An updated examination of the perception of barriers for pharmacogenomics implementation and the usefulness of drug/gene pairs in Latin America and the Caribbean by Aimeé Salas-Hernández, Macarena Galleguillos, Matías Carrasco, Andrés López-Cortés, María Ana Redal, Dora Fonseca-Mendoza, Patricia Esperón, Farith González-Martínez, Ismael Lares-Asseff, Alberto Lazarowski, Verónica Loera-Castañeda, Diadelis Remírez, Matías F. Martínez, Matías F. Martínez, Rodrigo Vargas, Fabricio Rios-Santos, Antonio Macho, Juan P. Cayún, Germán R. Perez, Carolina Gutierrez, Leslie C. Cerpa, Tamara Leiva, Susan Calfunao, Susan Calfunao, Lesly Xajil, Christopher Sandoval, Christopher Sandoval, Marcelo Suárez, Marcelo Suárez, Ariana Gonzalez, Gabriela Echeverría-Garcés, Luis Sullón-Dextre, Eugenia Cordero-García, Alexis R. Morales, Andrea Avendaño, Enrique Sánchez, Laura C. Bastone, Cesar Lara, Patricia Zuluaga-Arias, Ana María Soler, Julio Da Luz, Gabriela Burgueño-Rodríguez, Marcelo Vital, Elizabeth Reyes-Reyes, Alexander Huaccha, Yeimy V. Ariza, Naomi Tzul, Ana L. Rendón, Roberto Serrano, Larissa Acosta, Angelo Motta-Pardo, Leonardo Beltrán-Angarita, Leonardo Beltrán-Angarita, Erika Brand, Miguel A. Jiménez, Gladys Maribel Hidalgo-Lozada, Marina M. J. Romero-Prado, Karla Escobar-Castro, Mariel Umaña-Rivas, Juan D. Vivas, Paola Lagos, Yineth Ballén Martínez, Sharleth Quesada, Camila Calfio, Maria L. Arias, María A. Lavanderos, Dante D. Cáceres, Alberto Salazar-Granara, Nelson M. Varela, Luis A. Quiñones, Luis A. Quiñones

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Voxel based BED and EQD2Evaluation of the radiotherapy treatment plan by Gaganpreet Singh, Arun S Oinam, Rose Kamal, Bhumika Handa, Vivek Kumar, Bhavana Rai

“…Aims and Objective: The purpose of the present study is the development and implementation of radiobiological evaluation of the radiotherapy treatment plan incorporating the tissue-specific radiobiological parameters. …”
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Stereotactic inverse dose planning following yttrium-90 selective internal radiotherapy in hepatocellular cancer by Abbott, EM, Young, R, Hale, C, MItchell, K, Falzone, N, Vallis, K, Kennedy, A

“…A framework with radiobiological modelling was developed to manage the combined treatments in terms of their sum BED. …”

Updated Mortality Analysis of SELTINE, the French Cohort of Nuclear Workers, 1968–2014 by Olivier Laurent, Eric Samson, Sylvaine Caër-Lorho, Lucie Fournier, Dominique Laurier, Klervi Leuraud

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FAST NEUTRON THERAPY FOR CANCER PATIENTS by L. I. Musabaeva, V. M. Golovkov

“…The review presents the 30-year experience of using fast neutron therapy for patients with cancer of various sites. Radiobiological aspects of neutron fast therapy are analyzed.…”
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Architecture, flexibility and performance of a special electron linac dedicated to Flash radiotherapy research: electronFlash with a triode gun of the centro pisano flash radiother... by F. Di Martino, F. Di Martino, F. Di Martino, D. Del Sarto, D. Del Sarto, D. Del Sarto, G. Bass, S. Capaccioli, S. Capaccioli, M. Celentano, M. Celentano, D. Coves, A. Douralis, M. Marinelli, M. Marrale, M. Marrale, M. Marrale, L. Masturzo, L. Masturzo, G. Milluzzo, M. Montefiori, M. Montefiori, F. Paiar, F. Paiar, J. H. Pensavalle, J. H. Pensavalle, L. Raffaele, F. Romano, A. Subiel, E. Touzain, G. Verona Rinati, G. Felici

“…The FLASH effect is a radiobiological phenomenon that has garnered considerable interest in the clinical field. …”
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Status of charged particle microbeams for radiation biology by Folkard, M, Prise, K, Vojnovic, B

“…The Gray Cancer Institute is one of a small number of laboratories worldwide routinely using particle microbeam techniques for radiobiological applications. Cellular micro-irradiation methods have been used to provide experimental opportunities not possible with typical broad-field irradiation methods. …”

Immunologic changes after diode laser inferior turbinoplasty in allergic rhinitis by Hazem M. A. Saleh, Dalia R. Ibrahim, Michael I. Michael, Amal M. Kamal, Ahmed M. El-Kharbotly, Mervate M. Bahgat

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Evaluation of Epigenetic and Radiomodifying Effects during Radiotherapy Treatments in Zebrafish by Gaia Pucci, Giusi Irma Forte, Vincenzo Cavalieri

“…This review aims to provide the literature state of the art of zebrafish in vivo model for radiobiological studies, particularly focusing on the epigenetic and radiomodifying effects produced during fish embryos’ and larvae’s exposure to radiotherapy treatments.…”
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Mechanistic Modelling of DNA Damage Repair by the Radiation Adaptive Response Mechanism and Its Significance by Łukasz Piotrowski, Julianna Krasowska, Krzysztof W. Fornalski

“…This can be observed in dedicated radiobiological experiments, e.g., where the small priming dose of ionising radiation is given before the high challenging one (the so-called Raper–Yonezawa effect). …”
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Analysis of correspondence between the current individual monitoring system of internal exposure caused by plutonium intake and the relevant ICRP recommendations by A. B. Sokolova, A. V. Efimov, A. B. Dzhunushaliev

“…It was found that following the introduction of new requirements of the International Commission on Radiobiological Protection for Type M compounds, an intake of more than 1/4 of annual limit of plutonium intake could be determined within a year after intake using the method of alpha spectrometry. …”
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Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review by Bolland, H, Ma, T, Ramlee, S, Ramadan, K, Hammond, E

“…Hypoxia is a feature of most solid tumours and predicts for poor prognosis. In radiobiological hypoxia (<0.1% O2) cells become up to three times more resistant to radiation. …”

Imaging Biomarkers of Tumour Proliferation and Invasion for Personalised Lung Cancer Therapy by Loredana G. Marcu

“…Personalised treatment in oncology has seen great developments over the last decade, due to both technological advances and more in-depth knowledge of radiobiological processes occurring in tumours. Lung cancer therapy is no exception, as new molecular targets have been identified to further increase treatment specificity and sensitivity. …”
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Dosimetric Optimization of a Laser-Driven Irradiation Facility Using the G4-ELIMED Application by Sergio Mingo Barba, Francesco Schillaci, Roberto Catalano, Giada Petringa, Daniele Margarone, Giuseppe Antonio Pablo Cirrone

“…This paper aims to investigate the feasibility to perform radiobiological experiments using laser-accelerated proton beams with intermediate energies (up to 30 MeV). …”
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FLASH Radiotherapy: Expectations, Challenges, and Current Knowledge by Andrea Borghini, Luca Labate, Simona Piccinini, Costanza Maria Vittoria Panaino, Maria Grazia Andreassi, Leonida Antonio Gizzi

“…We also highlight the ongoing developments of technologies for delivering FLASH-compliant beams, with a focus on laser-driven plasma accelerators suitable for performing basic radiobiological research on the UHDR effects.…”
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Fast and Furious: Fast Neutron Therapy in Cancer Treatment by Konstantin Gordon, PhD, Igor Gulidov, PhD, Timur Fatkhudinov, PhD, Sergey Koryakin, PhD, Andrey Kaprin, PhD

“…This mini-review recalls the history of medical research on fast neutrons, considers their physical and radiobiological properties alongside their benefits for cancer treatment, and discusses their place in modern radiation oncology.…”
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Analysing Tumour Growth Delay Data from Animal Irradiation Experiments with Deviations from the Prescribed Dose by Leonhard Karsch, Elke Beyreuther, Doreen Eger Passos, Jörg Pawelke, Steffen Löck

“…Exemplarily, the necessary radiobiological experiments with laser-accelerated electrons are challenged by fluctuating beam intensities. …”
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Intrinsic Radiosensitivity Is Not the Determining Factor in Treatment Response Differences between HPV Negative and HPV Positive Head and Neck Cancers by Paul Reid, Alexander H. Staudacher, Loredana G. Marcu, Ian Olver, Leyla Moghaddasi, Michael P. Brown, Yanrui Li, Eva Bezak

“…As a group, the HPV positive cell lines were more radiosensitive, but with changes following repeated fractions of dose, and modelling of response as a function of dose, both statuses displayed large radiobiological heterogeneity. These findings challenge current radiobiological assumptions of head and neck cancers as early responding tissue to radiation and may go some way in explaining difficulties reaching consensus in stratification of treatment by HPV status. …”
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New insights on clinical perspectives of FLASH radiotherapy: from low- to very high electron energy by Stefano Ursino, Stefano Ursino, Stefano Ursino, Giovanni Gadducci, Giovanni Gadducci, Noemi Giannini, Noemi Giannini, Alessandra Gonnelli, Alessandra Gonnelli, Taiushia Fuentes, Taiushia Fuentes, Fabio Di Martino, Fabio Di Martino, Fabiola Paiar, Fabiola Paiar, Fabiola Paiar

“…Although several physical, dosimetric, and radiobiological aspects need to be clarified, current preclinical “in vivo” studies have reported a significant protective effect of FLASH RT on neurocognitive function, skin toxicity, lung fibrosis, and bowel injury. …”
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The Role of Particle Therapy in Adenoid Cystic Carcinoma and Mucosal Melanoma of the Head and Neck by Daniel K. Ebner, MD, MPH, Timothy D. Malouff, MD, Steven J. Frank, MD, Masashi Koto, MD, PhD

“…Particle irradiation is suitable for resistant histologies owing to a combination of improved dose delivery with potential radiobiologic advantages in high linear energy transfer radiation. …”
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