Phyllanthus tenellus Roxb. and Kaempferia parviflora Wall. ex Baker compounds as inhibitors of SARS-CoV-2 main protease and RNA-dependent RNA polymerase: A molecular docking study by Suhaina Supian, Muhamad Aizuddin Ahmad, Lina Rozano, Machap Chandradevan, Zuraida Ab Rahman

“…Aims: To evaluate bioactive compounds from Phyllanthus tenellus and Kaempferia parviflora as inhibitorsagainst two essential SARS-CoV-2 proteins, main protease (Mpro) and RNA-dependent RNA polymerase (RdRp), through molecular docking studies and to predict the drug-likeness properties of the compounds. …”
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Genome sequence of Leishmania mexicana MNYC/BZ/62/M379 expressing Cas9 and T7 RNA polymerase [version 1; peer review: 2 approved, 1 approved with reservations] by Ulrich Dobramysl, Tom Beneke, Jeremy Charles Mottram, Carolina Moura Costa Catta-Preta, Richard Wheeler, Eva Gluenz

“…We present the genome sequence of Leishmania mexicana MNYC/BZ/62/M379 modified to express Cas9 and T7 RNA-polymerase, revealing high similarity to the reference genome (MHOM/GT2001/U1103). …”
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Analysis the Effectiveness of Remdesivir, Galidesivir, Sofosbuvir, Tenofovir and Ribavirin as Potential Therapeutic Drug target against SARS-Cov-2 RNA-Dependent RNA Polymerase (RdRp): An in Silico Docking Study by Rajneesh Prajapat, Suman Jain

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An Adenovirus Vector Expressing FMDV RNA Polymerase Combined with a Chimeric VLP Harboring a Neutralizing Epitope as a Prime Boost Strategy to Induce FMDV-Specific Humoral and Cellular Responses by Giselle Rangel, Verónica Martín, Juan Bárcena, Esther Blanco, Alí Alejo

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A Single Nonsynonymous Substitution in the RNA-Dependent RNA Polymerase of <i>Potato virus Y</i> Allows the Simultaneous Breakdown of Two Different Forms of Antiviral Resistance in <i>Capsicum annuum</i> by Benoît Moury, Thierry Michon, Vincent Simon, Alain Palloix

“…The corresponding avirulence factor in the PVY genome is the NIb cistron (i.e., RNA-dependent RNA polymerase). Here, we describe a new source of potyvirus resistance in the Guatemalan accession <i>C. annuum</i> cv. …”
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Identifying non-nucleoside inhibitors of RNA-dependent RNA-polymerase of SARS-CoV-2 through per-residue energy decomposition-based pharmacophore modeling, molecular docking, and molecular dynamics simulation by Shahkaar Aziz, Muhammad Waqas, Tapan Kumar Mohanta, Sobia Ahsan Halim, Aqib Iqbal, Amjad Ali, Asaad Khalid, Ashraf N. Abdalla, Ajmal Khan, Ahmed Al-Harrasi

Subjects: “…RNA-dependent RNA-polymerase…”
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Genome-Wide Identification and Characterization of <i>Argonaute</i>, <i>Dicer-like</i> and <i>RNA-Dependent RNA Polymerase</i> Gene Families and Their Expression Analyses in <i>Fragaria</i> spp. by Xiaotong Jing, Linlin Xu, Xinjia Huai, Hong Zhang, Fengli Zhao, Yushan Qiao

“…In these processes, the protein factors Argonaute (AGO), Dicer-like (DCL), and RNA-dependent RNA polymerase (RDR) play very important roles in the synthesis of sRNAs respectively. …”
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Transcription inhibition by the depsipeptide antibiotic salinamide A by David Degen, Yu Feng, Yu Zhang, Katherine Y Ebright, Yon W Ebright, Matthew Gigliotti, Hanif Vahedian-Movahed, Sukhendu Mandal, Meliza Talaue, Nancy Connell, Eddy Arnold, William Fenical, Richard H Ebright

Subjects: “…RNA polymerase…”
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Targeting Ribosome Biogenesis in Cancer: Lessons Learned and Way Forward by Asimina Zisi, Jiri Bartek, Mikael S. Lindström

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GUN1 and Plastid RNA Metabolism: Learning from Genetics by Luca Tadini, Nicolaj Jeran, Paolo Pesaresi

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Nutrient-Driven O-GlcNAcylation at Promoters Impacts Genome-Wide RNA Pol II Distribution by Michael W. Krause, Dona C. Love, Salil K. Ghosh, Peng Wang, Sijung Yun, Tetsunari Fukushige, John A. Hanover

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Characterization of the PB2 Cap Binding Domain Accelerates Inhibitor Design by Amanda E. Constantinides, Chelsea C. Severin, Ryan H. Gumpper, Xiaofeng Zheng, Ming Luo

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Nucleic Acid Science – The Excitement of Discovery: Annual Symposium of the Chemical Society Zürich CGZ, Zürich, October 26, 2007 by Imre Berger, Christiane Schaffitzel, Christoph Bieniossek

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Molecular architecture of the yeast Mediator complex by Philip J Robinson, Michael J Trnka, Riccardo Pellarin, Charles H Greenberg, David A Bushnell, Ralph Davis, Alma L Burlingame, Andrej Sali, Roger D Kornberg

Subjects: “…RNA polymerase II…”
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Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy by Nikolas T. Martin, Mathieu J. F. Crupi, Zaid Taha, Joanna Poutou, Jack T. Whelan, Sydney Vallati, Julia Petryk, Ricardo Marius, Bradley Austin, Taha Azad, Mason Boulanger, Tamara Burgess, Ilson Sanders, Camille Victoor, Bryan C. Dickinson, Jean-Simon Diallo, Carolina S. Ilkow, John C. Bell

Subjects: “…Split-T7 RNA polymerase…”
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Editorial: Nucleic Acid Polymerases: The Two-Metal-Ion Mechanism and Beyond by Janice D. Pata, Janice D. Pata, Y. Whitney Yin, Indrajit Lahiri

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Predicting bacterial promoter function and evolution from random sequences by Mato Lagator, Srdjan Sarikas, Magdalena Steinrueck, David Toledo-Aparicio, Jonathan P Bollback, Calin C Guet, Gašper Tkačik

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TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer by Umakanta Swain, Gilgi Friedlander, Urmila Sehrawat, Avital Sarusi-Portuguez, Ron Rotkopf, Charlotte Ebert, Tamar Paz-Elizur, Rivka Dikstein, Thomas Carell, Nicholas E. Geacintov, Zvi Livneh

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Molecular Epidemiology and Characterization of Picobirnavirus in Wild Deer and Cattle from Australia: Evidence of Genogroup I and II in the Upper Respiratory Tract by Jose L. Huaman, Carlo Pacioni, Subir Sarker, Mark Doyle, David M. Forsyth, Anthony Pople, Jordan O. Hampton, Teresa G. Carvalho, Karla J. Helbig

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Molnupiravir—A Novel Oral Anti-SARS-CoV-2 Agent by Ching-Chi Lee, Chih-Chia Hsieh, Wen-Chien Ko

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