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In- silico evaluation of bioactive compounds from selected medicinal plants from Southern Nigeria against hepatitis C virus genotype 1 RNA-directed RNA polymerase
Published 2023-11-01“…List of Abbreviations and Units: AA, Amino Acid; HCV, Hepatitis C Virus; HBV, Hepatitis B Virus; GC–MS, Gas chromatograph-mass spectrophotometer; MD, Molecular docking; PDB, Protein Data Bank; RdRp, RNA directed RNA polymerase; RNA, Ribonucleic Acid; HIV, Human Immunodeficiency virus; NIST, National Institute of Standards and Technology; WHO, World Health Organization…”
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585
Synthesis of Nucleoside-like Molecules from a Pyrolysis Product of Cellulose and Their Computational Prediction as Potential SARS-CoV-2 RNA-Dependent RNA Polymerase Inhibitors
Published 2022-01-01“…An in silico screening of these compounds as inhibitors of SARS-CoV-2 RNA-dependent RNA polymerase has been carried out in comparison with both remdesivir, a mono-phosphoramidate prodrug recently approved for COVID-19 treatment, and its ribonucleoside metabolite GS-441524. …”
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586
RNA polymerase II transcription attenuation at the yeast DNA repair gene <i>DEF1</i> is biologically significant and dependent on the Hrp1 RNA-recognition motif
Published 2022-10-01“… AbstractPremature transcription termination (i.e. attenuation) is a potent gene regulatory mechanism that represses mRNA synthesis. Attenuation of RNA polymerase II is more prevalent than once appreciated, targeting 10–15% of mRNA genes in yeast through higher eukaryotes, but its significance and mechanism remain obscure. …”
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587
Analysis of the PcrA-RNA polymerase complex reveals a helicase interaction motif and a role for PcrA/UvrD helicase in the suppression of R-loops
Published 2021-07-01“…The PcrA/UvrD helicase binds directly to RNA polymerase (RNAP) but the structural basis for this interaction and its functional significance have remained unclear. …”
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588
Genome sequence of Leishmania mexicana MNYC/BZ/62/M379 expressing Cas9 and T7 RNA polymerase [version 2; peer review: 3 approved]
Published 2023-02-01“…We present the genome sequence of Leishmania mexicana MNYC/BZ/62/M379 modified to express Cas9 and T7 RNA-polymerase, revealing high similarity to the reference genome (MHOM/GT2001/U1103). …”
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589
Loss of <i>rpoE</i> Encoding the δ-Factor of RNA Polymerase Impacts Pathophysiology of the <i>Streptococcus pyogenes</i> M1T1 Strain 5448
Published 2022-08-01“…Taken together, these findings demonstrate that the delta (δ) subunit of RNA polymerase is vital in GAS gene expression and virulence.…”
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590
Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.
Published 2010“…In embryonic stem (ES) cells many genes that regulate subsequent stages in development are enriched at their promoters for PRC1, PRC2 and Ser 5-phosphorylated RNA Polymerase II (RNAP), and contain domains of 'bivalent' chromatin (enriched for H3K4me3; histone H3 di- or trimethylated at Lys 4 and H3K27me3; histone H3 trimethylated at Lys 27). …”
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Evidence for a neotropical origin of Leishmania
Published 2000-08-01Subjects: Get full text
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594
KSHV-encoded LANA bypasses transcriptional block through the stabilization of RNA Pol II in hypoxia
Published 2024-01-01Subjects: Get full text
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595
Promoter nucleosome dynamics regulated by signalling through the CTD code
Published 2015-06-01Subjects: “…RNA polymerase…”
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596
Archaeal GPN-loop GTPases involve a lock-switch-rock mechanism for GTP hydrolysis
Published 2023-12-01Subjects: Get full text
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597
Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae
Published 2014-05-01Subjects: Get full text
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598
The Mammalian and Yeast A49 and A34 Heterodimers: Homologous but Not the Same
Published 2021-04-01Subjects: Get full text
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Transcription-Based Amplified Colorimetric Thrombin Sensor Using Non-Crosslinking Aggregation of DNA-Modified Gold Nanoparticles
Published 2021-06-01Subjects: Get full text
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600
Decoding the Role of Temperature in RNA Virus Infections
Published 2022-10-01Subjects: Get full text
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