Therapeutic Potential of TAAR1 Agonists in Schizophrenia: Evidence from Preclinical Models and Clinical Studies by Nina Dedic, Heather Dworak, Courtney Zeni, Grazia Rutigliano, Oliver D. Howes

“…The identification of endogenous TAAR1 ligands and subsequent development of small-molecule agonists has revealed antipsychotic-, anxiolytic-, and antidepressant-like properties, as well as pro-cognitive and REM-sleep suppressing effects of TAAR1 activation in rodents and non-human primates. …”
Get full text

Neuroimaging in pre-motor Parkinson's disease by Thomas R. Barber, Johannes C. Klein, Clare E. Mackay, Michele T.M. Hu

“…In recent years, recognition that patients with REM sleep behaviour disorder (RBD) are at particularly high risk of future parkinsonism has enabled the development of large prodromal cohorts in which to investigate novel biomarkers, and neuroimaging has generated some of the most promising results to date. …”
Get full text

Behavior in Free-Living American Black Bear Dens: Parturition, Maternal Care, and Cub Behavior by Lynn L. Rogers, Linda McColley, Janet Dalton, Jim Stroner, Douglas Hajicek, Adam Partin, Gordon M. Burghardt

“…Observations included types of dens, labor, pre-parturient genital swelling, birthing positions, post-partum vocalizations, mothers removing amniotic tissues and warming newborn cubs in sub-freezing temperatures, frequency of nursing, cubs establishing nipple order, yearlings suckling, the ingestion of snow and icicles, the ingestion of foot pads, urination and defecation in latrine areas, toilet-licking, eye opening, reciprocal tongue-licking, play, rapid eye movement (REM) sleep and possible dreaming, and reactions to wildlife intruders. …”
Get full text

Heart Rate Variability Monitoring during Sleep Based on Capacitively Coupled Textile Electrodes on a Bed by Hong Ji Lee, Su Hwan Hwang, Hee Nam Yoon, Won Kyu Lee, Kwang Suk Park

“…We also showed the potential of our developed system for rapid eye movement (REM) sleep and wake detection as well as for recording of abnormal states.…”
Get full text

EEG Findings in Infants With Neonatal Abstinence Syndrome Presenting With Clinical Seizures by Murali Reddy Palla, Gulam Khan, Zahra M. Haghighat, Henrietta Bada

“…VEEG showed disturbed non-rapid eye movement (REM) sleep with frequent arousal, jittery movements, or sleep myoclonus.Conclusion: Clinical seizure-like activity correlates poorly with epileptic seizures in infants with NAS. …”
Get full text

Cerebrospinal Fluid Hypocretin and Nightmares in Dementia Syndromes by Lynn Marie Trotti, Donald L. Bliwise, Glenda L. Keating, David B. Rye, William T. Hu

“…Background/Aims: Hypocretin promotes wakefulness and modulates REM sleep. Alterations in the hypocretin system are increasingly implicated in dementia. …”
Get full text

Sleep Disturbances as a Risk Factor for Stroke by Dae Lim Koo, Hyunwoo Nam, Robert J. Thomas, Chang-Ho Yun

“…Abrupt irregular swings in sympathovagal balance during REM sleep act as phasic loads on the resting cardiovascular system. …”
Get full text

Slow wave synchronization and sleep state transitions by Dan Guo, Robert J. Thomas, Yanhui Liu, Steven A. Shea, Jun Lu, Chung-Kang Peng

“…The current sleep classification schema is based on electroencephalography and provides common criteria for clinicians and researchers to describe stages of non-rapid eye movement (NREM) sleep as well as rapid eye movement (REM) sleep. These sleep stage classifications have been based on convenient heuristic criteria, with little consideration of the accompanying normal physiological changes across those same sleep stages. …”
Get full text

Computationally efficient permutation-based confidence interval estimation for tail-area FDR by Joshua eMillstein, Dmitri eVolfson

“…An application of this approach to relate sleep patterns to gene expression patterns in mouse hypothalamus yielded a set of 11 transcripts associated with 24 hour REM sleep (FDR = .15 (.08, .26)). Two of the corresponding genes, Sfrp1 and Sfrp4, are involved in wnt signaling and several others, Irf7, Ifit1, Iigp2, and Ifih1, have links to interferon signaling. …”
Get full text

Sleep-disordered breathing in cystic fibrosis pediatric subjects by Magali Santos Lumertz, Leonardo Araujo Pinto

“…Additionally, chronic airway colonization by Pseudomonas aeruginosa was associated with mean EtpCO2 in non-REM sleep (p=0.024). Discussion: SDB was frequently observed in this sample of children with CF. …”
Get full text

The role of sleep in neuromuscular disorders by Corrado I. Angelini, Carl Ansevin, Gabriele Siciliano

“…Other types of sleep dysfunction such as insomnia, a reduction in rapid eye movement (REM) sleep, loss of normal REM, or sleep-disordered breathing are found in other disorders including myasthenia, ataxias, spastic paraparesis, Charcot–Marie–Tooth disease, and neurogenic disorders, including polyneuropathies, and need appropriate treatment. …”
Get full text

Sleep does not influence schema-facilitated motor memory consolidation by Serena Reverberi, Nina Dolfen, Anke Van Roy, Genevieve Albouy, Bradley R. King

“…Furthermore, in Experiment 1, we found no correlation between sleep features (non-REM sleep duration, spindle and slow wave activity) and post-sleep behavioral performance. …”
Get full text

Orexin/Hypocretin and MCH Neurons: Cognitive and Motor Roles Beyond Arousal by Cristina Concetti, Denis Burdakov

“…Optogenetic manipulations of orexin and MCH neurons during sleep indicate that they promote awakening and REM sleep, respectively. However, recordings from orexin and MCH neurons in awake, moving animals suggest that they also act outside sleep/wake switching. …”
Get full text

A role for <it>cryptochromes</it> in sleep regulation by Sancar Aziz, Kilduff Thomas S, Selby Chris P, Terao Akira, O'Hara Bruce F, Wisor Jonathan P, Edgar Dale M, Franken Paul

“…</p> <p>Results</p> <p>Under all three conditions, <it>cry1,2</it>^-/-mice exhibit the hallmarks of high non-REM sleep (NREMS) drive (i.e., increases in NREMS time, NREMS consolidation, and EEG delta power during NREMS). …”
Get full text

Subjective sleep quality, unstimulated sexual arousal, and sexual frequency by Rui Costa, David Costa, José Pestana

“…Introduction: REM sleep deprivation increases unstimulated erections in rats, and total sleep deprivation increases erections during audiovisual sexual stimulation in men, but the effects of sleep problems on human unstimulated sexual arousal are unknown. …”
Get full text

Beyond factor analysis: Multidimensionality and the Parkinson's Disease Sleep Scale-Revised. by Maria E Pushpanathan, Andrea M Loftus, Natalie Gasson, Meghan G Thomas, Caitlin F Timms, Michelle Olaithe, Romola S Bucks

“…Using PDSS-R data, we compared three models: a unidimensional model; a 3-factor model consisting of sub-factors measuring insomnia, motor symptoms and obstructive sleep apnoea (OSA) and REM sleep behaviour disorder (RBD) symptoms; and, a confirmatory bifactor model with both a general factor and the same three sub-factors. …”
Get full text

Disorders of Arousal in adults: new diagnostic tools for clinical practice by Giuseppe Loddo, Régis Lopez, Rosalia Cilea, Yves Dauvilliers, Federica Provini

“…Furthermore, adult DOA need to be differentiated from other sleep disorders such as Sleep-related Hypermotor Epilepsy or REM Sleep Behavior Disorder. Although many aspects of DOA have been clarified in the last two decades there is still a lack of objective and quantitative diagnostic criteria for DOA. …”
Get full text

Could exercise hormone irisin be a therapeutic agent against Parkinson’s and other neurodegenerative diseases? by Konstantinos I. Avgerinos, Junli Liu, Maria Dalamaga

“…Clinical features of PD include motor symptoms such as bradykinesia, rigidity, tremors, postural instability, and gait impairment, and non-motor symptoms such as constipation, orthostatic hypotension, REM sleep disorder, depression and dementia. Currently, there is no disease-modifying therapy for PD. …”
Get full text

Mutual interaction between visual homeostatic plasticity and sleep in adult humans by Danilo Menicucci, Claudia Lunghi, Andrea Zaccaro, Maria Concetta Morrone, Angelo Gemignani

“…Here, we demonstrate that non-REM sleep stabilizes homeostatic plasticity of ocular dominance induced in adult humans by short-term monocular deprivation: the counterintuitive and otherwise transient boost of the deprived eye was preserved at the morning awakening (&gt;6 hr after deprivation). …”
Get full text

Transient Destabilization of Declarative Memory—Opposing Impact of Physical Exercise or Rest after Encoding in Typically Developing Children and Children with Attention Deficit Hyp... by Manuel Munz, Lioba Baving, Alexander Prehn-Kristensen

“…Rapid eye movement (REM) sleep latency was prolonged after exercise in both groups. …”
Get full text