Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation by Hanhan Shi, Peiwei Chai, Renbing Jia, Xianqun Fan

“…Most of these modifications contribute to pre-mRNA splicing, nuclear export, transcript stability and translation initiation in eukaryotic cells. …”
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RNAcontext: a new method for learning the sequence and structure binding preferences of RNA-binding proteins. by Hilal Kazan, Debashish Ray, Esther T Chan, Timothy R Hughes, Quaid Morris

“…These proteins regulate post-transcriptional gene expression and have critical roles in numerous cellular processes including mRNA splicing, export, stability and translation. Despite their ubiquity and importance, the binding preferences for most RBPs are not well characterized. …”
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Recognition and cleavage mechanism of intron-containing pre-tRNA by human TSEN endonuclease complex by Ling Yuan, Yaoyao Han, Jiazheng Zhao, Yixiao Zhang, Yadong Sun

“…Here we present a 3.2 Å-resolution cryo-EM structure of an active human tRNA splicing endonuclease complex bound to an intron-containing pre-tRNA. …”
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Age-Related Alternative Splicing: Driver or Passenger in the Aging Process? by Marco Baralle, Maurizio Romano

“…A greater understanding of how RNA splicing machinery and downstream targets are impacted by aging is essential to conclusively establish the role of splicing in driving aging, representing a promising area with key implications for understanding aging, developing novel therapeutical options, and ultimately leading to an increase in the healthy human lifespan.…”
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STAT5 as a Key Protein of Erythropoietin Signalization by Zuzana Tóthová, Jana Tomc, Nataša Debeljak, Peter Solár

“…The involvement of EPOR/JAK2/STAT5 in other processes such as mRNA splicing, cytoskeleton reorganization, and cell metabolism has been recently described. …”
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Effective RNA Regulation by Combination of Multiple Programmable RNA-Binding Proteins by Misaki Sugimoto, Akiyo Suda, Shiroh Futaki, Miki Imanishi

“…RNAs play important roles in gene expression through translation and RNA splicing. Regulation of specific RNAs is useful to understand and manipulate specific transcripts. …”
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Global donor and acceptor splicing site kinetics in human cells by Leonhard Wachutka, Livia Caizzi, Julien Gagneur, Patrick Cramer

“…RNA splicing is an essential part of eukaryotic gene expression. …”
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Cigarette smoke toxin hydroquinone and misfolding pancreatic lipase variant cooperatively promote endoplasmic reticulum stress and cell death by Norbert Kassay, Vanda Toldi, József Tőzsér, András Szabó

“…The more substantial viability loss was due to increased endoplasmic reticulum stress, as demonstrated by elevated levels of X-box binding protein 1 mRNA splicing and immunoglobulin binding protein, NAD(P)H:quinone oxidoreductase 1 and C/EBP homologous protein expression. …”
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Alternative splicing in the differentiation of human embryonic stem cells into cardiac precursors. by Nathan Salomonis, Brandon Nelson, Karen Vranizan, Alexander R Pico, Kristina Hanspers, Allan Kuchinsky, Linda Ta, Mark Mercola, Bruce R Conklin

“…Splice events for these groups corresponded to the pathways of cytoskeletal remodeling, RNA splicing, muscle specification, and cell cycle checkpoint control as well as genes with serine/threonine kinase and helicase activity. …”
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How Driver Oncogenes Shape and Are Shaped by Alternative Splicing Mechanisms in Tumors by Weronika Wojtyś, Magdalena Oroń

“…The development of RNA sequencing methods has allowed us to study and better understand the landscape of aberrant pre-mRNA splicing in tumors. Altered splicing patterns are observed in many different tumors and affect all hallmarks of cancer: growth signal independence, avoidance of apoptosis, unlimited proliferation, invasiveness, angiogenesis, and metabolism. …”
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The Role of Protein Arginine Methyltransferases in DNA Damage Response by Charles Brobbey, Liu Liu, Shasha Yin, Wenjian Gan

“…Protein arginine methyltransferases (PRMTs) either directly methylate DNA repair proteins or deposit methylation marks on histones to regulate their transcription, RNA splicing, protein stability, interaction with partners, enzymatic activities, and localization. …”
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Cell-specific exon methylation and CTCF binding in neurons regulate calcium ion channel splicing and function by Eduardo Javier López Soto, Diane Lipscombe

“…The mechanisms governing alternative splicing are known for relatively few genes and typically focus on RNA splicing factors. In sensory neurons, cell-specific alternative splicing of the presynaptic CaV channel Cacna1b gene modulates opioid sensitivity. …”
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Coordination of RNA Processing Regulation by Signal Transduction Pathways by Veronica Ruta, Vittoria Pagliarini, Claudio Sette

“…This review provides a broad overview of the post-translational regulation of factors involved in RNA processing events by signal transduction pathways, with particular focus on the regulation of pre-mRNA splicing, cleavage and polyadenylation. The effects of several post-translational modifications (i.e., sumoylation, ubiquitination, methylation, acetylation and phosphorylation) on the expression, subcellular localization, stability and affinity for RNA and protein partners of many RNA-binding proteins are highlighted. …”
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Targeted Therapy for EWS-FLI1 in Ewing Sarcoma by Helong Gong, Busheng Xue, Jinlong Ru, Guoqing Pei, Yan Li

“…In addition to its involvement in RNA splicing and the DNA damage response, this chimeric protein directly binds to GGAA repeats, thereby modifying the transcriptional profile of EwS. …”
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Specificity, synergy, and mechanisms of splice-modifying drugs by Yuma Ishigami, Mandy S. Wong, Carlos Martí-Gómez, Andalus Ayaz, Mahdi Kooshkbaghi, Sonya M. Hanson, David M. McCandlish, Adrian R. Krainer, Justin B. Kinney

“…Abstract Drugs that target pre-mRNA splicing hold great therapeutic potential, but the quantitative understanding of how these drugs work is limited. …”
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Comprehensive Transcriptome Analysis Reveals Genome-Wide Changes Associated with Endoplasmic Reticulum (ER) Stress in Potato (<i>Solanum tuberosum</i> L.) by Venura Herath, Jeanmarie Verchot

“…Limited genome-wide changes in alternative RNA splicing patterns of protein-coding transcripts were also discovered. …”
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The Influence of Arginine Methylation in Immunity and Inflammation by Srour N, Khan S, Richard S

“…Protein arginine methylation is known to regulate fundamental cellular processes, such as transcription; pre-mRNA splicing and other RNA processing mechanisms; signal transduction, including the anti-viral response; and cellular metabolism. …”
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Monovalent metal ion binding promotes the first transesterification reaction in the spliceosome by Jana Aupič, Jure Borišek, Sebastian M. Fica, Wojciech P. Galej, Alessandra Magistrato

“…A recent high-resolution structure of the spliceosome, essential for pre-mRNA splicing in eukaryotes, revealed a potassium ion in the active site. …”
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GBPL3 localizes to the nuclear pore complex and functionally connects the nuclear basket with the nucleoskeleton in plants. by Yu Tang, Man Ip Ho, Byung-Ho Kang, Yangnan Gu

“…Proximity labeling proteomics and protein-protein interaction assays revealed that GBPL3 is predominantly distributed at the NPC basket, where it physically associates with NB nucleoporins and recruits chromatin remodelers, transcription apparatus and regulators, and the RNA splicing and processing machinery, suggesting a conserved function of the NB in transcription regulation as reported in yeasts and animals. …”
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Understanding Flavivirus Capsid Protein Functions: The Tip of the Iceberg by Stephanea Sotcheff, Andrew Routh

“…Capsid may interact with host RNAs, resulting in altered RNA splicing and RNA transcription. Capsid may also bind short interfering-RNAs and has been proposed to sequester these species to protect flaviviruses from the invertebrate siRNA pathways. …”
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