Dysregulation of Respiratory Center Drive (P0.1) and Muscle Strength in Patients With Early Stage Idiopathic Parkinson's Disease by Wei Zhang, Lei Zhang, Ning Zhou, Enqiang Huang, Qi Li, Tongyu Wang, Chunchao Ma, Bin Li, Chen Li, Yanfen Du, Jing Zhang, Xiaofeng Lei, Alysia Ross, Hongyu Sun, Xiaodong Zhu

“…All IPD patients were also subjected to a series of neuropsychological tests, including Non-Motor Symptoms Questionnaire (NMSQ), REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ), Beck Depression Inventory (BDI) and Mini Mental State Examination (MMSE).Results: IPD patients and healthy individuals have similar forced vital capacity (FVC), forced expiratory volume in 1s (FEV1), forced expiratory volume in 1s/forced vital capacity (FEV1/FVC), peak expiratory flow (PEF), and carbon monoxide diffusion capacity (DLCOcSB). …”
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Sleep structure and related clinical characteristics in drug-naïve Parkinson's disease with subjectively different sleep quality by Yinyin Jiang, Yaning Chen, Dongfeng Li, Sha Zhu, Ruxin Gu, Yaxi Wang, Jun Zhu, Xu Jiang, Bo Shen, Yang Pan, Jun Yan, Li Zhang, Li Zhang

“…For poor sleepers, rapid eye movement (REM) sleep percentage was negatively related to the Hoehn-Yahr (H-Y) stage, WASO increased with UPDRS-III, periodic limb movement index (PLMI) increased with the NMS score, and N2 sleep percentage was negatively related to the score of life quality.ConclusionNight awakening is the main manifestation of decreased sleep quality in drug-naive PD patients. …”
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AI-Driven sleep staging from actigraphy and heart rate. by Tzu-An Song, Samadrita Roy Chowdhury, Masoud Malekzadeh, Stephanie Harrison, Terri Blackwell Hoge, Susan Redline, Katie L Stone, Richa Saxena, Shaun M Purcell, Joyita Dutta

“…In this paper, we present an artificial intelligence (AI) technique termed sequence-to-sequence LSTM for automated mobile sleep staging (SLAMSS), which can perform three-class (wake, NREM, REM) and four-class (wake, light, deep, REM) sleep classification from activity (i.e., wrist-accelerometry-derived locomotion) and two coarse heart rate measures-both of which can be reliably obtained from a consumer-grade wrist-wearable device. …”
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Trastornos del sueño no respiratorios en relación con ictus by J.M. Marquez-Romero, M. Morales-Ramírez, A. Arauz

“…This also happens with other sleep disorders occurring as the result of a stroke (insomnia, narcolepsy, restless legs syndrome, periodic limb movement disorder and REM sleep behavior disorder), which are nevertheless potentially treatable. …”
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Sex-specific associations with cerebrospinal fluid biomarkers in dementia with Lewy bodies by M. van de Beek, R. Babapour Mofrad, I. van Steenoven, H. Vanderstichele, P. Scheltens, C. E. Teunissen, A. W. Lemstra, W. M. van der Flier

“…In addition, we analyzed sex differences in core clinical features (i.e., visual hallucinations, parkinsonism, cognitive fluctuations, and REM sleep behavior disorder (RBD) and cognitive test scores using age- and education-adjusted GLM. …”
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Associations of Baseline Sleep Microarchitecture with Cognitive Function After 8 Years in Middle-Aged and Older Men from a Community-Based Cohort Study by Parker JL, Vakulin A, Melaku YA, Wittert GA, Martin SA, D'Rozario AL, Catcheside PG, Lechat B, Toson B, Teare AJ, Appleton SL, Adams RJ

“…In adjusted analyses, NREM and REM sleep EEG spectral power was not associated with TMT-A, TMT-B, or SMMSE performance (all p> 0.05). …”
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Cannabinol (CBN; 30 and 300 mg) effects on sleep and next-day function in insomnia disorder (‘CUPID’ study): protocol for a randomised, double-blind, placebo-controlled, cross-over... by Ronald R Grunstein, Bandana Saini, Christopher J Gordon, Anastasia Suraev, Angela L D'Rozario, Chris Irwin, Camilla M Hoyos, Iain McGregor, Brendon Yee, Isobel Lavender, Danielle McCartney, Nathaniel Marshall

“…Tertiary outcomes include changes to sleep spindles during NREM sleep, arousal indices, absolute spectral power during REM sleep and subjective sleep quality. Safety-related and exploratory outcomes include changes to next-day simulated driving performance, subjective mood and drug effects, postural sway, alertness and reaction time, overnight memory consolidation, pre and post-sleep subjective and objective sleepiness; and plasma, urinary, and salivary cannabinoid concentrations. …”
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Dream incorporation of three different bodily stimuli by Emma Peters, Xinlin Wang, Martin Dresler, Daniel Erlacher

“…The three stimulation methods consisted of electrical forearm muscle stimulation (EMS), galvanic vestibular stimulation (GVS), and haptic vibration stimulation (HS). During REM sleep, one of the three stimuli was presented or a sham condition was applied in a counterbalanced order. …”
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Leptin Receptor Blockade Attenuates Hypertension, but Does Not Affect Ventilatory Response to Hypoxia in a Model of Polygenic Obesity by Lenise J. Kim, Mi-Kyung Shin, Huy Pho, Laszlo Otvos, Laszlo Otvos, Laszlo Otvos, Sergio Tufik, Monica L. Andersen, Luu V. Pham, Vsevolod Y. Polotsky

“…Ventilation, apnea index, and oxygen desaturation during NREM and REM sleep did not change with leptin receptor blockade.ConclusionSystemic leptin receptor blockade attenuates hypertension in NZO mice, but does not exacerbate obesity and SDB. …”
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Effects of acute bouts of evening resistance or endurance exercises on sleep EEG and salivary cortisol by Joy Perrier, Joy Perrier, Antoine Langeard, Chandrou Koumar Ouma, Bruno Sesboüé, Bruno Sesboüé, Patrice Clochon, Jean-Noël Prevost, Françoise Bertran, Damien Davenne, Nicolas Bessot

“…The endurance exercise led to greater beta power during N2 sleep stage, greater alpha power during REM sleep, and higher cortisol levels compared to the control condition (trend), and compared to the resistance exercise condition (significant). …”
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Non-breathing-related sleep disorders following stroke by J.M. Marquez-Romero, M. Morales-Ramírez, A. Arauz

“…This also happens with other sleep disorders occurring as the result of a stroke (insomnia, narcolepsy, restless legs syndrome, periodic limb movement disorder and REM sleep behaviour disorder), which are nevertheless potentially treatable. …”
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Investigating the endoplasmic reticulum unfolded protein response and its role in sleep by Chakrabarty, A

“…Sleep deprivation is also associated with an increase in cortical slow wave activity (SWA) during subsequent non-REM sleep, reflecting increased sleep intensity. However, the effect of sleep deprivation upon the UPR has not been thoroughly characterised across different regions or cell types within cortex. …”

The treatment efficacy of pharmacotherapies for rapid eye movement sleep behavior disorder with polysomnography evaluation: A systematic review and meta-analysis by Zhiqiang Que, Cuifeng Zheng, Zhenhua Zhao, Yanhong Weng, Zhibao Zhu, Yuqi Zeng, Qinyong Ye, Fabin Lin, Guoen Cai

“…Clonazepam and melatonin are commonly used as first-line medications for the treatment of rapid eye movement (REM) sleep behavior disorder (RBD), with other medications used in the clinic including pramipexole, ramelteon, and rotigotine. …”
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Baseline characteristics of the North American prodromal Synucleinopathy cohort by Jonathan E. Elliott, Miranda M. Lim, Allison T. Keil, Ronald B. Postuma, Amelie Pelletier, Jean‐François Gagnon, Erik K. St. Louis, Leah K. Forsberg, Julie A. Fields, Daniel E. Huddleston, Donald L. Bliwise, Alon Y. Avidan, Michael J. Howell, Carlos H. Schenck, Jennifer McLeland, Susan R. Criswell, Aleksandar Videnovic, Emmanuel H. During, Mitchell G. Miglis, David R. Shprecher, Joyce K. Lee‐Iannotti, Bradley F. Boeve, Yo‐El S. Ju, the North American Prodromal Synucleinopathy (NAPS) Consortium

“…Abstract Objective Rapid eye movement (REM) sleep behavior disorder (RBD) is widely considered a prodromal synucleinopathy, as most with RBD develop overt synucleinopathy within ~10 years. …”
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Dysfunctional hippocampal-prefrontal network underlies a multidimensional neuropsychiatric phenotype following early-life seizure by Rafael Naime Ruggiero, Danilo Benette Marques, Matheus Teixeira Rossignoli, Jana Batista De Ross, Tamiris Prizon, Ikaro Jesus Silva Beraldo, Lezio Soares Bueno-Junior, Ludmyla Kandratavicius, Jose Eduardo Peixoto-Santos, Cleiton Lopes-Aguiar, Joao Pereira Leite

“…Furthermore, ELS rats displayed impaired HPC-PFC theta-gamma coordination and an abnormal brain state during active behavior resembling rapid eye movement (REM) sleep oscillatory dynamics. Our results point to impaired HPC-PFC functional connectivity as a possible pathophysiological mechanism by which ELS can cause cognitive deficits and psychiatric-like manifestations even without neuronal loss, bearing translational implications for understanding the spectrum of multidimensional developmental disorders linked to early-life seizures.…”
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Dreaming Characteristics in Non-Rapid Eye Movement Parasomnia and Idiopathic Rapid Eye Movement Sleep Behaviour Disorder: Similarities and Differences by See QR, Raheel K, Duncan I, Biabani N, Di Giulio I, Romigi A, Kumari V, O'Regan D, Cairney S, Urso D, Chaudhuri KR, Gnoni V, Drakatos P, Rosenzweig I

“…Here, using SGA and other dream content analyses, we set to investigate structural and thematic differences in morning dream recalls of patients diagnosed with Non-Rapid Eye Movement Parasomnia (NREMP) and Idiopathic REM Sleep Behavior Disorder (iRBD).Methods: A retrospective cross-sectional study of morning dream recalls of iRBD and NREMP patients was undertaken. …”
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Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients by Luca Baldelli, Sebastian Schade, Silvia Jesús, Sebastian R. Schreglmann, Luisa Sambati, Pilar Gómez-Garre, Claire Halsband, Giovanna Calandra-Buonaura, Astrid Daniela Adarmes-Gómez, Friederike Sixel-Döring, Corrado Zenesini, Chiara Pirazzini, Paolo Garagnani, Maria Giulia Bacalini, Kailash P. Bhatia, Pietro Cortelli, Brit Mollenhauer, Claudio Franceschi, PROPAG-AGEING consortium, Pablo Mir, Claudia Trenkwalder, Federica Provini

“…No differences were found for olfaction and overall cognition; German-siblings performed worse than CTRs in visuospatial-executive and language tasks. 3/147 siblings had video-polysomnography-confirmed REM sleep behavior disorder (RBD), none was positive on the RBD Screening Questionnaire. 173/300 siblings had <1% probability of having prodromal PD; 100 between 1 and 10%, 26 siblings between 10 and 80%, one fulfilled the criteria for prodromal PD. …”
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Sleep Is Compromised in −12° Head Down Tilt Position by Alessa L. Boschert, David Elmenhorst, David Elmenhorst, Peter Gauger, Zhili Li, Maria T. Garcia-Gutierrez, Darius Gerlach, Bernd Johannes, Jochen Zange, Andreas Bauer, Andreas Bauer, Jörn Rittweger, Jörn Rittweger

“…Endpoints were sleep efficiency, sleep onset latency, number of sleep state changes and arousals, percentages of N3, REM, light sleep stages and subjective sleep parameters. N3 and REM sleep reduced by 25.6 and 19.1 min, respectively (P = 0.002, g = -0.898; P = 0.035, g = -0.634) during −12° HDT. …”
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Seizure Susceptibility and Sleep Disturbance as Biomarkers of Epileptogenesis after Experimental TBI by Pedro Andrade, Leonardo Lara-Valderrábano, Eppu Manninen, Robert Ciszek, Jesse Tapiala, Xavier Ekolle Ndode-Ekane, Asla Pitkänen

“…Sleep analysis revealed that the number of transitions to N3 or rapid eye movement (REM) sleep, along with the total number of transitions, was increased in the TBI group during the lights-on period (all <i>p</i> < 0.05). …”
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Characteristics of Attention Deficit and Hyperactivity Disorder in Children with Sleep-disordered Breathing by WU Yunxiao, WAN Zhen, KONG Fanying, XU Zhifei

“…Polysomnographic parameters〔total sleep time, sleep efficiency, non-rapid eye movement (NREM) sleep stage 1 (N1%) , stage 2 (N2%) , and stage 3 (N3%) and REM sleep percentage of total sleep time (R%) , OAHI, arousal index (ArI) , oxygen desaturation index (ODI) , average oxygen saturation (SpO2) and SpO2 nadir〕 were compared by the severity of OSA. …”
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