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221
Budding yeast RNA polymerases I and II employ parallel mechanisms of transcriptional termination.
Published 2008“…Both RNA polymerase I and II (Pol I and Pol II) in budding yeast employ a functionally homologous "torpedo-like" mechanism to promote transcriptional termination. …”
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222
Mass spectrometry reveals stable modules in holo and apo RNA polymerases I and III.
Published 2011“…RNA polymerases are essential enzymes which transcribe DNA into RNA. …”
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223
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Transcription reinitiation by recycling RNA polymerase that diffuses on DNA after releasing terminated RNA
Published 2020“…Our single-molecule fluorescence study unveils that RNA transcript release precedes RNA polymerase (RNAP) dissociation from the DNA template much more often than their concurrent dissociations in intrinsic termination of bacterial transcription. …”
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225
Regional specialization in human nuclei: visualization of discrete sites of transcription by RNA polymerase III.
Published 1999“…Mammalian nuclei contain three different RNA polymerases defined by their characteristic locations and drug sensitivities; polymerase I is found in nucleoli, and polymerases II and III in the nucleoplasm. …”
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226
The structural basis for RNA specificity and Ca2+ inhibition of an RNA-dependent RNA polymerase.
Published 2004“…The RNA-dependent RNA polymerase of bacteriophage phi6 transcribes mRNA from the three segments of the dsRNA viral genome. …”
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227
Structures of influenza A virus RNA polymerase offer insight into viral genome replication
Published 2019“…Influenza A viruses contain a segmented negative-sense RNA genome, which is transcribed and replicated by the viral-RNA-dependent RNA polymerase (FluPolA) composed of PB1, PB2 and PA subunits3,4,5. …”
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228
Numbers and organization of RNA polymerases, nascent transcripts, and transcription units in HeLa nuclei.
Published 1998“…Using HeLa cells, we have developed methods to determine 1) the number of RNA polymerases that are active at any moment, 2) the number of transcription sites, and 3) the number of polymerases associated with one transcription unit. …”
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229
Numbers and organization of RNA polymerases, nascent transcripts, and transcription units in HeLa nuclei
Published 1998“…Using HeLa cells, we have developed methods to determine 1) the number of RNA polymerases that are active at any moment, 2) the number of transcription sites, and 3) the number of polymerases associated with one transcription unit. …”
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230
Performance comparison between bootstrap and multiscale bootstrap for assessing phylogenetic tree for RNA polymerase
Published 2015“…The aim of this study was to compare the performance between the AU value and BP value for assessing phylogenetic tree of RNA polymerase. The results have shown that multiscale bootstrap analysis can detect high sampling errors but not in bootstrap analysis. …”
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231
Ubiquitin proteomics identifies RNA polymerase I as a target of the Smc5/6 complex
Published 2023-05-01“…In addition, our analysis suggests a connection between Nse1 and RNA polymerase I (RNA Pol I) ubiquitination. Specifically, Nse1 and the Smc5/6 complex promote ubiquitination of K408 and K410 in the clamp domain of Rpa190, a modification that induces its degradation in response to blocks in transcriptional elongation. …”
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232
Integrative analysis reveals histone demethylase LSD1 promotes RNA polymerase II pausing
Published 2022-10-01“…Here, we report that LSD1 promotes RNA polymerase II (RNAPII) pausing, a rate-limiting step in transcription regulation, in ESCs. …”
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233
Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase
Published 2023-01-01“…T7 RNA polymerase (RNAP) is widely used for synthesizing RNA molecules with synthetic modifications and unnatural base pairs (UBPs). …”
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234
A New Insight into MYC Action: Control of RNA Polymerase II Methylation and Transcription Termination
Published 2023-01-01Subjects: Get full text
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235
Characterizing single-molecule dynamics of viral RNA-dependent RNA polymerases with multiplexed magnetic tweezers
Published 2022-09-01“…Summary: Multiplexed single-molecule magnetic tweezers (MT) have recently been employed to probe the RNA synthesis dynamics of RNA-dependent RNA polymerases (RdRp). Here, we present a protocol for simultaneously probing the RNA synthesis dynamics of hundreds of single polymerases with MT. …”
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236
MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass
Published 2022-05-01Subjects: Get full text
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237
Virtual Screening and Molecular Docking Studies for Discovery of Potential RNA-Dependent RNA Polymerase Inhibitors
Published 2021-04-01“…Since SARS-CoV-2 is a positive-strand RNA virus, its replication requires the viral RNA-dependent RNA polymerase (RdRp) enzyme. In this study, we report the discovery of new potential RdRp enzyme inhibitors based on computer modeling and simulation methodologies. …”
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238
Target-dependent RNA polymerase as universal platform for gene expression control in response to intracellular molecules
Published 2023-11-01“…Here to address these issues, we present a Target-dependent RNA polymerase (TdRNAP) that can induce RNA transcription in response to the intracellular target specifically recognized by single antibody. …”
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239
Structural bases of norovirus RNA dependent RNA polymerase inhibition by novel suramin-related compounds.
Published 2014-01-01“…We previously identified Suramin (9) as a potent inhibitor of NV-RNA dependent RNA polymerase (NV-RdRp). Despite significant in vitro activities versus several pharmacological targets, Suramin clinical use is hampered by pharmacokinetics/toxicity problems. …”
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240
Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis
Published 2021-06-01Subjects: Get full text
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