Striking circadian neuron diversity and cycling of Drosophila alternative splicing by Qingqing Wang, Katharine C Abruzzi, Michael Rosbash, Donald C Rio

“…Although alternative pre-mRNA splicing (AS) significantly diversifies the neuronal proteome, the extent of AS is still unknown due in part to the large number of diverse cell types in the brain. …”
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Histone methyltransferase SETD2: An epigenetic driver in clear cell renal cell carcinoma by Mengxue Yu, Kaiyu Qian, Gang Wang, Gang Wang, Yu Xiao, Yu Xiao, Yuan Zhu, Lingao Ju, Lingao Ju

“…SET domain-containing 2 (SETD2) is a lysine methyltransferase that catalyzes histone H3 lysine36 trimethylation (H3K36me3) and has been revealed to play important roles in the regulation of transcriptional elongation, RNA splicing, and DNA damage repair. SETD2 mutations have been documented in several cancers, including clear cell renal cell carcinoma (ccRCC). …”
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Novel Insights into YB-1 Signaling and Cell Death Decisions by Aneri Shah, Jonathan A. Lindquist, Lars Rosendahl, Ingo Schmitz, Peter R. Mertens

“…YB-1 is a well-known transcriptional and translational regulator, involved in cell cycle progression, DNA damage repair, RNA splicing, and stress responses. Cell stress occurs in many forms, e.g., radiation, hyperthermia, lipopolysaccharide (LPS) produced by bacteria, and interferons released in response to viral infection. …”
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Mass spectrometry-based proteomic analysis to characterize cisplatin induced early signaling events in head and neck squamous cell carcinoma by Ankit P. Jain, Vivek Ghose, Srijon Munshi, Firdous A. Bhat, Gourav Dey, Vishalakshi Nanjappa

“…Bioinformatics analysis of differentially regulated proteins revealed proteins implicated in DNA damage bypass pathway, translation and mRNA splicing to be enriched. Further, proteins associated with cisplatin resistance exhibited alterations following short-term cisplatin exposure. …”
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<i>CDK12</i>: A Potent Target and Biomarker for Human Cancer Therapy by Shujing Liang, Lifang Hu, Zixiang Wu, Zhihao Chen, Shuyu Liu, Xia Xu, Airong Qian

“…It shows versatile roles in regulating gene transcription, RNA splicing, translation, DNA damage response (DDR), cell cycle progression and cell proliferation. …”
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Galectin-3 in Inflammasome Activation and Primary Biliary Cholangitis Development by Aleksandar Arsenijevic, Bojana Stojanovic, Jelena Milovanovic, Dragana Arsenijevic, Nebojsa Arsenijevic, Marija Milovanovic

“…Galectin-3 is a β-galactoside-binding lectin that plays important roles in various biological processes including cell proliferation, differentiation, transformation and apoptosis, pre-mRNA splicing, inflammation, fibrosis and host defense. …”
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Elucidating the role of RBM5 in osteoclastogenesis: a novel potential therapeutic target for osteoporosis by Yuyang Zhang, Xue Chen, Yuan Xiao, Yibo Mei, Tong Yang, Dongchen Li, Xiaohui Wang, Hao Yang, Dageng Huang, Dingjun Hao

“…Enrichment analysis showed that these genes were primarily involved in RNA splicing and osteoclast differentiation pathways. …”
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Endogenous Opioid Peptides and Alternatively Spliced Mu Opioid Receptor Seven Transmembrane Carboxyl-Terminal Variants by Anna Abrimian, Tamar Kraft, Ying-Xian Pan

“…The MOR gene, OPRM1, undergoes extensive alternative pre-mRNA splicing, generating multiple splice variants or isoforms. …”
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Neuronal Protection by Ha-RAS-GTPase Signaling through Selective Downregulation of Plasmalemmal Voltage-Dependent Anion Channel-1 by Sebastian Neumann, Konstantin Kuteykin-Teplyakov, Rolf Heumann

“…We observed a corresponding reduction in the levels of mRNA splicing variant coding for plasma membrane-targeted VDAC-1 (pl-VDAC-1) while mRNA levels for mitochondrial membrane VDAC-1 (mt-VDAC-1) remained constant. …”
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Large dynamics of a phase separating arginine-glycine-rich domain revealed via nuclear and electron spins by Giuseppe Sicoli, Daniel Sieme, Kerstin Overkamp, Mahdi Khalil, Robin Backer, Christian Griesinger, Dieter Willbold, Nasrollah Rezaei-Ghaleh

“…A highly dynamic cellular body with rapid component exchange is Cajal body (CB), which supports the extensive compositional dynamics of the RNA splicing machinery, spliceosome. Here, we select an arginine-glycine (RG)-rich segment of coilin, the major component of CB, establish its RNA-induced phase separation, and through combined use of nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) probes, interrogate its dynamics within the crowded interior of formed droplets. …”
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Friend or Foe? The fascinating Tudor-SN protein by Gao Xingjie, Xin Lingbiao, Yao Zhi, Silvennoinen Olli, Yang Jie

“…Under physiological conditions, Tudor-SN regulates DNA transcription, RNA splicing, RNA stability, RNA interference, and RNA editing, and it is essential for a series of cellular biological events, such as cell cycle progression, cell metabolism, and cell survival, in response to harmful stimuli; thus, Tudor-SN functions as a “friend” to the body. …”
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Genome-wide association between branch point properties and alternative splicing. by André Corvelo, Martina Hallegger, Christopher W J Smith, Eduardo Eyras

“…The branch point (BP) is one of the three obligatory signals required for pre-mRNA splicing. In mammals, the degeneracy of the motif combined with the lack of a large set of experimentally verified BPs complicates the task of modeling it in silico, and therefore of predicting the location of natural BPs. …”
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Novel GPR156 variants confirm its role in moderate sensorineural hearing loss by Memoona Ramzan, Nazim Bozan, Serhat Seyhan, Mohammad Faraz Zafeer, Aburrahman Ayral, Duygu Duman, Guney Bademci, Mustafa Tekin

“…The in silico predictions and a minigene assay showed that the c.600G > A variant disrupts mRNA splicing. This gene belongs to the family of G protein-coupled receptors whose function is not well established in the inner ear. …”
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RNA m6A Methylation Regulators Multi-Omics Analysis in Prostate Cancer by Hao Su, Yutao Wang, Hongjun Li

“…M6A modification has evident impacts on many aspects of RNA metabolism, just like RNA splicing, processing, translation, and stability. …”
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Correlation between LSM1 Expression and Clinical Outcomes in Glioblastoma and Functional Mechanisms by Changcheng Cai, Xingyu Chen, Jimin He, Chengwei Xiang, Yinggang Liu, Ke Wu, Ke Luo

“…Although the role of Like-Sm 1 (LSM1), a component of the mRNA splicing machinery, has been studied in various cancers, its significance in GBM remains unclear. …”
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Intractable epileptic spasms in a patient with Pontocerebellar hypoplasia: Severe phenotype of type 2 or another subtype? by Debopam Samanta, Erin Willis

“…Mutations in the tRNA splicing endonuclease complex (TSEN) 54 gene can be responsible for PCH type 2, 4 and 5. …”
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Mapping the Interactome of the Nuclear Heparan Sulfate Proteoglycan Syndecan-1 in Mesothelioma Cells by Ashish Kumar-Singh, Jatin Shrinet, Malgorzata Maria Parniewska, Jonas Fuxe, Katalin Dobra, Anders Hjerpe

“…In support of this, the top RNA splicing candidates were verified to interact with SDC1 by Co-IP and subsequent Western blot analysis. …”
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A putative frameshift variant in the CHM gene is associated with an unexpected splicing alteration in a choroideremia patient by Tiziana Fioretti, Silvana Ungari, Maria Savarese, Fabio Cattaneo, Enza Pirozzi, Gabriella Esposito

“…Herein we report an exonic frameshift variant associated with an mRNA splicing alteration that leads to a CHM hypomorphic allele. …”
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The rice blast fungus SR protein 1 regulates alternative splicing with unique mechanisms. by Wei Shi, Jun Yang, Deng Chen, Changfa Yin, Huixia Zhang, Xiaozhou Xu, Xiao Pan, Ruijin Wang, Liwang Fei, Mengfei Li, Linlu Qi, Vijai Bhadauria, Junfeng Liu, You-Liang Peng

“…However, they are largely unknown in regulating pre-mRNA splicing of filamentous fungi. Here we report that the SR protein MoSrp1 enhances and suppresses alternative splicing in a model fungal plant pathogen Magnaporthe oryzae. …”
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ITPKC polymorphism (rs7251246 T > C), coronary artery aneurysms, and thrombosis in patients with Kawasaki disease in a Southern Han Chinese population by Jie Liu, Piaoliu Yuan, Yusheng Pang, Danyan Su

“…In children with KD, the CC genotype showed lower mRNA levels of ITPKC (P=0.035).ConclusionThe ITPKC rs7251246 T&gt;C polymorphism may be a risk factor for CAA and thrombosis in children with KD in the Han Chinese population, likely due to differences in mature mRNA levels caused by interference of RNA splicing. Dual antiplatelet therapy for thrombosis is recommended for male children with the rs7251246 CC genotype.…”
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