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Dysregulation of RNA Splicing in Tauopathies
Published 2019-12-01“…Summary: Pathological aggregation of RNA binding proteins (RBPs) is associated with dysregulation of RNA splicing in PS19 P301S tau transgenic mice and in Alzheimer’s disease brain tissues. …”
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RNA splicing: disease and therapy.
Published 2011“…The majority of human genes that encode proteins undergo alternative pre-mRNA splicing and mutations that affect splicing are more prevalent than previously thought. …”
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Therapeutic Targeting of RNA Splicing in Cancer
Published 2023-06-01“…RNA splicing is a key regulatory step in the proper control of gene expression. …”
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RNA Splicing in Cancer and Targeted Therapies
Published 2023-10-01“…Since the discovery of RNA splicing as a fundamental step to remove introns from pre-mRNA to produce mature mRNAs, substantial research in the past decades has highlighted RNA splicing as a critical mediator of gene expression and proteome diversity, also being important in many developmental and biological processes [...]…”
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RNA splicing is responsive to MBNL1 dose.
Published 2012-01-01“…In DM1 expanded CUG repeat RNAs form hairpin secondary structures that bind and aberrantly sequester the RNA splice regulator, MBNL1. RNA splice defects resulting as a consequence of MBNL1 depletion have been shown to play a key role in the development of DM1 pathology. …”
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Alternative RNA Splicing in Fatty Liver Disease
Published 2021-02-01Subjects: “…RNA splicing…”
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Phosphorylation mediated regulation of RNA splicing in plants
Published 2023-09-01Subjects: Get full text
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RNA Splicing of FLC Modulates the Transition to Flowering
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Oncogenes and RNA splicing of human tumor viruses
Published 2014-01-01“…Infection with a tumor virus affects the expression of host genes, including host RNA splicing factors, which play a key role in regulating viral RNA splicing of oncogene transcripts. …”
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Aberrant RNA Splicing in Cancer and Drug Resistance
Published 2018-11-01“…More than 95% of the 20,000 to 25,000 transcribed human genes undergo alternative RNA splicing, which increases the diversity of the proteome. …”
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Learning alternative RNA splicing with applications to mutagenesis
Published 2022“…Alternative RNA splicing is the process by which a single gene generates a large diversity of transcripts, but how the DNA sequence results in particular transcript abundances remains incompletely known. …”
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Alternative mRNA Splicing and Promising Therapies in Cancer
Published 2023-03-01Subjects: “…alternative mRNA splicing…”
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