The Effect of DREADD Activation of Leptin Receptor Positive Neurons in the Nucleus of the Solitary Tract on Sleep Disordered Breathing by Mateus R. Amorim, Olga Dergacheva, Thomaz Fleury-Curado, Huy Pho, Carla Freire, David Mendelowitz, Luiz G. S. Branco, Vsevolod Y. Polotsky

“…J60 was a potent activator of LEPR^b positive NTS neurons, but did not stimulate breathing or upper airway muscles during NREM and REM sleep. We conclude that, in DIO mice, the stimulating effects of leptin on breathing during sleep are independent of LEPR^b signaling in the NTS.…”
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Cardiac Sympathetic Activity differentiates Idiopathic and Symptomatic Rapid Eye Movement Sleep Behaviour Disorder by Lucie Barateau, Isabelle Jaussent, Régis Lopez, Elisa Evangelista, Sofiene Chenini, Meriem Benkiran, Denis Mariano-Goulart, Yves Dauvilliers

“…Patients with iRBD were older, had an older RBD onset age and higher REM sleep phasic and tonic muscular activities than NT1-RBD. …”
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Quantitative analysis of wrist electrodermal activity during sleep by Sano, Akane, Picard, Rosalind W., Stickgold, Robert

“…We found that more than 80% of the EDA peaks occurred in non-REM sleep, specifically during slow-wave sleep (SWS) and non-REM stage 2 sleep (NREM2). …”
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Neurophysiological features of STN LFP underlying sleep fragmentation in Parkinson’s disease by Zhang, G, Yu, H, Chen, Y, Gong, C, Hao, H, Guo, Y, Xu, S, Zhang, Y, Yuan, X, Yin, G, Zhang, J, Tan, H, Li, L

“…The STN LFP features that characterised different sleep stages, correlated with arousal and sleep fragmentation index, and preceded stage transitions during N2 and REM sleep were analysed. Results: Both beta and low gamma oscillations in non-rapid eye movement (NREM) sleep increased with the severity of sleep disturbance (arousal index (ArI)-betaNREM: r=0.9, p=0.0001, sleep fragmentation index (SFI)-betaNREM: r=0.6, p=0.0301; SFI-gammaNREM: r=0.6, p=0.0324). …”

Homeostatic regulation of sleep in the white-crowned sparrow (Zonotrichia leucophrys gambelii) by Jones, S, Vyazovskiy, V, Cirelli, C, Tononi, G, Benca, R

“…Four vigilance states were reliably distinguished based on behavior, visual inspection of the EEG, and spectral EEG analysis: Wakefulness (W), Drowsiness (D), slow wave sleep (SWS) and rapid-eye movement (REM) sleep. During baseline, SWA during D, SWS, and NREM sleep (defined as D and SWS combined) was highest at the beginning of the major sleep period and declined thereafter. …”

Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease by Huebecker, M, Moloney, EB, van der Spoel, AC, Priestman, DA, Isacson, O, Hallett, PJ, Platt, FM

“…GM1a) in substantia nigra, CSF and serum in ageing, PD, and REM sleep behaviour disorder, which is a strong predictor of PD.…”

Insomnia and depression as risk factors for dementia. A scoping review by I. Duran-Cristobal, A. Noguero-Alegre, A. M. Matas-Ochoa, S. Rubio-Corgo, F. J. Gomez-Beteta

“… Introduction One of the most important functions of sleep may be the promotion of brain development. The non-REM and REM sleep sequences show the succession of cerebral processing phenomena that underlie memory consolidation. …”
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Abnormalities in the Polysomnographic, Adenosine and Metabolic Response to Sleep Deprivation in an Animal Model of Hyperammonemia by Selena Marini, Selena Marini, Olena Santangeli, Pirjo Saarelainen, Benita Middleton, Namrata Chowdhury, Debra J. Skene, Rodolfo Costa, Tarja Porkka-Heiskanen, Sara Montagnese

“…In both groups the recovery period was characterized by a significant decrease in wakefulness/increase in NREM and REM sleep. However, while control animals exhibited a gradual compensatory effect, hyperammonemic animals showed a significantly shorter recovery phase. …”
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Hypocretinergic and cholinergic contributions to sleep-wake disturbances in a mouse model of traumatic brain injury by Hannah E. Thomasy, Heidi Y. Febinger, Kristyn M. Ringgold, Carmelina Gemma, Mark R. Opp

“…There were no differences between groups in REM sleep time, nor were there differences between groups in sleep during the light period. …”
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All-night spectral and microstate EEG analysis in patients with recurrent isolated sleep paralysis by Filip Černý, Filip Černý, Václava Piorecká, Václava Piorecká, Monika Kliková, Jana Kopřivová, Jana Kopřivová, Jitka Bušková, Jitka Bušková, Marek Piorecký, Marek Piorecký

“…This study aimed to investigate whether sleep is disturbed even without the occurrence of a RISP episode and in a stage different than conventional REM sleep. 17 RISP patients and 17 control subjects underwent two consecutive full-night video-polysomnography recordings. …”
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A Systematic Review, Meta-Analysis and Meta-Regression on the Effects of Carbohydrates on Sleep by Angelos Vlahoyiannis, Christoforos D. Giannaki, Giorgos K. Sakkas, George Aphamis, Eleni Andreou

“…Carbohydrate quantity was shown to affect sleep architecture, and especially N3 and REM sleep stages. Alterations in both quantity and quality of carbohydrate intake showed a significant effect on sleep initiation. …”
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Difference in Psychological Distress between Patients with Periodic Limb Movement Disorder and Restless Legs Syndrome by Jung-Ick Byun, Jeong-Su Kim, Yu Yong Shin, Kyoung Jin Hwang, Yu Jin Jung, Won Chul Shin

“…Compared with the patients with RLS, the patients with PLMD exhibited a reduced total sleep time (276.6 ± 41.3 vs. 322.4 ± 42.9, p = 0.04) and a decreased proportion of REM sleep (12.5 ± 6.6 vs. 17.8 ± 7.8, p = 0.009). The patients with RLS exhibited higher SCL-90-R T-scores on the somatization (post hoc p < 0.001), obsessive-compulsive (post hoc p < 0.001), interpersonal sensitivity (post hoc p = 0.003), anxiety (post hoc p = 0.005), and psychoticism (post hoc p = 0.004) domains than the controls. …”
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Effects of knockout of MT3R/Nqo2 gene on sleep/wake behaviors and EEG power spectrum in rats by LI Xin, LI Shiyin, LUO Fenlan, REN Shuancheng, REN Shuancheng

“…Results After MT3R/Nqo2 knockout, the knockout rats showed decreased arousal time and increased NREM and REM sleep time during the first 3 h (ZT12~15) after the onset of the dark phase (active phase) when compared with the control rats (P < 0.05).In addition, a significant increase in the number of sleep/wake transitions, a reduction in the duration of wakefulness, and appearance of wake fragmentation were also observed after MT3R/Nqo2 knockout during this period (P < 0.05).EEG power spectrum analysis revealed that NREM sleep θ band energy was elevated in the knockout rats than the control rats (P < 0.05). …”
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Sleep Promotes, and Sleep Loss Inhibits, Selective Changes in Firing Rate, Response Properties and Functional Connectivity of Primary Visual Cortex Neurons by Brittany C. Clawson, Jaclyn Durkin, Aneesha K. Suresh, Emily J. Pickup, Christopher G. Broussard, Sara J. Aton

“…These population-specific changes in firing rate are blocked by sleep disruption either early or late in the day, and appear to be brought about by increases in neuronal firing rates across bouts of rapid eye movement (REM) sleep. Following a patterned visual experience that induces orientation-selective response potentiation (OSRP) in V1, sparsely firing and weakly population-coupled neurons show the highest level of sleep-dependent response plasticity. …”
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Event-related potentials as a measure of sleep disturbance: A tutorial review by Kenneth Campbell

“…The P2, N350 and N550 processes are thus conceived as sleep protective mechanisms, activated sequentially as the risk for disturbance increases. During REM sleep, the transient detector system again becomes somewhat activated, the amplitude of N1 reaching from 15 to 40% of its waking level. …”
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Diagnostic value of skin RT-QuIC in Parkinson’s disease: a two-laboratory study by Anastasia Kuzkina, Connor Bargar, Daniela Schmitt, Jonas Rößle, Wen Wang, Anna-Lena Schubert, Curtis Tatsuoka, Steven A. Gunzler, Wen-Quan Zou, Jens Volkmann, Claudia Sommer, Kathrin Doppler, Shu G. Chen

“…Higher α-synuclein seeding activity in RT-QuIC was shown in patients with longer disease duration and more advanced disease stage and correlated with the presence of REM sleep behavior disorder, cognitive impairment, and constipation. …”
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A Review of Scales to Evaluate Sleep Disturbances in Movement Disorders by Mónica M. Kurtis, Roberta Balestrino, Carmen Rodriguez-Blazquez, Maria João Forjaz, Pablo Martinez-Martin

“…Patients with movement disorders have a high prevalence of sleep disturbances that can be classified as (1) nocturnal sleep symptoms, such as insomnia, nocturia, restless legs syndrome (RLS), periodic limb movements (PLM), obstructive sleep apnea (OSA), and REM sleep behavior disorder; and (2) diurnal problems that include excessive daytime sleepiness (EDS) and sleep attacks. …”
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Sleep disorders in Parkinson’s disease, an early and multiple problem by Pauline Dodet, Marion Houot, Smaranda Leu-Semenescu, Jean-Christophe Corvol, Stéphane Lehéricy, Graziella Mangone, Marie Vidailhet, Emmanuel Roze, Isabelle Arnulf

“…Abstract In Parkinson’s disease (PD), it remains unclear whether sleep disorders including insomnia, REM sleep behavior disorder (RBD), excessive daytime sleepiness (EDS), restless legs syndrome (RLS) and sleep-disordered breathing (SDB), are isolated or combined, interact with each other and are associated with clinical factors. …”
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Alpha reactivity to first names differs in subjects with high and low dream recall frequency by Perrine Marie RUBY, Camille eBlochet, Jean-Baptiste eEichenlaub, Olivier eBertrand, Dominique eMorlet, Aurélie eBidet-Caulet

“…First names induced a more sustained decrease in alpha activity in HR than in LR at Pz (1000-1200ms) during wakefulness, but no group difference was found in REM sleep. The current dominant hypothesis proposes that alpha rhythms would be involved in the active inhibition of the brain regions not involved in the ongoing brain operation. …”
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Rhythmicity in heart rate and its surges usher a special period of sleep, a likely home for PGO waves by Andreas A. Ioannides, Gregoris A. Orphanides, Lichan Liu

“…The hypnogram is also difficult to define during normal sleep, particularly at the start of sleep and the periods that precede and follow rapid eye movement (REM) sleep. Here, we use objective quantitative criteria that group together periods that cannot be assigned to a conventional sleep stage into what we call REM0 periods, with the presence of a HRS one of their defining properties. …”
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