Ribavirin Treatment Failure-Associated Mutation, Y1320H, in the RNA-Dependent RNA Polymerase of Genotype 3 Hepatitis E Virus (HEV) Enhances Virus Replication in a Rabbit HEV Infection Model by Bo Wang, Hassan M. Mahsoub, Wen Li, C. Lynn Heffron, Debin Tian, Anna M. Hassebroek, Tanya LeRoith, Xiang-Jin Meng

“…In the absence of an HEV-specific antiviral, ribavirin (RBV) has been used off-label, but treatment failure may occur due to mutations in the viral RNA-dependent RNA polymerase (RdRp), including Y1320H, K1383N, and G1634R. …”
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Discovery of Bispecific Lead Compounds from <i>Azadirachta indica</i> against ZIKA NS2B-NS3 Protease and NS5 RNA Dependent RNA Polymerase Using Molecular Simulations by Sanjay Kumar, Sherif A. El-Kafrawy, Shiv Bharadwaj, S. S. Maitra, Thamir A. Alandijany, Arwa A. Faizo, Aiah M. Khateb, Vivek Dhar Dwivedi, Esam I. Azhar

“…In this context, the present study adopted a strategy to explore the lead compounds from <i>Azadirachta indica</i> against ZIKV via concurrent inhibition of the NS2B-NS3 protease (ZIKV^pro) and NS5 RNA dependent RNA polymerase (ZIKV^RdRp) proteins using molecular simulations. …”
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Transient SARS-CoV-2 RNA-Dependent RNA Polymerase Mutations after Remdesivir Treatment for Chronic COVID-19 in Two Transplant Recipients: Case Report and Intra-Host Viral Genomic Investigation by Shangxin Yang, Ashrit Multani, Jacob M. Garrigues, Michael S. Oh, Peera Hemarajata, Taylor Burleson, Nicole M. Green, Caspian Oliai, Pryce T. Gaynor, Omer E. Beaird, Drew J. Winston, Christopher S. Seet, Joanna M. Schaenman

“…Remdesivir is the first FDA-approved drug for treating severe SARS-CoV-2 infection and targets RNA-dependent RNA polymerase (RdRp) that is required for viral replication. …”
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RNA Polymerase II Transcription in <i>Pneumocystis</i>: TFIIB from <i>Pneumocystis carinii</i> Can Replace the Transcriptional Functions of Fission Yeast <i>Schizosaccharomyces pombe</i> TFIIB In Vivo and In Vitro by Diego A. Rojas, Fabiola Urbina, Aldo Solari, Edio Maldonado

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Performance Evaluation of Rapid Antigen Test for COVID-19 with SARS-CoV-2 RT-PCR using Nasopharyngeal Swab with Special Reference to RNA Dependent RNA Polymerase (RdRp) Cycle Threshold Values by Vidyut Prakash, Kumar Saurabh, Rishikesh Kumar, Randhir Kumar, Namrata Kumari, Shailesh Kumar

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Sustainability of Populations of Wild Rice Species in Natural in situ Conservation Sites of South and West Sulawesi by Rinaldi Sjahril, Nurhaya J. Panga, Muhammad Riadi, Tadashi Sato, Ikuo Nakamura

Subjects: “…wild rice species, oryza, pola1, rna polymerase i largest subunit…”
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RNA interference of Aspergillus flavus in response to Aspergillus flavus partitivirus 1 infection by Yinhui Jiang, Yinhui Jiang, Xiang Liu, Xiang Liu, Xun Tian, Xun Tian, Jianhong Zhou, Jianhong Zhou, Qinrong Wang, Qinrong Wang, Bi Wang, Bi Wang, Wenfeng Yu, Wenfeng Yu, Yanping Jiang, Tom Hsiang, Xiaolan Qi, Xiaolan Qi

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Amino Acid Substitutions in NS5 Contribute Differentially to Tembusu Virus Attenuation in Ducklings and Cell Cultures by Xue Sun, Mengxu Sun, Lijiao Zhang, Ziding Yu, Jinxin Li, Wanying Xie, Jingliang Su

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Diverse Functions of KDM5 in Cancer: Transcriptional Repressor or Activator? by Yasuyo Ohguchi, Hiroto Ohguchi

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Preclinical Study of ZSP1273, a Potent Antiviral Inhibitor of Cap Binding to the PB2 Subunit of Influenza A Polymerase by Xiaoxin Chen, Qinhai Ma, Manyu Zhao, Yuqin Yao, Qianru Zhang, Miao Liu, Zifeng Yang, Wenbin Deng

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Indirubin-3′-monoxime exhibits potent antiviral and anti-inflammatory effects against human adenoviruses in vitro and in vivo by Junyu Wang, Chaojie Yang, Zhixin Liang, Junping Sun, Mingyue Zhang, Shaofu Qiu, Xinying Du, Xi He, Xiaoying Pang, Xidong Ma, Mei Xie, Xinjie Han, Ru Fan, Enlu Zhou, Hairong Yu, Danyang She, Hongbin Song, Jianxin Wang

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Uncovering Plant Virus Species Forming Novel Provisional Taxonomic Units Related to the Family <i>Benyviridae</i> by Andrey G. Solovyev, Sergey Y. Morozov

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Pol IV-Dependent siRNA Production is Reduced in Brassica rapa by Rebecca A. Mosher, Yi Huang, Timmy Kendall

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Potential Role of Colchicine in Combating COVID-19 Cytokine Storm and Its Ability to Inhibit Protease Enzyme of SARS-CoV-2 as Conferred by Molecular Docking Analysis by Noha A. Kamel, Nasser S. M. Ismail, Ibrahim S. Yahia, Khaled M. Aboshanab

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<i>Bacillus subtilis</i> PcrA Helicase Removes Trafficking Barriers by María Moreno-del Álamo, Begoña Carrasco, Rubén Torres, Juan Carlos Alonso

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Remdesivir—Bringing Hope for COVID-19 Treatment by Naser F. Al-Tannak, Ladislav Novotny, Adel Alhunayan

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Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor by Juncao Xu, Kaijie Cui, Liqiang Shen, Jing Shi, Lingting Li, Linlin You, Chengli Fang, Guoping Zhao, Yu Feng, Bei Yang, Yu Zhang

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Harnessing the Nucleolar DNA Damage Response in Cancer Therapy by Jiachen Xuan, Kezia Gitareja, Natalie Brajanovski, Elaine Sanij

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Editorial: Transcription and its regulation in bacteria by Dong Wang, Dmytro Kompaniiets, Yangbo Hu, Bin Liu

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Cyclin-Dependent Kinases and CTD Phosphatases in Cell Cycle Transcriptional Control: Conservation across Eukaryotic Kingdoms and Uniqueness to Plants by Zhi-Liang Zheng

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