How Single-Molecule Localization Microscopy Expanded Our Mechanistic Understanding of RNA Polymerase II Transcription by Peter Hoboth, Ondřej Šebesta, Pavel Hozák

“…Although the spatial organization and dynamics of RNA polymerase II (RNAPII) transcription machinery have fundamental functional consequences for gene expression, its detailed studies have been abrogated by the limits of classical light microscopy for a long time. …”
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Conserved Curvature of RNA Polymerase I Core Promoter Beyond rRNA Genes: The Case of the Tritryps by Pablo Smircich, María Ana Duhagon, Beatriz Garat

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Genome‐wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling by Astrid Eijkelenboom, Michal Mokry, Elzo de Wit, Lydia M Smits, Paulien E Polderman, Miranda H van Triest, Ruben van Boxtel, Almut Schulze, Wouter de Laat, Edwin Cuppen, Boudewijn M T Burgering

“…Correlative analysis of FOXO3 and RNA polymerase II ChIP‐seq profiles demonstrates FOXO3 to act as a transcriptional activator. …”
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Reporter-ChIP-nexus reveals strong contribution of the Drosophila initiator sequence to RNA polymerase pausing by Wanqing Shao, Sergio G-M Alcantara, Julia Zeitlinger

Subjects: “…RNA polymerase II pausing…”
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Current understanding of nucleoside analogs inhibiting the SARS-CoV-2 RNA-dependent RNA polymerase by Tiantian Xu, Lu Zhang

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RNA polymerase II stalling at pre-mRNA splice sites is enforced by ubiquitination of the catalytic subunit by Laura Milligan, Camille Sayou, Alex Tuck, Tatsiana Auchynnikava, Jane EA Reid, Ross Alexander, Flavia de Lima Alves, Robin Allshire, Christos Spanos, Juri Rappsilber, Jean D Beggs, Grzegorz Kudla, David Tollervey

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Bridged filaments of histone-like nucleoid structuring protein pause RNA polymerase and aid termination in bacteria by Matthew V Kotlajich, Daniel R Hron, Beth A Boudreau, Zhiqiang Sun, Yuri L Lyubchenko, Robert Landick

“…In this study, we report that bridged H-NS filaments strongly increase pausing by E. coli RNA polymerase at a subset of pause sites with high potential for backtracking. …”
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Targeting RNA Polymerase I Transcription Activity in Osteosarcoma: Pre-Clinical Molecular and Animal Treatment Studies by Chang-Won Kang, Anneke C. Blackburn, Amos Hong Pheng Loh, Kuick Chick Hong, Jian Yuan Goh, Nadine Hein, Denis Drygin, Chris R. Parish, Ross D. Hannan, Katherine M. Hannan, Lucy A. Coupland

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In silico screening of drug inhibitors of SARS-CoV-2 RNA-dependent RNA polymerase target by Thanh Tung Bui, Bao Kim Nguyen, Minh Ngoc Le, The Toan Nguyen, The Hai Pham

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Characterization of RNA polymerase II trigger loop mutations using molecular dynamics simulations and machine learning. by Bercem Dutagaci, Bingbing Duan, Chenxi Qiu, Craig D Kaplan, Michael Feig

“…Catalysis and fidelity of multisubunit RNA polymerases rely on a highly conserved active site domain called the trigger loop (TL), which achieves roles in transcription through conformational changes and interaction with NTP substrates. …”
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Hmo1 Promotes Efficient Transcription Elongation by RNA Polymerase I in <i>Saccharomyces cerevisiae</i> by Abigail K. Huffines, David A. Schneider

Subjects: “…RNA polymerase I…”
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What is the role of motif D in the nucleotide incorporation catalyzed by the RNA-dependent RNA polymerase from poliovirus? by Hujun Shen, Hui Sun, Guohui Li

“…Poliovirus (PV) is a well-characterized RNA virus, and the RNA-dependent RNA polymerase (RdRp) from PV (3D(pol)) has been widely employed as an important model for understanding the structure-function relationships of RNA and DNA polymerases. …”
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Fibrillarin methylates H2A in RNA polymerase I trans-active promoters in Brassica oleracea by lloyd eLoza-Muller, ulises eRodríguez-Corona, Margarita eSobol, Luis Carlos eRodríguez-Zapata, Pavel eHozak, Enrique eCastano

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Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases by Victoria A. Kleiner, Thierry O. Fischmann, John A. Howe, Douglas C. Beshore, Michael J. Eddins, Yan Hou, Todd Mayhood, Daniel Klein, Debbie D. Nahas, Bob J. Lucas, He Xi, Edward Murray, Daphne Y. Ma, Krista Getty, Rachel Fearns

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HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells by Jonathan E Reeder, Youn-Tae Kwak, Ryan P McNamara, Christian V Forst, Iván D'Orso

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Transcription by the Three RNA Polymerases under the Control of the TOR Signaling Pathway in <i>Saccharomyces cerevisiae</i> by Francisco Gutiérrez-Santiago, Francisco Navarro

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Identification of a New Drug Binding Site in the RNA-Dependent-RNA-Polymerase (RdRp) Domain by Aparna S. Gana, James N. Baraniuk

Subjects: “…RNA-dependent-RNA-polymerase (RdRp)…”
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RNA Polymerase II “Pause” Prepares Promoters for Upcoming Transcription during <i>Drosophila</i> Development by Marina Yu. Mazina, Elena V. Kovalenko, Aleksandra A. Evdokimova, Maksim Erokhin, Darya Chetverina, Nadezhda E. Vorobyeva

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Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp) by Yifei Wu, David Crich, Scott D. Pegan, Lei Lou, Madelyn C. Hansen, Carson Booth, Ellison Desrochers, Lauren Nicole Mullininx, Edward B. Starling, Kuan Y. Chang, Zhong-Ru Xie

“…Here we applied computational approaches to examine if some polyphenols can also inhibit RNA polymerase (RdRp) in SARS-CoV-2, and we identified some better candidates than remdesivir, the FDA-approved drug against RdRp, in terms of estimated binding affinities. …”
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Defining the Influence of the A12.2 Subunit on Transcription Elongation and Termination by RNA Polymerase I In Vivo by Andrew M. Clarke, Abigail K. Huffines, Yvonne J. K. Edwards, Chad M. Petit, David A. Schneider

Subjects: “…RNA polymerase I…”
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