-
681
Ribavirin Treatment Failure-Associated Mutation, Y1320H, in the RNA-Dependent RNA Polymerase of Genotype 3 Hepatitis E Virus (HEV) Enhances Virus Replication in a Rabbit HEV Infection Model
Published 2023-04-01“…In the absence of an HEV-specific antiviral, ribavirin (RBV) has been used off-label, but treatment failure may occur due to mutations in the viral RNA-dependent RNA polymerase (RdRp), including Y1320H, K1383N, and G1634R. …”
Get full text
Article -
682
Discovery of Bispecific Lead Compounds from <i>Azadirachta indica</i> against ZIKA NS2B-NS3 Protease and NS5 RNA Dependent RNA Polymerase Using Molecular Simulations
Published 2022-04-01“…In this context, the present study adopted a strategy to explore the lead compounds from <i>Azadirachta indica</i> against ZIKV via concurrent inhibition of the NS2B-NS3 protease (ZIKV<sup>pro</sup>) and NS5 RNA dependent RNA polymerase (ZIKV<sup>RdRp</sup>) proteins using molecular simulations. …”
Get full text
Article -
683
Transient SARS-CoV-2 RNA-Dependent RNA Polymerase Mutations after Remdesivir Treatment for Chronic COVID-19 in Two Transplant Recipients: Case Report and Intra-Host Viral Genomic Investigation
Published 2023-08-01“…Remdesivir is the first FDA-approved drug for treating severe SARS-CoV-2 infection and targets RNA-dependent RNA polymerase (RdRp) that is required for viral replication. …”
Get full text
Article -
684
-
685
-
686
Sustainability of Populations of Wild Rice Species in Natural in situ Conservation Sites of South and West Sulawesi
Published 2015-12-01Subjects: “…wild rice species, oryza, pola1, rna polymerase i largest subunit…”
Get full text
Article -
687
RNA interference of Aspergillus flavus in response to Aspergillus flavus partitivirus 1 infection
Published 2023-11-01Subjects: Get full text
Article -
688
Amino Acid Substitutions in NS5 Contribute Differentially to Tembusu Virus Attenuation in Ducklings and Cell Cultures
Published 2021-05-01Subjects: Get full text
Article -
689
Diverse Functions of KDM5 in Cancer: Transcriptional Repressor or Activator?
Published 2022-07-01Subjects: Get full text
Article -
690
Preclinical Study of ZSP1273, a Potent Antiviral Inhibitor of Cap Binding to the PB2 Subunit of Influenza A Polymerase
Published 2023-02-01Subjects: Get full text
Article -
691
Indirubin-3′-monoxime exhibits potent antiviral and anti-inflammatory effects against human adenoviruses in vitro and in vivo
Published 2024-05-01Subjects: Get full text
Article -
692
Uncovering Plant Virus Species Forming Novel Provisional Taxonomic Units Related to the Family <i>Benyviridae</i>
Published 2022-11-01Subjects: Get full text
Article -
693
Pol IV-Dependent siRNA Production is Reduced in Brassica rapa
Published 2013-09-01Subjects: Get full text
Article -
694
-
695
<i>Bacillus subtilis</i> PcrA Helicase Removes Trafficking Barriers
Published 2021-04-01Subjects: Get full text
Article -
696
Remdesivir—Bringing Hope for COVID-19 Treatment
Published 2020-06-01Subjects: Get full text
Article -
697
Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor
Published 2019-12-01Subjects: Get full text
Article -
698
Harnessing the Nucleolar DNA Damage Response in Cancer Therapy
Published 2021-07-01Subjects: Get full text
Article -
699
Editorial: Transcription and its regulation in bacteria
Published 2023-05-01Subjects: Get full text
Article -
700