Anti-BVDV Activity of Traditional Chinese Medicine Monomers Targeting NS5B (RNA-Dependent RNA Polymerase) In Vitro and In Vivo by Nannan Chen, Dongjun Jiang, Baihui Shao, Tongtong Bai, Jinwei Chen, Yu Liu, Zecai Zhang, Yulong Zhou, Xue Wang, Zhanbo Zhu

“…The nonstructural protein NS5B (RNA-dependent RNA polymerase) of NADL strain BVDV was used as the action target based on a molecular docking technique to screen herbal monomers for anti-BVDV viral activity. …”
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Correction: Small RNA Deep Sequencing Reveals Role for Arabidopsis thaliana RNA-Dependent RNA Polymerases in Viral siRNA Biogenesis

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Connecting mutations of the RNA polymerase II C-terminal domain to complex phenotypic changes using combined gene expression and network analyses. by Carlyle Rogers, Zhenhua Guo, John W Stiller

“…The C-terminal domain (CTD) of the largest subunit in DNA-dependent RNA polymerase II (RNAP II) is essential for mRNA synthesis and processing, through coordination of an astounding array of protein-protein interactions. …”
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Global Analysis of RNA-Dependent RNA Polymerase-Dependent Small RNAs Reveals New Substrates and Functions for These Proteins and SGS3 in Arabidopsis by Xia Hua, Nathan D. Berkowitz, Matthew R. Willmann, Xiang Yu, Eric Lyons, Brian D. Gregory

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Cross-regulome profiling of RNA polymerases highlights the regulatory role of polymerase III on mRNA transcription by maintaining local chromatin architecture by Yongpeng Jiang, Jie Huang, Kai Tian, Xiao Yi, Haonan Zheng, Yi Zhu, Tiannan Guo, Xiong Ji

Subjects: “…RNA polymerases II and III…”
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Machine learning unveils RNA polymerase II binding as a predictor for SMAD2‐dependent transcription dynamics in response to Actvin signalling by Dan Shi, Weihua Feng, Zhike Zi

“…Results showed that RNA polymerase II binding was the most informative feature for predicting the expression patterns of SMAD2‐binding genes. …”
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Plastid Deficient 1 Is Essential for the Accumulation of Plastid-Encoded RNA Polymerase Core Subunit β and Chloroplast Development in <i>Arabidopsis</i> by Zhipan Yang, Mingxin Liu, Shunhua Ding, Yi Zhang, Huixia Yang, Xiaogang Wen, Wei Chi, Congming Lu, Qingtao Lu

“…Plastid-encoded RNA polymerase (PEP)-dependent transcription is an essential process for chloroplast development and plant growth. …”
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RETRACTED: RNA polymerase II subunit 3 regulates vesicular, overexpressed in cancer, prosurvival protein 1 expression to promote hepatocellular carcinoma by Peng Hu, Binfeng Wang, Ting Chen, Yongfu Xu, Guoqun Zheng, Yu Zhu, Xuefeng Du

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A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription by Matthew A Sdano, James M Fulcher, Sowmiya Palani, Mahesh B Chandrasekharan, Timothy J Parnell, Frank G Whitby, Tim Formosa, Christopher P Hill

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Super-resolution imaging of fluorescently labeled, endogenous RNA Polymerase II in living cells with CRISPR/Cas9-mediated gene editing by Cho, Won-ki, Jayanth, Namrata, Mullen, Susan, Tan, Tzer Han, Jung, Yoon, Cisse, Ibrahim I

“…Live cell imaging of mammalian RNA polymerase II (Pol II) has previously relied on random insertions of exogenous, mutant Pol II coupled with the degradation of endogenous Pol II using a toxin, α-amanitin. …”
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Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold by Tan, Yaw Bia, Lello, Laura Sandra, Liu, Xin, Law, Yee-Song, Kang, Congbao, Lescar, Julien, Zheng, Jie, Merits, Andres, Luo, Dahai

“…Nonstructural protein 4 (nsP4) of alphaviruses possesses RNA-dependent RNA polymerase (RdRp) activity essential for viral RNA replication. …”
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Rct1, a nuclear RNA recognition motif-containing cyclophilin, regulates phosphorylation of the RNA polymerase II C-terminal domain. by Gullerova, M, Barta, A, Lorkovic, Z

“…Phosphorylation of the C-terminal domain (CTD) of RNA polymerase II (RNAP II) is a dynamic process that regulates transcription and coordinates it with pre-mRNA processing. …”

Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. by Zhang, W, Prakash, C, Prakash, C, Sum, C, Sum, C, Gong, Y, Gong, Y, Li, Y, Li, Y, Kwok, J, Kwok, J, Thiessen, N, Thiessen, N, Pettersson, S, Pettersson, S, Jones, S, Jones, S, Knapp, S, Knapp, S, Yang, H, Yang, H, Chin, K, Chin, K

“…Transcriptional elongation by RNA polymerase II (Pol II) is regulated by positive transcription elongation factor b (P-TEFb) in association with bromodomain-containing protein 4 (BRD4). …”

Insights into the pre-initiation events of bacteriophage phi 6 RNA-dependent RNA polymerase: towards the assembly of a productive binary complex. by Sarin, L, Poranen, M, Lehti, N, Ravantti, J, Koivunen, MR, Aalto, A, van Dijk, A, Stuart, D, Grimes, J, Bamford, D

“…The RNA-dependent RNA polymerase (RdRP) of double-stranded RNA (dsRNA) viruses performs both RNA replication and transcription. …”

A modular and optimized single marker system for generating Trypanosoma brucei cell lines expressing T7 RNA polymerase and the tetracycline repressor. by Poon, S, Peacock, L, Gibson, W, Gull, K, Kelly, S

“…Here, we present a simple modular extendable vector system for introducing the T7 RNA polymerase and tetracycline repressor genes into Trypanosoma brucei. …”

Insights into the pre-initiation events of bacteriophage Φ6 RNA-dependent RNA polymerase: towards the assembly of a productive binary complex by Sarin, L, Poranen, M, Lehti, N, Ravantti, J, Koivunen, M, Aalto, A, van Dijk, A, Stuart, D, Grimes, J, Bamford, D

“…The RNA-dependent RNA polymerase (RdRP) of double-stranded RNA (dsRNA) viruses performs both RNA replication and transcription. …”

RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation. by Ni, Z, Xu, C, Guo, X, Hunter, G, Kuznetsova, O, Tempel, W, Marcon, E, Zhong, G, Guo, H, Kuo, W, Li, J, Young, P, Olsen, J, Wan, C, Loppnau, P, El Bakkouri, M, Senisterra, G, He, H, Huang, H, Sidhu, S, Emili, A, Murphy, S, Mosley, A, Arrowsmith, C, Min, J

“…The RNA polymerase II (RNAPII) C-terminal domain (CTD) heptapeptide repeats (1-YSPTSPS-7) undergo dynamic phosphorylation and dephosphorylation during the transcription cycle to recruit factors that regulate transcription, RNA processing and chromatin modification. …”

The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. by Bitoun, E, Oliver, P, Davies, K

“…Here, we provide the first evidence for a direct role of AF4 in the regulation of transcriptional elongation by RNA polymerase II (Pol II). We demonstrate that mouse Af4 functions as a positive regulator of Pol II transcription elongation factor b (P-TEFb) kinase and, in complex with MLL fusion partners Af9, Enl and Af10, as a mediator of histone H3-K79 methylation by recruiting Dot1 to elongating Pol II. …”

Influence of irofulven, a transcription-coupled repair-specific antitumor agent, on RNA polymerase activity, stability and dynamics in living mammalian cells. by Escargueil, A, Poindessous, V, Soares, D, Sarasin, A, Cook, P, Larsen, A

“…Transcription-coupled repair (TCR) plays a key role in the repair of DNA lesions induced by bulky adducts and is initiated when the elongating RNA polymerase II (Pol II) stalls at DNA lesions. This is accompanied by alterations in Pol II activity and stability. …”

Cytoplasmic polyadenylation in S. pombe by Stevenson, A, Stevenson, Abigail Louise

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