Targeting pre-mRNA splicing in cancers: roles, inhibitors, and therapeutic opportunities by Shinsuke Araki, Momoko Ohori, Masato Yugami

“…Accumulating evidence has indicated that pre-mRNA splicing plays critical roles in a variety of physiological processes, including development of multiple diseases. …”
Get full text

Identification of host proteins differentially associated with HIV-1 RNA splice variants by Rachel Knoener, Edward Evans III, Jordan T Becker, Mark Scalf, Bayleigh Benner, Nathan M Sherer, Lloyd M Smith

Get full text

A Bayesian model for unsupervised detection of RNA splicing based subtypes in cancers by David Wang, Mathieu Quesnel-Vallieres, San Jewell, Moein Elzubeir, Kristen Lynch, Andrei Thomas-Tikhonenko, Yoseph Barash

“…RNA splicing variations could help identify cancer subtypes, but this task is computationally challenging. …”
Get full text

RNA editing regulates lncRNA splicing in human early embryo development. by Jiajun Qiu, Xiao Ma, Fanyi Zeng, Jingbin Yan

“…In addition, RNA editing was more likely to occur on RNA splicing sites during human early embryo development. …”
Get full text

Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice by Roman M Stilling, Gerard M Moloney, Feargal J Ryan, Alan E Hoban, Thomaz FS Bastiaanssen, Fergus Shanahan, Gerard Clarke, Marcus J Claesson, Timothy G Dinan, John F Cryan

Get full text

The kinetics of pre-mRNA splicing in the Drosophila genome and the influence of gene architecture by Henriques, Telmo, McCue, Kayla, Burkholder, Adam, Adelman, Karen, Pai, Athma A., Burge, Christopher B

Get full text
Get full text

A diversified and segregated mRNA spliced-leader system in the parasitic Perkinsozoa by Alacid, E, Irwin, NAT, Smilansky, V, Milner, DS, Kilias, ES, Leonard, G, Richards, TA

Towards understanding pre-mRNA splicing mechanisms and the role of SR proteins by Sahebi, Mahbod, Musa, Mohamed Hanafi, Wijnen, Andre J. van, Azizi, Parisa, Abiri, Rambod, Ashkani, Sadegh, Taheri, Sima

“…Alternative pre-mRNA splicing provides a source of vast protein diversity by removing non-coding sequences (introns) and accurately linking different exonic regions in the correct reading frame. …”
Get full text

Detecting and understanding meaningful cancerous mutations based on computational models of mRNA splicing by Nicolas Lynn, Tamir Tuller

Get full text

RNA splicing programs define tissue compartments and cell types at single-cell resolution by Julia Eve Olivieri, Roozbeh Dehghannasiri, Peter L Wang, SoRi Jang, Antoine de Morree, Serena Y Tan, Jingsi Ming, Angela Ruohao Wu, Tabula Sapiens Consortium, Stephen R Quake, Mark A Krasnow, Julia Salzman

Get full text

Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP by Andrea Pawellek, Ursula Ryder, Triin Tammsalu, Lewis J King, Helmi Kreinin, Tony Ly, Ronald T Hay, Richard C Hartley, Angus I Lamond

Subjects: Get full text

Abnormal Pre-mRNA Splicing in Exonic Fabry Disease-Causing GLA Mutations by Franziska Alfen, Elena Putscher, Michael Hecker, Uwe Klaus Zettl, Andreas Hermann, Jan Lukas

Get full text

Random genetic drift sets an upper limit on mRNA splicing accuracy in metazoans by Florian Bénitière, Anamaria Necsulea, Laurent Duret

Get full text

Gene expression and RNA splicing explain large proportions of the heritability for complex traits in cattle by Ruidong Xiang, Lingzhao Fang, Shuli Liu, Iona M. Macleod, Zhiqian Liu, Edmond J. Breen, Yahui Gao, George E. Liu, Albert Tenesa, Brett A. Mason, Amanda J. Chamberlain, Naomi R. Wray, Michael E. Goddard

Subjects: Get full text

Biology of the mRNA Splicing Machinery and Its Dysregulation in Cancer Providing Therapeutic Opportunities by Maxime Blijlevens, Jing Li, Victor W. van Beusechem

“…Dysregulation of messenger RNA (mRNA) processing—in particular mRNA splicing—is a hallmark of cancer. Compared to normal cells, cancer cells frequently present aberrant mRNA splicing, which promotes cancer progression and treatment resistance. …”
Get full text

Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing by Kavi Gupta, Chenxi Yang, Kayla McCue, Osbert Bastani, Phillip A. Sharp, Christopher B. Burge, Armando Solar-Lezama

Get full text

Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoter by Veenu Tripathi, Ying E. Zhang

“…Our recent discovery of SMAD3-PCBP1 complex with direct RNA-binding properties has shed light on how this conversion is implemented by controlling pre-mRNA splicing patterns.…”
Get full text

The Heterochromatin protein 1 is a regulator in RNA splicing precision deficient in ulcerative colitis by Jorge Mata-Garrido, Yao Xiang, Yunhua Chang-Marchand, Caroline Reisacher, Elisabeth Ageron, Ida Chiara Guerrera, Iñigo Casafont, Aurelia Bruneau, Claire Cherbuy, Xavier Treton, Anne Dumay, Eric Ogier-Denis, Eric Batsché, Mickael Costallat, Gwladys Revêchon, Maria Eriksson, Christian Muchardt, Laurence Arbibe

“…This study reports reduced expression of the chromatin and splicing regulator HP1γ in inflammatory bowel disease (IBD) and shows that HP1γ protects against pervasive RNA splicing leading to toxic mRNA products detected in IBD, like progerin.…”
Get full text

Phase separation of Arabidopsis EMB1579 controls transcription, mRNA splicing, and development. by Yiling Zhang, Zhankun Li, Naizhi Chen, Yao Huang, Shanjin Huang

“…Tight regulation of gene transcription and mRNA splicing is essential for plant growth and development. …”
Get full text

Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing by Gupta, Kavi, Yang, Chenxi, McCue, Kayla, Bastani, Osbert, Sharp, Phillip A., Burge, Christopher B., Solar-Lezama, Armando

Get full text