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381
CDK9 and PP2A regulate RNA polymerase II transcription termination and coupled RNA maturation
Published 2022“…CDK9 is a kinase critical for the productive transcription of protein-coding genes by RNA polymerase II (pol II). As part of P-TEFb, CDK9 phosphorylates the carboxyl-terminal domain (CTD) of pol II and elongation factors, which allows pol II to elongate past the early elongation checkpoint (EEC) encountered soon after initiation. …”
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382
Mutational analysis of the PA and PB2 subunits of the influenza RNA polymerase complex leads to new insights into function
Published 2004“…The RNA-dependent RNA polymerase complex of influenza A virus consists of three subunits, PB1, PB2 and PA. …”
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383
Design and use of Chikungunya virus replication templates utilizing mammalian and mosquito RNA polymerase I mediated transcription
Published 2019“…In contrast, RNA polymerase I promoters from <em>Aedes</em> mosquitoes exhibited strong species specificity. …”
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384
Plasmodium falciparum var gene expression is developmentally controlled at the level of RNA polymerase II-mediated transcription initiation.
Published 2007“…We demonstrate here that exclusive var gene expression is controlled at the level of transcription initiation during ring stages and that var genes are transcribed by RNA polymerase II. This represents another example where P. falciparum differs from the paradigm for antigenic variation, Trypanosoma brucei.…”
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385
RNA polymerase clamp conformational dynamics: long-lived states and modulation by crowding, cations, and nonspecific DNA binding
Published 2021“…The RNA polymerase (RNAP) clamp, a mobile structural element conserved in RNAP from all domains of life, has been proposed to play critical roles at different stages of transcription. …”
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386
Archaeal RNA polymerase: the influence of the protruding stalk in crystal packing and preliminary biophysical analysis of the Rpo13 subunit.
Published 2011“…We review recent results on the complete structure of the archaeal RNAP (RNA polymerase) enzyme of Sulfolobus shibatae. We compare the three crystal forms in which this RNAP packs (space groups P2₁2₁2₁, P2₁2₁2 and P2₁) and provide a preliminary biophysical characterization of the newly identified 13-subunit Rpo13. …”
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387
Repurposing of potential antiviral drugs against RNA-dependent RNA polymerase of SARS-CoV-2 by computational approach
Published 2022-11-01Subjects: Get full text
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388
Global Genomic Analysis of SARS-CoV-2 RNA Dependent RNA Polymerase Evolution and Antiviral Drug Resistance
Published 2021-05-01“…Currently, the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp, encoded by <i>nsp12-nsp7-nsp8</i>) has been targeted by numerous inhibitors, e.g., remdesivir, the only provisionally approved treatment to-date, although the clinical impact of these interventions remains inconclusive. …”
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389
Genistein is effective in inhibiting Orf virus infection in vitro by targeting viral RNA polymerase subunit RPO30 protein
Published 2024-02-01“…Poxviruses encode a multisubunit DNA-dependent RNA polymerase (vRNAP) that carries out viral gene expression in the host cytoplasm, which is a viral factor essential to poxvirus replication. …”
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390
PARP1′s Involvement in RNA Polymerase II Elongation: Pausing and Releasing Regulation through the Integrator and Super Elongation Complex
Published 2022-10-01“…RNA polymerase elongation along the gene body is tightly regulated to ensure proper transcription and alternative splicing events. …”
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391
Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach
Published 2016-10-01Subjects: “…NS5 RNA-dependent RNA-polymerase…”
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392
Reprogramming mRNA Expression in Response to Defect in RNA Polymerase III Assembly in the Yeast <i>Saccharomyces cerevisiae</i>
Published 2021-07-01Subjects: Get full text
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393
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394
Heat Treatment Promotes Ubiquitin-Mediated Proteolysis of SARS-CoV-2 RNA Polymerase and Decreases Viral Load
Published 2022-01-01“…Here, we reveal a potential mechanism by which mild heat treatment destabilizes the wild-type RNA-dependent RNA polymerase (also known as nonstructural protein 12 (NSP12)) of SARS-CoV-2 as well as the P323L mutant commonly found in SARS-CoV-2 variants, including omicron and IHU. …”
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395
Binding of GS-461203 and Its Halogen Derivatives to HCV Genotype 2a RNA Polymerase Drug Resistance Mutants
Published 2022-04-01“…Hepatitis C Virus (HCV) is reported to develop GS-461203 resistance because of multiple mutations within the RNA-dependent RNA Polymerase (RdRp) of HCV. The lack of a high-resolution structure of these RdRp mutants in complex with GS-461203 hinders efforts to understand the drug resistance. …”
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396
Rifampicin exerts anti-mucoviscous activity against hypervirulent Klebsiella pneumoniae via binding to the RNA polymerase β subunit
Published 2023-03-01“…We previously discovered that rifampicin (RFP), a bactericidal drug that binds to and inhibits the β subunit of RNA polymerase (RpoB), elicits anti-mucoviscous activity against hvKP by suppressing rmpA, a regulator of capsule production. …”
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397
Structural and Functional Insight into the Mechanism of <i>Bacillus subtilis</i> 6S-1 RNA Release from RNA Polymerase
Published 2022-02-01“…Here we investigated the refolding of <i>Bacillus subtilis</i> 6S-1 RNA and its release from σ<sup>A</sup>-RNA polymerase (σ<sup>A</sup>-RNAP) in vitro using truncated and mutated 6S-1 RNA variants. …”
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398
HSV-1 ICP22 Is a Selective Viral Repressor of Cellular RNA Polymerase II-Mediated Transcription Elongation
Published 2021-09-01“…ICP22 inhibits phosphorylation of Ser2 of the RNA polymerase II (pol II) carboxyl-terminal domain (CTD) and productive elongation of pol II. …”
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399
Investigation of Multi-Subunit <i>Mycobacterium tuberculosis</i> DNA-Directed RNA Polymerase and Its Rifampicin Resistant Mutants
Published 2023-02-01Subjects: Get full text
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400
Dynamics of RNA Polymerase II Pausing and Bivalent Histone H3 Methylation during Neuronal Differentiation in Brain Development
Published 2017-08-01“…During cellular differentiation, genes important for differentiation are expected to be silent in stem/progenitor cells yet can be readily activated. RNA polymerase II (Pol II) pausing and bivalent chromatin marks are two paradigms suited for establishing such a poised state of gene expression; however, their specific contributions in development are not well understood. …”
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