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141
RNA polymerase II clusters form in line with surface condensation on regulatory chromatin
Published 2021-09-01“…In eukaryotes, two major control points are recruitment of RNA polymerase II (Pol II) into a paused state, and subsequent pause release toward transcription. …”
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142
RNA Polymerase II transcription independent of TBP in murine embryonic stem cells
Published 2023-03-01“…Transcription by RNA Polymerase II (Pol II) is initiated by the hierarchical assembly of the pre-initiation complex onto promoter DNA. …”
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143
Argonaute-Bound Small RNAs from Promoter-Proximal RNA Polymerase II
Published 2017“…A subset of promoter-proximal RNA polymerase II (RNAPII) complexes produces hairpin RNAs that are processed in a DiGeorge syndrome critical region gene 8 (Dgcr8)/Drosha-independent but Dicer-dependent manner. …”
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144
Functional Association of Gdown1 with RNA Polymerase II Poised on Human Genes
Published 2018“…Most human genes are loaded with promoter-proximally paused RNA polymerase II (Pol II) molecules that are poised for release into productive elongation by P-TEFb. …”
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145
CTD kinase associated with yeast RNA polymerase II initiation factor b.
Published 1991“…A kinase activity specific for the C-terminal repeat domain (CTD) of RNA polymerase II is associated with nearly homogeneous yeast general initiation factor b by three criteria: cofractionation on the basis of size and charge and coinactivation by mild heat treatment. …”
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146
CHARACTERIZATION OF YEAST RNA POLYMERASE-II TRANSCRIPTION FACTOR-B AND CTD KINASE
Published 1993Journal article -
147
Multiple transcript cleavage precedes polymerase release in termination by RNA polymerase II.
Published 2001“…The requirement of poly(A) signals to elicit transcription termination of RNA polymerase II (pol II) is firmly established. However, little else is known about the actual process of pol II transcription termination. …”
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148
RNA polymerase II activity is located on the surface of protein-rich transcription factories.
Published 2008Journal article -
149
Regulation of expression of human RNA polymerase II-transcribed snRNA genes
Published 2017“…In addition to protein-coding genes, RNA polymerase II (pol II) transcribes numerous genes for non-coding RNAs, including the small-nuclear (sn)RNA genes. snRNAs are an important class of non-coding RNAs, several of which are involved in pre-mRNA splicing. …”
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150
Regulation of expression of RNA polymerase II-transcribed human snRNA genes
Published 2019“…Transcription initiation of snRNA genes is mediated by transcription factors like Oct-1, which recognize the DSE element, and by PTF, which recognizes the PSE and nucleates a pre-initiation complex (PIC) comprising general transcription factors TFIIA, B, C, E, F and H, TBP and some TBPassociated factors, and Mediator. RNA polymerase II (pol II) is then recruited with the carboxylterminal domain (CTD) of the large subunit in a hypophosphorylated form. …”
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151
The fitness cost of rifampicin resistance in Pseudomonas aeruginosa depends on demand for RNA polymerase.
Published 2011“…In this article, we show that the average cost of rifampicin resistance in the pathogenic bacterium Pseudomonas aeruginosa is reduced by the addition of ribosome inhibitors (chloramphenicol or streptomycin) that indirectly constrain transcription rate and therefore reduce demand for RNA polymerase activity. This effect is consistent with predictions from metabolic control theory. …”
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152
Active RNA polymerase I is fixed within the nucleus of HeLa cells.
Published 1990“…We have investigated whether active RNA polymerase I, the enzyme responsible for transcribing ribosomal RNA, is immobilized by attachment to a large subnuclear structure in HeLa cells. …”
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153
Interplay between influenza virus and the host RNA polymerase II transcriptional machinery
Published 2019“…The influenza virus RNA-dependent RNA polymerase (RdRP) cleaves the 5′ end of nascent capped host RNAs and uses the capped RNA fragment to prime viral transcription in a mechanism called ‘cap snatching’. …”
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154
Role of R-loops in pause-dependent transcriptional termination of RNA polymerase II
Published 2012“…Transcription termination of RNA polymerase II (Pol II) in mammals requires a functional poly(A) signal and either downstream pause sites or co-transcriptional cleavage (CoTC) sequences together with 3’transcript degradation by the nuclear 5’-3’ exonuclease Xrn2. …”
Thesis -
155
Terminal exon definition occurs cotranscriptionally and promotes termination of RNA polymerase II.
Published 1999Journal article -
156
In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading.
Published 2003“…HaploChIP showed close correlation between the level of bound phosphorylated RNA polymerase II at the SNRPN locus and allele-specific expression. …”
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157
Does transcription by RNA polymerase play a direct role in the initiation of replication?
Published 1994“…RNA polymerases have been implicated in the initiation of replication in bacteria. …”
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158
RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates
Published 2020“…We identify five mutations in these genes that each increase resistance to ceftriaxone, including one mutation that arose independently in two lineages, and show that clinical isolates from multiple lineages are a single nucleotide change from ceftriaxone resistance. These RNA polymerase mutations cause large-scale transcriptional changes without altering susceptibility to other antibiotics, reducing growth rate, or deranging cell morphology. …”
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159
Live-cell superresolution microscopy reveals the organization of RNA polymerase in the bacterial nucleoid
Published 2015“…Despite the fundamental importance of transcription, a comprehensive analysis of RNA polymerase (RNAP) behavior and its role in the nucleoid organization in vivo is lacking. …”
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160
Active RNA polymerases are localized within discrete transcription "factories' in human nuclei.
Published 1996“…A typical site contained a cluster (diameter 71 nm) of at least 4, and probably about 20, engaged polymerases, plus associated transcripts that partially overlapped a zone of RNA polymerase II, ribonucleoproteins, and proteins rich in thiols and acidic groups. …”
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