Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis by Christopher Duncan-Lewis, Ella Hartenian, Valeria King, Britt A Glaunsinger

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Condensin II Counteracts Cohesin and RNA Polymerase II in the Establishment of 3D Chromatin Organization by M. Jordan Rowley, Xiaowen Lyu, Vibhuti Rana, Masami Ando-Kuri, Rachael Karns, Giovanni Bosco, Victor G. Corces

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Repression of RNA polymerase II elongation in vivo is critically dependent on the C-terminus of Spt5. by Hui Chen, Xavier Contreras, Yuki Yamaguchi, Hiroshi Handa, B Matija Peterlin, Su Guo

“…The stalling of RNA polymerase II (RNAPII) at the promoters of many genes, including developmental regulators, stress-responsive genes, and HIVLTR, suggests transcription elongation as a critical regulatory step in addition to initiation. …”
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BRCA2 Regulates Transcription Elongation by RNA Polymerase II to Prevent R-Loop Accumulation by Mahmud K.K. Shivji, Xavier Renaudin, Çiğdem H. Williams, Ashok R. Venkitaraman

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Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1 by Rina Hirano, Haruhiko Ehara, Tomoya Kujirai, Tamami Uejima, Yoshimasa Takizawa, Shun-ichi Sekine, Hitoshi Kurumizaka

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Condensin controls recruitment of RNA polymerase II to achieve nematode X-chromosome dosage compensation by William S Kruesi, Leighton J Core, Colin T Waters, John T Lis, Barbara J Meyer

“…Here we define TSSs and the distribution of transcriptionally engaged RNA polymerase II (Pol II) genome-wide in wild-type and dosage-compensation-defective animals to dissect this regulatory mechanism. …”
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Maintenance of long-range DNA interactions after inhibition of ongoing RNA polymerase II transcription. by Robert-Jan Palstra, Marieke Simonis, Petra Klous, Emilie Brasset, Bart Eijkelkamp, Wouter de Laat

“…We demonstrate that upon transcription inhibition binding of RNA polymerase II to gene regulatory elements is severely reduced. …”
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Autophagy receptor NDP52 alters DNA conformation to modulate RNA polymerase II transcription by Ália dos Santos, Daniel E. Rollins, Yukti Hari-Gupta, Hannah McArthur, Mingxue Du, Sabrina Yong Zi Ru, Kseniia Pidlisna, Ane Stranger, Faeeza Lorgat, Danielle Lambert, Ian Brown, Kevin Howland, Jesse Aaron, Lin Wang, Peter J. I. Ellis, Teng-Leong Chew, Marisa Martin-Fernandez, Alice L. B. Pyne, Christopher P. Toseland

“…We find that NDP52 clusters with RNA Polymerase II (RNAPII) at transcription initiation sites and that its overexpression promotes the formation of additional transcriptional clusters. …”
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Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone. by Giorgio Giacomo Galli, Kristian Honnens de Lichtenberg, Matteo Carrara, Wolfgang Hans, Manuela Wuelling, Bettina Mentz, Hinke Arnolda Multhaupt, Cathrine Kolster Fog, Klaus Thorleif Jensen, Juri Rappsilber, Andrea Vortkamp, Les Coulton, Helmut Fuchs, Valérie Gailus-Durner, Martin Hrabě de Angelis, Raffaele Adolfo Calogero, John Robert Couchman, Anders Henrik Lund

“…In particular, we show that Prdm5 controls both Collagen I transcription and fibrillogenesis by binding inside the Col1a1 gene body and maintaining RNA polymerase II occupancy. In vivo, Prdm5 loss results in delayed ossification involving a pronounced impairment in the assembly of fibrillar collagens. …”
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A DNA damage response system associated with the phosphoCTD of elongating RNA polymerase II. by Tiffany Sabin Winsor, Bartlomiej Bartkowiak, Craig B Bennett, Arno L Greenleaf

“…RNA polymerase II translocates across much of the genome and since it can be blocked by many kinds of DNA lesions, detects DNA damage proficiently; it thereby contributes to DNA repair and to normal levels of DNA damage resistance. …”
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Poised RNA Polymerase II Changes over Developmental Time and Prepares Genes for Future Expression by Bjoern Gaertner, Jeff Johnston, Kai Chen, Nina Wallaschek, Ariel Paulson, Alexander S. Garruss, Karin Gaudenz, Bony De Kumar, Robb Krumlauf, Julia Zeitlinger

“…Poised RNA polymerase II (Pol II) is predominantly found at developmental control genes and is thought to allow their rapid and synchronous induction in response to extracellular signals. …”
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Recruitment of TREX to the transcription machinery by its direct binding to the phospho-CTD of RNA polymerase II. by Dominik M Meinel, Cornelia Burkert-Kautzsch, Anja Kieser, Eoghan O'Duibhir, Matthias Siebert, Andreas Mayer, Patrick Cramer, Johannes Söding, Frank C P Holstege, Katja Sträßer

“…Here, we show that TREX is recruited to the transcription machinery by direct interaction of its subcomplex THO with the serine 2-serine 5 (S2/S5) diphosphorylated CTD of RNA polymerase II. S2 and/or tyrosine 1 (Y1) phosphorylation of the CTD is required for TREX occupancy in vivo, establishing a second interaction platform necessary for TREX recruitment in addition to RNA. …”
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Distinct Cdk9-phosphatase switches act at the beginning and end of elongation by RNA polymerase II by Pabitra K. Parua, Sampada Kalan, Bradley Benjamin, Miriam Sansó, Robert P. Fisher

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Phosphorylation Status of RNA Polymerase II Carboxyl-terminal Domain in Porcine Oocytes and Early Embryos by Reza K. Oqani, Jin Yu Zhang, Min Gu Lee, Yun Fei Diao, Dong-Il Jin

Subjects: “…RNA Polymerase II…”
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Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides. by Jamie J Arnold, Suresh D Sharma, Joy Y Feng, Adrian S Ray, Eric D Smidansky, Maria L Kireeva, Aesop Cho, Jason Perry, Jennifer E Vela, Yeojin Park, Yili Xu, Yang Tian, Darius Babusis, Ona Barauskus, Blake R Peterson, Averell Gnatt, Mikhail Kashlev, Weidong Zhong, Craig E Cameron

“…We show that all of the anti-HCV ribonucleoside analogues are substrates for human mitochondrial RNA polymerase (POLRMT) and eukaryotic core RNA polymerase II (Pol II) in vitro. Unexpectedly, analogues containing 2'-C-methyl, 4'-methyl and 4'-azido substituents were inhibitors of POLRMT and Pol II. …”
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The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome by Tim Krischuns, Benoît Arragain, Catherine Isel, Sylvain Paisant, Matthias Budt, Thorsten Wolff, Stephen Cusack, Nadia Naffakh

“…Abstract The current model is that the influenza virus polymerase (FluPol) binds either to host RNA polymerase II (RNAP II) or to the acidic nuclear phosphoprotein 32 (ANP32), which drives its conformation and activity towards transcription or replication of the viral genome, respectively. …”
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The nucleosomal barrier to promoter escape by RNA polymerase II is overcome by the chromatin remodeler Chd1 by Peter J Skene, Aaron E Hernandez, Mark Groudine, Steven Henikoff

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GRANT Motif Regulates CENP-A Incorporation and Restricts RNA Polymerase II Accessibility at Centromere by Hwei Ling Tan, Ee Sin Chen

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The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity by Cian J. Lynch, Raquel Bernad, Isabel Calvo, Sandrina Nóbrega-Pereira, Sergio Ruiz, Nuria Ibarz, Ana Martinez-Val, Osvaldo Graña-Castro, Gonzalo Gómez-López, Eduardo Andrés-León, Vladimir Espinosa Angarica, Antonio del Sol, Sagrario Ortega, Oscar Fernandez-Capetillo, Enrique Rojo, Javier Munoz, Manuel Serrano

“…Keywords: transcription, RNA polymerase II, Mediator, cell identity, differentiation, interactome, enhancer…”
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Striatal NELF-mediated RNA polymerase II stalling controls l-dopa induced dyskinesia by Matthieu F. Bastide, Simone Bido, Nathalie Duteil, Erwan Bézard

“…Their rapid transcription involves the stalling of RNA polymerase II on IEG promoters, a mechanism that critically depends on the presence of the negative elongation factor (NELF) protein complex. …”
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