Study of Eclipta prostrata compounds with potential inhibition of RNA-dependent RNA polymerase (RdRp) enzyme of Sars-CoV-2 virus using molecular docking by Hồ Thiên Hoàng, Nguyễn Thị Uyên Thanh, Quan Quốc Đăng, Bùi Đình Thạch

Subjects: Get full text

Erratum: Remdesivir strongly binds to RNA-dependent RNA polymerase, membrane protein, and main protease of SARS-CoV-2: Indication from molecular modeling and simulations by Frontiers Production Office

Subjects: Get full text

In- silico evaluation of bioactive compounds from selected medicinal plants from Southern Nigeria against hepatitis C virus genotype 1 RNA-directed RNA polymerase by Clement I. Mboto, Uwem O. Edet, Elizabeth N. Mbim, Wilfred O. Ndifon, Eno E. Ebenso, Henry O. Egharevba, Uwem E. George, Francisca O. Nwaokorie, Samuel.I. Udo

“…List of Abbreviations and Units: AA, Amino Acid; HCV, Hepatitis C Virus; HBV, Hepatitis B Virus; GC–MS, Gas chromatograph-mass spectrophotometer; MD, Molecular docking; PDB, Protein Data Bank; RdRp, RNA directed RNA polymerase; RNA, Ribonucleic Acid; HIV, Human Immunodeficiency virus; NIST, National Institute of Standards and Technology; WHO, World Health Organization…”
Get full text

Performance of Reverse Transcription Loop-Mediated Isothermal Amplification (RT-LAMP) Targeting the RNA Polymerase Gene for the Direct Detection of SARS-CoV2 in Nasopharyngeal Swabs by Elias da Rosa Hoffmann, Lisiane da Rocha Balzan, Everton Inamine, Lisiane Rech Pancotto, Guilherme Gaboardi, Vlademir Vicente Cantarelli

Get full text

Synthesis of Nucleoside-like Molecules from a Pyrolysis Product of Cellulose and Their Computational Prediction as Potential SARS-CoV-2 RNA-Dependent RNA Polymerase Inhibitors by Andrea Defant, Federico Dosi, Nicole Innocenti, Ines Mancini

“…An in silico screening of these compounds as inhibitors of SARS-CoV-2 RNA-dependent RNA polymerase has been carried out in comparison with both remdesivir, a mono-phosphoramidate prodrug recently approved for COVID-19 treatment, and its ribonucleoside metabolite GS-441524. …”
Get full text

RNA polymerase II transcription attenuation at the yeast DNA repair gene <i>DEF1</i> is biologically significant and dependent on the Hrp1 RNA-recognition motif by Maria E Amodeo, Shane P C Mitchell, Vincent Pavan, Jason N Kuehner

“… AbstractPremature transcription termination (i.e. attenuation) is a potent gene regulatory mechanism that represses mRNA synthesis. Attenuation of RNA polymerase II is more prevalent than once appreciated, targeting 10–15% of mRNA genes in yeast through higher eukaryotes, but its significance and mechanism remain obscure. …”
Get full text

Analysis of the PcrA-RNA polymerase complex reveals a helicase interaction motif and a role for PcrA/UvrD helicase in the suppression of R-loops by Inigo Urrutia-Irazabal, James R Ault, Frank Sobott, Nigel J Savery, Mark S Dillingham

“…The PcrA/UvrD helicase binds directly to RNA polymerase (RNAP) but the structural basis for this interaction and its functional significance have remained unclear. …”
Get full text

Genome sequence of Leishmania mexicana MNYC/BZ/62/M379 expressing Cas9 and T7 RNA polymerase [version 2; peer review: 3 approved] by Ulrich Dobramysl, Tom Beneke, Jeremy Charles Mottram, Carolina Moura Costa Catta-Preta, Richard J. Wheeler, Eva Gluenz

“…We present the genome sequence of Leishmania mexicana MNYC/BZ/62/M379 modified to express Cas9 and T7 RNA-polymerase, revealing high similarity to the reference genome (MHOM/GT2001/U1103). …”
Get full text

Loss of <i>rpoE</i> Encoding the δ-Factor of RNA Polymerase Impacts Pathophysiology of the <i>Streptococcus pyogenes</i> M1T1 Strain 5448 by Joseph S. Rom, Yoann Le Breton, Emrul Islam, Ashton T. Belew, Najib M. El-Sayed, Kevin S. McIver

“…Taken together, these findings demonstrate that the delta (δ) subunit of RNA polymerase is vital in GAS gene expression and virulence.…”
Get full text

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. by Landeira, D, Sauer, S, Poot, R, Dvorkina, M, Mazzarella, L, Jørgensen, H, Pereira, C, Leleu, M, Piccolo, F, Spivakov, M, Brookes, E, Pombo, A, Fisher, C, Skarnes, W, Snoek, T, Bezstarosti, K, Demmers, J, Klose, R, Casanova, M, Tavares, L, Brockdorff, N, Merkenschlager, M, Fisher, A

“…In embryonic stem (ES) cells many genes that regulate subsequent stages in development are enriched at their promoters for PRC1, PRC2 and Ser 5-phosphorylated RNA Polymerase II (RNAP), and contain domains of 'bivalent' chromatin (enriched for H3K4me3; histone H3 di- or trimethylated at Lys 4 and H3K27me3; histone H3 trimethylated at Lys 27). …”

Sequence analysis of RNA-dependent RNA polymerase and development of a TaqMan real-time RT-PCR assay for detection of Macrobrachium rosenbergii nodavirus in giant freshwater prawns by Mohammadi, Zeinabsadat

Subjects: Get full text

The two sides of Tat by Matjaz Barboric, Koh Fujinaga

Subjects: Get full text

Evidence for a neotropical origin of Leishmania by HA Noyes, DA Morrison, ML Chance, JT Ellis

Subjects: Get full text

KSHV-encoded LANA bypasses transcriptional block through the stabilization of RNA Pol II in hypoxia by Dipayan Bose, Rajnish Kumar Singh, Erle S. Robertson

Subjects: Get full text

Promoter nucleosome dynamics regulated by signalling through the CTD code by Philippe Materne, Jayamani Anandhakumar, Valerie Migeot, Ignacio Soriano, Carlo Yague-Sanz, Elena Hidalgo, Carole Mignion, Luis Quintales, Francisco Antequera, Damien Hermand

Subjects: “…RNA polymerase…”
Get full text

Archaeal GPN-loop GTPases involve a lock-switch-rock mechanism for GTP hydrolysis by Lukas Korf, Xing Ye, Marian S. Vogt, Wieland Steinchen, Mohamed Watad, Chris van der Does, Maxime Tourte, Shamphavi Sivabalasarma, Sonja-Verena Albers, Lars-Oliver Essen

Subjects: Get full text

Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae by Cedric Leyrat, Max Renner, Karl Harlos, Juha T Huiskonen, Jonathan M Grimes

Subjects: Get full text

The Mammalian and Yeast A49 and A34 Heterodimers: Homologous but Not the Same by Rachel McNamar, Katrina Rothblum, Lawrence I. Rothblum

Subjects: Get full text

Transcription-Based Amplified Colorimetric Thrombin Sensor Using Non-Crosslinking Aggregation of DNA-Modified Gold Nanoparticles by Yu Muto, Gen Hirao, Tamotsu Zako

Subjects: Get full text

Decoding the Role of Temperature in RNA Virus Infections by Karishma Bisht, Aartjan J. W. te Velthuis

Subjects: Get full text