Decreasing mitochondrial RNA polymerase activity reverses biased inheritance of hypersuppressive mtDNA by Corbi, Daniel, Amon, Angelika

“…This suppression required <jats:italic>PET127</jats:italic> binding to the mitochondrial RNA polymerase <jats:italic>RPO41</jats:italic> but not <jats:italic>PET127</jats:italic> exonuclease activity. …”
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Cisplatin-induced nucleosome and RNA polymerase II modification mediate cellular response to the drug by Wang, Dong, 1975-

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A 'resource allocator' for transcription based on a highly fragmented T7 RNA polymerase by Segall-Shapiro, Thomas Hale, Meyer, Adam J., Ellington, Andrew D., Sontag, Eduardo D., Voigt, Christopher A.

“…Synthetic genetic systems share resources with the host, including machinery for transcription and translation. Phage RNA polymerases (RNAPs) decouple transcription from the host and generate high expression. …”
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Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies by Keown, J, Zhu, Z, Carrique, L, Fan, H, Walker, A, Serna Martin, I, Pardon, E, Steyaert, J, Fodor, E, Grimes, J

“…Central to the replication cycle of influenza viruses is the viral RNA-dependent RNA polymerase which transcribes and replicates the viral RNA genome. …”

Connections between RNA Polymerase II transcriptional regulation, nucleosome arrangement and DNA damage by Foxwell, J

Subjects:

Role of the RNA/DNA kinase Grc3 in transcription termination by RNA polymerase I. by Braglia, P, Heindl, K, Schleiffer, A, Martinez, J, Proudfoot, N

“…Transcription termination by RNA polymerase I in Saccharomyces cerevisiae is mediated by a 'torpedo' mechanism: co-transcriptional RNA cleavage by Rnt1 at the ribosomal DNA 3'-region generates a 5'-end that is recognized by the 5'-3' exonuclease Rat1; this degrades the downstream transcript and eventually causes termination. …”

Messenger RNAs that are not synthesized by RNA polymerase II can be 3' end cleaved and polyadenylated. by Fodor, E, Mikulasova, A, Mingay, L, Poon, L, Brownlee, G

“…The poly(A) tail of influenza virus mRNAs is synthesized by the viral RNA polymerase by reiterative copying of a U5-7 sequence near the 5' end of the viral RNA (vRNA) template. …”

The structural basis for RNA specificity and Ca2+ inhibition of an RNA-dependent RNA polymerase. by Salgado, P, Makeyev, E, Butcher, S, Bamford, D, Stuart, D, Grimes, J

“…The RNA-dependent RNA polymerase of bacteriophage phi6 transcribes mRNA from the three segments of the dsRNA viral genome. …”

Transcriptional termination by RNA polymerase I requires the small subunit Rpa12p. by Prescott, E, Osheim, Y, Jones, H, Alen, C, Roan, J, Reeder, R, Beyer, A, Proudfoot, N

“…We identify Rpa12p of RNA polymerase I (Pol I) as a termination factor. Combined analyses using transcription run-on, electron microscopy-visualized chromatin spreading and RT-PCR have been applied to the rRNA-encoding genes of Saccharomyces cerevisiae. …”

Characterizing Influenza a RNA Polymerase - Promoter Interaction using Ensemble Fluorescence Spectroscopy by Tomescu, A, Robb, N, Hengrung, N, Fodor, E, Kapanidis, A

RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation by Martell, DJ, Merens, HE, Fiorini, C, Caulier, A, Ulirsch, JC, Ietswaart, R, Choquet, K, Graziadei, G, Brancaleoni, V, Cappellini, MD, Scott, C, Roberts, N, Proven, M, Roy, NB, Babbs, C, Higgs, DR, Sankaran, VG, Churchman, LS

“…The controlled release of promoter-proximal paused RNA polymerase II (Pol II) into productive elongation is a major step in gene regulation. …”

Association of the influenza virus RNA polymerase subunit PB2 with the host chaperonin CCT. by Fislová, T, Thomas, B, Graef, K, Fodor, E

“…The RNA polymerase of influenza A virus is a host range determinant and virulence factor. …”

The RNA polymerase of influenza a virus is stabilized by interaction with its viral RNA promoter. by Brownlee, G, Sharps, J

“…The RNA polymerase of the influenza virus is responsible for the transcription and replication of the segmented RNA viral genome during infection of host cells. …”

Differential effects of pre-mRNA splicing inhibitors on RNA polymerase II transcription by Tellier, M, Ansa, G, Murphy, S

“…The production of eukaryotic mRNA requires transcription by RNA polymerase (pol) II and co-transcriptional processing, including capping, splicing, and cleavage and polyadenylation (CPA). …”

BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II. by Cabart, P, Chew, H, Murphy, S

“…The tumor suppressor gene product BRCA1 is a component of the RNA polymerase II (pol II) holoenzyme that is involved, through binding to various regulatory proteins, in either activation or repression of transcription. …”

The PB2 subunit of the influenza A virus RNA polymerase is imported into the mitochondrial matrix by Long, J, Fodor, E

“…The PB2 subunit of the RNA polymerase complex of seasonal human influenza A viruses has been shown to localise to the mitochondria. …”

RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation. by Martell, DJ, Merens, HE, Caulier, A, Fiorini, C, Ulirsch, JC, Ietswaart, R, Choquet, K, Graziadei, G, Brancaleoni, V, Cappellini, MD, Scott, C, Roberts, N, Proven, M, Roy, NBA, Babbs, C, Higgs, DR, Sankaran, VG, Churchman, LS

“…Controlled release of promoter-proximal paused RNA polymerase II (RNA Pol II) is crucial for gene regulation. …”

Establishment of a fluorescent reporter of RNA-polymerase II activity to identify dormant cells by Freter, R, Falletta, P, Omrani, O, Herbert, K, Goding, C

“…Here, we develop a live cell ratiometric fluorescent Optical Stem Cell Activity Reporter (OSCAR) based on the observation that phosphorylation of RNA Polymerase II (RNApII), a hallmark of active mRNA transcription elongation, is largely absent in dormant stem cells from multiple lineages. …”

Horizontally acquired AT-rich genes in Escherichia coli cause toxicity by sequestering RNA polymerase by Lamberte, L, Baniulyte, G, Singh, S, Stringer, A, Bonocora, R, Stracy, M, Kapanidis, A, Wade, J, Grainger, D

“…Left unchecked, this causes titration of RNA polymerase and a global downshift in host gene expression. …”

Photobleaching reveals complex effects of inhibitors on transcribing RNA polymerase II in living cells. by Fromaget, M, Cook, P

“…RNA polymerase II transcribes most eukaryotic genes. Photobleaching studies have revealed that living Chinese hamster ovary cells expressing the catalytic subunit of the polymerase tagged with the green fluorescent protein contain a large rapidly exchanging pool of enzyme, plus a smaller engaged fraction; genetic complementation shows this tagged polymerase to be fully functional. …”