From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease by Stefani, A, Antelmi, E, Arnaldi, D, Arnulf, I, During, E, Högl, B, Hu, MMT, Iranzo, A, Luke, R, Peever, J, Postuma, RB, Videnovic, A, Gan-Or, Z

“…The neurophysiological hallmark of RBD is REM sleep without atonia (RWSA), i.e. the loss of physiological muscle atonia during REM sleep. …”

Associations of accelerometer-measured physical activity, sedentary behaviour, and sleep with next-day cognitive performance in older adults: a micro-longitudinal study by Bloomberg, M, Brocklebank, L, Doherty, A, Hamer, M, Steptoe, A

“…Each 30-min increase in REM sleep on the previous night was associated with 0.13 SD (0.00 to 0.25) higher attention scores (p = 0.04); a 30-min increase in SWS was associated with 0.17 SD (0.05 to 0.29) higher episodic memory scores (p = 0.008). …”

Rapid eye movement sleep deprivation induces vascular endothelial dysfunction in rats: roles of oxidative stress-mediated nitric oxide signalling and vitamin c supplementation by Nawi, Afifah

“…Rapid eye movement (REM) sleep deprivation (REMsd) is associated with oxidative stress, the primary factor in the mechanism of endothelial dysfunction. …”
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Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice by Traut, J, Mengual, JP, Meijer, E, McKillop, L, Alfonsa, H, Hoerder-Suabedissen, A, Song, SH, Fehér, KD, Riemann, D, Molnar, Z, Akerman, CJ, Vyazovskiy, VV, Krone, LB

“…Using electroencephalography (EEG) and electromyography (EMG) to analyse sleep, we found a dose-dependent suppression of rapid eye movement (REM) sleep, changes in EEG spectral power during non-REM (NREM) sleep, and altered sleep architecture in a pattern previously reported for clozapine. …”

RADAR-AD: assessment of multiple remote monitoring technologies for early detection of Alzheimer’s disease by Lentzen, M, Vairavan, S, Muurling, M, Alepopoulos, V, Atreya, A, Boada, M, de Boer, C, Conde, P, Curcic, J, Frisoni, G, Galluzzi, S, Gjestsen, MT, Gkioka, M, Grammatikopoulou, M, Hausner, L, Hinds, C, Lazarou, I, de Mendonça, A, Nikolopoulos, S, Religa, D, Scebba, G, Jelle Visser, P, Wittenberg, G, Narayan, V

“…Results: The ANCOVA results indicated significant differences between healthy and AD subjects regarding reduced physical activity, less REM sleep, altered gait patterns, and decreased cognitive functioning. …”