Independently evolved pollution resistance in four killifish populations is largely explained by few variants of large effect by Jeffrey T. Miller, Bryan W. Clark, Noah M. Reid, Sibel I. Karchner, Jennifer L. Roach, Mark E. Hahn, Diane Nacci, Andrew Whitehead

“…We created multiple quantitative trait locus (QTL) mapping families using progenitors from four different resistant populations, and using RAD‐seq genetically mapped variation in sensitivity (developmental perturbations) following embryonic exposure to a model toxicant PCB‐126. …”
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Integrated analysis strategy of genome-wide functional gene mining reveals DKK2 gene underlying meat quality in Shaziling synthesized pigs by Shuaihan He, Yubei Wang, Yabiao Luo, Mingming Xue, Maisheng Wu, Hong Tan, Yinglin Peng, Kejun Wang, Meiying Fang

“…Of them, dickkopf WNT signaling pathway inhibitor 2 (DKK2), the antagonist of Wnt signaling pathway, was the most promising candidate gene which was not only identified an association of palmitic acid and palmitoleic acid quantitative trait locus in PigQTLdb, but also specifically selected in S compared to other 48 Chinese local pigs of 12 populations and 39 foreign pigs of 4 populations. …”
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High density linkage maps, genetic architecture, and genomic prediction of growth and wood properties in Pinus radiata by Jules S. Freeman, Gancho T. Slavov, Jakob B. Butler, Tancred Frickey, Natalie J. Graham, Jaroslav Klápště, John Lee, Emily J. Telfer, Phillip Wilcox, Heidi S. Dungey

“…We constructed robust high-density linkage maps based on exome-capture genotyping in two F1 populations, and used these populations to perform quantitative trait locus (QTL) scans, genomic prediction and quantitative analyses of genetic architecture for key traits targeted by tree improvement programmes. …”
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Genome-Wide Association Studies on the Kernel Row Number in a Multi-Parent Maize Population by Yizhu Wang, Fengyun Ran, Xingfu Yin, Fuyan Jiang, Yaqi Bi, Ranjan K. Shaw, Xingming Fan

“…Our study successfully identified 277 significant Quantitative trait locus (QTLs) and 53 significant Single Nucleotide Polymorphism (SNPs) related to KRN. …”
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Mapping QTL Associated with Resistance to Avian Oncogenic Marek’s Disease Virus (MDV) Reveals Major Candidate Genes and Variants by Jacqueline Smith, Ehud Lipkin, Morris Soller, Janet E. Fulton, David W. Burt

“…In this study, one of the largest to date, we used a multi-facetted approach to identify quantitative trait locus regions (QTLR) influencing resistance to MDV, including an F₆ population from a full-sib advanced intercross line (FSIL) between two elite commercial layer lines differing in resistance to MDV, RNA-seq information from virus challenged chicks, and genome wide association study (GWAS) from multiple commercial lines. …”
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Investigation of the acute pathogenesis of spondyloarthritis/HLA-B27-associated anterior uveitis based on genome-wide association analysis and single-cell transcriptomics by Shuming Chen, Weidi Huang, Qiaoqian Wan, Zichun Tang, Xie Li, Fang Zeng, Shuyan Zheng, Zhuo Li, Xiao Liu

“…The MR incorporated publicly available protein quantitative trait locus data from previous studies, along with genome-wide association study data from public databases. …”
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<i>Ace2</i> and <i>Tmprss2</i> Expressions Are Regulated by <i>Dhx32</i> and Influence the Gastrointestinal Symptoms Caused by SARS-CoV-2 by Fuyi Xu, Jun Gao, Buyan-Ochir Orgil, Akhilesh Kumar Bajpai, Qingqing Gu, Enkhsaikhan Purevjav, Athena S. Davenport, Kui Li, Jeffrey A. Towbin, Dennis D. Black, Joseph F. Pierre, Lu Lu

“…We identified a significant expression quantitative trait locus on chromosome 7 that controls the expression of both <i>Tmprss2</i> and <i>Ace2</i>. …”
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Construction of a Tomato (<i>Solanum lycopersicum</i> L.) Introgression Line Population and Mapping of Major Agronomic Quantitative Trait Loci by Yifan Chen, Shuliang Qiu, Hui Zhou, Wenzheng Gao, Lipeng Cui, Zhuoyao Qiu, Chenchen Dong, Xiaoxuan Wang

“…Moreover, phenotype data of major agronomic traits in BC₅ progeny after selfing two times, were analyzed for quantitative trait locus (QTL) mapping, and a total of 11 QTLs distributed on 6 chromosomes were identified, including 3 QTLs regulating plant height, 1 QTL regulating leaf size, 1 QTL regulating fruit color, 4 QTLs regulating fruit weight, and 2 QTLs regulating soluble solids content in ripening fruits. …”
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QTL analysis reveals genomic variants linked to high-temperature fermentation performance in the industrial yeast by Zhen Wang, Qi Qi, Yuping Lin, Yufeng Guo, Yanfang Liu, Qinhong Wang

“…The understanding of genetic basis behind high-temperature fermentation performance is still limited. Quantitative trait locus (QTL) mapping by pooled-segregant whole genome sequencing has been proved to be a powerful and reliable approach to identify the loci, genes and single nucleotide polymorphism (SNP) variants linked to quantitative traits of yeast. …”
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Association of Butyrophilin gene polymorphism (A465G) with milk production traits in Holstein Friesian crossbred cattle of Kerala by Potu Hemanth, F. A. Lali, K. Anilkumar, T.V. Aravindakshan, M. T. Dipu

“…The butyrophilin (BTN1A1) gene is found at a quantitative trait locus (QTL) in cattle for milk production traits. …”
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Role of Sex on the Genetic Susceptibility to Childhood Asthma in Latinos and African Americans by Antonio Espuela-Ortiz, Esther Herrera-Luis, Fabián Lorenzo-Díaz, Donglei Hu, Celeste Eng, Jesús Villar, Jose R. Rodriguez-Santana, Esteban G. Burchard, María Pino-Yanes

“…Additionally, protein quantitative trait locus (pQTL) information was gathered for the suggestively associated variants, and enrichment analyses of the proteins identified were carried out. …”
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QTLs and Candidate Loci Associated with Drought Tolerance Traits of Kaybonnet x ZHE733 Recombinant Inbred Lines Rice Population by Yheni Dwiningsih, Julie Thomas, Anuj Kumar, Chirag Gupta, Navdeep Gill, Charles Ruiz, Jawaher Alkahtani, Niranjan Baisakh, Andy Pereira

“…Rice is the most important staple crop for the sustenance of the world’s population, and drought is a major factor limiting rice production. Quantitative trait locus (QTL) analysis of drought-resistance-related traits was conducted on a recombinant inbred line (RIL) population derived from the self-fed progeny of a cross between the drought-resistant <i>tropical japonica</i> U.S. adapted cultivar Kaybonnet and the drought-sensitive <i>indica</i> cultivar ZHE733. …”
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Natural variants and editing events provide insights into routes for spike architecture modification in common wheat by Min Fan, Xiaoyu Zhang, Ragupathi Nagarajan, Wenxuan Zhai, Yahya Rauf, Haiyan Jia, Zhengqiang Ma, Liuling Yan

“…A segregating population was generated for mapping genes contributing to spike morphometric traits by crossing the two common wheat cultivars 'CItr 17600' with branching spikes and 'Yangmai 18' with normal spikes. A major quantitative trait locus for spike length was mapped to the Q5A region of chromosome 5A. …”
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Identifying QTL and candidate genes for prolificacy in maize by Min Wang, Renyu Zhang, Yangzi Zhao, Jieyuan Yao, Weiya Li, Zhixing Yang, Fei Sun, Xiaohong Yang

“…We identified a stable quantitative trait locus, qEN7, for ear number on chromosome 7 in both F2 and F2:3 populations derived from a single cross between the nonprolific inbred line Mo17 and the prolific inbred line LAN404 derived from the landrace PI217404. qEN7 explained 10.7%–11.9% of phenotypic variation, and the LAN404 allele at this locus was associated with an increase of around one ear per plant. qEN7 was confined by fine-mapping to a 0.56-Mb region containing eight annotated genes. …”
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Skeletal muscle overexpression of sAnk1.5 in transgenic mice does not predispose to type 2 diabetes by E. Pierantozzi, L. Raucci, S. Buonocore, E. M. Rubino, Q. Ding, A. Laurino, F. Fiore, M. Soldaini, J. Chen, D. Rossi, P. Vangheluwe, H. Chen, V. Sorrentino

“…Abstract Genome-wide association studies (GWAS) and cis-expression quantitative trait locus (cis-eQTL) analyses indicated an association of the rs508419 single nucleotide polymorphism (SNP) with type 2 diabetes (T2D). rs508419 is localized in the muscle-specific internal promoter (P2) of the ANK1 gene, which drives the expression of the sAnk1.5 isoform. …”
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DNA primase large subunit is an essential plant gene for geminiviruses, putatively priming viral ss-DNA replication by Lampros Siskos, Maria Antoniou, Jose Riado, Montserrat Enciso, Carlos Garcia, Daniele Liberti, Danny Esselink, Andrey G. Baranovskiy, Tahir H. Tahirov, Richard G. F. Visser, Richard Kormelink, Yuling Bai, Henk J. Schouten

“…In this study, sequencing of melon (Cucumis melo) accession K18 carrying the Tomato leaf curl New Delhi virus (ToLCNDV) recessive resistance quantitative trait locus (QTL) in chromosome 11, and analyses of DNA sequence data from 100 melon genomes, showed a conservation of a shared mutation in the DNA Primase Large subunit (PRiL) of all accessions that exhibited resistance upon a challenge with ToLCNDV. …”
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Effect of drought stress on flowering characteristics in rice (Oryza sativa L.): a study using genotypes contrasting in drought tolerance and flower opening time by Tsutomu Ishimaru, Kazuhiro Sasaki, Patrick D. Lumanglas, Carlo Leo U. Cabral​, Changrong Ye, Mayumi Yoshimoto, Arvind Kumar, Amelia Henry

“…This study therefore proposes that a breeding strategy that transfers the EMF trait into drought tolerant lines could enhance the resilience of rice spikelets to the combined stresses of heat and drought at flowering.Abbreviations: Analysis of variance (ANOVA), dry season (DS), early-morning flowering (EMF), flower opening time (FOT), near-isogenic line (NIL), panicle water potential (PWP), quantitative trait locus (QTL), wet season (WS)…”
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Cis-eQTL Analysis and Functional Validation of Candidate Genes for Carcass Yield Traits in Beef Cattle by Tianzhen Wang, Qunhao Niu, Tianliu Zhang, Xu Zheng, Haipeng Li, Xue Gao, Yan Chen, Huijiang Gao, Lupei Zhang, George E. Liu, Junya Li, Lingyang Xu

“…In this study, we performed an integrative analysis of gene-based GWAS with expression quantitative trait locus (eQTL) analysis to detect candidate genes for carcass yield traits and validate their effects on bovine skeletal muscle satellite cells (BSCs). …”
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Multi-ethnic genome-wide association study for atrial fibrillation by Roselli, C, Chaffin, MD, Weng, L-C, Aeschbacher, S, Ahlberg, G, Albert, CM, Almgren, P, Alonso, A, Anderson, CD, Aragam, KG, Arking, DE, Barnard, J, Bartz, TM, Benjamin, EJ, Bihlmeyer, NA, Bis, JC, Bloom, HL, Boerwinkle, E, Bottinger, EB, Brody, JA, Calkins, H, Campbell, A, Cappola, TP, Carlquist, J, Chasman, DI, Chen, LY, Chen, Y-DI, Choi, E-K, Choi, SH, Christophersen, IE, Chung, MK, Cole, JW, Conen, D, Cook, J, Crijns, HJ, Cutler, MJ, Damrauer, SM, Daniels, BR, Darbar, D, Delgado, G, Denny, JC, Dichgans, M, Dörr, M, Dudink, EA, Dudley, SC, Esa, N, Esko, T, Eskola, M, Fatkin, D, Felix, SB, Ford, I, Franco, OH, Geelhoed, B, Grewal, RP, Gudnason, V, Guo, X, Gupta, N, Gustafsson, S, Gutmann, R, Hamsten, A, Harris, TB, Hayward, C, Heckbert, SR, Hernesniemi, J, Hocking, LJ, Hofman, A, Horimoto, ARVR, Huang, J, Huang, PL, Huffman, J, Ingelsson, E, Ipek, EG, Ito, K, Jimenez-Conde, J, Johnson, R, Jukema, JW, Kääb, S, Kähönen, M, Kamatani, Y, Kane, JP, Kastrati, A, Kathiresan, S, Katschnig-Winter, P, Kavousi, M, Kessler, T, Kietselaer, BL, Kirchhof, P, Kleber, ME, Knight, S, Krieger, JE, Kubo, M, Launer, LJ, Laurikka, J, Lehtimäki, T, Leineweber, K, Lemaitre, RN, Li, M, Lim, HE, Lin, HJ, Lin, H, Lind, L, Lindgren, CM, Lokki, M-L, London, B, Loos, RJF, Low, S-K, Lu, Y, Lyytikäinen, L-P, Macfarlane, PW, Magnusson, PK, Mahajan, A, Malik, R, Mansur, AJ, Marcus, GM, Margolin, L, Margulies, KB, März, W, McManus, DD, Melander, O, Mohanty, S, Montgomery, JA, Morley, MP, Morris, AP, Müller-Nurasyid, M, Natale, A, Nazarian, S, Neumann, B, Newton-Cheh, C, Niemeijer, MN, Nikus, K, Nilsson, P, Noordam, R, Oellers, H, Olesen, MS, Orho-Melander, M, Padmanabhan, S, Pak, H-N, Paré, G, Pedersen, NL, Pera, J, Pereira, A, Porteous, D, Psaty, BM, Pulit, SL, Pullinger, CR, Rader, DJ, Refsgaard, L, Ribasés, M, Ridker, PM, Rienstra, M, Risch, L, Roden, DM, Rosand, J, Rosenberg, MA, Rost, N, Rotter, JI, Saba, S, Sandhu, RK, Schnabel, RB, Schramm, K, Schunkert, H, Schurman, C, Scott, SA, Seppälä, I, Shaffer, C, Shah, S, Shalaby, AA, Shim, J, Shoemaker, MB, Siland, JE, Sinisalo, J, Sinner, MF, Slowik, A, Smith, AV, Smith, BH, Smith, JG, Smith, JD, Smith, NL, Soliman, EZ, Sotoodehnia, N, Stricker, BH, Sun, A, Sun, H, Svendsen, JH, Tanaka, T, Tanriverdi, K, Taylor, KD, Teder-Laving, M, Teumer, A, Thériault, S, Trompet, S, Tucker, NR, Tveit, A, Uitterlinden, AG, Van Der Harst, P, Van Gelder, IC, Van Wagoner, DR, Verweij, N, Vlachopoulou, E, Völker, U, Wang, B, Weeke, PE, Weijs, B, Weiss, R, Weiss, S, Wells, QS, Wiggins, KL, Wong, JA, Woo, D, Worrall, BB, Yang, P-S, Yao, J, Yoneda, ZT, Zeller, T, Zeng, L, Lubitz, SA, Lunetta, KL, Ellinor, PT

“…We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. …”

Conditionally immortalised equine skeletal muscle cell lines for in vitro analysis by Mary F. Rooney, Nuno G.B. Neto, Michael G. Monaghan, Emmeline W. Hill, Richard K. Porter

“…Background: Thoroughbred racehorse performance is largely influenced by a major quantitative trait locus at the myostatin (MSTN) gene which determines aptitude for certain race distances due to a promoter region insertion mutation influencing functional phenotypes in skeletal muscle. …”
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