Marine Brown Algae-Derived Compounds as Potential Inhibitors of Japanese Encephalitis Virus RNA-Dependent RNA Polymerase by Saud O. Alshammari

“…This investigation explores compounds derived from marine brown algae (Phaeophyceae) as potential inhibitors of JEV RNA-dependent RNA polymerase (RdRp), a critical enzyme in the virus’s replication cycle. …”
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<i>M. tuberculosis</i> Transcription Machinery: A Review on the Mycobacterial RNA Polymerase and Drug Discovery Efforts by Filia Stephanie, Usman Sumo Friend Tambunan, Teruna J. Siahaan

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Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism by Manchuta Dangkulwanich, Toyotaka Ishibashi, Shixin Liu, Maria L Kireeva, Lucyna Lubkowska, Mikhail Kashlev, Carlos J Bustamante

Subjects: “…RNA polymerase II…”
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Pre-piRNA trimming safeguards piRNAs against erroneous targeting by RNA-dependent RNA polymerase by Benjamin Pastore, Hannah L. Hertz, Wen Tang

“…Untrimmed pre-piRNAs are misdirected by the terminal nucleotidyltransferase RDE-3 and RNA-dependent RNA polymerase EGO-1, leading to the formation of anti-piRNAs. …”
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Contrasting effects of whole-body and hepatocyte-specific deletion of the RNA polymerase III repressor Maf1 in the mouse by Gilles Willemin, François Mange, Viviane Praz, Séverine Lorrain, Pascal Cousin, Catherine Roger, Ian M. Willis, Ian M. Willis, Nouria Hernandez

“…MAF1 is a nutrient-sensitive, TORC1-regulated repressor of RNA polymerase III (Pol III). MAF1 downregulation leads to increased lipogenesis in Drosophila melanogaster, Caenorhabditis elegans, and mice. …”
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Inhibiting the oligomerization of mycobacterial DNA-directed RNA polymerase (RNAP) using natural compound via in-silico techniques by Ehssan H. Moglad

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Investigating the Mechanism of Action of Anti-Dengue Compounds as Potential Binders of Zika Virus RNA-Dependent RNA Polymerase by Thamir A. Alandijany, Mai M. El-Daly, Ahmed M. Tolah, Leena H. Bajrai, Aiah M. Khateb, Isra M. Alsaady, Sarah A. Altwaim, Amit Dubey, Vivek Dhar Dwivedi, Esam I. Azhar

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The use of viral RNA polymerase inhibitors in combination with a fusion inhibitor in the treatment of patients with COVID-19: hypothesis by O. V. Gaisenok

Subjects: “…inhibitors of viral rna polymerases…”
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Comparison of chicken 7SK and U6 RNA polymerase III promoters for short hairpin RNA expression by Cahill David M, Wise Terry G, Bannister Stephanie C, Doran Timothy J

“…<p>Abstract</p> <p>Background</p> <p>RNA polymerase III (pol III) type 3 promoters such as U6 or 7SK are commonly used to express short-hairpin RNA (shRNA) effectors for RNA interference (RNAi). …”
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Effects of glycine 64 substitutions in RNA-dependent RNA polymerase on ribavirin sensitivity and pathogenicity of coxsackievirus A6 by Rui Wang, Qiang Sun, Jinbo Xiao, Congcong Wang, Xiaoliang Li, Jichen Li, Yang Song, Huanhuan Lu, Ying Liu, Shuangli Zhu, Zhijun Liu, Yong Zhang

“…Previous studies have shown that mutations of glycine 64 in RNA-dependent RNA polymerase (3D polymerase), which is central to viral replication, cause phenotypic changes such as ribavirin resistance, increased replication fidelity, and virulence attenuation in poliovirus and enterovirus A71. …”
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Modeling the <i><b>Influenza A</b></i> NP-vRNA-Polymerase Complex in Atomic Detail by Jacob C. Miner, Anna Lappala, Paul W. Fenimore, William M. Fischer, Benjamin H. McMahon, Nicolas W. Hengartner, Karissa Y. Sanbonmatsu, Chang-Shung Tung

“…Each RNP incorporates multiple copies of nucleoprotein (NP), a fragment of the viral genome (vRNA), and a viral RNA-dependent RNA polymerase (POL), and is responsible for packaging the viral genome and performing critical functions including replication and transcription. …”
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Tail-tape-fused virion and non-virion RNA polymerases of a thermophilic virus with an extremely long tail by Anastasiia Chaban, Leonid Minakhin, Ekaterina Goldobina, Brain Bae, Yue Hao, Sergei Borukhov, Leena Putzeys, Maarten Boon, Florian Kabinger, Rob Lavigne, Kira S. Makarova, Eugene V. Koonin, Satish K. Nair, Shunsuke Tagami, Konstantin Severinov, Maria L. Sokolova

“…Here, we show that the N-terminal portion of P23-45 TMP is an unusual RNA polymerase (RNAP) homologous to cellular RNAPs. The TMP-fused virion RNAP transcribes pre-early phage genes, including a gene that encodes another, non-virion RNAP, that transcribes early and some middle phage genes. …”
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Immunoinformatics-Based Identification of B and T Cell Epitopes in RNA-Dependent RNA Polymerase of SARS-CoV-2 by Shabir Ahmad Mir, Mohammed Alaidarous, Bader Alshehri, Abdul Aziz Bin Dukhyil, Saeed Banawas, Yahya Madkhali, Suliman A. Alsagaby, Ayoub Al Othaim

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Stimulation of transcript elongation requires both the zinc finger and RNA polymerase II binding domains of human TFIIS by Agarwal, Kan, Baek, Kwanghee, Jeon, Choon Ju, Miyamoto, Kenichi, Ueno, Akemichi, Yoon, Ho Sup

“…These findings suggest that TFIIS may interact with RNA polymerase II such that the normally masked zinc finger can specifically contact nucleotides in the transcription elongation zone at a position juxtaposed to the polymerization site.…”
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The 3' ends of human pre-snRNAs are produced by RNA polymerase II CTD-dependent RNA processing. by Uguen, P, Murphy, S

Poly(A) signals and transcriptional pause sites combine to prevent interference between RNA polymerase II promoters. by Eggermont, J, Proudfoot, N

“…Transcriptional termination by RNA polymerase II at the 3' end of genes encoding poly(A)+ mRNAs is thought to require two distinct cis-active elements: a functional poly(A) signal and a downstream transcriptional pause site. …”

Analysis of HIV-1 Tat effects on expression of RNA polymerase (pol II)-transcribed snRNA genes by Zaborowska, J, Kollakowski, T, Murphy, S

Rct1, a nuclear RRM-containing cyclophilin, regulates phosphorylation of RNA polymerase IIC-terminal domain by Gullerova, M, Skrahina, T, Tschuden, B, Barta, A, Lorkovic, Z

Partial truncation of the yeast RNA polymerase II carboxyl-terminal domain preferentially reduces expression of glycolytic genes. by Meisels, E, Gileadi, O, Corden, J

“…The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) that consists of highly conserved heptapeptide repeats with the consensus sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser. …”

Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs. by Brookes, E, de Santiago, I, Hebenstreit, D, Morris, K, Carroll, T, Xie, S, Stock, J, Heidemann, M, Eick, D, Nozaki, N, Kimura, H, Ragoussis, J, Teichmann, SA, Pombo, A

“…Polycomb silencing in embryonic stem cells (ESCs) can be accompanied by active chromatin and primed RNA polymerase II (RNAPII), but the relationship between PRCs and RNAPII remains unclear genome-wide. …”