RNA polymerase II pausing is essential during spermatogenesis for appropriate gene expression and completion of meiosis by Emily G. Kaye, Kavyashree Basavaraju, Geoffrey M. Nelson, Helena D. Zomer, Debarun Roy, Irene Infancy Joseph, Reza Rajabi-Toustani, Huanyu Qiao, Karen Adelman, Prabhakara P. Reddi

“…We discover a requirement for pausing of RNA Polymerase II (Pol II) at the earliest stages of sperm differentiation to establish the landscape of gene activity across development. …”
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Dnmt2/Trdmt1 as Mediator of RNA Polymerase II Transcriptional Activity in Cardiac Growth. by Hossein Ghanbarian, Nicole Wagner, Beatrice Polo, Delphine Baudouy, Jafar Kiani, Jean-François Michiels, François Cuzin, Minoo Rassoulzadegan, Kay-Dietrich Wagner

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MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts by Papadopoulos, Dimitrios, Solvie, Daniel, Baluapuri, Apoorva, Endres, Theresa, Ha, Stefanie Anh, Herold, Steffi, Kalb, Jacqueline, Giansanti, Celeste, Schülein-Völk, Christina, Ade, Carsten Patrick, Schneider, Cornelius, Gaballa, Abdallah, Vos, Seychelle, Fischer, Utz, Dobbelstein, Matthias, Wolf, Elmar, Eilers, Martin

“…In the absence of the exosome, MYCN-directed elongation by RNA polymerase II (RNAPII) is slow and non-productive on a large group of cell-cycle-regulated genes. …”
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Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome by Flynn, Ryan A., Almada, Albert Ernesto, Zamudio, Jesse Ray, Sharp, Phillip A.

“…Divergent transcription occurs at the majority of RNA polymerase II (RNAPII) promoters in mouse embryonic stem cells (mESCs), and this activity correlates with CpG islands. …”
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Transcription termination and RNA degradation contribute to silencing of RNA polymerase II transcription within heterochromatin. by Vasiljeva, L, Kim, M, Terzi, N, Soares, L, Buratowski, S

“…Within the heterochromatin of budding yeast, RNA polymerase II (RNAPII) transcription is repressed by the Sir2 deacetylase. …”

An unusual eukaryotic protein phosphatase required for transcription by RNA polymerase II and CTD dephosphorylation in S. cerevisiae. by Kobor, MS, Archambault, J, Lester, W, Holstege, F, Gileadi, O, Jansma, D, Jennings, E, Kouyoumdjian, F, Davidson, A, Young, R, Greenblatt, J

“…We show here that the essential FCP1 gene of S. cerevisiae is linked genetically to RNA polymerase II and encodes a CTD phosphatase essential for dephosphorylation of RNA polymerase II in vivo. …”

Influenza virus mounts a two-pronged attack on host RNA polymerase II transcription by Bauer, D, Tellier, M, Martinez-Alonso, M, Nojima, T, Proudfoot, N, Murphy, S, Fodor, E

“…Influenza virus intimately associates with host RNA polymerase II (Pol II) and mRNA processing machinery. …”

AT-rich sequence elements promote nascent transcript cleavage leading to RNA polymerase II termination. by White, E, Kamieniarz-Gdula, K, Dye, M, Proudfoot, N

“…RNA Polymerase II (Pol II) termination is dependent on RNA processing signals as well as specific terminator elements located downstream of the poly(A) site. …”

Serine-7 of the RNA polymerase II CTD is specifically required for snRNA gene expression by Egloff, S, O'Reilly, D, Chapman, R, Taylor, A, Tanzhaus, K, Pitts, L, Eick, D, Murphy, S

“…RNA polymerase II (Pol II) transcribes genes that encode proteins and noncoding small nuclear RNAs (snRNAs). …”

Mammalian cell lines expressing functional RNA polymerase II tagged with the green fluorescent protein. by Sugaya, K, Vigneron, M, Cook, P

“…RNA polymerase II is a multi-subunit enzyme responsible for transcription of most eukaryotic genes. …”

A novel TBP-TAF complex on RNA polymerase II-transcribed snRNA genes. by Zaborowska, J, Taylor, A, Murphy, S

“…Initiation of transcription of most human genes transcribed by RNA polymerase II (RNAP II) requires the formation of a preinitiation complex comprising TFIIA, B, D, E, F, H and RNAP II. …”

Association of the influenza A virus RNA-dependent RNA polymerase with cellular RNA polymerase II. by Engelhardt, O, Smith, M, Fodor, E

“…Transcription by the influenza virus RNA-dependent RNA polymerase is dependent on cellular RNA processing activities that are known to be associated with cellular RNA polymerase II (Pol II) transcription, namely, capping and splicing. …”

Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity by Eaton, J, Davidson, L, Bauer, D, Natsume, T, Kanemaki, M, West, S

Role of the C-terminal domain of RNA polymerase II in expression of small nuclear RNA genes. by Egloff, S, Murphy, S

“…Pol II (RNA polymerase II) transcribes the genes encoding proteins and non-coding snRNAs (small nuclear RNAs). …”

Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II. by Morillon, A, Karabetsou, N, O'Sullivan, J, Kent, N, Proudfoot, N, Mellor, J

Cloning of a subunit of yeast RNA polymerase II transcription factor b and CTD kinase. by Gileadi, O, Feaver, W, Kornberg, R

“…Yeast RNA polymerase II initiation factor b copurifies with three polypeptides of 85, 73, and 50 kilodaltons and with a protein kinase that phosphorylates the carboxyl-terminal repeat domain (CTD) of the largest polymerase subunit. …”

Investigating the role of Dis2 phosphatase in RNA Polymerase II transcription termination in fission yeast by Kecman, T

“…<p>The end of the RNA polymerase II (Pol II) transcription cycle is a tightly regulated process that requires: (i) dissociation of elongation factors, (ii) recruitment of the 3' end processing machinery that is essential for premRNA cleavage and polyadenylation, and (iii) association of termination factors to dislodge Pol II from the DNA template. …”

Mechanisms and functional implications of the degradation of host RNA polymerase II in influenza virus infected cells. by Vreede, F, Chan, A, Sharps, J, Fodor, E

“…Here, we report that the large subunit of host RNA polymerase II (Pol II) is degraded in infected cells and propose that this degradation is mediated by the viral RNA polymerase that associates with Pol II. …”

Improving Saccharomyces cerevisiae ethanol production and tolerance via RNA polymerase II subunit Rpb7 by Zilong Qiu, Rongrong Jiang

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The cooperative action of CSB, CSA, and UVSSA target TFIIH to DNA damage-stalled RNA polymerase II by Yana van der Weegen, Hadar Golan-Berman, Tycho E. T. Mevissen, Katja Apelt, Román González-Prieto, Joachim Goedhart, Elisheva E. Heilbrun, Alfred C. O. Vertegaal, Diana van den Heuvel, Johannes C. Walter, Sheera Adar, Martijn S. Luijsterburg

“…The response to DNA damage-stalled RNA polymerase II leads to the assembly of the transcription-coupled repair (TCR) complex on actively transcribed strands. …”
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