Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation by Bullock, A, Das, S, Debreczeni, J, Rellos, P, Fedorov, O, Niesen, F, Guo, K, Papagrigoriou, E, Amos, A, Cho, S, Turk, B, Ghosh, G, Knapp, S

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7.343 An RNA Safari: Exploring the Surprising Diversity of Mammalian Transcriptomes, Spring 2016 by Pai, Athma, Taliaferro, Matthew

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Altered splicing of ATG16‐L1 mediates acquired resistance to tyrosine kinase inhibitors of EGFR by blocking autophagy in non‐small cell lung cancer by Anne‐Sophie Hatat, Clara Benoit‐Pilven, Amélie Pucciarelli, Florence deFraipont, Lucie Lamothe, Pascal Perron, Amandine Rey, Matteo Giaj Levra, Anne‐Claire Toffart, Didier Auboeuf, Beatrice Eymin, Sylvie Gazzeri

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Chromatin target of protein arginine methyltransferases alleviates cerebral ischemia/reperfusion-induced injury by regulating RNA alternative splicing by Yu Cui, Zhaolong Zhang, Mengfei Lv, Zhongying Duan, Wenhao Liu, Jingchen Gao, Rui Xu, Qi Wan

“…Summary: RNA splicing is a post-transcriptional event that regulates many physiological and pathological events. …”
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The role of splicing factor mutations in the pathogenesis of the myelodysplastic syndromes. by Boultwood, J, Dolatshad, H, Varanasi, S, Yip, B, Pellagatti, A

“…Accurate pre-mRNA splicing by the spliceosome is a fundamental cellular mechanism required to remove introns that are present in most protein-coding transcripts. …”

Splice Variants of the RTK Family: Their Role in Tumour Progression and Response to Targeted Therapy by Cherine Abou-Fayçal, Anne-Sophie Hatat, Sylvie Gazzeri, Beatrice Eymin

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Alternative splicing: an important mechanism for myometrial gene regulation that can be manipulated to target specific genes associated with preterm labour by Tyson-Capper Alison

“…There is ample evidence to suggest that specific genes are co-ordinately regulated within the upper and lower regions of the myometrium prior to and during parturition and many of these genes are regulated by alternative pre-mRNA splicing. This mini-review highlights that expression of a range of different splicing factors, with defined roles in pre-mRNA splicing, is both temporally and spatially regulated within the uterine smooth muscle during pregnancy and labour. …”

Impact of Alternative Splicing on the Human Proteome by Yansheng Liu, Mar Gonzàlez-Porta, Sergio Santos, Alvis Brazma, John C. Marioni, Ruedi Aebersold, Ashok R. Venkitaraman, Vihandha O. Wickramasinghe

“…Here, we have developed an integrative approach to ask whether perturbations in mRNA splicing patterns alter the composition of the proteome. …”
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Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome. by Ronghui Li, Qiping Dong, Xinni Yuan, Xin Zeng, Yu Gao, Cassandra Chiao, Hongda Li, Xinyu Zhao, Sunduz Keles, Zefeng Wang, Qiang Chang

“…To reveal the functional consequence of altered RNA splicing due to the loss of MeCP2, we focused on the regulation of the splicing of the flip/flop exon of Gria2 and other AMPAR genes. …”
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PRMT5 and CDK4/6 inhibition result in distinctive patterns of alternative splicing in melanoma. by Lok Hang Chan, Peihan Wang, Shatha Abuhammad, Lydia Rui Jia Lim, Joseph Cursons, Karen E Sheppard, David L Goode

“…We performed full-length mRNA sequencing on CHL1 and A375 melanoma cell lines treated with the CDK4/6 inhibitor palbociclib and the PRMT5 inhibitor GSK3326595 and analysed data for differential gene expression and differential pre-mRNA splicing induced by these agents. Changes in gene expression and RNA splicing were more extensive under PRMT5 inhibition than under CDK4/6 inhibition. …”
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Functional genetic analysis of motor neuron disease by Bäumer, D

“…The results indicate that altered pre-mRNA splicing is a late occurrence in disease and more likely to be a consequence rather than the cause of motor neuron degeneration. …”

Insights into the U1 small nuclear ribonucleoprotein complex superfamily by Guiro, J, O'Reilly, D

“…Although best known for its role in pre-messenger RNA (mRNA) splicing events, research over the past 20 years has revealed diverse functions of this ncRNA in mammalian cell types. …”

Genome- and transcriptome-wide splicing associations with alcohol use disorder by Spencer B. Huggett, Ami S. Ikeda, Qingyue Yuan, Chelsie E. Benca-Bachman, Rohan H. C. Palmer

“…Abstract Genetic mechanisms of alternative mRNA splicing have been shown in the brain for a variety of neuropsychiatric traits, but not substance use disorders. …”
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DNA/RNA structure and processing in vitro and in cells: from probing to prediction by Korsakova, Anna

“…Contextual machine learning is further applied to predict alternative RNA splicing in cells using RNA-binding protein (RBP) levels. …”
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The role of the U5 snRNP in genetic disorders and cancer  by Wood, KA, Eadsforth, MA, Newman, WG, O’Keefe, RT

“…Pre-mRNA splicing is performed by the spliceosome, a dynamic macromolecular complex consisting of five small uridine-rich ribonucleoprotein complexes (the U1, U2, U4, U5, and U6 snRNPs) and numerous auxiliary splicing factors. …”

Splicing factor SF3B1K700E mutant dysregulates erythroid differentiation via aberrant alternative splicing of transcription factor TAL1. by Shuiling Jin, Hairui Su, Ngoc-Tung Tran, Jing Song, Sydney S Lu, Ying Li, Suming Huang, Omar Abdel-Wahab, Yanyan Liu, Xinyang Zhao

“…In addition, K700E mutant alters the RNA splicing of transcription factors TAL1 and GATA1. …”
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A novel heterozygous splice-altering mutation in HFM1 may be a cause of premature ovarian insufficiency by Jing Zhe, Shiling Chen, Xin Chen, Yudong Liu, Ying Li, Xingyu Zhou, Jun Zhang

“…Results of the minigene assay revealed that the mutation changed the mRNA splicing repertory. Conclusions The missense mutation of the HFM1 gene (c.3470G > A) may be a cause of POI. …”
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An investigation of the role of mutations in the spliceosome machinery in the myelodysplastic syndromes by Lee, J

“…Mutations in splicing factor genes (including SF3B1, SRSF2 and U2AF1) occur in over half of MDS patients and result in aberrant pre-mRNA splicing of many target genes, indicating that aberrant spliceosome function plays a key role in the pathogenesis of MDS. …”

The genetics of myelodysplastic syndromes and the opportunities for tailored treatments by Christina-Nefeli Kontandreopoulou, Konstantinos Kalopisis, Nora-Athina Viniou, Panagiotis Diamantopoulos

“…RNA-splicing and DNA methylation mutations seem to occur early and are reported as driver mutations in over 50% of MDS patients. …”
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N6-methyladenosine reader protein YTHDC1 regulates influenza A virus NS segment splicing and replication. by Yinxing Zhu, Ruifang Wang, Jiahui Zou, Shan Tian, Luyao Yu, Yuanbao Zhou, Ying Ran, Meilin Jin, Huanchun Chen, Hongbo Zhou

“…However, its role in virus mRNA splicing is largely unknown. Here, we identify the m6A reader protein YTHDC1 as a host factor that associates with influenza A virus NS1 protein and modulates viral mRNA splicing. …”
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