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321
Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts
Published 2018-02-01Subjects: Get full text
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322
X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct
Published 2013“…Here we report the structure of a transcribing RNA polymerase II (pol II) complex stalled at a site-specific monofunctional pyriplatin-DNA adduct in the active site. …”
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323
Effect of a Monofunctional Phenanthriplatin-DNA Adduct on RNA Polymerase II Transcriptional Fidelity and Translesion Synthesis
Published 2014“…Understanding the functional consequences of DNA damage by phenanthriplatin for the normal functions of RNA polymerase II (Pol II), the major cellular transcription machinery component, is an important step toward elucidating its mechanism of action. …”
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324
Improving Saccharomyces cerevisiae ethanol production and tolerance via RNA polymerase II subunit Rpb7
Published 2018“…Here we try to improve Saccharomyces cerevisiae ethanol tolerance and productivity by reprogramming its transcription profile through rewiring its key transcription component RNA polymerase II (RNAP II), which plays a central role in synthesizing mRNAs. …”
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325
CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation
Published 2020“…Cyclin-dependent kinase 12 (CDK12) phosphorylates the carboxyl-terminal domain (CTD) of RNA polymerase II (pol II) but its roles in transcription beyond the expression of DNA damage response genes remain unclear. …”
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326
Crystallization and preliminary X-ray crystallographic studies on the bacteriophage phi6 RNA-dependent RNA polymerase.
Published 2000“…The RNA-dependent RNA polymerase (P2) from bacteriophage Phi6 has been cloned and the protein overexpressed in Escherichia coli to produce an active enzyme. …”
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327
Human Pcf11 enhances degradation of RNA polymerase II-associated nascent RNA and transcriptional termination.
Published 2008“…The poly(A) (pA) signal possesses a dual function in 3' end processing of pre-mRNA and in transcriptional termination of RNA polymerase II (Pol II) for most eukaryotic protein-coding genes. …”
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328
Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks
Published 2019“…Here we show that the Abelson tyrosine kinase c-Abl/ABL1 causes formation of RNA polymerase II (RNAPII) foci, predominantly phosphorylated at carboxy-terminal domain (CTD) residue Tyr1, at DSBs. …”
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329
Mass spectrometry of Escherichia coli RNA polymerase: interactions of the core enzyme with sigma70 and Rsd protein.
Published 2004“…The E. coli RNA polymerase core enzyme is a multisubunit complex of 388,981 Da. …”
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330
Sequence context effects on oligo(dT) termination signal recognition by Saccharomyces cerevisiae RNA polymerase III.
Published 2005“…Eukaryotic RNA polymerase (Pol) III terminates transcription at short runs of T residues in the coding DNA strand. …”
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331
RNA polymerase II phosphorylated on CTD serine 5 interacts with the spliceosome during co-transcriptional splicing
Published 2018“…Immunoprecipitation of MNase-digested chromatin with antibodies against RNA polymerase II (Pol II) shows that active spliceosomes (both snRNA and proteins) are complexed to Pol II S5P CTD during elongation and co-transcriptional splicing. …”
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332
The integrator complex recognizes a new double mark on the RNA polymerase II carboxyl-terminal domain
Published 2010“…The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II (pol II) comprises multiple tandem repeats of the heptapeptide Tyr 1-Ser 2-Pro 3-Thr 4-Ser 5-Pro 6-Ser 7. …”
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333
Co-transcriptional RNA cleavage provides a failsafe termination mechanism for yeast RNA polymerase I.
Published 2011“…Ribosomal RNA, transcribed by RNA polymerase (Pol) I, accounts for most cellular RNA. …”
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334
Cleavage/polyadenylation factor IA associates with the carboxyl-terminal domain of RNA polymerase II in Saccharomyces cerevisiae.
Published 2001“…The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II plays an important role in transcription and processing of the nascent transcript by interacting with both transcription and RNA processing factors. …”
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335
The integrator complex recognizes a new double mark on the RNA polymerase II carboxyl-terminal domain.
Published 2010“…The carboxyl-terminal domain (CTD) of the largest subunit of RNA polymerase II (pol II) comprises multiple tandem repeats of the heptapeptide Tyr(1)-Ser(2)-Pro(3)-Thr(4)-Ser(5)-Pro(6)-Ser(7). …”
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336
Isolation and characterization of monoclonal antibodies directed against subunits of human RNA polymerases I, II, and III.
Published 2000“…Human nuclei contain three different RNA polymerases: polymerases I, II, and III. Each polymerase is a multi-subunit enzyme with 12-17 subunits. …”
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337
Effect of CTCF and Cohesin on the dynamics of RNA polymerase II transcription and coupled pre-messenger RNA processing
Published 2013“…However, CTCF-binding does mediate RNA Polymerase II (Pol II) pausing at the site of recruited CTCF. …”
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338
The trypanosomatid-specific N terminus of RPA2 is required for RNA polymerase I assembly, localization, and function.
Published 2012“…African trypanosomes are the only organisms known to use RNA polymerase I (pol I) to transcribe protein-coding genes. …”
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339
Two aromatic residues in the PB2 subunit of influenza A RNA polymerase are crucial for cap binding.
Published 2003“…The purpose of the present study was to test whether a similar cap recognition mechanism had independently evolved for the RNA polymerase of influenza virus. Combining in vivo and in vitro methods, we characterized two crucial aromatic amino acids, Phe363 and Phe404, in the PB2 subunit of the viral RNA polymerase that are essential for cap binding. …”
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340
Role of ran binding protein 5 in nuclear import and assembly of the influenza virus RNA polymerase complex.
Published 2006“…The influenza A virus RNA-dependent RNA polymerase is a heterotrimeric complex of polymerase basic protein 1 (PB1), PB2, and polymerase acidic protein (PA) subunits. …”
Journal article