Inhibition of pre-mRNA splicing by a synthetic Blom7α-interacting small RNA. by Marlies Löscher, Markus Schosserer, Eric Dausse, Kiseok Lee, Paul Ajuh, Regina Grillari-Voglauer, Angus I Lamond, Jean-Jacques Toulmé, Johannes Grillari, Johannes Grillari

“…Originally the novel protein Blom7α was identified as novel pre-mRNA splicing factor that interacts with SNEV(Prp19/Pso4), an essential protein involved in extension of human endothelial cell life span, DNA damage repair, the ubiquitin-proteasome system, and pre-mRNA splicing. …”
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RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer by Adam E. Hall, Sebastian Öther-Gee Pohl, Patrizia Cammareri, Stuart Aitken, Nicholas T. Younger, Michela Raponi, Caroline V. Billard, Alfonso Bolado Carrancio, Aslihan Bastem, Paz Freile, Fiona Haward, Ian R. Adams, Javier F. Caceres, Paula Preyzner, Alex von Kriegsheim, Malcolm G. Dunlop, Farhat V. Din, Kevin B. Myant

“…The influence of mRNA splicing on colon cancer development and progression is unclear. …”
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Transcriptome-wide analysis of alternative RNA splicing events in Epstein-Barr virus-associated gastric carcinomas. by Victoria E S Armero, Marie-Pier Tremblay, Andréa Allaire, Simon Boudreault, Camille Martenon-Brodeur, Cyntia Duval, Mathieu Durand, Elvy Lapointe, Philippe Thibault, Maude Tremblay-Létourneau, Jean-Pierre Perreault, Michelle S Scott, Martin Bisaillon

“…Multiple human diseases including cancer have been associated with a dysregulation in RNA splicing patterns. In the current study, modifications to the global RNA splicing landscape of cellular genes were investigated in the context of Epstein-Barr virus-associated gastric cancer. …”
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Food-Derived Compounds Apigenin and Luteolin Modulate mRNA Splicing of Introns with Weak Splice Sites by Masashi Kurata, Naoko Fujiwara, Ken-ichi Fujita, Yasutaka Yamanaka, Shigeto Seno, Hisato Kobayashi, Yusaku Miyamae, Nobuyuki Takahashi, Yasuyuki Shibuya, Seiji Masuda

“…They bind to mRNA splicing-related proteins to induce a widespread change of splicing patterns in treated cells. …”
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Short-term hypoxia triggers ROS and SAFB mediated nuclear matrix and mRNA splicing remodeling by Chrysa Taze, Sotiria Drakouli, Martina Samiotaki, George Panayotou, George Simos, Eleni Georgatsou, Ilias Mylonis

“…Depletion of SAFB1/2 under normoxia phenocopies the hypoxic and ROS-mediated switch in VEGF mRNA splicing. These data suggest that ROS-dependent remodeling of the nuclear architecture can promote production of splicing variants that facilitate adaptation to hypoxia.…”
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Comparison of in silico strategies to prioritize rare genomic variants impacting RNA splicing for the diagnosis of genomic disorders by Charlie Rowlands, Huw B. Thomas, Jenny Lord, Htoo A. Wai, Gavin Arno, Glenda Beaman, Panagiotis Sergouniotis, Beatriz Gomes-Silva, Christopher Campbell, Nicole Gossan, Claire Hardcastle, Kevin Webb, Christopher O’Callaghan, Robert A. Hirst, Simon Ramsden, Elizabeth Jones, Jill Clayton-Smith, Andrew R. Webster, Genomics England Research Consortium, Andrew G. L. Douglas, Raymond T. O’Keefe, William G. Newman, Diana Baralle, Graeme C. M. Black, Jamie M. Ellingford

“…Abstract The development of computational methods to assess pathogenicity of pre-messenger RNA splicing variants is critical for diagnosis of human disease. …”
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Vex-seq: high-throughput identification of the impact of genetic variation on pre-mRNA splicing efficiency by Scott I. Adamson, Lijun Zhan, Brenton R. Graveley

“…Although many synonymous and non-coding variants act through altering the efficiency of pre-mRNA splicing, it is difficult to predict how these variants impact pre-mRNA splicing. …”
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CPSF3 Promotes Pre-mRNA Splicing and Prevents CircRNA Cyclization in Hepatocellular Carcinoma by Ying Huang, Haofei Ji, Jiani Dong, Xueying Wang, Zhilin He, Zeneng Cheng, Qubo Zhu

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Optimized approach for Ion Proton RNA sequencing reveals details of RNA splicing and editing features of the transcriptome. by Roger B Brown, Nathaniel J Madrid, Hideaki Suzuki, Scott A Ness

“…RNA-sequencing (RNA-seq) has become the standard method for unbiased analysis of gene expression but also provides access to more complex transcriptome features, including alternative RNA splicing, RNA editing, and even detection of fusion transcripts formed through chromosomal translocations. …”
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Do Fragile X Syndrome and Other Intellectual Disorders Converge at Aberrant Pre-mRNA Splicing? by Sneha Shah, Joel D. Richter

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Altered Expression of RNA Splicing Proteins in Alzheimer's Disease Patients: Evidence from Two Microarray Studies by Jenny Wong

“…Background/Aims: Dysregulation of pre-mRNA splicing from an altered expression of RNA splice-regulatory proteins may act as the convergence point underlying aberrant gene expression changes in Alzheimer's disease (AD). …”
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Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow by Patrick A Murphy, Vincent L Butty, Paul L Boutz, Shahinoor Begum, Amy L Kimble, Phillip A Sharp, Christopher B Burge, Richard O Hynes

“…Endothelial deletion of Rbfox2, the only family member expressed in arterial endothelium, suppresses a subset of the changes in transcription and RNA splicing induced by low flow. Our data reveal an alternative splicing program activated by Rbfox2 in the endothelium on recruitment of platelets and macrophages and demonstrate its relevance in transcriptional responses during flow-driven vascular inflammation.…”
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Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow by Kimble, Amy L., Murphy, Patrick A., Butty, Vincent L. G., Boutz, Paul, Begum, Shahinoor, Sharp, Phillip A., Burge, Christopher B., Hynes, Richard O.

“…Endothelial deletion of Rbfox2, the only family member expressed in arterial endothelium, suppresses a subset of the changes in transcription and RNA splicing induced by low flow. Our data reveal an alternative splicing program activated by Rbfox2 in the endothelium on recruitment of platelets and macrophages and demonstrate its relevance in transcriptional responses during flow-driven vascular inflammation.…”
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The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages by Hassan, Musa A., Saeij, Jeroen, Butty, Vincent L G, Jensen, Kirk D.

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Identification of cis-acting elements and splicing factors involved in the regulation of BIM pre-mRNA splicing by Juan, Wen Chun, Roca, Xavier, Ong, S. Tiong

“…Altering BIM pre-mRNA splicing is an attractive approach to modulate apoptosis because BIM activity is partly determined by the alternative splicing of exons 3 or 4, whereby exon 3-containing transcripts are not apoptotic. …”
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Sustained cancer‐relevant alternative RNA splicing events driven by PRMT5 in high‐risk neuroblastoma by Bate‐Eya, LT, Albayrak, G, Carr, SM, Shrestha, A, Kanapin, A, Samsonova, A, La Thangue, NB

“…Our findings suggest that a sustained cancer‐relevant alternative RNA splicing programme desensitises NB cells to apoptosis, and identify PRMT5 as a potential therapeutic target for high‐risk disease.…”

Alternative splicing and disease / by Jeanteur, Ph. (Philippe)

Subjects:

Alternative Splicing in Myeloid Malignancies by Carmelo Gurnari, Simona Pagliuca, Valeria Visconte

Subjects: “…RNA-splicing…”
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Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's diseaseResearch in context by Vincent Tano, Kagistia Hana Utami, Nur Amirah Binte Mohammad Yusof, Jocelyn Bégin, Willy Wei Li Tan, Mahmoud A. Pouladi, Sarah R. Langley

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Exon junction complex proteins bind nascent transcripts independently of pre-mRNA splicing in Drosophila melanogaster by Subhendu Roy Choudhury, Anand K Singh, Tina McLeod, Marco Blanchette, Boyun Jang, Paul Badenhorst, Aditi Kanhere, Saverio Brogna

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