomic architecture of these heritable traits in a wild great tit (Parus major) population, using three marker-based approaches - chromosome partitioning, quantitative trait locus (QTL) mapping and a genome-wide association study (GWAS). …”
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354
PARL Leu262Val is not associated with fasting insulin levels in UK populations.
Published 2006“…AIMS/HYPOTHESIS: PARL, the gene encoding presenilins-associated rhomboid-like protein, maps to chromosome 3q27 within a quantitative trait locus that influences components of the metabolic syndrome. …”
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355
Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse genome
Published 2004“…The draft genomic sequence of the rat now provides essential information for annotating rat quantitative trait locus (QTL) maps. Following the survey of unique rat microsatellite (11,585 including 1648 new markers) and EST (10,067) markers currently available, we have incorporated a selection of 7952 rat EST sequences in an improved version of the integrated linkage-radiation hybrid map of the rat containing 2058 microsatellite markers which provided over 10,000 potential anchor points between rat QTL and the genomic sequence of the rat. …”
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356
Rrp1b, a new candidate susceptibility gene for breast cancer progression and metastasis.
Published 2007-11-01“…To investigate the relationship between ECM genes and poor prognosis in breast cancer, expression quantitative trait locus analysis of polyoma middle-T transgene-induced mammary tumor was performed. …”
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357
Independent control of organ number and distribution pattern in rice panicle
Published 2023-02-01“…To validate our method for practical application in biology, we integrated this method into a quantitative trait locus (QTL) analysis and identified QTLs for panicle organ distribution patterns in rice. …”
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358
Amoeba predation of Cryptococcus: A quantitative and population genomic evaluation of the accidental pathogen hypothesis.
Published 2023-11-01“…Here, we investigate this hypothesis in the human fungal pathogens Cryptococcus neoformans and Cryptococcus deneoformans. Applying quantitative trait locus (QTL) mapping and comparative genomics, we discovered a cross-species QTL region that is responsible for variation in resistance to amoeba predation. …”
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359
Selection on a Subunit of the NURF Chromatin Remodeler Modifies Life History Traits in a Domesticated Strain of Caenorhabditis elegans.
Published 2016-07-01“…We identified a quantitative trait locus (QTL) of large effect that controls 24%-75% of the total trait variance in reproductive timing at various timepoints. …”
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360
<b>Molecular markers associated with the agronomic traits in the medicinal plant lemon balm
Published 2017-06-01“…Some of ISSR and RAPD markers were associated with more than one trait in multiple regression analysis that may be due to pleiotropic effect of the linked quantitative trait locus on different traits or its linkage to different genes. …”
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