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361
Marine Brown Algae-Derived Compounds as Potential Inhibitors of Japanese Encephalitis Virus RNA-Dependent RNA Polymerase
Published 2024-02-01“…This investigation explores compounds derived from marine brown algae (Phaeophyceae) as potential inhibitors of JEV RNA-dependent RNA polymerase (RdRp), a critical enzyme in the virus’s replication cycle. …”
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362
<i>M. tuberculosis</i> Transcription Machinery: A Review on the Mycobacterial RNA Polymerase and Drug Discovery Efforts
Published 2022-11-01Subjects: Get full text
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363
Complete dissection of transcription elongation reveals slow translocation of RNA polymerase II in a linear ratchet mechanism
Published 2013-09-01Subjects: “…RNA polymerase II…”
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364
Pre-piRNA trimming safeguards piRNAs against erroneous targeting by RNA-dependent RNA polymerase
Published 2024-02-01“…Untrimmed pre-piRNAs are misdirected by the terminal nucleotidyltransferase RDE-3 and RNA-dependent RNA polymerase EGO-1, leading to the formation of anti-piRNAs. …”
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365
Contrasting effects of whole-body and hepatocyte-specific deletion of the RNA polymerase III repressor Maf1 in the mouse
Published 2023-12-01“…MAF1 is a nutrient-sensitive, TORC1-regulated repressor of RNA polymerase III (Pol III). MAF1 downregulation leads to increased lipogenesis in Drosophila melanogaster, Caenorhabditis elegans, and mice. …”
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366
Inhibiting the oligomerization of mycobacterial DNA-directed RNA polymerase (RNAP) using natural compound via in-silico techniques
Published 2024-03-01Subjects: Get full text
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367
Investigating the Mechanism of Action of Anti-Dengue Compounds as Potential Binders of Zika Virus RNA-Dependent RNA Polymerase
Published 2023-07-01Subjects: Get full text
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368
The use of viral RNA polymerase inhibitors in combination with a fusion inhibitor in the treatment of patients with COVID-19: hypothesis
Published 2020-07-01Subjects: “…inhibitors of viral rna polymerases…”
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369
Comparison of chicken 7SK and U6 RNA polymerase III promoters for short hairpin RNA expression
Published 2007-11-01“…<p>Abstract</p> <p>Background</p> <p>RNA polymerase III (pol III) type 3 promoters such as U6 or 7SK are commonly used to express short-hairpin RNA (shRNA) effectors for RNA interference (RNAi). …”
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370
Effects of glycine 64 substitutions in RNA-dependent RNA polymerase on ribavirin sensitivity and pathogenicity of coxsackievirus A6
Published 2024-01-01“…Previous studies have shown that mutations of glycine 64 in RNA-dependent RNA polymerase (3D polymerase), which is central to viral replication, cause phenotypic changes such as ribavirin resistance, increased replication fidelity, and virulence attenuation in poliovirus and enterovirus A71. …”
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371
Modeling the <i><b>Influenza A</b></i> NP-vRNA-Polymerase Complex in Atomic Detail
Published 2021-01-01“…Each RNP incorporates multiple copies of nucleoprotein (NP), a fragment of the viral genome (vRNA), and a viral RNA-dependent RNA polymerase (POL), and is responsible for packaging the viral genome and performing critical functions including replication and transcription. …”
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372
Tail-tape-fused virion and non-virion RNA polymerases of a thermophilic virus with an extremely long tail
Published 2024-01-01“…Here, we show that the N-terminal portion of P23-45 TMP is an unusual RNA polymerase (RNAP) homologous to cellular RNAPs. The TMP-fused virion RNAP transcribes pre-early phage genes, including a gene that encodes another, non-virion RNAP, that transcribes early and some middle phage genes. …”
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373
Immunoinformatics-Based Identification of B and T Cell Epitopes in RNA-Dependent RNA Polymerase of SARS-CoV-2
Published 2022-10-01Subjects: Get full text
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374
Stimulation of transcript elongation requires both the zinc finger and RNA polymerase II binding domains of human TFIIS
Published 2012“…These findings suggest that TFIIS may interact with RNA polymerase II such that the normally masked zinc finger can specifically contact nucleotides in the transcription elongation zone at a position juxtaposed to the polymerization site.…”
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Journal Article -
375
The 3' ends of human pre-snRNAs are produced by RNA polymerase II CTD-dependent RNA processing.
Published 2003Journal article -
376
Poly(A) signals and transcriptional pause sites combine to prevent interference between RNA polymerase II promoters.
Published 1993“…Transcriptional termination by RNA polymerase II at the 3' end of genes encoding poly(A)+ mRNAs is thought to require two distinct cis-active elements: a functional poly(A) signal and a downstream transcriptional pause site. …”
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377
Analysis of HIV-1 Tat effects on expression of RNA polymerase (pol II)-transcribed snRNA genes
Published 2010Conference item -
378
Rct1, a nuclear RRM-containing cyclophilin, regulates phosphorylation of RNA polymerase IIC-terminal domain
Published 2007Conference item -
379
Partial truncation of the yeast RNA polymerase II carboxyl-terminal domain preferentially reduces expression of glycolytic genes.
Published 1995“…The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) that consists of highly conserved heptapeptide repeats with the consensus sequence Tyr-Ser-Pro-Thr-Ser-Pro-Ser. …”
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380
Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs.
Published 2012“…Polycomb silencing in embryonic stem cells (ESCs) can be accompanied by active chromatin and primed RNA polymerase II (RNAPII), but the relationship between PRCs and RNAPII remains unclear genome-wide. …”
Journal article