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441
Updating the Breeding Philosophy of Wheat to Fusarium Head Blight (FHB): Resistance Components, QTL Identification, and Phenotyping—A Review
Published 2020-12-01“…Type II QTL (quantitative trait locus) <i>Fhb1</i> on 3BS from Sumai 3 descendant CM82036 secures about the same resistance level as Type I QTL does on <i>5AS</i> and <i>5ASc</i> in terms of visual symptoms, FDK (Fusarium damaged kernel), and deoxynivalenol response. …”
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442
QTL discovery for resistance to black spot and cercospora leaf spot, and defoliation in two interconnected F1 bi-parental tetraploid garden rose populations
Published 2023-07-01“…With the use of newly developed software tools for autopolyploid genetics, two interconnected tetraploid garden rose F1 populations (phenotyped over the course of 3 years) were used for quantitative trait locus (QTL) analysis of black spot and cercospora leaf spot resistance as well as plant defoliation. …”
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443
A single nucleotide polymorphism of the porcine CXCL8 gene is associated with serum CXCL8 level
Published 2019-01-01“…Previous studies have reported that the CXCL8 gene resides within the quantitative trait locus (QTL). In this report, the porcine CXCL8 gene was selected to investigate its effect on serum immune traits. …”
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444
DEPTOR Cell-Autonomously Promotes Adipogenesis, and Its Expression Is Associated with Obesity
Published 2014“…Previous work indicates that Deptor is part of the Fob3a quantitative trait locus (QTL) linked to obesity/leanness in mice, with Deptor expression being elevated in white adipose tissue (WAT) of obese animals. …”
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445
Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells
Published 2016“…Further, we characterize highly coordinated genetic effects on gene expression, methylation, and histone variation through quantitative trait locus (QTL) mapping and allele-specific (AS) analyses. …”
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446
The impact of genetic variation on IFITM3 related influenza virus restriction
Published 2018“…We show that rs12252 is an expression Quantitative Trait Locus (eQTL) for IFITM3, and its activity is potentially tissue dependent. …”
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447
High dimensional endophenotype ranking in the search for major depression risk genes
Published 2012“…A genome-wide significant quantitative trait locus was localized on chromsome 4p15 (logarithm of odds = 3.5) exhibiting pleiotropic effects on both the endophenotype (lymphocyte-derived expression levels of the <em>RNF123</em> gene) and disease risk.…”
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448
Genome-Wide Association Study of Cryptosporidiosis in Infants Implicates PRKCA
Published 2020“…The strongest meta-analytic association was with rs58296998 (P = 3.73 × 10−8), an intronic SNP and expression quantitative trait locus (eQTL) of protein kinase C alpha (PRKCA). …”
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449
Collaborative Cross mice and their power to map host susceptibility to Aspergillus fumigatus infection
Published 2011“…The survival time after infection varied significantly between CC lines. Quantitative trait locus (QTL) mapping identified genome-wide significant QTLs on chromosomes 2, 3, 8, 10 (two QTLs), 15, and 18. …”
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450
Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1.
Published 2016“…In primary human macrophages, we identified a novel expression quantitative trait locus (eQTL) specific for this short transcript, whereby the risk allele at CAD risk SNP rs9349379 is associated with reduced PHACTR1 expression, similar to the effect of an inflammatory stimulus.…”
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451
Variation in the glucose transporter gene SLC2A2 is associated with glycaemic response to metformin
Published 2016“…The C allele of rs8192675 in the intron of SLC2A2, which encodes the facilitated glucose transporter GLUT2, was associated with a 0.17% (P = 6.6 × 10−14) greater metformin-induced reduction in hemoglobin A1c (HbA1c) in 10,577 participants of European ancestry. rs8192675 was the top cis expression quantitative trait locus (cis-eQTL) for SLC2A2 in 1,226 human liver samples, suggesting a key role for hepatic GLUT2 in regulation of metformin action. …”
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452
HLA-C level is regulated by a polymorphic Oct1 binding site in the HLA-C promoter region
Published 2016“…This imputed expression quantitative trait locus, termed impeQTL, was also shown to associate with HLA-C expression in a genome-wide association study of 273 donors in which HLA-C mRNA expression levels were determined by quantitative PCR (qPCR) (p = 1.8 × 10(-20)) and in two cohorts where HLA-C cell surface levels were determined directly by flow cytometry (n = 369 combined, p < 10(-15)). rs2395471 is located in an Oct1 transcription factor consensus binding site motif where the A allele is predicted to have higher affinity for Oct1 than the G allele. …”
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453
Genetic and environmental risk factors for atherosclerosis regulate transcription of phosphatase and actin regulating gene PHACTR1
Published 2016“…In primary human macrophages, we identified a novel expression quantitative trait locus (eQTL) specific for this short transcript, whereby the risk allele at CAD risk SNP rs9349379 is associated with reduced PHACTR1 expression, similar to the effect of an inflammatory stimulus. …”
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454
The presence of methylation quantitative trait loci indicates a direct genetic influence on the level of DNA methylation in adipose tissue
Published 2013“…We find that none of the 149 meQTL top SNPs is a significant expression quantitative trait locus in our expression data, but we observed association between expression levels of two mRNA transcripts and cis-methylation status. …”
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455
Genetics and genomics of animal behaviour and welfare-Challenges and possibilities
Published 2008“…As a next step, it is necessary to map the loci involved in affecting these traits, and quantitative trait locus (QTL) analysis have been used for this. …”
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456
Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice.
Published 2011“…In several instances, these regions proved to contain 2 quantitative trait loci: the region on chromosome 2 included the C5 fraction of complement known to be required for K/BxN serum-transfer arthritis but also contained a second adjacent quantitative trait locus, for which an intriguing candidate is Ptgs1 (Cox1). …”
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457
Epistasis between mutator alleles contributes to germline mutation spectrum variability in laboratory mice
Published 2024-02-01“…Previously, we used quantitative trait locus mapping to discover candidate mutator alleles in the DNA repair gene Mutyh that increased the C>A germline mutation rate in a family of inbred mice known as the BXDs (Sasani et al., 2022, Ashbrook et al., 2021). …”
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458
Transcriptome Analysis Reveals Inhibitory Effects of Lentogenic Newcastle Disease Virus on Cell Survival and Immune Function in Spleen of Commercial Layer Chicks
Published 2020-08-01“…Sprouty RTK signaling antagonist 1 (<i>SPRY1</i>), a DEG in the current study, is in a significant quantitative trait locus associated with virus load at 6 dpi in the same population. …”
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459
An Overview of the Bionomics, Host Plant Resistance and Molecular Perspectives of <i>Sesamia inferens</i> Walker in Cereals and Millets
Published 2020-11-01“…Thus, molecular markers and Quantitative Trait Locus (QTL) mapping offer a more efficient approach to entomologists and plant breeders wherein they can work with traits like QTLs for stem borer resistance. …”
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460
Genetic basis of the early heading of high-latitude weedy rice
Published 2022-12-01“…At the same time, we developed recombinant inbred lines (RILs) crossed by the early-heading weedy rice WR04-6 and its accompanied japonica cultivar ShenNong 265 (SN265) to carry out a QTL mapping analysis of the heading date and mapped four quantitative trait locus (QTLs) and three epistatic effect gene pairs. …”
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