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361
The Power of Single-Cell RNA Sequencing in eQTL Discovery
Published 2022-03-01“…During the last decade, functional genomics approaches combining genotype information with bulk RNA-sequencing data have identified genes regulated by GWAS loci through expression quantitative trait locus (eQTL) analysis. Single-cell RNA-Sequencing (scRNA-Seq) technologies have created new exciting opportunities for spatiotemporal assessment of changes in gene expression at the single-cell level in complex and inherited conditions. …”
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362
Development of a MAGIC population and high-resolution quantitative trait mapping for nicotine content in tobacco
Published 2023-01-01“…Multiparent Advanced Generation Inter-Cross (MAGIC) population is an ideal genetic and breeding material for quantitative trait locus (QTL) mapping and molecular breeding. …”
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363
Fine mapping spatiotemporal mechanisms of genetic variants underlying cardiac traits and disease
Published 2023-02-01“…Here, we leverage spatiotemporal information on 966 RNA-seq cardiac samples and perform an expression quantitative trait locus (eQTL) analysis detecting eQTLs considering both eGenes and eIsoforms. …”
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364
PRTN3 variant correlates with increased autoantigen levels and relapse risk in PR3-ANCA versus MPO-ANCA disease
Published 2023-02-01“…The variant (G allele) was shown to be an expression quantitative trait locus in healthy controls, but the clinical impact remains unknown. …”
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365
A Novel QTL and a Candidate Gene Are Associated with the Progressive Motility of Franches-Montagnes Stallion Spermatozoa after Thaw
Published 2021-09-01“…We identified one significant (<i>p</i> < 1.69 × 10<sup>−7</sup>) quantitative trait locus (QTL) on ECA6 within the <i>SCN8A</i> gene for progressive motility after thaw, which was previously associated with progressive motility in boars. …”
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366
Genetic dissection of MHC-associated susceptibility to <it>Lepeophtheirus salmonis </it>in Atlantic salmon
Published 2009-04-01“…In this study, we used quantitative trait locus (QTL) analysis to test the effect of genomic regions linked to MHC class I and II on linkage groups (LG) 15 and 6, respectively.…”
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367
Haplotype-based genome-wide association study identifies loci and candidate genes for milk yield in Holsteins.
Published 2018-01-01“…We further identified the nearest gene of each haplotype block and annotated the genes with milk-associated quantitative trait locus (QTL) intervals and ingenuity pathway analysis (IPA) networks. …”
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368
Accounting for isoform expression increases power to identify genetic regulation of gene expression.
Published 2024-02-01“…A core problem in genetics is molecular quantitative trait locus (QTL) mapping, in which genetic variants associated with changes in the molecular phenotypes are identified. …”
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369
Gene expression genetics of the striatum of Diversity Outbred mice
Published 2023-08-01“…Abstract Brain transcriptional variation is a heritable trait that mediates complex behaviors, including addiction. Expression quantitative trait locus (eQTL) mapping reveals genomic regions harboring genetic variants that influence transcript abundance. …”
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370
The role of Sp140 revealed in IgE and mast cell responses in Collaborative Cross mice
Published 2021-06-01“…Among strains tested, C57BL/6J and CC027 mice showed, respectively, moderate and uniquely potent MC activity. Quantitative trait locus analysis and RNA sequencing of BM-derived cultured MCs (BMCMCs) from CC027 mice suggested Sp140 as a candidate gene for MC activation. siRNA-mediated knock-down of Sp140 in BMCMCs decreased IgE-dependent histamine release and cytokine production. …”
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371
Pan-European study of genotypes and phenotypes in the Arabidopsis relative Cardamine hirsuta reveals how adaptation, demography, and development shape diversity patterns.
Published 2023-07-01“…We identified a quantitative trait locus (QTL) in the heterochronic SPL9 transcription factor as a determinant of an Azorean morphotype. …”
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372
Genetic variation on chromosome 6 influences F cell levels in healthy individuals of African descent and HbF levels in sickle cell patients.
Published 2009“…We investigated if a quantitative trait locus on chromosome 6q23 was significantly associated with HbF and F cell levels in individuals of African descent. …”
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373
Susceptibility to klebsiella pneumonaie infection in collaborative cross mice is a complex trait controlled by at least three loci acting at different time points.
Published 2014“…We performed the first quantitative trait locus (QTL) mapping study of host susceptibility to Kp infection in immunocompetent Collaborative Cross mice (CC). …”
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374
Colocalization analysis of polycystic ovary syndrome to identify potential disease-mediating genes and proteins
Published 2021“…We evaluated the posterior probabilities of evidence consistent with shared causal variants between 14 PCOS genetic risk loci and intermediate cellular phenotypes in one protein (N = 3301) and two expression quantitative trait locus datasets (N = 31,684 and N = 80–491). …”
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375
Inflammatory bowel disease: progress toward a gene.
Published 2000“…Animal studies have provided insights from targeted mutations and quantitative trait locus analysis. The goals of continuing research include narrowing the regions of linkages and analysis of candidate genes, and possibly the application of newly developed methods using single nucleotide polymorphisms. …”
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376
Measured haplotype analysis of the angiotensin-I converting enzyme gene.
Published 1998“…Linkage and segregation analysis have shown that circulating angiotensin-I converting enzyme (ACE) levels are influenced by a major quantitative trait locus that maps within or close to the ACE gene. …”
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377
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma
Published 2022“…We found that rs16906115 forms a B cell-specific expression quantitative trait locus (eQTL) to <em>IL7</em> in patients. …”
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378
A chromosome-level genome of Astyanax mexicanus surface fish for comparing population-specific genetic differences contributing to trait evolution
Published 2021“…Using this resource, we performed quantitative trait locus (QTL) mapping analyses and found new candidate genes for eye loss such as dusp26. …”
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379
The presence of methylation quantitative trait loci indicate a direct genetic influence on the level of methylation in adipose tissue
Published 2011“…We find that none of the 149 meQTL top SNPs is a significant expression quantitative trait locus in our expression data, but we observed association between expression levels of two mRNA transcripts and cis-methylation status. …”
Conference item -
380
Angiotensin-1-converting enzyme (ACE) plasma concentration is influenced by multiple ACE-linked quantitative trait nucleotides.
Published 2002“…The strong effect of the locus, and the interest in ACE as a candidate gene for cardiovascular disorders, has led to extensive investigation of its relationship to the ACE phenotype, providing one of the most complete examples of quantitative trait locus (QTL) analysis in humans. Resequencing of ACE followed by haplotype analysis in families of British and French origin has shown that the genetic variants that are primarily associated with the ACE trait map to an 18 kb interval flanked by two intragenic, ancestral recombination breakpoints. …”
Journal article